Sektion Immuno-Imaging

• Molecular and cellular imaging
• High field MRI (Bruker, 9.4 Tesla)
• Optical Imaging
• Iron oxide nanoparticles
• Theranostics nanoparticles
• Preclinical therapy development
• Gliom-Modelle
• Multiple Sklerose und Experimentelle Autoimmune Enzephalomyelitis)

Es kommen neuartige MRT-Kontrastmittel (Eisenoxid-Nanopartikel) zum Einsatz, welche spezifisch von Immunzellen des Tumormikromilieus aufgenommen werden. Mit diesen Sensoren kann das Tumormikromilieu nicht invasiv charakterisiert werden. Korrelativ kommen optische Bildgebungsverfahren (2-Photonen Mikroskopie, Ultramikroskopie von geclearten Geweben, Konfokalmikroskopie, Immunhistochemie) sowie molekularbiologische und immunologische Techniken (FACS, RT-PCR etc.) zum Einsatz.

• Klinische Kooperationseinheit Neuroimmunologie und Hirntumorimmunologie, DKFZ, Leiter Prof. Michael Platten)
• Klinische Kooperationseinheit Neuroonkologie und Experimentelle Neuroonkologie (Prof. Wolfgang Wick, Prof. Frank Winkler)
• Sektion Computational Neuroimaging (Neuroradiologie, Marianne Schell)
• AG Eisenstoffwechsel, Molekulare Medizin, Zentrum für Kinder- und Jugendmedizin (Prof. Dr. Martina Muckenthaler)
• Center for System Biology, Massachusetts General Hospital / Harvard Medical School, Boston, USA  (Ralph Weissleder)
• Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School (John W. Chen)
• School of Biomedical Engineering, Drexel University (Christopher Rodell)

seit 2024                     Clinician-Scientist Professur Else Kröner Fresenius Stiftung

2023 – 2027              Projektleiter SFB 1389, Unite Glioblastoma, DFG (2. Förderperiode)

seit 9/2021               Emmy Noether Gruppe (DFG)

9/2019 – 8/2021      Memorial Stipendium, Else Kröner-Fresenius Stiftung

7/2019 – 6/2023      Projektleiter: “Imaging immune signatures of glioma response and resistance towards immunotherapy”  im SFB 1389 “Understanding

                                      and targeting resistance in glioblastoma”

1/2018                        Projektförderung: „Gd-MRT Kontrastmittel im Therapiemonitoring bei Multipler Sklerose“, Novartis

4/2017                        Einzelantrag, Else Kröner-Fresenius Stiftung

6/2016                        Graduiertenstipendium Novartis Stiftung

2015 – 2016              Physician-Scientist Fellowship, Medizinische Fakultät Heidelberg

2015 – 2016              Hoffmann-Klose Stiftung, „MRT von vaskulären und immunologischen Krankheitssignaturen in Neuroonkologie und

                                      Neuroinflammation“   

1. Three-photon microscopy: an emerging technique for deep intravital brain imaging.
   Prevedel R, Ferrer Ortas J, Kerr JND, Waters J, Breckwoldt MO, Deneen B, Monje M, Soyka SJ, Venkataramani V. Nat Rev Neurosci. 2025 Sep;26(9):521-537
    
2. Differentiating Glioma Recurrence and Pseudoprogression by APTw CEST MRI.
   Karimian-Jazi K, Enbergs N, Golubtsov E, Schregel K, Ungermann J, Fels-Palesandro H, Schwarz D, Sturm V, Kernbach JM, Batra D, Ippen FM, Pflüger I, von Knebel Doeberitz N, Heiland S, Bunse L, Platten M, Winkler F, Wick W, Paech D, Bendszus M, Breckwoldt MO. Invest Radiol. 2025 Jun 1;60(6):414-422
    
3. Assessment of Tumor Cell Invasion and Radiotherapy Response in Experimental Glioma by Magnetic Resonance Elastography.
   Fels-Palesandro H, Heuer S, Boztepe B, Streibel Y, Ungermann J, Pan C, Scheck JG, Fischer M, Sturm VJ, Azorín DD, Karimian-Jazi K, Annio G, Abdollahi A, Weidenfeld I, Wick W, Venkataramani V, Heiland S, Winkler F, Bendszus M, Sinkus R, Breckwoldt MO^#, Schregel K^#. J Magn Reson Imaging. 2025 Mar;61(3):1203-1218
   
    
4. Efficacy of Hand Cooling and Compression in Preventing Taxane-Induced Neuropathy: The POLAR Randomized Clinical Trial.
   Michel LL, Schwarz D, Romar P, Feisst M, Hamberger D, Priester A, Kurre E, Klein E, Müller J, Schinköthe T, Weiler M, Smetanay K, Fremd C, Heublein S, Thewes V, Breckwoldt MO, Jäger D, Bendszus M, Marmé F, Schneeweiss A. JAMA Oncol. 2025 Apr 1;11(4):408-415
    
5. Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing.
   Tetzlaff SK, Reyhan E, Layer N, Bengtson CP, Heuer A, Schroers J, Faymonville AJ, Langeroudi AP, Drewa N, Keifert E, Wagner J, Soyka SJ, Schubert MC, Sivapalan N, Pramatarov RL, Buchert V, Wageringel T, Grabis E, Wißmann N, Alhalabi OT, Botz M, Bojcevski J, Campos J, Boztepe B, Scheck JG, Conic SH, Puschhof MC, Villa G, Drexler R, Zghaibeh Y, Hausmann F, Hänzelmann S, Karreman MA, Kurz FT, Schröter M, Thier M, Suwala AK, Forsberg-Nilsson K, Acuna C, Saez-Rodriguez J, Abdollahi A, Sahm F, Breckwoldt MO, Suchorska B, Ricklefs FL, Heiland DH, Venkataramani V. Cell. 2025 Jan 23;188(2):390-411.e36
    
6. Tumor biomechanics as a novel imaging biomarker to assess response to immunotherapy in a murine glioma model.
   Streibel Y*, Breckwoldt MO*, Hunger J, Pan C, Fischer M, Turco V, Boztepe B, Fels-Palesandro H, Scheck JG, Sturm V, Karimian-Jazi K, Agardy DA, Annio G, Mustapha R, Soni SS, Alasa A, Weidenfeld I, Rodell CB, Wick W, Heiland S, Winkler F, Platten M, Bendszus M, Sinkus R, Schregel K. Sci Rep. 2024 Jul 6;14(1):15613
   
    
7. Grassl N, Poschke I, Lindner K, Bunse L, Mildenberger I, Boschert T, Jähne K, Green EW, Hülsmeyer I, Jünger S, Kessler T, Suwala AK, Eisele P, Breckwoldt MO, Vajkoczy P, Grauer OM, Herrlinger U, Tonn JC, Denk M, Sahm F, Bendszus M, von Deimling A, Winkler F, Wick W, Platten M, Sahm K, A H3K27M-targeted vaccine in adults with diffuse midline glioma.  Nat Med.2023
    
8. J  Hunger, K Schregel, B Boztepe, DA Agardy, V Turco, K Karimian-Jazi, I Weidenfeld, Y Streibel, M Fischer, V Sturm, R Santarella-Mellwig, M Kilian, K Jähne, K Sahm, W Wick, L Bunse, S Heiland, T Bunse, M Bendszus, M Platten and MO Breckwoldt, In vivo nanoparticle-based T cell imaging can predict therapy 1 response towards adoptive T cell therapy in experimental glioma, Theranostics 2023, in press
    
9. V Turco, K Pfleiderer, J Hunger, NK Horvat, K Karimian-Jazi, K Schregel, M Fischer, G Brugnara, K Jaehne, V Sturm, Y Streibel, D Nguyen, S Altamura, DA Agardy, Shreya S. Soni, A Alsasa, T Bunse, M Schlesner, MU Muckenthaler, R Weissleder, W Wick, S Heiland, P Vollmuth, M Bendszus, CB Rodell, MO Breckwoldt^# and M Platten^#, T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles, Nature Commun, 2023, 14:771
    
10. K Schregel^#, L Heinz, J Hunger, C Pan, J Bode, M Fischer, V Sturm, V Venkataramani, K Karimian-Jazi, D Agardy, Y Streibel, R Zerelles, W Wick, S Heiland, T Bunse, B Tews, M Platten, F Winkler, M Bendszus, and MO Breckwoldt^#, A cellular ground truth to develop MRI signatures in glioma models by correlative light sheet microscopy and atlas-based co-registration, J Neurosci, 2023 7:JN-RM-1470-22
     
11. K Karimian-Jazi, D F Vollherbst, D Schwarz, M Fischer, K Schregel, G Bauer, A Kocharyan, V Sturm, U Neuberger, J Jesser, C Herweh, C Ulfert, T Hilgenfeld, F Seker, F Preisner, N Schmitt, T Charlet, S Hamelmann^, F Sahm, S Heiland, W Wick, PA Ringleb, L Schirmer, M Bendszus, MA Möhlenbruch and MO Breckwoldt, MR microscopy to assess clot composition following mechanical thrombectomy predicts recanalization and clinical outcome, J Neurointerv Surg. 2023 Aug 1:jnis-2023-02059
     
12. M Platten, L Bunse, A Wick, T Bunse, L Le Cornet, I Harting, F Sahm, K Sanghvi, C Leng Tan, I Poschke, E Green, S Justesen, G Behrens, MO Breckwoldt, A Freitag, LM Rother, A Schmitt, O Schnell, J Hense, M Misch, D Krex, D Stevanovic, G Tabatabai, JP Steinbach, M Bendszus, A von Deimling, M Schmitt, W Wick, Phase 1 trial of IDH1-vac, a peptide vaccine for IDH1R132H glioma, Nature, 2021, 592, 463–468
     
13. K Karimian-Jazi*, P Münch*, A Alexander, M Fischer, K Pfleiderer, M Piechutta, MA Karreman, GM Solecki, AS Berghoff, M Friedrich, K Deumelandt, FT Kurz, W Wick, S Heiland, M Bendszus, F Winkler, M Platten and MO Breckwoldt, Monitoring innate immune cell dynamics in the glioma microenvironment by correlated magnetic resonance imaging and multiphoton microscopy (MR-MPM), Theranostics, 2020; 10(4): 1873-1883, *equal contribution  
     
14. A Hahn, J Bode, A Alexander, K Karimian-Jazi, K Schregel, D Schwarz, AC Sommerkamp, T Krüwel, A Abdollahi, W Wick, M Platten, M Bendszus, B Tews, FT Kurz and MO Breckwoldt, Large-scale characterization of the microvascular geometry in development and disease by tissue clearing and quantitative ultramicroscopy, J Cerebr Blood Flow Metab, 2020, 12:271678X20961854
     
15. K Aslan, V Turco, J Blobner, JK Sonner,  AR Liuzzi, N Gonzalo Núñez, D de Feo, P Kickingereder, M Fischer, E Green, A Sadik, M Friedrich, K Sanghvi, M Kilian, F Cichon, L Wolf, K Jähne, A von Landenberg, L Bunse, F Sahm, D Schrimpf, J Meyer, A Alexander, G Brugnara, R Röth, K Pfleiderer, B Niesler, A von Deimling, C Opitz, MO Breckwoldt, S Heiland, M Bendszus, W Wick, B 
Becher and Michael Platten
, Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas, Nature Commun, 2020 18;11(1):931
     
16. A Hoffmann, J Pfeil, AK Mueller, J Jin, K Deumelandt, X Helluy, C Wang, S Heiland, M Platten, JW Chen, M Bendszus, MO Breckwoldt, MRI of Iron Oxide Nanoparticles and Myeloperoxidase Activity Links Inflammation to Brain Edema in Experimental Cerebral Malaria, Radiology, 290(2):359-367
     
17. K Karimian-Jazi, B Wildemann, R Diem, D Schwarz, T Hielscher, W Wick, M Bendszus, MO Breckwoldt, Gd-contrast administration is dispensable in multiple sclerosis patients without new T2/FLAIR lesions on follow-up MRI, Neurol Neuroimmunol Neuroinflamm (2018). 5(5), e480.
     
18. K Kirschbaum*, J Sonner*, M Zeller, K Deumelandt, J Bode, R Sharma, T Kruewel, M Fischer, A Hoffmann, M Costa da Silva, MU Muckenthaler, W Wick, B Tews, JW Chen, S Heiland, M Bendszus, M Platten and MO Breckwoldt, In vivo nanoparticle imaging of innate immune cells can serve as a marker of disease severity in a mouse model of multiple sclerosis, PNAS, 2016 113(46), 13227–13232.  *equal contribution
     
19. MO Breckwoldt^*, J Bode^*, FT Kurz, A Hoffmann, K Ochs, M Ott, K Deumelandt, T Krüwel, D Schwarz, M Fischer, X Helluy, D Milford, K Kirschbaum, G Solecki, S Chiblak, A Abdollahi, F Winkler, W Wick, M Platten, S Heiland, M Bendszus and B Tews Correlated MR imaging and ultramicroscopy (MR-UM) is a tool kit to assess the dynamics of glioma angiogenesis, eLIFE, 2015; 5:e11712, *equal contribution
     
20. Breckwoldt MO, Pfister F, Bradley, PM, Marinković P, Williams PR, Brill MS, Plomer B, Schmalz, A, St. Clair DK, Naumann R, Griesbeck O, Schwarzländer M, Godinho L, Bareyre FM, Dick TP, Kerschensteiner M* and Misgeld T*, Muti-parametric optical analysis of redox signals during neuronal physiology and pathology in vivo. Nature Medicine, 2014 May;20(5):555-60
     
21. MO Breckwoldt*, JW Chen*, L Stangenberg, E Aikawa, E Rodriguez, S Qiu, M Moskowitz, R Weissleder, Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase, PNAS, 2008, 25;105(47):18584-9. *equal contribution
     

Candidates interested in M.Sc., PhD, Dr med. or postdoc positions please contact Dr. Michael Breckwoldt (michael.breckwoldt@med.uni-heidelberg.de).

See Link.

Open Phd Position

Candidates should provide a CV including names of two references, as well as a letter of motivation. We seek highly motivated candidates with an interest in a translational research environment (imaging sciences, brain tumors, neuroimmunology). We offer a dynamic and supportive research environment within the Collaborative Research Center (CRC 1389, Unite Glioblastoma, www.unite-glioblastoma.de) with access to additional training in the graduate school of Neurooncology, international cooperations and plenty of opportunities to perform cutting edge research in one of the leading biomedical centers in Germany.

Deutsche Röntgengesellschaft verleiht Wilhelm-Conrad-Röntgen-Preis 2024 an PD Dr. med. Michael Breckwoldt vom Universitätsklinik | DRG.de

Ziel: Immun-Angriff auf Hirntumoren sichtbar machen (uni-heidelberg.de)

Chica und Heinz Schaller Preis: Förderung für heruasragende biomedizinische Forschung