Analytical Chemistry Lab



The Analytical Chemistry Lab develops or adopts validated methods for the quantification of drugs, their metabolites, and endogenous compounds in biological samples (isolated cells, body fluids, or tissue specimens of animal or human origin) to address pharmacokinetic, pathophysiological, and toxicological questions. Particular emphasis is put on efficient development processes and on the adherence to international validation standards (e.g. FDA- and EMA-approved criteria).




Jürgen Burhenne, PhD
Scientific Staff:

Margaux Fresnais, PhD
Max Sauter
Dr. rer. net. Philip Uhl

Technical Staff:Andrea Deschlmayr
Kevin Jansen
Magdalena Longo

Doctoral Students:

Yeliz Enderle, Pharmacist
Kathrin Foerster, Pharmacist
Manuela Vay, Pharmacist


Therapeutic Drug Monitoring (TDM)

The Department analyzes voriconazole plasma concentrations for the University Hospital and for external clients. Quality assurance involves participation in interlaboratory comparison programmes.


Initiates file downloadTDM Voriconazol (Vfend®) - TDM order form


In support of the Heidelberg Reference Lab for Pulmonary Arterial Hypertension (PAH), the department analyses patient samples for TDM for ambrisentan, bosentan, macitentan, sildenafil, tadalafil.


TDM Pulmonary Arterial Hypertension -TDM order form


The Department analyzes direct oral anticoagulant (dabigatran, rivaroxaban, apixaban, and edoxaban) plasma concentrations for the University Hospital and for external clients.


 Initiates file downloadTDM Direct Oral Anticoagulant - TDM order form


Research topics


Methods and equipment

Within the research topics, different analytical and extraction techniques will be applied. These methods are based on chromatography and mass spectrometry, and various processing techniques, including protein precipitation, solid phase extraction, and liquid/liquid extraction.

Besides others, the following analyses are frequently performed in clinical trials:

Instrumental analysis

Lab standards