Publications 2012

Ali R, Campos B, Dyckhoff G, Haefeli WE, Herold-Mende C, Burhenne J. Quantification of retinoid concentrations in human serum and brain tumor tissues. Anal Chim Acta 2012;725:57-66.


Baker U, Tomson G, Somé M, Kouyaté B, Williams J, Mpembeni R, Massawe S, Blank A, Gustafsson LL, Eriksen J. 'How to know what you need to do’: a cross-country comparison of maternal health guidelines in Burkina Faso, Ghana and Tanzania. Implement Sci 2012;7:31:1-13.


Bertsche T, Nachbar M, Fiederling J, Schmitt SPW, Kaltschmidt J, Seidling HM, Haefeli WE. Assessment of a computerised decision support system for allergic rhino-conjunctivitis counselling in German pharmacy. Int J Clin Pharm 2012;34:17-22


Billing H, Sommerer C, Giese T, Zeier M, Meuer S, Czock D, Tönshoff B. Increased cyclosporin A sensitivity in vivo in pediatric renal transplant recipients compared to adults. Ther Drug Monit 2012;34:554-60.


Burhenne J. Bioanalytical Method Validation. J Anal Bioanal Techniques 2012;3:e111. Editorial.


Burhenne J, Scope A. Evaluation of the influence of formulation, food intake, and species on voriconazole plasma concentration in birds. Vet Med Austria 2012;99:157-62.


Burhenne J, Halama B, Maurer M, Riedel K-D, Hohmann N, Mikus G, Haefeli WE. Quantification of femtomolar concentrations of the CYP3A substrate midazolam and its main metabolite 1'-hydroxymidazolam in human plasma using ultra-performance liquid chromatography coupled to tandem mass spectrometry. Anal Bioanal  Chem 2012;402:2439-50.


Carow F, Rieger K, Walter-Sack I, Meyer MR, Peters FT, Maurer HH, Haefeli WE. Objective assessment of nonadherence and unknown co-medication in hospitalized patients. Eur J Clin Pharmacol 2012;68:1191-9.


Czock D, Keller F, Seidling H. Pharmacokinetic predictions for patients with renal impairment: focus on peptides and protein drugs. Br J Clin Pharmacol 2012;74:66-74.


Erler A, Beyer M, Petersen JJ, Saal K, Rath T, Rochon J, Haefeli WE, Gerlach FM. How to improve drug dosing for patients with renal impairment in primary care - a cluster-randomized controlled trial. BMC Fam Pract 2012;13:91.


Grün B, Merkel U, Riedel KD, Weiss J, Mikus G. Contribution of CYP2C19 and CYP3A4 to the formation of the active nortilidine from the prodrug tilidine. Br J Clin Pharmacol 2012;74:854-63.


Haefeli WE. Polypharmazie: Therapien durchführbar machen und regelmäßig prüfen. Druckpunkt 2012;1:20-23.


Keubler A, Weiss J, Haefeli WE, Mikus G, Burhenne J. Drug interaction of efavirenz and midazolam: Efavirenz activates the CYP3A-mediated midazolam 1'-hydroxylation in vitro. Drug Metab Dispos 2012;40:1178-82.


Kleber CJ, Spiess A, Kleber JB, Hinz U, Holland-Cunz S, Weiss J. Urinary matrix metalloproteinases-2/9 in healthy infants and haemangioma patients prior to and during propranolol therapy. Eur J Pediatr 2012;171:941-6.


Mahler C, Hermann K, Janke S. Haefeli WE, Szecsenyi J. Can a feedback report and training on medication counseling for general practitioners improve patient satisfaction with information on medicines? Patient Prefer Adherence 2012;6:179-86.


Mahler C, Hermann K, Horne R, Jank S, Haefeli WE, Szecsenyi J. Patients' beliefs about medicines in a primary care setting in Germany. J Eval Clin Pract 2012;18:409-13.


Maxwell S, Eichler H-G, Busics A, Haefeli WE, Gustafsson LL. e-SPC - delivering drug information in the 21st century: developing new approaches to deliver drug information to prescribers. Br J Clin Pharmacol 2012;73:12-5.


Mugusi S, Ngaimisi E, Janabi M, Minzi O, Bakari M, Riedel KD, Burhenne J, Lindquist L, Mugusi F, Sandstrom E, Eklillu E. Liver enzyme abnormalities and associated risk factors in HIV patients on efavirenz-based HAART with or without tuberculosis co-infection in Tanzania. PloS One 2012;7:e40180.


Niethammer AG, Lubenau H, Mikus G, Hohmann N, Leowardi C, Beckhove P, Akhisaroglu M, Ge Y, Springer M, Grenacher L, Buchler MW, Koch M, Weitz J, Haefeli WE, Schmitz-Winnenthal FH. Double-blind, placebo-controlled first in human study to investigate an oral vaccine aimed to elicit an immune reaction against the VEGF-Receptor 2 in patients with stage IV and locally advanced pancreatic cancer. BMC Cancer 2012;12:361.


Pruszydlo MG, Walk-Fritz SU, Hoppe-Tichy T, Kaltschmidt J, Haefeli WE. Development and evaluation of a computerised clinical decision support system for switching drugs at the interface between primary and tertiary care. BMC Med Inform Decis Mak 2012;12:137.


Rigalli JP, Perdomo VG, Luquita MG, Villanueva SSM, Arias A, Theile D, Weiss J, Mottino AD, Ruiz ML, Catania VA. Regulation of Biotransformation Systems and ABC Transporters by Benznidazole in HepG2 Cells: Involvement of Pregnane X-Receptor. Plos Negl Trop Dis 2012;6:e1951.


Rother A, Glander P, Vitt E, Czock D, von Ahsen N, Armstrong VW, Oellerich M, Budde K, Feneberg R, Tönshoff B, Weber LT. Iosine monophosphate dehydrogenase activity in paediatrics: age-related regulation and response to mycophenolic acid. Eur J Clin Pharmacol 2012;68:913-22.


Theile D, Detering J-C, Herold-Mende C, Dyckhoff G, Haefeli WE. Weiss J, Burhenne J. Cellular pharmacokinetic/pharmacodynamic relationship of platinum cytostatics in head and neck squamous cell carcinoma evaluated by liquid chromatography coupled to tandem mass spectrometry. J Pharmacol Exp Ther 2012; J Pharmacol Exp Ther 2012;341:51-8.


Weiss J, Theile D, Haefeli WE. Rifampicin alters the expression of reference genes used to normalize real-time quantitative RT-PCR data. Naunyn-Schmiedebergs Arch Pharmacol 2012;385:1025-34


Weiss J, Fränkl SA, Flammer J, Grieshaber MC, Hollo G, Teuchner B, Haefeli WE. No difference in genotype frequencies of polymorphisms of the nitric oxide pathway between Caucasian normal and high tension glaucoma patients. Mol Vis 2012;18:2174-81.


Witticke D, Seidling HM, Klimm HD, Haefeli WE. Do we prescribe what patients prefer? A pilot study to assess patients' preferences for medication regimen characteristics. Patient Prefer Adherence 2012;6:679-84.


Wustrow I, Riedel K-D, Mikus G, Weiss J. In vitro identification of the cytochrome P450 isozymes involved in the N-demethylation of the active opiod metabolite nortilidine to bisnortilidine. Naunyn-Schmiedebergs Arch Pharmacol 2012;385:633-9.


Yimer G, Amogne W, Habtewold A, Makonnen E, Ueda N, Suda A, Worku A, Haefeli WE, Burhenne J, Aderaye G, Lindquist L, Aklillu E. High plasma efavirenz level and CYP2B*6 are associated with efavirenz-based HAART-induced liver injury in treatment of naïve HIV patients from Ethiopia: a prospective cohort study. Pharmacogenomics J 2012;12:499-506.


Zembruski NCL, Stache V, Haefeli WE, Weiss J. 7-Aminoactinomycin D for apoptosis staining in flow cytometry. Anal Biochem 2012;429:79-81.



Book Chapters

Konias M, Kaltschmidt J, Green K, Seidling HM, Haefeli WE. Entscheidungsunterstützung bei der medikamentösen Therapie älterer Patienten. In: Duesberg F, editor. e-Health 2012. Solingen: medical future verlag; 2012.


Blank A, Kaltschmidt J, Krings A,  Loukanova S,  Sauerborn R, Haefeli WE. e-Health in Afrika: Chancen eines Clinical Decision Support Systems in der medizinischen Grundversorgung im ländlichen Afrika. In: Duesberg F, editor. e-Health 2013. Solingen: medical future verlag; 2013.