Kliniken & Institute ... Institute Pathologisches Institut... Abteilungen Neuropathologie Forschung Publikationen 2009 ...

Publikationen 2009

Molecular Predictors of Progression-Free and Overall Survival in Patients With Newly Diagnosed Glioblastoma: A Prospective Translational Study of the German Glioma Network.

Weller M, Felsberg J, Hartmann C, Berger H, Steinbach JP, Schramm J, Westphal M, Schackert G, Simon M, Tonn JC, Heese O, Krex D, Nikkhah G, Pietsch T, Wiestler O, Reifenberger G, von Deimling A, Loeffler M.

J Clin Oncol. 2009 Oct 5. [Epub ahead of print]

Monoclonal antibody specific for IDH1 R132H mutation.

Capper D, Zentgraf H, Balss J, Hartmann C, von Deimling A.

Acta Neuropathol. 2009 Oct 2. [Epub ahead of print]

PCR- and Restriction Endonuclease-Based Detection of IDH1 Mutations.

Meyer J, Pusch S, Balss J, Capper D, Mueller W, Christians A, Hartmann C, von Deimling A.

Brain Pathol. 2009 Aug 18. [Epub ahead of print]

Epigenetic silencing of death receptor 4 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in gliomas.

Elias A, Siegelin MD, Steinmüller A, von Deimling A, Lass U, Korn B, Mueller W.

Clin Cancer Res. 2009 Sep 1;15(17):5457-65. Epub 2009 Aug 25.

First experiences with low-dose anti-angiogenic treatment in gliomatosis cerebri with signs of angiogenic activity.

Seiz M, Kohlhof P, Brockmann MA, Neumaier-Probst E, Hermes P, VON Deimling A, Vajkoczy P, Schmieder K, Tuettenberg J.

Anticancer Res. 2009 Aug;29(8):3261-7.

Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas.

Hartmann C, Meyer J, Balss J, Capper D, Mueller W, Christians A, Felsberg J, Wolter M, Mawrin C, Wick W, Weller M, Herold-Mende C, Unterberg A, Jeuken JW, Wesseling P, Reifenberger G, von Deimling A.

Acta Neuropathol. 2009 Oct.118(4):469-74. Epub Jun 25

Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma.

Korshunov A, Meyer J, Capper D, Christians A, Remke M, Witt H, Pfister S, von Deimling A, Hartmann C.

Acta Neuropathol. 2009 Sep,118(3):401-5. Epub Jun 19

Comparison of automated silver enhanced in situ hybridization and fluorescence in situ hybridization for evaluation of epidermal growth factor receptor status in human glioblastomas.

Gaiser T, Waha A, Moessler F, Bruckner T, Pietsch T, von Deimling A.

Mod Pathol. 2009 Sep, 22(9):1263-71. Epub Jun 12

Somatic mitochondrial mutations in pilocytic astrocytoma.

Lueth M, Wronski L, Giese A, Kirschner-Schwabe R, Pietsch T, von Deimling A, Henze G, Kurtz A, Driever PH.

Cancer Genet Cytogenet. 2009 Jul;192(1):30-5.

Novel oncogene amplifications in tumors from a family with Li-Fraumeni syndrome.

Rieber J, Remke M, Hartmann C, Korshunov A, Burkhardt B, Sturm D, Mechtersheimer G, Wittmann A, Greil J, Blattmann C, Witt O, Behnisch W, Halatsch ME, Orakcioglu B, von Deimling A, Lichter P, Kulozik A, Pfister S.

Genes Chromosomes Cancer. 2009 Jul;48(7):558-68.

Gene regulation by methylation.

Mueller WC, von Deimling A.

Recent Results Cancer Res. 2009;171:217-39. Review.

Hereditary tumor syndromes and gliomas.

Reuss D, von Deimling A.

Recent Results Cancer Res. 2009;171:83-102. Review.

Molecular pathology of oligodendroglial tumors.

Hartmann C, von Deimling A.

Recent Results Cancer Res. 2009;171:25-49. Review.

Characterization of novel and complex genomic aberrations in glioblastoma using a 32K BAC array.

Nord H, Hartmann C, Andersson R, Menzel U, Pfeifer S, Piotrowski A, Bogdan A, Kloc W, Sandgren J, Olofsson T, Hesselager G, Blomquist E, Komorowski J, von Deimling A, Bruder CE, Dumanski JP, Díaz de Ståhl T.

Neuro Oncol. 2009 Jun 12. [Epub ahead of print]

Stem-cell-like glioma cells are resistant to TRAIL/Apo2L and exhibit down-regulation of caspase-8 by promoter methylation.

Capper D, Gaiser T, Hartmann C, Habel A, Mueller W, Herold-Mende C, von Deimling A, Siegelin MD.

Acta Neuropathol. 2009 Apr;117(4):445-56. Epub 2009 Feb 12.

Decreased expression of the active subunit of the cystine/glutamate antiporter xCT is associated with loss of heterozygosity of 1p in oligodendroglial tumours WHO grade II.

Stockhammer F, von Deimling A, van Landeghem FK.

Histopathology. 2009 Jan;54(2):241-7.

Intraoperative radiofrequency ablation of lung metastases and histologic evaluation.

Schneider T, Warth A, Herpel E, Schnabel PA, von Deimling A, Eberhardt R, Herth FJ, Dienemann H, Hoffmann H.

Ann Thorac Surg. 2009 Feb;87(2):379-84.

Reversal of P-glycoprotein-mediated multidrug resistance by the murine double minute 2 antagonist nutlin-3.

Michaelis M, Rothweiler F, Klassert D, von Deimling A, Weber K, Fehse B, Kammerer B, Doerr HW, Cinatl J Jr.

Cancer Res. 2009 Jan 15;69(2):416-21.

Histone deacetylase 8 in neuroblastoma tumorigenesis.

Oehme I, Deubzer HE, Wegener D, Pickert D, Linke JP, Hero B, Kopp-Schneider A, Westermann F, Ulrich SM, von Deimling A, Fischer M, Witt O.

Clin Cancer Res. 2009 Jan 1;15(1):91-9.

Novel genomic amplification targeting the microRNA cluster at 19q13.42 in a pediatric embryonal tumor with abundant neuropil and true rosettes.

Pfister S, Remke M, Castoldi M, Bai AH, Muckenthaler MU, Kulozik A, von Deimling A, Pscherer A, Lichter P, Korshunov A.

Acta Neuropathol. 2009 Apr;117(4):457-64. Epub 2008 Dec 5.

Stepwise accumulation of distinct genomic aberrations in a patient with progressively metastasizing ependymoma.

Milde T, Pfister S, Korshunov A, Deubzer HE, Oehme I, Ernst A, Starzinski-Powitz A, Seitz A, Lichter P, von Deimling A, Witt O.

Genes Chromosomes Cancer. 2009 Mar;48(3):229-38.

Quercetin promotes degradation of survivin and thereby enhances death-receptor-mediated apoptosis in glioma cells.

Siegelin MD, Reuss DE, Habel A, Rami A, von Deimling A.

Neuro Oncol. 2009 Apr;11(2):122-31. Epub 2008 Oct 29.

RASSF1A, BLU, NORE1A, PTEN and MGMT expression and promoter methylation in gliomas and glioma cell lines and evidence of deregulated expression of de novo DNMTs.

Lorente A, Mueller W, Urdangarín E, Lázcoz P, Lass U, von Deimling A, Castresana JS.

Brain Pathol. 2009 Apr;19(2):279-92. Epub 2008 Jun 25.

Long-term outcome and survival of surgically treated supratentorial low-grade glioma in adult patients.

Ahmadi R, Dictus C, Hartmann C, Zürn O, Edler L, Hartmann M, Combs S, Herold-Mende C, Wirtz CR, Unterberg A.

Acta Neurochir (Wien). 2009 Sep 4. [Epub ahead of print] No abstract available.

The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair.

Corsini NS, Sancho-Martinez I, Laudenklos S, Glagow D, Kumar S, Letellier E, Koch P, Teodorczyk M, Kleber S, Klussmann S, Wiestler B, Brüstle O, Mueller W, Gieffers C, Hill O, Thiemann M, Seedorf M, Gretz N, Sprengel R, Celikel T, Martin-Villalba A.

Cell Stem Cell. 2009 Aug 7;5(2):178-90.

A primary malignant ependymoma of the abdominal cavity: a case report and review of the literature.

Mogler C, Kohlhof P, Penzel R, Grenacher L, Haag GM, Schirmacher P, Mueller W.

Virchows Arch. 2009 Apr;454(4):475-8. Epub 2009 Feb 24.

Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci.

Pfister S, Remke M, Benner A, Mendrzyk F, Toedt G, Felsberg J, Wittmann A, Devens F, Gerber NU, Joos S, Kulozik A, Reifenberger G, Rutkowski S, Wiestler OD, Radlwimmer B, Scheurlen W, Lichter P, Korshunov A.

J Clin Oncol. 2009 Apr 1;27(10):1627-36. Epub 2009 Mar 2.

The metastasis-associated genes MTA1 and MTA3 are abundantly expressed in human placenta and chorionic carcinoma cells.

Brüning A, Makovitzky J, Gingelmaier A, Friese K, Mylonas I.

Histochem Cell Biol. 2009 Jul;132(1):33-8. Epub 2009 Apr 12.

First János Fischer Memorial Symposium. Editorial.

Makovitzky J, Richter S.

Acta Histochem. 2009;111(4):268. Epub 2009 Jan 1. No abstract available.

To the memory of Prof. Dr. Rer. Nat. János Fischer (1945-1999), a pioneer of sugar histochemistry and biochemistry.

Emödy L, Makovitzky J.

Acta Histochem. 2009;111(4):269-72. No abstract available.

The relevance of the aldehyde bisulfite toluidine blue reaction and its variants in the submicroscopic carbohydrate research.

Makovitzky J, Richter S.

Acta Histochem. 2009;111(4):273-91. Epub 2009 Jan 20.

Topo-optical reactions for the identification of O-acyl sugars in amyloid deposits.

Richter S, Makovitzky J.

Acta Histochem. 2009;111(4):292-7. Epub 2009 Feb 4.

Topo-optical investigations of AA-amyloid deposits from various species.

Kröger M, Richter S, Gruys E, Kovács MB, Makovitzky J.

Acta Histochem. 2009;111(4):298-9. Epub 2009 Jan 18. No abstract available.

Topo-optical investigations on the surface of bacterial cells during the phagocytosis of Klebsiella pneumoniae in mouse.

Tigyi Z, Gährs W, Emody L, Makovitzky J.

Acta Histochem. 2009;111(4):300-7. Epub 2009 Jan 1.

Polarization optical analysis of the surface structures of various fungi.

Gährs W, Tigyi Z, Emody L, Makovitzky J.

Acta Histochem. 2009;111(4):308-15. Epub 2009 Jan 18.

Interaction of tomato lectin with ABC transporter in cancer cells: glycosylation confers functional conformation of P-gp.

Molnár J, Kars MD, Gündüz U, Engi H, Schumacher U, Van Damme EJ, Peumans WJ, Makovitzky J, Gyémánt N, Molnár P.

Acta Histochem. 2009;111(4):329-33. Epub 2009 Jan 4.

Immunohistochemical labelling of steroid receptors in normal and malignant human endometrium.

Mylonas I, Makovitzky J, Friese K, Jeschke U.

Acta Histochem. 2009;111(4):349-59. Epub 2009 Feb 4.

Invasive hydatidiform mole: immunohistochemical labelling of inhibin/activin subunits, Ki67, p53 and glycodelin A in a rare case.

Makovitzky J, Radtke A, Shabani N, Friese K, Gerber B, Mylonas I.

Acta Histochem. 2009;111(4):360-5. Epub 2009 Feb 4.

Development and characterisation of an antibody for the immunohistochemical detection of inhibin/activin betaE (betaE) in normal human ovarian and placental tissue.

Mylonas I, Makovitzky J, Shabani N, Gingelmaier A, Dian D, Kuhn C, Schulze S, Kunze S, Jeschke U, Friese K.

Acta Histochem. 2009;111(4):366-71. Epub 2009 Feb 4.

Peroxisome proliferator-activated receptor-gamma in normal human pregnancy and miscarriage.

Toth B, Bastug M, Mylonas I, Scholz C, Makovitzky J, Kunze S, Thaler C, Friese K, Jeschke U.

Acta Histochem. 2009;111(4):372-8. Epub 2009 Apr 1.

Characteristics of thoracolumbar intramedullary subependymomas.

Orakcioglu B, Schramm P, Kohlhof P, Aschoff A, Unterberg A, Halatsch ME.

J Neurosurg Spine. 2009 Jan;10(1):54-9.

COX-2 expression in malignant melanoma: a novel prognostic marker?

Becker MR, Siegelin MD, Rompel R, Enk AH, Gaiser T.

Melanoma Res. 2009 Feb;19(1):8-16.

Daidzein overcomes TRAIL-resistance in malignant glioma cells by modulating the expression of the intrinsic apoptotic inhibitor, bcl-2.

Siegelin MD, Gaiser T, Habel A, Siegelin Y.

Neurosci Lett. 2009 May 1;454(3):223-8. Epub 2009 Mar 14.

p53-mediated inhibition of angiogenesis in diffuse low-grade astrocytomas.

Gaiser T, Becker MR, Meyer J, Habel A, Siegelin MD.

Neurochem Int. 2009 Jun;54(7):458-63. Epub 2009 Feb 6.

The XIAP inhibitor Embelin enhances TRAIL-mediated apoptosis in malignant glioma cells by down-regulation of the short isoform of FLIP.

Siegelin MD, Gaiser T, Siegelin Y.

Neurochem Int. 2009 Nov;55(6):423-30. Epub 2009 May 4.

Myricetin sensitizes malignant glioma cells to TRAIL-mediated apoptosis by down-regulation of the short isoform of FLIP and bcl-2.

Siegelin MD, Gaiser T, Habel A, Siegelin Y.

Cancer Lett. 2009 Apr 25. [Epub ahead of print]

KAAD-cyclopamine augmented TRAIL-mediated apoptosis in malignant glioma cells by modulating the intrinsic and extrinsic apoptotic pathway.

Siegelin MD, Siegelin Y, Habel A, Rami A, Gaiser T.

Neurobiol Dis. 2009 May;34(2):259-66.

Genistein enhances proteasomal degradation of the short isoform of FLIP in malignant glioma cells and thereby augments TRAIL-mediated apoptosis.

Siegelin MD, Siegelin Y, Habel A, Gaiser T.

Neurosci Lett. 2009 Apr 3;453(2):92-7. Epub 2009 Feb 13.

Impressive regression of visceral and cerebral melanoma metastases under combination treatment including dacarbacine, radiotherapy and celecoxib.

Becker MR, Gaiser T.

Int J Dermatol. 2009 Feb;48(2):207-9. No abstract available.

17-AAG sensitized malignant glioma cells to death-receptor mediated apoptosis.

Siegelin MD, Habel A, Gaiser T.

Neurobiol Dis. 2009 Feb;33(2):243-9. Epub 2008 Nov 10.

Cerebral non-Langerhans cell histiocytosis in a 17-year-old patient with a headache: case report.

Barrows RJ, Siegelin M, Vogt-Schaden M, Kress B, Hähnel S.

J Neurol. 2009 Apr 12. [Epub ahead of print] No abstract available.

Fulminant onset of cerebral immunocomplex vasculitis as first manifestation of neuropsychiatric systemic lupus erythematosus (NPSLE).

Rizos T, Siegelin M, Hähnel S, Storch-Hagenlocher B, Hug A.

Lupus. 2009 Apr;18(4):361-3.