Kliniken & Institute ... Institute Pathologisches Institut... Abteilungen Angewandte... Forschung HPV-assoziierte Tumoren... HOCC

Human Papillomavirus Infection and Oropharygeal Cancer Consortium (HOCC)

The Human Papillomavirus Infection and Oropharygeal Cancer Consortium (HOCC) is a network of clinicians and scientists providing a platform for research on head and neck cancers and their association with human papillomaviruses (HPV) in Germany. HOCC was founded in 2010 and currently encompasses more than ten German ENT centers and associated pathologists, virologists, immunologists, tumor biologists, epidemiologists and biometricians.

Key publications

  • Prigge ES, von Knebel Doeberitz M, Reuschenbach M. Clinical relevance and implications of HPV-induced neoplasia in different anatomical locations. Mutat Res. 2017;772:51-66.  
  • Reuschenbach M, Wagner S, Würdemann N, Sharma SJ, Prigge ES, Sauer M, Wittig A, Wittekindt C, von Knebel Doeberitz M, Klussmann JP. [Human papillomavirus and squamous cell cancer of the head and neck region -prognostic, therapeutic and prophylactic implications.] HNO 2016;64(7):450-9. (Article in German).
  • Reuschenbach M, Huebbers CU, Prigge ES, Bermejo JL, Lateis, MS, Preuss SF, Seuthe IM, Kolligs J, Spee EJ, Oltholf N, Kremer B, Wagner S, Klussmann JP, Vinokurova S, von Knebel Doeberitz M. Methylation staus of HPV16 E2-binding sites classifies subtypes of HPV-associated oropharyngeal cancers. Cancer 2015 Jun 121 (12) 1966-76.
  • Prigge ES, Toth C, Dyckhoff G, Wagner S, Müller F, Wittekindt C, Freier K, Plinkert P, Hoffmann J, Vinokurova S, Klussmann JP, von Knebel Doeberitz M, Reuschenbach M. p16(INK4a) /Ki-67 co-expression specifically identifies transformed cells in the head and neck region. Int J Cancer. 2015 Apr 1;136(7):1589-99.
  • Prigge ES, Urban K, Stiegler S, Müller M, Kloor M, Mai S, Ottstadt M, Lohr F, Wenz F, Wagner S, Wittekindt C, Klussmann JP, Hampl M, von Knebel Doeberitz M, Reuschenbach M. No evidence of oncogenic KRAS mutations in squamous cell carcinomas of the anogenital tract and head and neck region independent of human papillomavirus and p16INK4a status. Hum Pathol 2014 Nov;45(11):2347-54.