Originalarbeiten (aktuelle Auswahl)

Inhibition of cardiac Kv4.3 (Ito) channel isoforms by class I antiarrhythmic drugs lidocaine and mexiletine.
Rahm AK, Müller ME, Gramlich D, Lugenbiel P, Uludag E, Rivinius R, Ullrich ND, Schmack B, Ruhparwar A, Heimberger T, Weis T, Karck M, Katus HA, Thomas D. Rahm AK, et al. Eur J Pharmacol. 2020 Apr 29;880:173159. doi: 10.1016/j.ejphar.2020.173159. Online ahead of print.

Pacemaker cell characteristics of differentiated and HCN4-transduced human mesenchymal stem cells.
Darche FF, Rivinius R, Köllensperger E, Leimer U, Germann G, Seckinger A, Hose D, Schröter J, Bruehl C, Draguhn A, Gabriel R, Schmidt M, Koenen M, Thomas D, Katus HA, Schweizer PA.Darche FF, et al. Among authors: Thomas D. Life Sci. 2019 Sep 1;232:116620. doi: 10.1016/j.lfs.2019.116620. Epub 2019 Jul 7.
 
Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cells.
Schweizer PA, Darche FF, Ullrich ND, Geschwill P, Greber B, Rivinius R, Seyler C, Müller-Decker K, Draguhn A, Utikal J, Koenen M, Katus HA, Thomas D.
 
Inhibition of Histone Deacetylases Induces K+ Channel Remodeling and Action Potential Prolongation in HL-1 Atrial Cardiomyocytes.
Lugenbiel P, Govorov K, Rahm AK, Wieder T, Gramlich D, Syren P, Weiberg N, Seyler C, Katus HA, Thomas D.Lugenbiel P, et al. Among authors: Thomas D. Cell Physiol Biochem. 2018;49(1):65-77. doi: 10.1159/000492840. Epub 2018 Aug 22.
 
Feasibility Study on Cardiac Arrhythmia Ablation Using High-Energy Heavy Ion Beams.
Lehmann HI, Graeff C, Simoniello P, Constantinescu A, Takami M, Lugenbiel P, Richter D, Eichhorn A, Prall M, Kaderka R, Fiedler F, Helmbrecht S, Fournier C, Erbeldinger N, Rahm AK, Rivinius R, Thomas D, Katus HA, Johnson SB, Parker KD, Debus J, Asirvatham SJ, Bert C, Durante M, Packer DL.Lehmann HI, et al. Among authors: Rahm AK. Sci Rep. 2016 Dec 20;6:38895. doi: 10.1038/srep38895.

Bikou O*, Thomas D*, Trappe K, Lugenbiel P, Kelemen K, Koch M, Soucek R, Voss F, Becker R, Katus HA, Bauer A (2011) Connexin 43 gene therapy prevents persistent atrial fibrillation in a porcine model. Cardiovasc Res 92: 218-225

Duhme N*, Schweizer PA*, Thomas D, Becker R, Schröter J, Barends TR, Schlichting I, Draguhn A, Bruehl C, Katus HA, Koenen M (2013) Altered HCN4 channel C-linker interaction is associated with familial tachycardia-bradycardia syndrome and atrial fibrillation. Eur Heart J 34: 2768-2775

Li J, Seyler C, Wiedmann F, Schmidt C, Schweizer PA, Becker R, Katus HA, Thomas D (2013) Anti-KCNQ1 K+ channel autoantibodies increase IKs current and are associated with QT interval shortening in dilated cardiomyopathy. Cardiovasc Res 98: 496-503

Li J, Franke J, Pribe-Wolferts R, Meder B, Ehlermann P, Mereles D, Andre F, Abdelrazek MA, Merten C, Schweizer PA, Becker R, Katus HA, Thomas D (2015) Effects of β-blocker therapy on electrocardiographic and echocardiographic characteristics of left ventricular noncompaction. Clin Res Cardiol 104: 241-249

Lugenbiel P, Bauer A, Kelemen K, Schweizer PA, Becker R, Katus HA, Thomas D (2012) Biological heart rate reduction through genetic suppression of Gαs protein in the sinoatrial node. J Am Heart Assoc 1: jah3-e000372

Lugenbiel P*, Thomas D*, Kelemen K, Trappe K, Bikou O, Schweizer PA, Voss F, Becker R, Katus HA, Bauer A (2012) Genetic suppression of Gαs protein provides rate control in atrial fibrillation. Basic Res Cardiol 107: 1-12

Schmidt C, Wiedmann F, Langer C, Tristram F, Anand P, Wenzel W, Lugenbiel P, Schweizer PA, Katus HA, Thomas D (2014) Cloning, functional characterization and remodeling of K2P3.1 (TASK-1) potassium channels in a porcine model of atrial fibrillation and heart failure. Heart Rhythm 11: 1798-1805

Schweizer PA*, Duhme N*, Thomas D, Becker R, Zehelein J, Draguhn A, Bruehl C, Katus HA, Koenen M (2010) cAMP sensitivity of HCN pacemaker channels determines basal heart rate but is not critical for autonomic rate control. Circ Arrhythm Electrophysiol 3: 542-552

Schweizer PA, Schröter J, Greiner S, Haas J, Yampolsky P, Mereles D, Buss SJ, Seyler C, Bruehl C, Draguhn A, Koenen M, Meder B, Katus HA, Thomas D (2014) The symptom complex of familial sinus node dysfunction and myocardial non-compaction is associated with mutations in the HCN4 channel. J Am Coll Cardiol 64: 757-767

Schmidt C, Wiedmann F, Voigt N, Zhou XB, Heijman J, Lang S, Albert V, Kallenberger S, Ruhparwar A, Szabo G, Kallenbach K, Karck M, Borggrefe M, Biliczki P, Ehrlich JR, Baczko I, Lugenbiel P, Schweizer PA, Donner B, Katus HA, Dobrev D, Thomas D (2015) Upregulation of K2P3.1 K+ current causes action potential shortening in patients with chronic atrial fibrillation. Circulation 132: 82-92

Soucek R*, Thomas D*, Kelemen K, Bikou O, Seyler C, Voss F, Becker R, Koenen M, Katus HA, Bauer A (2012) Genetic suppression of atrial fibrillation using a dominant-negative ether-a-go-go-related gene mutant. Heart Rhythm 9: 265-272

Thomas D, Plant LD, Wilkens CM, McCrossan ZA, Goldstein SAN (2008) Alternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodium. Neuron 58: 859-870

Trappe K*, Thomas D*, Bikou O, Kelemen K, Lugenbiel P, Voss F, Becker R, Katus HA, Bauer A (2013) Suppression of persistent atrial fibrillation by genetic knockdown of caspase 3 – a preclinical pilot study. Eur Heart J 34: 147-157

Zylla MM, Pohlmeier M, Hess A, Mereles D, Kieser M, Bruckner T, Scholz E, Zitron E, Schweizer PA, Katus HA, Thomas D (2015) Prevalence of intracardiac thrombi under phenprocoumon, direct oral anticoagulants (dabigatran, rivaroxaban) and bridging therapy in patients with atrial fibrillation and flutter. Am J Cardiol 115: 635-640 

Übersichtsartikel (aktuelle Auswahl)

Role of ion channels in heart failure and channelopathies.
Rahm AK, Lugenbiel P, Schweizer PA, Katus HA, Thomas D.Rahm AK, et al. Biophys Rev. 2018 Aug;10(4):1097-1106. doi: 10.1007/s12551-018-0442-3. Epub 2018 Jul 17.

Hancox JC, James AF, Marrion NV, Zhang H, Thomas D (2016) Novel ion channel targets in atrial fibrillation. Expert Opin Ther Targets, doi: 10.1517/14728222.2016.1159300

Schmidt C*, Kisselbach J*, Schweizer PA, Katus HA, Thomas D (2011) The pathology and treatment of cardiac arrhythmias: Focus on atrial fibrillation. Vasc Health Risk Manag 7: 193-202

Schmidt C, Wiedmann F, Schweizer PA, Katus HA, Thomas D (2012) Kardiale Zwei-Porendomänen-Kaliumkanäle (K2P): Physiologie, Pharmakologie und therapeutisches Potenzial. Dtsch Med Wochenschr 137: 1654-1658

Schmidt C, Wiedmann F, Schweizer PA, Katus HA, Thomas D (2014) Inhibition of cardiac two-pore-domain K+ (K2P) channels – an emerging antiarrhythmic concept. Eur J Pharmacol 738: 250-255

Thomas D, Eckardt L, Estner HL, Kuniss M, Meyer C, Neuberger HR, Sommer P, Steven D, Voss F, Bonnemeier H (2016) Typisches Vorhofflattern - Diagnostik und Therapie. Herzschrittmacherther Elektrophysiol, doi: 10.1007/s00399-016-0413-y