Kliniken & Institute ... Institute Pathologisches Institut... Abteilungen Neuropathologie Forschung Publikationen 2012 ...

Publikationen 2012

Suppression of proinvasive RGS4 by mTOR inhibition optimizes glioma treatment.
Weiler M, Pfenning P-N, A-L. T, Blaes J, Jestaedt L, Gronych J, Dittmann L, Berger B, Jugold M, Kosch M, Combs S, von Deimling A, Weller M, Bendszus M, Platten M, Wick W.
Oncogene. Epub ahead of print

DH1/2 mutations in WHO grade II astrocytomas associated with localization and seizure as the initial symptom.
Stockhammer F, Misch M, Helms H, Lengler U, Prall F, von Deimling A, Hartmann C.
Seizure. Epub ahead of print

Distinct requirement for an intact dimer interface in wildtype, V600E and kinase-dead B-Raf signalling.
Röring M, Herr R, Fiala G, Heilmann K, Braun S, Eisenhardt A, Halbach S, Capper D, von Deimling A, Schamel W, Saunders D, Brummer T.
EMBO. Epub ahead of print

Nestin expression identifies ependymoma patients with poor outcome.
Milde T, Hielscher T, Witt H, Kool M, Mack S, Deubzer H, Oehme I, Lodrini M, Benner A, Taylor M, von Deimling A, Kulozik A, Pfister S, Witt O, Korshunov A.
Brain Pathology. Epub ahead of print

Presence of an oligodendroglioma-like component in newly diagnosed glioblastoma identifies a pathogenetically heterogeneous subgroup and lacks prognostic value: central pathology review of the EORTC_26981/NCIC_CE.3 trial.
Hegi M, Janzer R, Lambiv W, Gorlia T, Kouwenhoven M, Hartmann C, von Deimling A, Martinet D, Besuchet Schmutz N, Diserens A-C, Hamou M-F, Bady P, Weller M, van den Bent M, Mason W, Mirimanoff R-O, Stupp R, Mokhtari K, Wesseling P.
Acta Neuropathologica. Epub ahead of print

2-hydroxyglutarate concentration in serum from patients with gliomas does not correlate with IDH1/2 mutation status or tumor size.
Capper D, Simon M, Langhans C-D, Okun J, Tonn J, Weller M, von Deimling A, Hartmann C, Network ftGG.
International Journal of Cancer. Epub ahead of print

Epigenetically mediated downregulation of the differentiation - promoting chaperon protein CRABP2 in astrocytic gliomas.
Campos B, Warta R, Chaisaingmongkol J, Geiselhart L, Popanda O, Hartmann C, von Deimling A, Unterberg A, Plass C, Schmezer P, Herold-Mende C.
International Journal of Cancer. Epub ahead of print

Application of a BRAF V600E mutation-specific antibody for the diagnosis of Hairy Cell Leukemia.
Andrulis M, Penzel R, Weichert W, von Deimling A, Capper D.
American Journal of Surgical Pathology. Epub ahead of print

No prognostic value of IDH1 mutations in a series of 100 WHO grade II astrocytomas Ahmadi R, Stockhammer F, Becker N, Hohlen K, Misch M, Christians A, Dictus C, Herold-Mende C, Capper D, Unterberg A, von Deimling A, Wick W, Hartmann C.
Journal of Neuro-Oncology. Epub ahead of print

Long-term Outcome After Radiotherapy in Patients with Atypical and Malignant Meningiomas-Clinical Results in 85 Patients Treated in a Single Institution Leading to Optimized Guidelines for Early Radiation Therapy.
Adeberg S, Hartmann C, Welzel T, Rieken S, Habermehl D, von Deimling A, Debus J, Combs SE.
International Journal of Radiation Oncology, Biology, Physics. Epub ahead of print

Driver mutations in histone H3.3 and chromatin remodelling genes in pediatric glioblastoma.
Schwartzentruber J, Korshunov A, Liu X, Jones D, Pfaff E, Jacob K, Sturm D, Fontebasso A, Khuong Quang D, Tönjes M, Hovestadt V, Albrecht S, Kool M, Nantel A, Konermann C, Lindroth A, Jäger N, Rausch T, Ryzhova M, Korbel J, Hielscher T, Hauser P, Garami M, Klekner A, Bognar L, Ebinger M, Schuhmann M, Scheurlen W, Pekrun A, Frühwald M, Roggendorf W, Kramm C, Dürken M, Atkinson J, Lepage P, Montpetit A, Zakrzewska M, Zakrzewski K, Liberski P, Dong Z, Siegel P, Kulozik A, Zapatka M, Guha A, Malkin D, Felsberg J, Reifenberger G, von Deimling A, Ichimura K, Collins V, Witt H, Milde T, Witt O, Zhang C, Castelo-Branco P, Lichter P, Faury D, Tabori U, Plass C, Majewski J, Pfister S, Jabado N.
Nature. 2012 492(7384):226-231


Addressing diffuse glioma as a systemic brain disease with single-cell analysis.
Sahm F, Capper D, Jeibmann A, Habel A, Paulus W, Troost D, von Deimling A.
Archives of Neurology. 2012 69(4):523-526


Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations.
Rausch T, Jones D, Zapatka M, Stütz A, Zichner T, Weischenfeldt J, Jäger N, Remke M, Shih D, Northcott P, Pfaff E, Tica J, Wang Q, Massimi L, Witt H, Bender S, Pleier S, Cin H, Hawkins C, Beck C, von Deimling A, Hans V, Brors B, Eils R, Scheurlen W, Blake J, Benes V, Kulozik A, Witt O, Martin D, Zhang C, Porat R, Merino D, Wasserman J, Jabado N, Fontebasso A, Bullinger L, Rücker F, Döhner K, Döhner H, Koster J, Molenaar J, Versteeg R, Kool M, Tabori U, Malkin D, Korshunov A, Taylor M, Lichter P, Pfister S, Korbel J.
Cell. 2012 148(1-2):59-71


Brain metastases: pathobiology and emerging targeted therapies.
Preusser M, Capper D, Ilhan-Mutlu A, Berghoff A, Birner P, Bartsch R, Marosi C, Zielinski C, Metha M, Winkler F, Wick W, von Deimling A.
Acta Neuropathologica. 2012 123(2):205-222


Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents.
Michaelis M, Rothweiler F, Agha B, Barth S, Voges Y, Löschmann N, von Deimling A, Breitling R, Doerr H, Rödel F, Speidel D, Cinatl J.
Cell Death and Disease. 2012 5(3):e294


Comparison of immunohistochemistry, DNA sequencing and allele-specific PCR for the detection of IDH1 mutations in gliomas.
Loussouarn D, Le Loupp A, Frenel J, Leclair F, von Deimling A, Aumont M, Martin S, Campone M, Denis M.
International Journal of Oncology. 2012 40(6):2058-2062


Biological and clinical heterogeneity of MYCN-amplified medulloblastoma.
Korshunov A, Remke M, Kool M, Hielscher T, Northcott P, Williamson D, Pfaff E, Witt H, Jones D, Ryzhova M, Cho Y-J, Wittmann A, Benner A, Weiss W, von Deimling A, Scheurlen W, Kulozik A, Clifford S, Collins V, Westermann F, Taylor M, Lichter P, Pfister S.
Acta Neuropathologica. 2012 123(4):515-527


Prognostic value of three different methods of MGMT promoter methylation analysis in a prospective trial on newly diagnosed glioblastoma.
Christians A, Hartmann C, Benner A, Meyer J, von Deimling A, Weller M, Wick W, Weiler M.
PLoS One. 2012 7(3):e33449


Immunohistochemical testing of BRAF V600E status in 1,120 tumor tissue samples of patients with brain metastases.
Capper D, Berghoff A, Magerle M, Ilhan A, Wöhrer A, Hackl M, Pichler J, Pusch S, Meyer J, Habel A, Petzelbauer P, Birner P, von Deimling A, Preusser M.
Acta Neuropathologica. 2012 123(22):223-233


The Wnt secretion protein Evi/Gpr177  promotes glioma tumourigenesis.
Augustin I, Goidts V, Bongers A, Kerr G, Vollert G, Radlwimmer B, Hartmann C, Herold-Mende C, Reifenberger G, von Deimling A, Boutros M.
EMBO Mol Med. 2012 4(1):38-51