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Brain tumors


I.  Brain tumor research

The Pediatric Brain Tumors unit aims at translating the latest research findings on the formation and growth of brain tumors in children and adolescents into new treatment concepts of a personalized and specific therapy. To this end the unit cooperates closely with the Opens external link in new windowDivision of Pediatric Neurooncology and Opens external link in new windowCCU Pediatric Oncology of the German Cancer Research Center. The development and implementation of clinical phase I-III studies with innovative treatment concepts is another priority of this unit that is implemented in cooperation with the Opens external link in new windowTrial Center of the National Center for Tumor Diseases .

 

Cooperation partners in this research area are the Division of Pediatric Neurooncology, DKFZ: Stefan Pfister (department head), and the CCU Pediatric Oncology: Olaf Witt (department head), Till Milde (group leader)


II.  Staff

Olaf Witt
Stefan Pfister
Till Milde
Hendrik Witt
Ruth Witt
Pascal Johann
Cornelis van Tilburg


and the staff of the Opens external link in new windowDivision of Pediatric Neurooncology/DKFZ and the Opens external link in new windowCCU Pediatric Oncology/DKFZ.

III. Project funding

Opens external link in new windowAktion Krebskranke Kinder Heidelberg e. V.: Projekt Pädiatrische Neuroonkologie zur Förderung der translationalen Forschung und klinischen Versorgung von Kindern und Jugendlichen mit Hirntumoren (PI: Olaf Witt und Andreas Kulozik)

 

German Cancer Aid (Deutsche Krebshilfe)/German Federal Ministry for Education and Research (BMBF): ICGC-PedBrainTumor: ICGC-PedBrainTumor:whole genome sequencing of childhood brain tumors within the International Cancer Genome Consortium (ICGC), WP5 – genome sequencing (Co-PI Stefan Pfister together with Peter Lichter)

 

James S. McDonnell Foundation (USA): Use of cerebrospinal fluid genetics for the diagnosis, subgrouping, and minimal residual disease monitoring in medulloblastoma (PI: Stefan Pfister)

 

German Pediatric Cancer Foundation (Deutsche Kinderkrebsstiftung): Molecular characterization and targeted therapy of recurrent medulloblastoma (PI: Stefan Pfister, Olaf Witt)



German Pediatric Cancer Foundation (Deutsche Kinderkrebsstiftung): Phase I/II study of vorinostat in children with relapsed or refractory solid tumor, leukemia, and lymphoma (PI/LKP: Olaf Witt)



NCT-funding program: New ways of treating brain tumors in children: from the molecular signature and the in-vivo model to specific therapy concepts (PI: Till Milde, Stefan Pfister, Axel Benner)



BMBF CancerSYS: MYC-Driven Unsensitivities to Chemotherapeutic Drugs in NeuroEctodermal Tumors (coordinators: Thomas Höfer, Frank Westermann, Stefan Pfister)



WP4: Validation of mathematical models in preclinical models (PI: Olaf Witt)

 

WP5: Validation of mathematial models in primary tumor samples (PI: Stefan Pfister)

 


IV.  Publications

Selected publications from the past 3 years

 

Opens external link in new windowHotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.
Sturm D, Witt H, Hovestadt V, Quang D-AK, Jones DT, Konermann C, Pfaff E, Sill M, Bender S, Kool M, Becker N, Zucknick M, Hielscher T, Xiao-Yang L, Fontebasso AM, Ryzhova M, Tönjes M, Albrecht S, Jacob K, Wolter M, Ebinger M, Schuhmann MU, van Meter T, Frühwald MC, Hauch H, Pekrun A, Radlwimmer B, Niehues T, von Komorowski G, Dürken M, Kulozik AE, Madden J, Donson A, Foreman NK, Drissi R, Fouladi M, Scheurlen W, von Deimling A, Monuranu C, Roggendorf W, Herold-Mende C, Unterberg A, Kramm CM, Felsberg J, Hartmann C, Milde T, Witt O, Lindroth AM, Schwartzentruber J, Faury D, Fleming A, Zakrzewska M, Liberski PP, Zakrzewski K, Zapatka M, Hauser P, Garami M, Klekner A, Bognar L, Morissy S, Cavalli F, Taylor MD, Wiestler B, Wick W, van Sluis P, Koster J, Versteeg R, Volkmann R, Mikkelsen T, Aldape K, Reifenberger G, Collins VP, Majewksi J, Korshunov A, Lichter P, Plass C*, Jabado N*, Pfister SM*
Cancer Cell. 2012 Oct 16;22(4):425-37. doi: 10.1016/j.ccr.2012.08.024.

Opens external link in new windowDissecting the genomic complexity underlying medulloblastoma.
Jones DT, Jäger N, Kool M, Zichner T, Hutter B, Sultan M, Cho YJ, Pugh TJ, Hovestadt V, Stütz AM, Rausch T, Warnatz HJ, Ryzhova M, Bender S, Sturm D, Pleier S, Cin H, Pfaff E, Sieber L, Wittmann A, Remke M, Witt H, Hutter S, Tzaridis T, Weischenfeldt J, Raeder B, Avci M, Amstislavskiy V, Zapatka M, Weber UD, Wang Q, Lasitschka B, Bartholomae CC, Schmidt M, von Kalle C, Ast V, Lawerenz C, Eils J, Kabbe R, Benes V, van Sluis P, Koster J, Volckmann R, Shih D, Betts MJ, Russell RB, Coco S, Tonini GP, Schüller U, Hans V, Graf N, Kim YJ, Monoranu C, Roggendorf W, Unterberg A, Herold-Mende C, Milde T, Kulozik AE, von Deimling A, Witt O, Maass E, Rössler J, Ebinger M, Schuhmann MU, Frühwald MC, Hasselblatt M, Jabado N, Rutkowski S, von Bueren AO, Williamson D, Clifford SC, McCabe MG, Collins VP, Wolf S, Wiemann S, Lehrach H, Brors B, Scheurlen W, Felsberg J, Reifenberger G, Northcott PA, Taylor MD, Meyerson M, Pomeroy SL, Yaspo ML, Korbel JO, Korshunov A, Eils R, Pfister SM, Lichter P.
Nature
. 2012 Aug 2;488(7409):100-5


Opens external link in new windowPhase I/II Intra-patient Dose Escalation Study of Vorinostat in Children with Relapsed Solid Tumor, Lymphoma or Leukemia.
Witt O, Milde T, Deubzer HE, Oehme I, Witt R, Kulozik A, Eisenmenger A, Abel U, Karapanagiotou-Schenkel I.
Klin Padiatr. 2012 Aug 22. [Epub ahead of print]


Opens external link in new windowNestin Expression Identifies Ependymoma Patients with Poor Outcome.
Milde T, Hielscher T, Witt H, Kool M, Mack SC, Deubzer HE, Oehme I, Lodrini M, Benner A, Taylor MD, von Deimling A, Kulozik AE, Pfister SM, Witt O, Korshunov A.
Brain Pathol. 2012 May 9. doi: 10.1111/j.1750-3639.2012.00600.x. [Epub ahead of print]


Opens external link in new windowDriver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma.
Schwartzentruber J, Korshunov A, Liu XY, Jones DT, Pfaff E, Jacob K, Sturm D, Fontebasso AM, Quang DA, Tönjes M, Hovestadt V, Albrecht S, Kool M, Nantel A, Konermann C, Lindroth A, Jäger N, Rausch T, Ryzhova M, Korbel JO, Hielscher T, Hauser P, Garami M, Klekner A, Bognar L, Ebinger M, Schuhmann MU, Scheurlen W, Pekrun A, Frühwald MC, Roggendorf W, Kramm C, Dürken M, Atkinson J, Lepage P, Montpetit A, Zakrzewska M, Zakrzewski K, Liberski PP, Dong Z, Siegel P, Kulozik AE, Zapatka M, Guha A, Malkin D, Felsberg J, Reifenberger G, von Deimling A, Ichimura K, Collins VP, Witt H, Milde T, Witt O, Zhang C, Castelo-Branco P, Lichter P, Faury D, Tabori U, Plass C, Majewski J, Pfister SM, Jabado N.
Nature
. 2012 Jan 29;482(7384):226-31. doi: 10.1038/nature10833. Erratum in: Nature. 2012 Apr 5;484(7392):130


Opens external link in new windowGenome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations.
Rausch T, Jones DT, Zapatka M, Stütz AM, Zichner T, Weischenfeldt J, Jäger N, Remke M, Shih D, Northcott PA, Pfaff E, Tica J, Wang Q, Massimi L, Witt H, Bender S, Pleier S, Cin H, Hawkins C, Beck C, von Deimling A, Hans V, Brors B, Eils R, Scheurlen W, Blake J, Benes V, Kulozik AE, Witt O, Martin D, Zhang C, Porat R, Merino DM, Wasserman J, Jabado N, Fontebasso A, Bullinger L, Rücker FG, Döhner K, Döhner H, Koster J, Molenaar JJ, Versteeg R, Kool M, Tabori U, Malkin D, Korshunov A, Taylor MD, Lichter P, Pfister SM, Korbel JO.
Cell
. 2012 Jan 20;148(1-2):59-71