Kliniken & Institute ... Institute NCT-Gewebebank Aktivitäten Publikationen

Publikationen

Publikationen zum Thema Biobanking:

Die Sicherung der Nachhaltigkeit von Biobanken

Kirsten R., Hummel M.

Gesundheitsforschung Gesundheitsschutz (2016) Band 59, Heft 3

Qualität von Biomaterialien im Biobanking von Flüssig- und Gewebeproben

Herpel E., Schmitt S., Kiehntopf M.

Gesundheitsforschung Gesundheitsschutz (2016) Band 59, Heft 3

Challenges for quality management in implementation, maintenance, and sustainability of research tissue biobanks.

Schmitt S., Kynast K., Schirmacher P., Herpel E.

Virchows Arch. 2015 Aug 14

Maintainance of a research tissue bank : (Infra)structural and quality aspects

Schmitt S., Kynast K., Schirmacher P., Herpel E.

Pathologe. 2015 Sep 21

Structure of biobanks for urological research

Hatiboglu, G., Huber, J., Herpel, E., Popeneciu, I. V., Nyarangi-Dix, J., Teber, D., Hadaschik, B. A., Pahernik, S., Duensing, S. and Hohenfellner, M

Urologe A. 2014 Dec 14

Einsatz von Tumorgewebe neu geregelt

Schirmacher P.

31. Deutscher Krebskongress, 2014 Feb 

Gewebebanken – die Beteiligung der außeruniversitären Pathologie ist wichtig!

Herpel E.

PathoPunkt 04/13, 8-9, 2013 Nov 

Tumordatenbanken - ein Goldschatz für die personalisierte Medizin

Bördlein, I., ÄrzteZeitung 2013 Juli, S.2

Gewebebank - Service für Forscher
Bördlein, I., ÄrzteZeitung 2013 Juli, S.3

Biobanken – Entwicklung und Struktur.
Herpel E, Hummel M.Dtsch Med Wochenschr. 2013 May;138(20):1069-72. Epub 2013 May 13.

  Krebsforschung - Biobanken boomen

von der Weiden S. Der Tagesspiegel. 23.03.2013

  Tumorbiologie benötigt sehr gute Gewebebanken.

Schirmacher P, Herpel E, Kirsten R. UroForum 05/12. 2012 Sep.

 Two decades' experience with a prospective biobank for urologic oncology: research, clinical care, and the patients' view.
Huber J, Herpel E, Jakobi H, Hadaschik BA, Pahernik S, Hohenfellner M. Urol Oncol. 2012 Mar 1. [Epub ahead of print]

Stellungnahme zu PATH. 
Herpel, E. Senologie - Zeitschrift für Mammadiagnostik und -therapie. 2012 Mar;1:19-20.

Structural requirements of research tissue banks derived from standardized project surveillance.
Herpel E, Koleganova N, Schreiber B, Walter B, Kalle CV, Schirmacher P. Virchows Arch. 2012 Jun 1. [Epub ahead of print]

Gewebebanken in der Tumorforschung. 
Herpel E, Hummel M, Dietel M, Schirmacher P. Forum. Volume 27, Number 1 (2012), 47-53

Collection of Biospecimen Resources for Cancer Research. Ethical Framework and Acceptance from the Patients’ Point of View.
Huber J, Herpel E, Autschbach F, Buse S, Hohenfellner M. Trust in Biobanking. Veröffentlichungen des Instituts für Deutsches, Europäisches und Internationales Medizinrecht, Gesundheitsrecht und Bioethik der Universitäten Heidelberg und Mannheim, 2012, Volume 33, Part 2, 97-110.

Quality management and accreditation of research tissue banks: experience of the National Center for Tumor Diseases (NCT) Heidelberg.
Herpel E, Röcken C, Manke H, Schirmacher P, Flechtenmacher C. Virchows Arch. 2010 Dec;457(6):741-7. Epub 2010 Oct 27.

Gewebebank des Nationalen Centrums für Tumorerkrankungen (NCT) Heidelberg. Eine innovative Plattform für die Translationale Tumorforschung. 
Herpel E, Koleganova N, Schirmacher P. Pathologe. 2008 Oct 4

Publikationen die durch Proben und/oder die Technologieplattform der Gewebebank des NCT erzielt wurden:

2016

Cellular apoptosis susceptibility (CAS) is overexpressed in thyroid carcinoma and maintains tumor cell growth: A potential link to the BRAFV600E mutation

Holzer, K., Drucker, E., Oliver, S., Winkler, J., Eiteneuer, E., Herpel, E., Breuhahn, K. and Singer, S.

Int J Oncol. 2016 Apr;48(4):1679-87. doi: 10.3892/ijo.2016.3388

Genotyping of colorectal cancer for cancer precision medicine: Results from the IPH Center for Molecular Pathology

Jesinghaus, Moritz, Pfarr, Nicole, Endris, Volker, Kloor, Matthias, Volckmar, Anna-Lena, Brandt, Regine, Herpel, Esther, Muckenhuber, Alexander, Lasitschka, Felix, Schirmacher, Peter, Penzel, Roland, Weichert, Wilko and Stenzinger, Albrecht

Genes, Chromosomes and Cancer, DOI: 10.1002/gcc.22352

Cellular apoptosis susceptibility (CAS) is linked to integrin beta1 and required for tumor cell migration and invasion in hepatocellular carcinoma (HCC)

Winkler, J., Roessler, S., Sticht, C., DiGuilio, A. L., Drucker, E., Holzer, K., Eiteneuer, E., Herpel, E., Breuhahn, K., Gretz, N., Schirmacher, P., Ori, A. and Singer, S

Oncotarget. 2016 Mar 23. doi: 10.18632/oncotarget.8256.

Activity of immune checkpoint inhibition in platinum refractory germ cell tumors

Zschäbitz, S., Lasitschka, F., Jäger, D. and Grüllich, C

DOI: 10.1093/annonc/mdw146

PI3K/AKT/mTOR-dependent stabilization of oncogenic far-upstream element binding proteins in hepatocellular carcinoma cells

Samarin, J., Laketa, V., Malz, M., Roessler, S., Stein, I., Horwitz, E., Singer, S., Dimou, E., Cigliano, A., Bissinger, M., Falk, C. S., Chen, X., Dooley, S., Pikarsky, E., Calvisi, D. F., Schultz, C., Schirmacher, P. and Breuhahn, K.

Hepatology. 2016 Mar;63(3):813-26. doi: 10.1002/hep.28357

2015

Uncoupling of PUMA Expression and Apoptosis Contributes to Functional Heterogeneity in Renal Cell Carcinoma - Prognostic and Translational Implications

Zhou, X., Li, J., Marx, C., Tolstov, Y., Rauch, G., Herpel, E., Macher-Goeppinger, S., Roth, W., Grullich, C., Pahernik, S., Hohenfellner, M. and Duensing, S

Transl Oncol. 2015 Dec;8(6):480-6. doi: 10.1016/j.tranon.2015.11.003.

NUT carcinoma of the thorax: Case report and review of the literature

Harms, Alexander, Herpel, Esther, Pfarr, Nicole, Penzel, Roland, Heussel, Claus-Peter, Herth, Felix J. F., Dienemann, Hendrik, Weichert, Wilko and Warth, Arne

Lung Cancer, Volume: 90, Issue: 3, Pages: 484-491

Prognostic Significance and Functional Role of CEP57 in Prostate Cancer

Mang, Josef, Korzeniewski, Nina, Dietrich, Dimo, Sailer, Verena, Tolstov, Yanis, Searcy, Sam, von Hardenberg, Jost, Perner, Sven, Kristiansen, Glen, Marx, Alexander, Roth, Wilfried, Herpel, Esther, Grüllich, Carsten, Popeneciu, Valentin, Pahernik, Sascha, Hadaschik, Boris, Hohenfellner, Markus and Duensing, Stefan

Translational Oncology, Volume: 8, Issue: 6, Pages: 487-496

Methylation status at HYAL2 predicts overall and progression-free survival of colon cancer patients under 5-FU chemotherapy

Pfutze, K., Benner, A., Hoffmeister, M., Jansen, L., Yang, R., Blaker, H., Herpel, E., Ulrich, A., Ulrich, C. M., Chang-Claude, J., Brenner, H. and Burwinkel, B.

Genomics. 2015 Dec;106(6):348-54. doi: 10.1016/j.ygeno.2015.10.002.

Expression of the apoptosis repressor with caspase recruitment domain (ARC) in liver metastasis of colorectal cancer and its correlation with DNA mismatch repair proteins and p53

Toth, C., Meinrath, J., Herpel, E., Derix, J., Fries, J., Buettner, R., Schirmacher, P. and Heikaus, S.

J Cancer Res Clin Oncol. 2015 Dec 31

Differential diagnostic value of CD5 and CD117 expression in thoracic tumors: a large scale study of 1465 non-small cell lung cancer cases

Kriegsmann, M., Muley, T., Harms, A., Tavernar, L., Goldmann, T., Dienemann, H., Herpel, E. and Warth, A.

Diagn Pathol. 2015 Dec 8;10:210. doi: 10.1186/s13000-015-0441-7

The pregnancy associated protein glycodelin as a follow-up biomarker in a male non-small cell lung cancer patient

Schneider, Marc A., Kahn, Nicolas C., Thomas, Michael, Herth, Felix J. F., Muley, Thomas, Heussel, Claus P., Meister, Michael and Dienemann, Hendrik

Cancer Treatment Communications, 2015 Vol. 4

Overexpression of SIX1 is an independent prognostic marker in stage I-III colorectal cancer

Kahlert, C., Lerbs, T., Pecqueux, M., Herpel, E., Hoffmeister, M., Jansen, L., Brenner, H., Chang-Claude, J., Blaker, H., Kloor, M., Roth, W., Pilarsky, C., Rahbari, N. N., Scholch, S., Bork, U., Reissfelder, C., Weitz, J., Aust, D. and Koch, M.

Int J Cancer. 2015 Nov 1;137(9):2104-13. doi: 10.1002/ijc.29596

Metabolomics and transcriptomics identify pathway differences between visceral and subcutaneous adipose tissue in colorectal cancer patients: the ColoCare study

Liesenfeld, D. B., Grapov, D., Fahrmann, J. F., Salou, M., Scherer, D., Toth, R., Habermann, N., Bohm, J., Schrotz-King, P., Gigic, B., Schneider, M., Ulrich, A., Herpel, E., Schirmacher, P., Fiehn, O., Lampe, J. W. and Ulrich, C. M.

Am J Clin Nutr. 2015 Aug;102(2):433-43. doi: 10.3945/ajcn.114.103804

Concomitant expression of far upstream element (FUSE) binding protein (FBP) interacting repressor (FIR) and its splice variants induce migration and invasion of non-small cell lung cancer (NSCLC) cells

Muller, B., Bovet, M., Yin, Y., Stichel, D., Malz, M., Gonzalez-Vallinas, M., Middleton, A., Ehemann, V., Schmitt, J., Muley, T., Meister, M., Herpel, E., Singer, S., Warth, A., Schirmacher, P., Drasdo, D., Matthaus, F. and Breuhahn, K.

J Pathol. 2015 Jul 14. doi: 10.1002/path.4588.URL: www.ncbi.nlm.nih.gov/pubmed/26177862

Comprehensive genomic profiles of small cell lung cancer

Julie George, Jing Shan Lim, Se Jin Jang, Yupeng Cun, Luka Ozretić, Gu Kong, Frauke Leenders, Xin Lu,    Anette Fernández-Cuesta, Graziella Bosco, Christian Müller, Ilona Dahmen, Nadine S. Jahchan, Kwon-Sik Park,    Dian Yang, Anthony N. Karnezis, Dedeepya Vaka, Angela Torres, Maia Segura Wang, Jan O. Korbel, Roopika Menon, Sung-Min Chun, Deokhoon Kim, Matt Wilkerson, Neil Hayes   

Nature. 2015 Jul 13. doi: 10.1038/nature14664.

Prognostic Impact of Intra-alveolar Tumor Spread in Pulmonary Adenocarcinoma

Warth, A., Muley, T., Kossakowski, C. A., Goeppert, B., Schirmacher, P., Dienemann, H. and Weichert, W.

Am J Surg Pathol. 2015 Jun;39(6):793-801. doi: 10.1097/PAS.0000000000000409.

Diminished levels of the soluble form of RAGE are related to poor survival in malignant melanoma

Wagner, N. B., Weide, B., Reith, M., Tarnanidis, K., Kehrel, C., Lichtenberger, R., Pflugfelder, A., Herpel, E., Eubel, J., Ikenberg, K., Busch, C., Holland-Letz, T., Naeher, H., Garbe, C., Umansky, V., Enk, A., Utikal, J. and Gebhardt, C.

Int J Cancer.  doi: 10.1002/ijc.29619

Glycodelin: A new Biomarker with Immunomodulatory Functions in Non-Small Cell Lung Cancer
 

Schneider, Marc A., Granzow, Martin, Warth, Arne, Schnabel, Philip A, Thomas, Michael, Herth, Felix JF, Dienemann, Hendrik, Muley, Thomas and Meister, Michael

Clinical Cancer Research
DOI: 10.1158/1078-0432.ccr-14-2464"

Aggressive primary cutaneous B-cell lymphomas show increased Angiopoietin-2-induced angiogenesis

Teichert, Martin, Stumpf, Christine, Booken, Nina, Wobser, Marion, Nashan, Dorothee, Hallermann, Christian, Mogler, Carolin, Müller, Cornelia S. L., Becker, Jürgen C., Moritz, Rose K. C., Andrulis, Mindaugas, Nicolay, Jan P., Goerdt, Sergij, Thomas, Markus, Klemke, Claus-Detlev, Augustin, Hellmut G. and Felcht, Moritz

Experimental Dermatology DOI: 10.1111/exd.12688

Distribution of MED12 mutations in fibroadenomas and phyllodes tumors of the breast – implications for tumor biology and pathological diagnosis

Pfarr N, Kriegsmann M, Sinn P, Klauschen F, Endris V, Herpel E, Muckenhuber A, Jesinghaus M, Klosterhalfen B, Penzel R, Lennerz JK, Weichert W, Stenzinger A.

Genes Chromosomes Cancer. doi: 10.1002/gcc.22256.PMID: 25931199
 

Hepatic stellate cell‐expressed endosialin balances fibrogenesis and hepatocyte proliferation during liver damage

Mogler, Carolin, Wieland, Matthias, König, Courtney, Hu, Junhao, Runge, Anja, Korn, Claudia, Besemfelder, Eva, Breitkopf‐Heinlein, Katja, Komljenovic, Dorde, Dooley, Steven, Schirmacher, Peter, Longerich, Thomas and Augustin, Hellmut G

EmboMolMed 2015, DOI: 10.15252/emmm.201404246

Predictors of survival after operation among patients with large cell neuroendocrine carcinoma of the lung
Eichhorn, F., Dienemann, H., Muley, T., Warth, A., Hoffmann, H.

Ann Thorac Surg. 2015 Mar;99(3):983-9. doi: 10.1016/j.athoracsur.2014.10.015.

2014

Identification of NY-BR-1-specific CD4 T cell epitopes using HLA-transgenic mice

Gardyan, A., Osen, W., Zornig, I., Podola, L., Agarwal, M., Aulmann, S., Ruggiero, E., Schmidt, M., Halama, N., Leuchs, B., von Kalle, C., Beckhove, P., Schneeweiss, A., Jager, D. and Eichmuller, S.

Int J Cancer. 2014 Nov 12. doi: 10.1002/ijc.29322

Association of drug transporter expression with mortality and progression-free survival in stage IV head and neck squamous cell carcinoma

Warta, R., Theile, D., Mogler, C., Herpel, E., Grabe, N., Lahrmann, B., Plinkert, P. K., Herold-Mende, C., Weiss, J. and Dyckhoff, G.

PLoS One. 2014 Oct 2;9(9):e108908. doi: 10.1371

Acinar cell carcinomas of the pancreas: a molecular analysis in a series of 57 cases.

Bergmann, F., S. Aulmann, B. Sipos, M. Kloor, A. von Heydebreck, J. Schweipert, A. Harjung, P. Mayer, W. Hartwig, G. Moldenhauer, D. Capper, G. Dyckhoff, K. Freier, E. Herpel, A. Schleider, P. Schirmacher, G. Mechtersheimer, G. Klöppel and H. Bläker

Virchows Archiv, October 2014, Date: 09 Oct 2014 10.1007/s00428-014-1657-8

An inducible hepatocellular carcinoma model for preclinical evaluation of antiangiogenic therapy in adult mice

Runge, A., Hu, J., Wieland, M., Bergeest, J. P., Mogler, C., Neumann, A., Geraud, C., Arnold, B., Rohr, K., Komljenovic, D., Schirmacher, P., Goerdt, S. and Augustin, H. G.

Cancer Res. 2014 Aug 1;74(15):4157-69. doi: 10.1158/0008-5472

Validation of a blood protein signature for non-small cell lung cancer

M. R. Mehan, S. A. Williams, J. M. Siegfried, W. L. Bigbee, J. L. Weissfeld, D. O. Wilson, H. I. Pass, W. N. Rom, T. Muley, M. Meister, W. Franklin, Y. E. Miller, E. N. Brody and R. M. Ostroff

Clin Proteomics. 2014 Aug 1;11(1):32. doi: 10.1186/1559-0275-11-32

Long Noncoding RNA TARID Directs Demethylation and Activation of the Tumor Suppressor TCF21 via GADD45A

K. Arab, Y. J. Park, A. M. Lindroth, A. Schafer, C. Oakes, D. Weichenhan, A. Lukanova, E. Lundin, A. Risch, M. Meister, H. Dienemann, G. Dyckhoff, C. Herold-Mende, I. Grummt, C. Niehrs and C. Plass

Mol Cell. 2014 Aug 21;55(4):604-14. doi: 10.1016

Mutations in POLE and survival of colorectal cancer patients - link to disease stage and treatment

A. Stenzinger, N. Pfarr, V. Endris, R. Penzel, L. Jansen, T. Wolf, E. Herpel, A. Warth, F. Klauschen, M. Kloor, W. Roth, H. Blaker, J. Chang-Claude, H. Brenner, M. Hoffmeister and W. Weichert

Cancer Med. 2014 Aug 1. doi: 10.1002/cam4.305.

ROS1 expression and translocations in non-small-cell lung cancer: clinicopathological analysis of 1478 cases

A. Warth, T. Muley, H. Dienemann, B. Goeppert, A. Stenzinger, P. A. Schnabel, P. Schirmacher, R. Penzel and W. Weichert

Histopathology. 2014 Aug;65(2):187-94. doi: 10.1111/his.12379. Epub 2014 Apr 3

Molecular analysis of pancreatic acinar cell cystadenomas: Evidence of a non-neoplastic nature

F. Bergmann, S. Aulmann, T. Welsch, E. Herpel, J. Werner, P. Schirmacher and H. Blaker
Oncol Lett. 2014 Aug;8(2):852-858. Epub 2014 May 22.     

Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy

K. Shahzad, F. Bock, W. Dong, H. Wang, S. Kopf, S. Kohli, M. M. Al-Dabet, S. Ranjan, J. Wolter, C. Wacker, R. Biemann, S. Stoyanov, K. Reymann, P. Soderkvist, O. Gross, V. Schwenger, S. Pahernik,  P. P. Nawroth, H. J. Grone, T. Madhusudhan and B. Isermann
Kidney Int. 2014 Jul 30. doi: 10.1038/ki.2014.271.

Tumour cell proliferation (Ki-67) in non-small cell lung cancer: a critical reappraisal of its prognostic role

A. Warth, J. Cortis, A. Soltermann, M. Meister, J. Budczies, A. Stenzinger, B. Goeppert, M. Thomas, F. J. Herth, P. Schirmacher, P. A. Schnabel, H. Hoffmann, H. Dienemann, T. Muley and W. Weichert

Br J Cancer. 2014 Jul 22, doi: 10.1038/bjc.2014.402

Comprehensive molecular profiling of lung adenocarcinoma

The Cancer Genome Atlas Research Network

Nature. 2014 Jul 31;511(7511):543-50. doi: 10.1038/nature13385

Comparison of two ERCC1 antibodies as prognostic and predictive biomarkers for early non-small cell lung cancer

T. R. Muley, M. Sianidou, M. Thomas, H. Bischoff, H. Dienemann, M. Meister, M. A. Schneider, P. A. Schnabel and A. Warth

Anticancer Res. 2014 Jul;34(7):3707-13

Insulin-like growth factor 1 pathway mutations and protein expression in resected non-small cell lung cancer

N. Reinmuth, S. Kloos, A. Warth, A. Risch, T. Muley, H. Hoffmann, M. Thomas and M. Meister

Hum Pathol. 2014 Jun;45(6):1162-8. doi: 10.1016/j.humpath.2014.01.010. Epub 2014 Jan 31.

Protracted primary cytomegalovirus infection presenting as ileoanal pouchitis in a non-immunosuppressed patient: a case report       

C. Rupp, E. Herpel, P. Schnitzler, A. Zawierucha, P. Zwickel, L. Klute, M. Kadmon, W. Stremmel and A. Gauss
J Med Case Rep. 2014 May 26;8:163. doi: 10.1186/1752-1947-8-163.
 

Overexpression of far upstream element (FUSE) binding protein (FBP)-interacting repressor (FIR) supports growth of hepatocellular carcinoma
M. Malz, M. Bovet, J. Samarin, U. Rabenhorst, C. Sticht, M. Bissinger, S. Roessler, J. Lorenzo Bermejo, M. Renner, D. F. Calvisi, S. Singer, M. Ganzinger, A. Weber, N. Gretz, M. Zornig, P. Schirmacher and K. Breuhahn
Hepatology. 2014 May 13. doi: 10.1002/hep.27218.

Reduced promoter methylation and increased expression of CSPG4 negatively influences survival of HNSCC patients

R. Warta, C. Herold-Mende, J. Chaisaingmongkol, O. Popanda, A. Mock, C. Mogler, F. Osswald, E. Herpel, S. Kustner, V. Eckstein, C. Plass, P. Plinkert, P. Schmezer and G. Dyckhoff
Int J Cancer. 2014 Apr 17. doi: 10.1002/ijc.28906.

Global alterations of DNA methylation in cholangiocarcinoma target the Wnt signaling pathway

B. Goeppert, C. Konermann, C. R. Schmidt, O. Bogatyrova, L. Geiselhart, C. Ernst, L. Gu, N. Becker, M. Zucknick, A. Mehrabi, M. Hafezi, F. Klauschen, A. Stenzinger, A. Warth, K. Breuhahn, M. Renner, W. Weichert, P. Schirmacher, C. Plass and D. Weichenhan
Hepatology. 2014 Feb;59(2):544-54. doi: 10.1002/hep.26721. Epub 2013 Dec 24.

2013

Body mass index and microsatellite instability in colorectal cancer: a population-based study.
Hoffmeister M, Bläker H, Kloor M, Roth W, Toth C, Herpel E, Frank B, Schirmacher P, Chang-Claude J, Brenner H.
Cancer Epidemiol Biomarkers Prev. 2013 Oct 14. [Epub ahead of print]

A Genomics-Based Classification of Human Lung Tumors

T. C. L. C. G. Project and Network Genomic Medicine

Science Translational Medicine. October 30, 2013

stm.sciencemag.org/content/5/209/209ra153.full.pdf

Heart failure gene therapy: the path to clinical practice.
Pleger ST, Brinks H, Ritterhoff J, Raake P, Koch WJ, Katus HA, Most P.
Circ Res. 2013 Aug 30;113(6):792-809. doi: 10.1161/CIRCRESAHA.113.300269.

EGFR, KRAS, BRAF and ALK Gene alterations in lung adenocarcinomas: patient outcome, interplay with morphology and immunophenotype. 
Warth A, Penzel A, Lindenmaier H, Brandt R, Stenzinger A, Herpel H, Goeppert B, Thomas M, Herth FJF, Dienemann H, Schnabel PA, Schirmacher P, Hoffmann H, Muley T and Weichert W. ERJ Express, 2013 Aug 28. [Epub ahead of print]

A current perspective on the pathological assessment of FOXL2 in adult-type granulosa cell tumours of the ovary.
Kommoss S, Gilks CB, Penzel R, Herpel E, Mackenzie R, Huntsman D, Schirmacher P, Anglesio M, Schmidt D, Kommoss F.
Histopathology. 2013 Aug 14. doi: 10.1111/his.12253. [Epub ahead of print]

Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells

N. Fiegler, S. Textor, A. Arnold, A. Rolle, I. Oehme, K. Breuhahn, G. Moldenhauer, M. Witzens-Harig and A. Cerwenka

Blood. 2013 Aug 1;122(5):684-93. doi: 10.1182/blood-2013-02-482513. Epub 2013 Jun 25.

 

 

Tumor-infiltrating lymphocytes in colorectal tumors display a diversity of T cell receptor sequences that differ from the T cells in adjacent mucosal tissue.
Sherwood AM, Emerson RO, Scherer D, Habermann N, Buck K, Staffa J, Desmarais C, Halama N, Jaeger D, Schirmacher P, Herpel E, Kloor M, Ulrich A, Schneider M, Ulrich CM, Robins H. Cancer Immunol Immunother. 2013 Jun 16. [Epub ahead of print]

A complex secretory program orchestrated by the inflammasome controls paracrine senescence.
Acosta JC, Banito A, Wuestefeld T, Georgilis A, Janich P, Morton JP, Athineos D, Kang TW, Lasitschka F, Andrulis M, Pascual G, Morris KJ, Khan S, Jin H, Dharmalingam G, Snijders AP, Carroll T, Capper D, Pritchard C, Inman GJ, Longerich T, Sansom OJ, Benitah SA, Zender L, Gil J. Nat Cell Biol. 2013 Jun 16. [Epub ahead of print]

Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma

D. F. Tschaharganeh, X. Chen, P. Latzko, M. Malz, M. M. Gaida, K. Felix, S. Ladu, S. Singer, F. Pinna, N. Gretz, C. Sticht, M. L. Tomasi, S. Delogu, M. Evert, B. Fan, S. Ribback, L. Jiang, S. Brozzetti, F. Bergmann, F. Dombrowski, P. Schirmacher, D. F. Calvisi and K. Breuhahn

Gastroenterology. 2013 Jun;144(7):1530-1542.e12. doi: 10.1053/j.gastro.2013.02.009. Epub 2013 Feb 16.

A functional yeast survival screen of tumor-derived cDNA libraries designed to identify anti-apoptotic Mammalian oncogenes.
Eißmann M, Schwamb B, Melzer IM, Moser J, Siele D, Köhl U, Rieker RJ, Wachter DL, Agaimy A, Herpel E, Baumgarten P, Mittelbronn M, Rakel S, Kögel D, Böhm S, Gutschner T, Diederichs S, Zörnig M. PLoS One. 2013 May 22;8(5):e64873. Print 2013.

Follicle-stimulating hormone receptor expression in soft tissue sarcomas.
Renner M, Goeppert B, Siraj MA, Radu A, Penzel R, Wardelmann E, Lehner B, Ulrich A, Stenzinger A, Warth A, Vogel MN, Weichert W, Schirmacher P, Mechtersheimer G, Ghinea N. Histopathology. 2013 May 9. [Epub ahead of print]

HPV-related methylation signature predicts survival in oropharyngeal squamous cell carcinomas.
Kostareli E, Holzinger D, Bogatyrova O, Hielscher T, Wichmann G, Keck M, Lahrmann B, Grabe N, Flechtenmacher C, Schmidt CR, Seiwert T, Dyckhoff G, Dietz A, Höfler D, Pawlita M, Benner A, Bosch FX, Plinkert P, Plass C, Weichenhan D, Hess J. J Clin Invest. 2013 May 1. [Epub ahead of print]

 
Targeting the BRAF V600E Mutation in Multiple Myeloma.
Andrulis M, Lehners N, Capper D, Penzel R, Heining C, Huellein J, Zenz T, von Deimling A, Schirmacher P, Ho AD, Goldschmidt H, Neben K, Raab MS. Cancer Discov. 2013 Apr 23. [Epub ahead of print]

Correlation of radio- and histomorphological pattern of pulmonary adenocarcinoma

M. Lederlin, M. Puderbach, T. Muley, P. A. Schnabel, A. Stenzinger, H. U. Kauczor, C. P. Heussel, F. J. Herth, H. Hoffmann, H. Dienemann, W. Weichert and A. Warth

Eur Respir J. 2013 Apr;41(4):943-51. doi: 10.1183/09031936.00056612. Epub 2012 Jul 26.

Colorectal cancer risk associated with hormone use varies by expression of estrogen receptor beta.
Rudolph A, Toth C, Hoffmeister M, Roth W, Herpel E, Schirmacher P, Brenner H, Chang-Claude J. SourceDivision of Cancer Epidemiology, German Cancer Research Center. Cancer Res. 2013 Apr 12. [Epub ahead of print]

The endogenous tryptophan metabolite and NAD+ precursor quinolinic acid confers resistance of gliomas to oxidative stress.
Sahm F, Oezen I, Opitz CA, Radlwimmer B, von Deimling A, Ahrendt T, Adams S, Bode HB, Guillemin GJ, Wick W, Platten M. Cancer Res. 2013 Apr 2. [Epub ahead of print]

 
Hepatic metastases of colorectal cancer are rather homogeneous but differ from primary lesions in terms of immune cell infiltration.
Halama N, Spille A, Lerchl T, Brand K, Herpel E, Welte S, Keim S, Lahrmann B, Klupp F, Kahlert C, Weitz J, Grabe N, Jaeger D, Zoernig I. Oncoimmunology. 2013 Apr 1;2(4):e24116.

The PEA-15/PED protein regulates cellular survival and invasiveness in colorectal carcinomas.
Funke V, Lehmann-Koch J, Bickeböller M, Benner A, Tagscherer KE, Grund K, Pfeifer M, Herpel E, Schirmacher P, Chang-Claude J, Brenner H, Hoffmeister M, Roth W. Cancer Lett. 2013 Mar 6. pii: S0304-3835(13)00216-4. doi: 10.1016/j.canlet.2013.02.053. [Epub ahead of print]

Identification of oropharyngeal squamous cell carcinomas with active HPV16 involvement by immunohistochemical analysis of the retinoblastoma protein pathway.
Holzinger D, Flechtenmacher C, Henfling N, Kaden I, Grabe N, Lahrmann B, Schmitt M, Hess J, Pawlita M, Bosch FX. Int J Cancer. 2013 Mar 2. doi: 10.1002/ijc.28142. [Epub ahead of print]

Endogenous BTG2 expression stimulates migration of bladder cancer cells and correlates with poor clinical prognosis for bladder cancer patients.

Wagener N, Bulkescher J, Macher-Goeppinger S, Karapanagiotou-Schenkel I, Hatiboglu G, Abdel-Rahim M, Abol-Enein H, Ghoneim MA, Bastian PJ, Müller SC, Haferkamp A, Hohenfellner M, Hoppe-Seyler F, Hoppe-Seyler K. Br J Cancer. 2013 Jan 8. [Epub ahead of print]

Alterations in cardiac DNA methylation in human dilated cardiomyopathy
Haas J, Frese KS, Park YJ, Keller A, Vogel B, Lindroth AM, Weichenhan D, Franke J, Fischer S, Bauer A, Marquart S, Sedaghat-Hamedani F, Kayvanpour E, Köhler D, Wolf NM, Hassel S, Nietsch R, Wieland T, Ehlermann P, Schultz JH, Dösch A, Mereles D, Hardt S, Backs J, Hoheisel JD, Plass C, Katus HA, Meder B.
EMBO Mol Med. 2013 Mar;5(3):413-29. doi: 10.1002/emmm.201201553. Epub 2013 Jan 22.

Mesenchymal stem cells in non-small cell lung cancer-Different from others? Insights from comparative molecular and functional analyses.

Gottschling S, Granzow M, Kuner R, Jauch A, Herpel E, Xu EC, Muley T, Schnabel PA, Herth FJ, Meister M. Lung Cancer. 2013 Jan 4. pii: S0169-5002(12)00684-8. doi: 10.1016/j.lungcan.2012.12.015. [Epub ahead of print]

Nuclear Pore Component Nup98 Is a Potential Tumor Suppressor and Regulates Posttranscriptional Expression of Select p53 Target Genes.
Singer S, Zhao R, Barsotti AM, Ouwehand A, Fazollahi M, Coutavas E, Breuhahn K, Neumann O, Longerich T, Pusterla T, Powers MA, Giles KM, Leedman PJ, Hess J, Grunwald D, Bussemaker HJ, Singer RH, Schirmacher P, Prives C. Mol Cell. 2012 Oct 24. [Epub ahead of print]

Tumor-microenvironment interactions studied by zonal transcriptional profiling of squamous cell lung carcinoma.
Wu H, Haag D, Muley T, Warth A, Zapatka M, Toedt G, Pscherer A, Hahn M, Rieker RJ, Wachter DL, Meister M, Schnabel P, Müller-Decker K, Rogers MA, Hoffmann H, Lichter P. Genes Chromosomes Cancer. 2013 Mar;52(3):250-64.Epub 2012 Oct 17.

Stage-specific embryonic antigen-4 is expressed in basaloid lung cancer and associated with poor prognosis.
Gottschling S, Jensen K, Warth A, Herth FJ, Thomas M, Schnabel PA, Herpel E. Eur Respir J. 2013 Mar;41(3):656-63. Epub 2012 Jun 27.

Molecular profiles of non-small cell lung cancers in cigarette smoking and never-smoking patients

A. Szymanowska-Narloch, E. Jassem, M. Skrzypski, T. Muley, M. Meister, H. Dienemann, M. Taron, R. Rosell, R. Rzepko, M. Jarzab, T. Marjanski, R. Pawlowski, W. Rzyman and J. Jassem

Adv Med Sci. 2013;58(2):196-206. doi: 10.2478/ams-2013-0025

2012

Large-scale comparative analyses of immunomarkers for diagnostic subtyping of non-small-cell lung cancer biopsies

A. Warth, T. Muley, E. Herpel, M. Meister, F. J. Herth, P. Schirmacher, W. Weichert, H. Hoffmann and P. A. Schnabel

Histopathology. 2012 Dec;61(6):1017-25. doi: 10.1111/j.1365-2559.2012.04308.x. Epub 2012 Aug 8.

Epigenetic screen of human DNA repair genes identifies aberrant promoter methylation of NEIL1 in head and neck squamous cell carcinoma
J. Chaisaingmongkol, O. Popanda, R. Warta, G. Dyckhoff, E. Herpel, L. Geiselhart, R. Claus, F. Lasitschka, B. Campos, C. C. Oakes, J. L. Bermejo, C. Herold-Mende, C. Plass and P. Schmezer, Oncogene. 2012 Dec 6;31(49):5108-16.

Submaxillary gland androgen-regulated protein 3A expression is an unfavorable risk factor for the survival of oropharyngeal squamous cell carcinoma patients after surgery.
Koffler J, Holzinger D, Sanhueza GA, Flechtenmacher C, Zaoui K, Lahrmann B, Grabe N, Plinkert PK, Hess J. Eur Arch Otorhinolaryngol. 2012 Oct 5. [Epub ahead of print]

Adipophilin/perilipin-2 as a lipid droplet-specific marker for metabolically active cells and diseases associated with metabolic dysregulation.

Straub BK, Gyoengyoesi B, Koenig M, Hashani M, Pawella LM, Herpel E, Mueller W, Macher-Goeppinger S, Heid H, Schirmacher P. Histopathology. 2012 Oct 3. doi: 10.1111/his.12038. [Epub ahead of print]

SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.
Baldauf HM, Pan X, Erikson E, Schmidt S, Daddacha W, Burggraf M, Schenkova K, Ambiel I, Wabnitz G, Gramberg T, Panitz S, Flory E, Landau NR, Sertel S, Rutsch F, Lasitschka F, Kim B, König R, Fackler OT, Keppler OT. Nat Med. 2012 Sep 12. [Epub ahead of print]

Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis.
Faryna M, Konermann C, Aulmann S, Bermejo JL, Brugger M, Diederichs S, Rom J, Weichenhan D, Claus R, Rehli M, Schirmacher P, Sinn HP, Plass C, Gerhauser C. FASEB J. 2012 Aug 28. [Epub ahead of print]

Expression Analysis of Aldehyde Dehydrogenase 1A1 (ALDH1A1) in Colon and Rectal Cancer in Association with Prognosis and Response to Chemotherapy.
Kahlert C, Gaitzsch E, Steinert G, Mogler C, Herpel E, Hoffmeister M, Jansen L, Benner A, Brenner H, Chang-Claude J, Rahbari N, Schmidt T, Klupp F, Grabe N, Lahrmann B, Koch M, Halama N, Büchler M, Weitz J. Ann Surg Oncol. 2012 Aug 10. [Epub ahead of print]

Sequential metastases of colorectal cancer. Immunophenotypes and spatial distributions of infiltrating immune cells in relation to time and treatments.
Keim S, Zoernig I, Spille A, Lahrmann B, Brand K, Herpel E, Grabe N, Jäger D, Halama N. OncoImmunology. 2012 Aug 1;1(5):593-599. [Epub ahead of print]

Glutathione peroxidase 1 activity dictates the sensitivity of glioblastoma cells to oxidative stress.
Dokic I, Hartmann C, Herold-Mende C, Régnier-Vigouroux A. Glia. 2012 Nov;60(11):1785-800. Epub 2012 Aug 1.

Noncompaction myocardium in association with type Ib glycogen storage disease.
Goeppert B, Lindner M, Vogel MN, Warth A, Stenzinger A, Renner M, Schnabel P, Schirmacher P, Autschbach F, Weichert W. Pathol Res Pract. 2012 Jul 31. [Epub ahead of print]

The gefitinib long-term responder (LTR)--a cancer stem-like cell story? Insights from molecular analyses of German long-term responders treated in the IRESSA expanded access program (EAP)

S. Gottschling, E. Herpel, W. E. Eberhardt, D. F. Heigener, J. R. Fischer, C. H. Kohne, C. Kortsik, T. Kuhnt, T. Muley, M. Meister, H. G. Bischoff, P. Klein, I. Moldenhauer, P. A. Schnabel, M. Thomas and R. Penzel

Lung Cancer. 2012 Jul;77(1):183-91. doi: 10.1016/j.lungcan.2012.03.003. Epub 2012 Apr 7

 

Expression of oestrogen receptor β and prognosis of colorectal cancer.
Rudolph A, Toth C, Hoffmeister M, Roth W, Herpel E, Jansen L, Marx A, Brenner H, Chang-Claude J. Br J Cancer. 2012 Jul 24. [Epub ahead of print]

MicroRNA profiling of primary high-grade soft tissue sarcomas.
Renner M, Czwan E, Hartmann W, Penzel R, Brors B, Eils R, Wardelmann E, Büttner R, Lichter P, Schirmacher P, Mechtersheimer G. Genes Chromosomes Cancer. 2012 Jul 18. [Epub ahead of print]

From tissue to molecular phenotyping: Pre-analytical requirements Heidelberg Experience.

Muley T., Herth F.J., Schnabel P., Dienemann H., Meister M.

Translational Lung Cancer Research
1 (2), 111-121

SSEA-4 is Expressed in Basaloid Lung Cancer and Associated with Poor Prognosis.
Gottschling S, Jensen K, Warth A, Herth FJ, Thomas M, Schnabel PA, Herpel E. Eur Respir J. 2012 Jun 27. [Epub ahead of print]

Extensive promoter hypermethylation and hypomethylation is associated with aberrant microRNA expression in chronic lymphocytic leukemia.
Baer C, Claus R, Frenzel LP, Zucknick M, Park YJ, Gu L, Weichenhan D, Fischer M, Pallasch CP, Herpel E, Rehli M, Byrd JC, Wendtner CM, Plass C. Cancer Res. 2012 Jun 18. [Epub ahead of print]

Loss of endothelial thrombomodulin predicts response to steroid therapy and survival in acute intestinal graft-versus-host disease.
Andrulis M, Dietrich S, Longerich T, Koschny R, Burian M, Schmitt-Graeff A, Schirmacher P, Ho AD, Dreger P, Luft T. Haematologica. 2012 Jun 11. [Epub ahead of print]

Clonality of multifocal nonsmall cell lung cancer: implications for staging and therapy.
Warth A, Macher-Goeppinger S, Muley T, Thomas M, Hoffmann H, Schnabel PA, Penzel R, Schirmacher P, Aulmann S.
Eur Respir J. 2012 Jun;39(6):1437-42. doi: 10.1183/09031936.00105911. Epub 2011 Nov 10.

Large-scale comparative analyses of immunomarkers for diagnostic subtyping of non-small-cell lung cancer biopsies.
Warth A, Muley T, Herpel E, Meister M, Herth FJ, Schirmacher P, Weichert W, Hoffmann H, Schnabel PA. Histopathology. 2012 May 31.

Serum mesothelin for diagnosing malignant pleural mesothelioma: an individual patient data meta-analysis
Hollevoet, K.,Reitsma, J. B., Creaney, J., Grigoriu, B. D., Robinson, B. W., Scherpereel, A., Cristaudo, A., Pass, H. I., Nackaerts, K., Rodriguez Portal, J. A.,, Schneider, J., Muley, T., Di Serio, F., Baas, P., Tomasetti, M., Rai, A. J., van, Meerbeeck, J. P. 
J Clin Oncol. 2012 May 1;30(13):1541-9. doi: 10.1200/JCO.2011.39.6671. Epub 2012 Mar 12.

Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP.
Straßburger K, Tiebe M, Pinna F, Breuhahn K, Teleman AA. Dev Biol. 2012 May 16. [Epub ahead of print]

The novel histologic International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification system of lung adenocarcinoma is a stage-independent predictor of survival.

Warth A, Muley T, Meister M, Stenzinger A, Thomas M, Schirmacher P, Schnabel PA, Budczies J, Hoffmann H, Weichert W.
J Clin Oncol. 2012 May 1;30(13):1438-46. doi: 10.1200/JCO.2011.37.2185. Epub 2012 Mar 5.

Application of a BRAF V600E Mutation-specific Antibody for the Diagnosis of Hairy Cell Leukemia.
Andrulis M, Penzel R, Weichert W, von Deimling A, Capper D. Am J Surg Pathol. 2012 Apr 22. [Epub ahead of print]

Unique cell type-specific junctional complexes in vascular endothelium of human and rat liver sinusoids.
Géraud C, Evdokimov K, Straub BK, Peitsch WK, Demory A, Dörflinger Y, Schledzewski K, Schmieder A, Schemmer P, Augustin HG, Schirmacher P, Goerdt S. PLoS One. 2012;7(4):e34206. Epub 2012 Apr 3.
 

Assessment of thymidylate synthase expression in biopsy specimens and corresponding resection specimens of non-small-cell lung cancer.
Herpel E, Schnabel PA, Steins M, Dienemann H, Herth FJ, Thomas M, Schirmacher P, Warth A. Histopathology. 2012 Sep;61(3):465-72.Epub 2012 Mar 28.

ErbB-2 signals through Plexin-B1 to promote breast cancer metastasis.
Worzfeld T, Swiercz JM, Looso M, Straub BK, Sivaraj KK, Offermanns S. J Clin Invest. 2012 Mar 1. [Epub ahead of print]

Opposing function of MYBBP1A in proliferation and migration of head and neck squamous cell carcinoma cells.
Acuna Sanhueza G, Faller L, George B, Koffler J, Misetic V, Flechtenmacher C, Dyckhoff G, Plinkert P, Angel P, Simon C, Hess J. BMC Cancer. 2012 Feb 17;12(1):72. [Epub ahead of print]

Phenotyping of pulmonary carcinoids and a Ki-67-based grading approach.
Zahel T, Krysa S, Herpel E, Stenzinger A, Goeppert B, Schirmacher P, Hoffmann H, Schnabel PA, Warth A. Virchows Arch. 2012 Feb 1. [Epub ahead of print]

Establishment and comparative characterization of novel squamous cell non-small cell lung cancer cell lines and their corresponding tumor tissue.
Gottschling S, Jauch A, Kuner R, Herpel E, Mueller-Decker K, Schnabel PA, Xu EC, Muley T, Sültmann H, Bender C, Granzow M, Efferth T, Hoffmann H, Dienemann H, Herth FJ, Meister M. Lung Cancer. 2012 Jan;75(1):45-57.

2011

The cancer stem cell antigens CD133, BCRP1/ABCG2 and CD117/c-KIT are not associated with prognosis in resected early-stage non-small cell lung cancer.
Herpel E, Jensen K, Muley T, Warth A, Schnabel PA, Meister M, Herth FJ, Dienemann H, Thomas M, Gottschling S.
Anticancer Res. 2011 Dec;31(12):4491-500.

Metastatic adrenocortical carcinoma: results of 56 pulmonary metastasectomies in 24 patients.
op den Winkel J, Pfannschmidt J, Muley T, Grünewald C, Dienemann H, Fassnacht M, Allolio B.
Ann Thorac Surg. 2011 Dec;92(6):1965-70. doi: 10.1016/j.athoracsur.2011.07.088. Epub 2011 Oct 13.

Urokinase receptor forms in serum from non-small cell lung cancer patients: relation to prognosis.
Almasi CE, Christensen IJ, Høyer-Hansen G, Danø K, Pappot H, Dienemann H, Muley T.
Lung Cancer. 2011 Dec;74(3):510-5. doi: 10.1016/j.lungcan.2011.05.008. Epub 2011 Jun 2.

The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis.
Augustin I, Goidts V, Bongers A, Kerr G, Vollert G, Radlwimmer B, Hartmann C, Herold-Mende C, Reifenberger G, von Deimling A, Boutros M. EMBO Mol Med. 2012 Jan;4(1):38-51. Epub 2011 Dec 7.

Comparison of serum cardiac specific biomarker release after non-cardiac thoracic surgery.
Muley T, Kurz M, Männle C, Alekozai A, Winteroll S, Dienemann H, Schmidt W, Pfannschmidt J.
Clin Lab. 2011;57(11-12):925-32.


Automatic tumor-stroma separation in fluorescence TMAs enables the quantitative high-throughput analysis of multiple cancer biomarkers.
Lahrmann B, Halama N, Sinn HP, Schirmacher P, Jaeger D, Grabe N. PLoS One. 2011;6(12):e28048. Epub 2011 Dec 2.

E-N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells.
Straub BK, Rickelt S, Zimbelmann R, Grund C, Kuhn C, Iken M, Ott M, Schirmacher P, Franke WW. J Cell Biol. 2011 Nov 28;195(5):873-87. Epub 2011 Nov 21.

Overexpression of ZEB2 at the invasion front of colorectal cancer is an independent prognostic marker and regulates tumor invasion in vitro.
Kahlert C, Lahes S, Radhakrishnan P, Dutta S, Mogler C, Herpel E, Brand K, Steinert G, Schneider M, Mollenhauer M, Reissfelder C, Klupp F, Fritzmann J, Wunder C, Benner A, Kloor M, Huth C, Contin P, Ulrich A, Koch M, Weitz J. Clin Cancer Res. 2011 Dec 15;17(24):7654-63. Epub 2011 Oct 31.


Localization and density of immune cells in the invasive margin of human colorectal cancer liver metastases are prognostic for response to chemotherapy.
Halama N, Michel S, Kloor M, Zoernig I, Benner A, Spille A, Pommerencke T, von Knebel DM, Folprecht G, Luber B, Feyen N, Martens UM, Beckhove P, Gnjatic S, Schirmacher P, Herpel E, Weitz J, Grabe N, Jaeger D. Cancer Res. 2011 Sep 1;71(17):5670-7. Epub 2011 Aug 16.


In vivo expression profile of the antiviral restriction factor and tumor-targeting antigen CD317/BST-2/HM1.24/tetherin in humans.
Erikson E, Adam T, Schmidt S, Lehmann-Koch J, Over B, Goffinet C, Harter C, Bekeredjian-Ding I, Sertel S, Lasitschka F, Keppler OT. Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13688-93. Epub 2011 Aug 1.


EZH2 depletion blocks the proliferation of colon cancer cells.
Fussbroich B, Wagener N, Macher-Goeppinger S, Benner A, Fälth M, Sültmann H, Holzer A, Hoppe-Seyler K, Hoppe-Seyler F. PLoS One. 2011;6(7):e21651. Epub 2011 Jul 13.


Low expression of aldehyde dehydrogenase 1A1 (ALDH1A1) is a prognostic marker for poor survival in pancreatic cancer.
Kahlert C, Bergmann F, Beck J, Welsch T, Mogler C, Herpel E, Dutta S, Niemietz T, Koch M, Weitz J. BMC Cancer. 2011 Jun 27;11:275.


Immunohistochemical analysis of 1844 human epithelial and haematopoietic tumours and sarcomas for IDH1R132H mutation.
Sahm F, Capper D, Meyer J, Hartmann C, Herpel E, Andrulis M, Mechtersheimer G, Petersen I, Paulus W, von Deimling A. Histopathology. 2011 Jun;58(7):1167-72.

Management of chylothorax in adults: when is surgery indicated?
Zabeck H, Muley T, Dienemann H, Hoffmann H.
Thorac Cardiovasc Surg. 2011 Jun;59(4):243-6. doi: 10.1055/s-0030-1250374. Epub 2011 Mar 21.


Human polyomaviruses and other human viruses in neuroendocrine tumors.
Schmitt M, Höfler D, Koleganova N, Pawlita M. Cancer Epidemiol Biomarkers Prev. 2011 Jul;20(7):1558-61. Epub 2011 May 25.

Loss of aquaporin-4 expression and putative function in non-small cell lung cancer.
Warth A, Muley T, Meister M, Herpel E, Pathil A, Hoffmann H, Schnabel PA, Bender C, Buness A, Schirmacher P, Kuner R. BMC Cancer. 2011 May 6;11:161.


Aberrant expression of retinoic acid signaling molecules influences patient survival in astrocytic gliomas.
Campos B, Centner FS, Bermejo JL, Ali R, Dorsch K, Wan F, Felsberg J, Ahmadi R, Grabe N, Reifenberger G, Unterberg A, Burhenne J, Herold-Mende C. Am J Pathol. 2011 May;178(5):1953-64.

Survival after pulmonary metastasectomy in patients with malignant melanoma.
Schuhan C, Muley T, Dienemann H, Pfannschmidt J.

Thorac Cardiovasc Surg. 2011 Apr;59(3):158-62. doi: 10.1055/s-0030-1250669. Epub 2011 Apr 8.


p38 MAPK controls prothrombin expression by regulated RNA 3' end processing.
Danckwardt S, Gantzert AS, Macher-Goeppinger S, Probst HC, Gentzel M, Wilm M, Gröne HJ, Schirmacher P, Hentze MW, Kulozik AE. Mol Cell. 2011 Feb 4;41(3):298-310.

Expression and mutation analysis of EGFR, c-KIT, and β-catenin in pulmonary blastoma.
Macher-Goeppinger S, Penzel R, Roth W, Dienemann H, Thomas M, Schnabel PA, Schirmacher P, Bläker H. J Clin Pathol. 2011 Apr;64(4):349-53. Epub 2011 Feb 3.

Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma.
Schindler G, Capper D, Meyer J, Janzarik W, Omran H, Herold-Mende C, Schmieder K, Wesseling P, Mawrin C, Hasselblatt M, Louis DN, Korshunov A, Pfister S, Hartmann C, Paulus W, Reifenberger G, von Deimling A. Acta Neuropathol. 2011 Mar;121(3):397-405. Epub 2011 Jan 29.


Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment.
Reiss S, Rebhan I, Backes P, Romero-Brey I, Erfle H, Matula P, Kaderali L, Poenisch M, Blankenburg H, Hiet MS, Longerich T, Diehl S, Ramirez F, Balla T, Rohr K, Kaul A, Bühler S, Pepperkok R, Lengauer T, Albrecht M, Eils R, Schirmacher P, Lohmann V, Bartenschlager R. Cell Host Microbe. 2011 Jan 20;9(1):32-45.

Selective downregulation of retinoic acid-inducible gene I within the intestinal epithelial compartment in Crohn's disease.
Funke B, Lasitschka F, Roth W, Penzel R, Meuer S, Saile M, Gretz N, Sido B, Schirmacher P, Autschbach F. Inflamm Bowel Dis. 2011 Sep;17(9):1943-54. Epub 2011 Jan 6.

2010

Down-regulation of tumor suppressor A kinase anchor protein 12 in human hepatocarcinogenesis by epigenetic mechanisms.
Goeppert B, Schmezer P, Dutruel C, Oakes C, Renner M, Breinig M, Warth A, Vogel MN, Mittelbronn M, Mehrabi A, Gdynia G, Penzel R, Longerich T, Breuhahn K, Popanda O, Plass C, Schirmacher P, Kern MA. Hepatology. 2010 Dec;52(6):2023-33. doi: 10.1002/hep.23939. Epub 2010 Oct 26.

Antibodies to aquaporin-4 in non-small cell lung cancer: a study on 50 patients.
Jarius S, Warth A, Wandinger KP, Schnabel PA, Hoffmann H, Wildemann B, Muley T.

Neurol Sci. 2010 Dec;31(6):871-2. doi: 10.1007/s10072-010-0290-9. Epub 2010 May 27

Lipidtropfen-assoziierte Proteine bei Steatose. Effekte einer Induktion und siRNA-vermittelten Herunterregulation von PAT-Proteinen in hepatozytären Zellkulturmodellen.
Pawella LM, Hashani M, Schirmacher P, Straub BK. Pathologe. 2010 Oct;31 Suppl 2:126-31.

Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma.
Wagener N, Macher-Goeppinger S, Pritsch M, Hüsing J, Hoppe-Seyler K, Schirmacher P, Pfitzenmaier J, Haferkamp A, Hoppe-Seyler F, Hohenfellner M. BMC Cancer. 2010 Oct 4;10:524

S100-Protein-positive Sustentakularzellen in pulmonalen Karzinoiden und thorakalen Paragangliomen. Differenzialdiagnostische und prognostische Bedeutung.
Warth A, Krysa S, Zahel T, Hoffmann H, Schirmacher P, Schnabel PA und Herpel E. Pathologe. 2010 Sep;31(5):379-84.


Epidermal growth factor receptor in adrenocortical tumors: analysis of gene sequence, protein expression and correlation with clinical outcome.
Adam P, Hahner S, Hartmann M, Heinrich B, Quinkler M, Willenberg HS, Saeger W, Sbiera S, Schmull S, Voelker HU, Ströbel P, Allolio B, Fassnacht M. Mod Pathol. 2010 Dec;23(12):1596-604. Epub 2010 Aug 6.


A pragmatic approach to the diagnosis of nodal micrometastases in early stage non-small cell lung cancer.
Herpel E, Muley T, Schneider T, Palm E, Kieslich de Hol D, Warth A, Meister M, Storz K, Schnabel PA, Schirmacher P, Dienemann H, Hoffmann H. J Thorac Oncol. 2010 Aug;5(8):1206-12


Expression of an ASCL2 related stem cell signature and IGF2 in colorectal cancer liver metastases with 11p15.5 gain.
Stange DE, Engel F, Longerich T, Koo BK, Koch M, Delhomme N, Aigner M, Toedt G, Schirmacher P, Lichter P, Weitz J, Radlwimmer B. Gut. 2010 Sep;59(9):1236-44. Epub 2010 May 17.
 

Vectorial transport of nucleoside analogs from the apical to the basolateral membrane in double-transfected cells expressing the human concentrative nucleoside transporter hCNT3 and the export pump ABCC4.
Rius M, Keller D, Brom M, Hummel-Eisenbeiss J, Lyko F, Keppler D. Drug Metab Dispos. 2010 Jul;38(7):1054-63. Epub 2010 Apr 1.

Centre-independent detection of non-small cell lung cancer (NSCLC) by means of classification with receiver operating characteristic (ROC)-based data transformation.
Bitterlich N, Muley T, Schneider J.
Anticancer Res. 2010 May;30(5):1661-5.


Desmosomal plakophilins in the prostate and prostatic adenocarcinomas: implications for diagnosis and tumor progression.
Breuninger S, Reidenbach S, Sauer CG, Ströbel P, Pfitzenmaier J, Trojan L, Hofmann I. Am J Pathol. 2010 May;176(5):2509-19. Epub 2010 Mar 26.


Lipid droplet-associated PAT-proteins show frequent and differential expression in neoplastic steatogenesis.
Straub BK, Herpel E, Singer S, Zimbelmann R, Breuhahn K, Macher-Goeppinger S, Warth A, Lehmann-Koch J, Longerich T, Heid H, Schirmacher P. Mod Pathol. 2010 Jan 15.

2006 - 2009 


Upregulation of plakophilin-2 and its acquisition to adherens junctions identifies a novel molecular ensemble of cell-cell-attachment characteristic for transformed mesenchymal cells.
Rickelt S, Winter-Simanowski S, Noffz E, Kuhn C, Franke WW. Int J Cancer. 2009 Nov 1;125(9):2036-48.


Overexpression of far upstream element binding proteins: a mechanism regulating proliferation and migration in liver cancer cells.
Malz M, Weber A, Singer S, Riehmer V, Bissinger M, Riener MO, Longerich T, Soll C, Vogel A, Angel P, Schirmacher P, Breuhahn K. Hepatology. 2009 Oct;50(4):1130-9.


S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis.
Németh J, Stein I, Haag D, Riehl A, Longerich T, Horwitz E, Breuhahn K, Gebhardt C, Schirmacher P, Hahn M, Ben-Neriah Y, Pikarsky E, Angel P, Hess J. Hepatology. 2009 Oct;50(4):1251-62.

Expression and mutational status of PDGFR in thymic tumours.
Meister M, Kahl P, Muley T, Morresi-Hauf A, Sebening C, Kern MA, Breinig M, Schnabel P, Dienemann H, Schirmacher P, Rieker RJ.
Anticancer Res. 2009 Oct;29(10):4057-61.


Identification of immunohistochemical prognostic markers for survival after resection of pulmonary metastases from colorectal carcinoma.
Pfannschmidt J, Bade S, Hoheisel J, Muley T, Dienemann H, Herpel E. Thorac Cardiovasc Surg. 2009 Oct;57(7):403-8. Epub 2009 Sep 30.


Laryngeal cancer risk associated with smoking and alcohol consumption is modified by genetic polymorphisms in ERCC5, ERCC6 and RAD23B but not by polymorphisms in five other nucleotide excision repair genes.
Abbasi R, Ramroth H, Becher H, Dietz A, Schmezer P, Popanda O.Int J Cancer. 2009 Sep 15;125(6):1431-9.

 
A Histochemical Approach to the Diagnosis of Visceral Pleural Infiltration by Non-small Cell Lung.
Warth A, Muley T, Herpel E, Pfannschmidt J, Hoffmann H, Dienemann H, Schirmacher P, Schnabel PA.  Cancer. Pathol Oncol Res. 2009 Sep 3


Histone macroH2A isoforms predict the risk of lung cancer recurrence.
Sporn JC, Kustatscher G, Hothorn T, Collado M, Serrano M, Muley T, Schnabel P, Ladurner AG. Oncogene. 2009 Sep 24;28(38):3423-8. Epub 2009 Aug 3.


Frequent hypermethylation of RASSF1A tumour suppressor gene promoter and presence of Merkel cell polyomavirus in small cell lung cancer.
Helmbold P, Lahtz C, Herpel E, Schnabel PA, Dammann RH. Eur J Cancer. 2009 Aug;45(12):2207-11.

Gene expression analysis of endobronchial epithelial lining fluid in the evaluation of indeterminate pulmonary nodules.
Kahn N, Kuner R, Eberhardt R, Meister M, Muley T, Winteroll S, Schnabel PA, Ishizaka A, Herth FJ, Poustka A, Sültmann H, Hoffmann H.
J Thorac Cardiovasc Surg. 2009 Aug;138(2):474-9. doi: 10.1016/j.jtcvs.2009.04.024.


Increased expression of ALCAM/CD166 in pancreatic cancer is an independent prognostic marker for poor survival and early tumour relapse.
Kahlert C, Weber H, Mogler C, Bergmann F, Schirmacher P, Kenngott HG, Matterne U, Mollberg N, Rahbari NN, Hinz U, Koch M, Aigner M, Weitz J. Br J Cancer. 2009 Aug 4;101(3):457-64. Epub 2009 Jul 14.


Deleted in Malignant Brain Tumors 1 is up-regulated in bacterial endocarditis and binds to components of vegetations.
Müller H, Renner M, Helmke BM, End C, Weiss C, Poeschl J, Mollenhauer J. J Thorac Cardiovasc Surg. 2009 Sep;138(3):725-32. Epub 2009 Jul 1.


Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma.
Korshunov A, Meyer J, Capper D, Christians A, Remke M, Witt H, Pfister S, von Deimling A, Hartmann C. Acta Neuropathol. 2009 Sep;118(3):401-5. Epub 2009 Jun 19.

Estrogen-related receptor alpha expression and function is associated with the transcriptional coregulator AIB1 in breast carcinoma.
Heck S, Rom J, Thewes V, Becker N, Blume B, Sinn HP, Deuschle U, Sohn C, Schneeweiss A, Lichter P. Cancer Res. 2009 Jun 15;69(12):5186-93. Epub 2009 Jun 2.


Chromosomal instability is more frequent in metastasized than in non-metastasized pulmonary carcinoids but is not a reliable predictor of metastatic potential.
Warth A, Herpel E, Krysa S, Hoffmann H, Schnabel PA, Schirmacher P, Mechtersheimer G, Bläker H. Exp Mol Med. 2009 May 31;41(5):349-53.


Cordial connections: molecular ensembles and structures of adhering junctions connecting interstitial cells of cardiac valves in situ and in cell culture.
Barth M, Schumacher H, Kuhn C, Akhyari P, Lichtenberg A, Franke WW. Cell Tissue Res. 2009 Jul;337(1):63-77. Epub 2009 May 28.
 


Coordinated expression of stathmin family members by far upstream sequence element-binding protein-1 increases motility in non-small cell lung cancer.
Singer S, Malz M, Herpel E, Warth A, Bissinger M, Keith M, Muley T, Meister M, Hoffmann H, Penzel R, Gdynia G, Ehemann V, Schnabel PA, Kuner R, Huber P, Schirmacher P, Breuhahn K. Cancer Res. 2009 Mar 15;69(6):2234-43.

Prognostic Value of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) and TRAIL Receptors in Renal Cell Cancer.
Macher-Goeppinger S, Aulmann S, Tagscherer KE, Wagener N, Haferkamp A, Penzel R, Brauckhoff A, Hohenfellner M, Sykora J, Walczak H, Teh BT, Autschbach F, Herpel E, Schirmacher P, Roth W. Clin Cancer Res. 2009;15(2):650-659.


Perinephric and renal sinus fat infiltration in pT3a renal cell carcinoma: possible prognostic differences.
Bedke J, Buse S, Pritsch M, Macher-Goeppinger S, Schirmacher P, Haferkamp A, Hohenfellner M. BJU Int. 2009 May;103(10):1349-54. Epub 2008 Dec 8.

Functional characterisation of decoy receptor 3 in Crohn's disease.
Funke B, Autschbach F, Kim S, Lasitschka F, Strauch U, Rogler G, Gdynia G, Li L, Gretz N, Macher-Goeppinger S, Sido B, Schirmacher P, Meuer SC, Roth W. Gut. 2009 Apr;58(4):483-91. Epub 2008 Nov 27.

An immune response enriched 72-gene prognostic profile for early-stage non-small-cell lung cancer.
Roepman P, Jassem J, Smit EF, Muley T, Niklinski J, van de Velde T, Witteveen AT, Rzyman W, Floore A, Burgers S, Giaccone G, Meister M, Dienemann H, Skrzypski M, Kozlowski M, Mooi WJ, van Zandwijk N.
Clin Cancer Res. 2009 Jan 1;15(1):284-90. doi: 10.1158/1078-0432.CCR-08-1258.


Proinflammatory cytokines cause FAT10 upregulation in cancers of liver and colon.
Lukasiak S, Schiller C, Oehlschlaeger P, Schmidtke G, Krause P, Legler DF, Autschbach F, Schirmacher P, Breuhahn K, Groettrup M. Oncogene. 2008 Oct ;27(46):6068-74.

Decoy receptor 3 is a prognostic factor in renal cell cancer.
Macher-Goeppinger S, Aulmann S, Wagener N, Funke B, Tagscherer KE, Haferkamp A, Hohenfellner M, Kim S, Autschbach F, Schirmacher P, Roth W. Neoplasia. 2008 Oct;10(10):1049-56.


High nuclear Livin expression is a favourable prognostic indicator in renal cell carcinoma.
Axel Haferkamp, Jens Bedke, Caroline Vetter, Maria Pritisch, Nina Wagener, Stephan Buse, Irene Crnkovic-Mertens, Karin Hoppe-Seyler, Stephan Macher-Goeppinger, Felix Hoppe-Seyler, Frank Autschbach, Markus Hohenfellner BJU Int. 2008 Sep 18.

Differential expression pattern of protein ARVCF in nephron segments of human and mouse kidney.
Walter B, Schlechter T, Hergt M, Berger I, Hofmann I. Histochem Cell Biol. 2008 Nov;130(5):943-56. Epub 2008 Jul 4.


Absence of auto-antibodies against cardiac troponin I predicts improvement of left ventricular function after acute myocardial infarction.
Leuschner F, Li J, Göser S, Reinhardt L, Ottl R, Bride P, Zehelein J, Pfitzer G, Remppis A, Giannitsis E, Katus HA, Kaya Z. Eur Heart J. 2008 Aug;29(16):1949-55. Epub 2008 Jun 13.

 
Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma.
Bennett KL, Karpenko M, Lin MT, Claus R, Arab K, Dyckhoff G, Plinkert P, Herpel E, Smiraglia D, Plass C. Cancer Res. 2008 Jun 15;68(12):4494-9.


Tumor stroma marker endosialin (Tem1) is a binding partner of metastasis-related protein Mac-2 BP/90K.
Becker R, Lenter MC, Vollkommer T, Boos AM, Pfaff D, Augustin HG, Christian S. FASEB J.2008 Aug;22(8):3059-67. Epub 2008 May 19.

Global gene expression analysis reveals specific patterns of cell junctions in non-small cell lung cancer subtypes.
Kuner R, Muley T, Meister M, Ruschhaupt M, Buness A, Xu EC, Schnabel P, Warth A, Poustka A, Sültmann H, Hoffmann H. Lung Cancer. 2009 Jan;63(1):32-8. Epub 2008 May 16.


The histone acetyltransferase hMOF is frequently downregulated in primary breast carcinoma and medulloblastoma and constitutes a biomarker for clinical outcome in medulloblastoma.
Pfister S, Rea S, Taipale M, Mendrzyk F, Straub B, Ittrich C, Thuerigen O, Sinn HP, Akhtar A, Lichter P. Int J Cancer. 2008 Mar 15;122(6):1207-13.

BLOC1S2 interacts with the HIPPI protein and sensitizes NCH89 glioblastoma cells to apoptosis.
Gdynia G, Lehmann-Koch J, Sieber S, Tagscherer KE, Fassl A, Zentgraf H, Matsuzawa S, Reed JC, Roth W. Apoptosis. 2008 Mar;13(3):437-47.

Endosialin (Tem1) is a marker of tumor-associated myofibroblasts and tumor vessel-associated mural cells.
Christian S, Winkler R, Helfrich I, Boos AM, Besemfelder E, Schadendorf D, Augustin HG. Am J Pathol. 2008 Feb;172(2):486-94. Epub 2008 Jan 10.


Differential Pattern of Lipid Droplet–Associated Proteins and De Novo Perilipin Expression in Hepatocyte Steatogenesis.
Beate Katharina Straub,Pamela Stoeffel, Hans Heid, Ralf Zimbelmann, and Peter Schirmacher Hepatology, 2008;47:1936-1946

Expression of inhibitor of apoptosis protein Livin in renal cell carcinoma and non-tumorous adult kidney.
Wagener N, Crnković-Mertens I, Vetter C, Macher-Göppinger S, Bedke J, Gröne EF, Zentgraf H, Pritsch M, Hoppe-Seyler K, Buse S, Haferkamp A, Autschbach F, Hohenfellner M, Hoppe-Seyler F. Br J Cancer. 2007 Nov 5;97(9):1271-6. Epub 2007 Oct 30.

 
 
Characterization of a novel type of adherens junction in meningiomas and the derived cell line HBL-52.
Akat K, Bleck CK, Lee YM, Haselmann-Weiss U, Kartenbeck J. Cell Tissue Res. 2008 Feb;331(2):401-12. Epub 2007 Oct 27.
 

Kallikrein 6 induces E-cadherin shedding and promotes cell proliferation, migration, and invasion.
Klucky B, Mueller R, Vogt I, Teurich S, Hartenstein B, Breuhahn K, Flechtenmacher C, Angel P, Hess J. Cancer Res. 2007 Sep 1;67(17):8198-206.

Protumorigenic overexpression of stathmin/Op18 by gain-of-function mutation in p53 in human hepatocarcinogenesis.
Singer S, Ehemann V, Brauckhoff A, Keith M, Vreden S, Schirmacher P, Breuhahn K. Hepatology. 2007 Sep;46(3):759-68.

Targeted inhibition of Livin resensitizes renal cancer cells towards apoptosis.
Crnković-Mertens I, Wagener N, Semzow J, Gröne EF, Haferkamp A, Hohenfellner M, Butz K, Hoppe-Seyler F. Cell Mol Life Sci. 2007 May;64(9):1137-44.


The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function.
Brueckner B, Stresemann C, Kuner R, Mund C, Musch T, Meister M, Sültmann H, Lyko F. Cancer Res. 2007 Feb 15;67(4):1419-23.

 
The different structures containing tight junction proteins in epidermal and other stratified epithelial cells, including squamous cell metaplasia.
Schlüter H, Moll I, Wolburg H, Franke WW. Eur J Cell Biol. 2007 Dec; 86(11-12):645-55. Epub 2007 Feb 8.


 
FRMD3, a novel putative tumour suppressor in NSCLC.
Haase D, Meister M, Muley T, Hess J, Teurich S, Schnabel P, Hartenstein B, Angel P. Oncogene. 2007 Jun 28;26(30):4464-8. Epub 2007 Jan 29.


The anti-apoptotic livin gene is an important determinant for the apoptotic resistance of non-small cell lung cancer cells.
Crnkovic-Mertens I, Muley T, Meister M, Hartenstein B, Semzow J, Butz K, Hoppe-Seyler F. Lung Cancer. 2006 Nov;54(2):135-42. Epub 2006 Sep 11.

Mutational status of the epidermal growth factor receptor (EGFR) gene in thymomas and thymic carcinomas.

Meister M, Schirmacher P, Dienemann H, Mechtersheimer G, Schnabel PA, Kern MA, Herpel E, Xu EC, Muley T, Thomas M, Rieker RJ. Cancer Lett. 2007 Apr 18;248(2):186-91. Epub 2006 Aug 21.

A novel aspartic proteinase-like gene expressed in stratified epithelia and squamous cell carcinoma of the skin.
Rhiemeier V, Breitenbach U, Richter KH, Gebhardt C, Vogt I, Hartenstein B, Fürstenberger G, Mauch C, Hess J, Angel P. Am J Pathol. 2006 Apr;168(4):1354-64.