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3. Advanced Biological Modelling for Hadrontherapy

The current clinical standard worldwide administers proton therapy assuming an isotropic relative biological effectiveness (RBE) of 1.1, despite extensive evidence of variable RBE in the literature.  For heavier ions (e.g. carbon ions), multi-variable dependency of RBE, such as dose, linear energy transfer and tissue type, make practical assumptions clinically implausible. Various biophysical and phenomenological approaches exist, such as the microdosimetric kinetic model (MKM) and the local effect model (LEM). Recent works developed and validated a sophisticated data-driven approach to predicting and handling variable RBE for both proton and novel helium ion beams via coupling with FLUKA Monte Carlo code (MC) containing a detailed description of the beam-line at HIT (Fig. 1). Integration into the FRoG project is underway, in preparation for the upcoming helium ion beam therapy program, as well as our mission to uncover the untapped clinical advantages of therapeutic ion beams through analysis of patient-specific clinical outcome.

Fig. 1: Development and investigation of innovative models for biological effects using particle beams. (adapted from: http://iopscience.iop.org/article/10.1088/0031-9155/61/11/4283)


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