Kliniken & Institute ... Institute Pathologisches Institut... Abteilungen Neuropathologie Forschung Publikationen 2010 ...

Publikationen 2010


The Nature and Timing of Specific Copy Number Changes in the Course of Molecular Progression in Diffuse Gliomas: Further Elucidation of Their Genetic "Life Story" Jeuken JW, Sijben A, Bleeker FE, Boots-Sprenger SH, Rijntjes J, Gijtenbeek JM, Mueller W, Wesseling P. Brain Pathol. 2010 Sep 30. doi: 10.1111/j.1750-3639.2010.00447.x. [Epub ahead of print]

Immune reconstitution inflammatory syndrome after withdrawal of natalizumab? Lenhard T, Biller A, Mueller W, Metz I, Schönberger J, Wildemann B. Neurology. 2010 Aug 31;75(9):831-3. No abstract available.

 

The 4q12 amplicon in malignant peripheral nerve sheath tumors: consequences on gene expression and implications for sunitinib treatment Zietsch J, Ziegenhagen N, Reuss D, Heppner F, von Deimling A, Holtkamp N.
PLOSone. 2010 5(7):e11858

Chemoradiotherapy of newly diagnosed glioblastoma with intensified temozolomide.
Weiler M, Hartmann C, Wiewroth D, Herrlinger U, Gorlia T, Bahr O, Meyermann R, Bamberg M, Tatagiba M, von Deimling A, Weller M, Wick W.
International Journal of Radiation Oncology Biology Physics 2010 77(3):670-676

Role of LIM and SH3 protein 1 (LASP1) in the metastatic dissemination of medulloblastoma.
Traenka C, Remke M, Korshunov A, Bender S, Hielscher T, Northcott P, Witt H, Ryzhova M, Felsberg J, Benner A, Riester S, Scheurlen W, Grunewald T, von Deimling A, Kulozik A, Reifenberger G, Taylor M, Lichter P, E. B, Pfister S.
Cancer Research. 2010 70(20):8003-8014

The Inhibitor of Growth 1 (ING1) is involved in Trichostatin A-induced apoptosis and caspase 3-signaling in p53-deficient glioblastoma cells.
Tammanai M, Farhangi S, Truss M, Sinn B, Wurm R, Henze G, Riabowol K, von Deimling A, Tallen G.
Oncology Research. 2010 18(10):469-480

Guidelines on management of low grade gliomas: Report of an EFNS-EANO task force.
Soffietti R, Baumert B, Bello L, von Deimling A, Duffau H, Frénay M, Grisold W, Grant R, Graus F, Hoang-Xuan K, Klein M, Melin B, Rees J, Siegal T, Smits A, Stupp R, Wick W.
European Journal of Neurology. 2010 17(9):1124-1133

Detection of IDH1 mutations in gliomatosis cerebri, but only in tumors with additional solid component: evidence for molecular subtypes.
Seiz M, Tuettenberg J, Meyer J, Essig M, Schmieder K, Mawrin C, von Deimling A, Hartmann C.
Acta Neuropathologica Berlin. 2010 120(2):261-267

Sorafenib plus valproic acid for infant spinal glioblastoma.
Rokes CA, Remke M, Guha-Thakurta N, Witt O, Korshunov A, Pfister S, Wolff JE.
J Pediatr Hematol Oncol. 2010 32(6):511-514

Molecular diagnostics of CNS embryonal tumors.
Pfister SM, Korshunov A, Kool M, Hasselblatt M, Eberhart C, Taylor MD.
Acta Neuropathol. 2010 120(5):553-566

TP53 Mutation Is Frequently Associated With CTNNB1 Mutation or MYCN Amplification and Is Compatible With Long-Term Survival in Medulloblastoma.
Pfaff E, Remke M, Sturm D, Benner A, Witt H, Milde T, von Bueren A, Wittmann A, Schöttler A, Jorch N, Graf N, Kulozik A, Witt O, Scheurlen W, von Deimling A, Rutkowski S, Taylor M, Tabori U, Lichter P, Korshunov A, Pfister S.
Journal of Clinical Oncology. 2010 28(35):5188-5196

HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growth.
Milde T, Oehme I, Korshunov A, Kopp-Schneider A, Remke M, Northcott P, Deubzer H, Lodrini M, Taylor M, von Deimling A, Pfister S, Witt O.
Clinical Cancer Research. 2010 16(12):3240-3252

PCR and Restriction Endonuclease based Detection of IDH1 Mutations.
Meyer J, Pusch S, Balss J, Capper D, Mueller W, Christians A, Hartmann C, von Deimling A.
Brain Pathology. 2010 20(2):298-300

Presence of Alternative Lengthening of Telomeres Mechanism in Patients With Glioblastoma Identifies a Less Aggressive Tumor Type With Longer Survival.
McDonald KL, McDonnell J, Muntoni A, Henson JD, Hegi ME, von Deimling A, Wheeler HR, Cook RJ, Biggs MT, Little NS, Robinson BG, Reddel RR, Royds JA.
Journal of Neuropathology and Experimental Pathology. 2010 69(7):729-736

Medulloblastoma harbor somatic mitochondrial DNA mutations in the D-loop region.
Lueth M, von Deimling A, Pietsch T, Wong L, KLurtz A, Henze G, Driever P.
Journal of Pediatric Hematology and Oncology. 2010 32(2):156-159

Molecular staging of intracranial ependymoma in children and adults.
Korshunov A, Witt H, Hielscher T, Benner A, Remke M, Ryzhova M, Milde T, Bender S, Wittmann A, Schöttler A, Kulozik A, Witt O, von Deimling A, Lichter P, Pfister S.
Journal of Clinical Oncology. 2010 28(19):3182-3190

Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratification.
Korshunov A, Remke M, Werft W, Benner A, Ryzhova M, Witt H, Sturm D, Wittmann A, Schöttler A, Felsberg J, Reifenberger G, Rutkowski S, Scheurlen W, Kulozik A, von Deimling A, Lichter P, Pfister S.
Journal of Clinical Oncology. 2010 28(18):3054-3060

Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes.
Korshunov A, Remke M, Gessi M, Ryzhova M, Hielscher T, Witt H, Tobias V, Buccoliero A, Sardi I, Gardiman M, Bonnin J, Scheithauer B, Kulozik A, Witt O, Mork S, von Deimling A, Wiestler O, Giangaspero F, Rosenblum M, Pietsch T, Lichter P, Pfister S.
Acta Neuropathologica Berlin. 2010 120(2):253-260

International network of cancer genome projects.
Hudson TJ, Anderson W, Artez A, Barker AD, Bell C, Bernabe RR, Bhan MK, Calvo F, Eerola I, Gerhard DS, Guttmacher A, Guyer M, Hemsley FM, Jennings JL, Kerr D, Klatt P, Kolar P, Kusada J, Lane DP, Laplace F, Youyong L, Nettekoven G, Ozenberger B, Peterson J, Rao TS, Remacle J, Schafer AJ, Shibata T, Stratton MR, Vockley JG, Watanabe K, Yang H, Yuen MM, Knoppers BM, Bobrow M, Cambon-Thomsen A, Dressler LG, Dyke SO, Joly Y, Kato K, Kennedy KL, Nicolas P, Parker MJ, Rial-Sebbag E, Romeo-Casabona CM, Shaw KM, Wallace S, Wiesner GL, Zeps N, Lichter P, Biankin AV, Chabannon C, Chin L, Clement B, de Alava E, Degos F, Ferguson ML, Geary P, Hayes DN, Johns AL, Kasprzyk A, Nakagawa H, Penny R, Piris MA, Sarin R, Scarpa A, van de Vijver M, Futreal PA, Aburatani H, Bayes M, Botwell DD, Campbell PJ, Estivill X, Grimmond SM, Gut I, Hirst M, Lopez-Otin C, Majumder P, Marra M, McPherson JD, Ning Z, Puente XS, Ruan Y, Stunnenberg HG, Swerdlow H, Velculescu VE, Wilson RK, Xue HH, Yang L, Spellman PT, Bader GD, Boutros PC, Flicek P, Getz G, Guigo R, Guo G, Haussler D, Heath S, Hubbard TJ, Jiang T, Jones SM, Li Q, Lopez-Bigas N, Luo R, Muthuswamy L, Ouellette BF, Pearson JV, Quesada V, Raphael BJ, Sander C, Speed TP, Stein LD, Stuart JM, Teague JW, Totoki Y, Tsunoda T, Valencia A, Wheeler DA, Wu H, Zhao S, Zhou G, Lathrop M, Thomas G, Yoshida T, Axton M, Gunter C, Miller LJ, Zhang J, Haider SA, Wang J, Yung CK, Cross A, Liang Y, Gnaneshan S, Guberman J, Hsu J, Chalmers DR, Hasel KW, Kaan TS, Lowrance WW, Masui T, Rodriguez LL, Vergely C, Bowtell DD, Cloonan N, deFazio A, Eshleman JR, Etemadmoghadam D, Gardiner BA, Kench JG, Sutherland RL, Tempero MA, Waddell NJ, Wilson PJ, Gallinger S, Tsao MS, Shaw PA, Petersen GM, Mukhopadhyay D, DePinho RA, Thayer S, Shazand K, Beck T, Sam M, Timms L, Ballin V, Lu Y, Ji J, Zhang X, Chen F, Hu X, Yang Q, Tian G, Zhang L, Xing X, Li X, Zhu Z, Yu Y, Yu J, Tost J, Brennan P, Holcatova I, Zaridze D, Brazma A, Egevard L, Prokhortchouk E, Banks RE, Uhlen M, Viksna J, Ponten F, Skryabin K, Birney E, Borg A, Borresen-Dale AL, Caldas C, Foekens JA, Martin S, Reis-Filho JS, Richardson AL, Sotiriou C, Thoms G, van't Veer L, Birnbaum D, Blanche H, Boucher P, Boyault S, Masson-Jacquemier JD, Pauporte I, Pivot X, Vincent-Salomon A, Tabone E, Theillet C, Treilleux I, Bioulac-Sage P, Decaens T, Franco D, Gut M, Samuel D, Zucman-Rossi J, Eils R, Brors B, Korbel JO, Korshunov A, Landgraf P, Lehrach H, Pfister S, Radlwimmer B, Reifenberger G, Taylor MD, von Kalle C, Majumder PP, Pederzoli P, Lawlor RA, Delledonne M, Bardelli A, Gress T, Klimstra D, Zamboni G, Nakamura Y, Miyano S, Fujimoto A, Campo E, de Sanjose S, Montserrat E, Gonzalez-Diaz M, Jares P, Himmelbaue H, Bea S, Aparicio S, Easton DF, Collins FS, Compton CC, Lander ES, Burke W, Green AR, Hamilton SR, Kallioniemi OP, Ley TJ, Liu ET, Wainwright BJ.
Nature. 2010 464(7291):993-998

Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1 mutated glioblastomas and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas.
Hartmann C, Hentschel B, Wick W, Capper D, Felsberg J, Simon M, Westphal M, Schackert G, Meyermann R, Pietsch T, Reifenberger G, Weller M, Markus Loeffler M, Andreas von Deimling A.
Acta Neuropathologica Berlin. 2010 120(6):707-718

Imatinib Mesylate (Glivec) inhibits Schwann cell viability and reduces the size of human plexiform neurofibroma in a xenograft model.
Demestre M, Holtkamp N, Herzberg J, Hagel C, Reuss D, Friedrich R, Kluwe L, von Deimling A, Mautner V-F, Kurtz A.
Journal of Neuro-Oncology. 2010 98(1):11-19

Carbon ion radiation therapy for high-risk meningiomas Combs S, Hartmann C, Nikoghosyan A, Jäkel O, Karger C, Haberer T, von Deimling A, Münter M, Huber P, Debus J, Schulz-Ertner D.
Radiotherapy and Oncology 2010 95(1):54-59

Characterization of R132H Mutation Specific IDH1 Antibody binding in brain tumors.
Capper D, Weißert S, Balss J, Habel A, Meyer J, Jäger D, Ackermann U, Tessmer C, Korshunov A, Zentgraf H, Hartmann C, von Deimling A.
Brain Pathology. 2010 20(1):245-254

Application of mutant IDH1 antibody to differentiate diffuse glioma from non-neoplastic central nervous system lesions and therapy induced changes.
Capper D, Felix Sahm S, Hartmann C, Meyermann R, von Deimling A, Schittenhelm J.
American Journal of Surgical Pathology. 2010 34(8):1199-1204

Inositol-requiring enzyme 1{alpha} is a key regulator of angiogenesis and invasion in malignant glioma.
Auf G, Jabouille A, Guerit S, Pineau R, Delugin M, Bouchecareilh M, Magnin N, A. F, Maitre M, Gaiser T, von Deimling A, Czabanka M, Vajkoczy P, Chevet E, Bikfalvi A, Moenner M.
Proc Natl Acad Sci U S A. 2010 107(35):15553-15558

Detection of isocitrate dehydrogenase 1 mutation R132H in myelodysplastic syndrome by mutation specific antibody and direct sequencing.
Andrulis M, Capper D, Luft T, Hartmann C, Zentgraf H, von Deimling A.
Leukemia Research. 2010 34(8):1091 - 1093