Kliniken & Institute ... SFBs SFB 938 Publikationen

Projekt K - Platten/Wick

Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR.
Litzenburger UM, Opitz CA, Sahm F, Rauschenbach KJ, Trump S, Winter M, Ott M, Ochs K, Lutz C, Liu X, Anastasov N, Lehmann I, Höfer T, von Deimling A, Wick W, Platten M.
Oncotarget. 2014 Feb 28;5(4):1038-51.

mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy.
Weiler M, Blaes J, Pusch S, Sahm F, Czabanka M, Luger S, Bunse L, Solecki G, Eichwald V, Jugold M, Hodecker S, Osswald M, Meisner C, Hielscher T, Rübmann P, Pfenning PN, Ronellenfitsch M, Kempf T, Schnölzer M, Abdollahi A, Lang F, Bendszus M, von Deimling A, Winkler F, Weller M, Vajkoczy P, Platten M, Wick W.
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):409-14. doi:
10.1073/pnas.1314469111. Epub 2013 Dec 23.

The endogenous tryptophan metabolite and NAD+ precursor quinolinic acid confers resistance of gliomas to oxidative stress.
Sahm F, Oezen I, Opitz CA, Radlwimmer B, von Deimling A, Ahrendt T, Adams S, Bode HB, Guillemin GJ, Wick W, Platten M.
Cancer Res. 2013 Apr 2.

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor.(PubMed)
Opitz CA, Litzenburger UM, Sahm F, Ott M, Tritschler I, Trump S, Schumacher T, Jestaedt L, Schrenk D, Weller M, Jugold M, Guillemin GJ, Miller CL, Lutz C, Radlwimmer B, Lehmann I, von Deimling A, Wick W, Platten M.
Nature. 2011 Oct 5;478(7368):197-203. doi: 10.1038/nature10491.