CRC 1118 - Reactive metabolites as a cause of diabetic complications

A key objective of the CRC is to understand why in diabetes mellitus late complications occur even when blood sugar is well controlled. We are investigating the hypothesis that changes of important endogenous proteins by reactive metabolites are responsible. Reactive metabolites, which are the focus of the research, are dicarbonyls such as methylglyoxal and reactive oxygen species.
Further aims are to see how increased levels in reactive metabolites occur in diabetes, how they cause diabetic complications and thus as a long-term goal develop new/ innovative therapeutic procedures.