PD Dr. rer. nat. Margarida Souto-Carneiro

Promotion (Dr. rer. nat.)
Subject: „Molecular and functional analyses of human synovial B-lymphocytes in rheumatoid arthritis”, Julius-Maximilians, Universität, Würzburg

Habilitation
Specialty: Experimental Rheumatology, Medizinischen Fakultät der Universität Heidelberg (March 2024: Antrittsvorlesung)

Coordinator of the Gender-sensitive Medicine Network of the Medizinischen Fakultät der Universität Heidelberg

Privat Dozentin for Experimental Rheumatology at the Medizinischen Fakultät der Universität Heidelberg

Research coordinator for the Division for Rheumatology, Medical Clinic 5, Universitätsklinikum Heidelberg

Lecturer and course coordinator for Immunometabolism at the Medizinischen Fakultät der Universität Heidelberg

Principal Investigator at the Division for Rheumatology, Medical Clinic 5, Universitätsklinikum Heidelberg

Guest researcher at the Division for Rheumatology, Medical Clinic 5, Universitätsklinikum Heidelberg

Group Leader of the Immuno-Metabolic Pharmacology Group at Center for Neurosciences and Cell Biology, University of Coimbra, Portugal 

Invited Researcher, Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Portugal 

Marie Curie Fellow/ Junior Investigator, Instituto Gulbenkian de Ciência, Oeiras, Portugal 

Lecturer for Metabolism and Bioenergetics, Department of Chemistry & Biochemistry, University of Évora, Portugal 

Post-doctoral fellow, National Institute of Arthritis and Musculoskeletal Diseases (NIAMS), NIH, Bethesda (MD), USA 

Degree programme
Biochemistry (Diploma); Faculty of Sciences, University of Lisbon, Portugal 

Fellow of the Marie Skłodowska-Curie Programme from the European Union. 

Young Investigator Award bestowed by the European League Against Rheumatism (EULAR) 

Council member of the International Union of Immunological Societies 

Secretary General of the Portuguese Society for Immunology 

Member of the Gender-Medicine Network of the Ruprecht-KarlsUniversity Heidelberg; Currently: Coordinator

Member of the German Society for Immunology and the DGfI T cell interest group 

1: Gente K, Feisst M, Marx D, Klika KD, Christopoulos P, Graf J, Will J, Luft T, Hassel JC, Müller-Tidow C, Carvalho RA, Lorenz HM, Souto-Carneiro MM. Altered serum metabolome as an indicator of paraneoplasia or concomitant cancer in patients with rheumatic disease. Ann Rheum Dis. 2024 Jul 15;83(8):974-983. doi: 10.1136/ard-2023-224839. PMID: 38561219

2: Chakraborty S, Gupta R, Kubatzky KF, Kar S, Kraus FV, Souto-Carneiro MM, Lorenz HM, Kumar P, Kumar V, Mitra DK. Negative impact of Interleukin-9 on synovial regulatory T cells in rheumatoid arthritis. Clin Immunol. 2023 Dec;257:109814. doi: 10.1016/j.clim.2023.109814. Epub 2023 Oct 23. PMID: 37879380. 

3: Gente K, Diekmann L, Daniello L, Will J, Feisst M, Olsavszky V, Günther J, Lorenz HM, Souto-Carneiro MM, Hassel JC, Christopoulos P, Leipe J. Sex and anti- inflammatory treatment affect outcome of melanoma and non-small cell lung cancer patients with rheumatic immune-related adverse events. J Immunother Cancer. 2023 Sep;11(9):e007557. doi: 10.1136/jitc-2023-007557. PMID: 37730272; PMCID: PMC10510926. 

4: Seebach E, Elschner T, Kraus FV, Souto-Carneiro M, Kubatzky KF. Bacterial and Metabolic Factors of Staphylococcal Planktonic and Biofilm Environments Differentially Regulate Macrophage Immune Activation. Inflammation. 2023 Aug;46(4):1512-1530. doi: 10.1007/s10753-023-01824-3. Epub 2023 May 22. PMID: 37212952; PMCID: PMC10359233. 

5: Kraus FV, Keck S, Klika KD, Graf J, Carvalho RA, Lorenz HM, Souto-Carneiro MM. Reduction of Proinflammatory Effector Functions Through Remodeling of Fatty Acid Metabolism in CD8+ T Cells From Rheumatoid Arthritis Patients. Arthritis Rheumatol. 2023 Jul;75(7):10981109. doi: 10.1002/art.42456. Epub 2023 Apr 13. PMID: 36704915. 

6: Denkinger CM, Janssen M, Schäkel U, Gall J, Leo A, Stelmach P, Weber SF, Krisam J, Baumann L, Stermann J, Merle U, Weigand MA, Nusshag C, Bullinger L, Schrezenmeier JF, Bornhäuser M, Alakel N, Witzke O, Wolf T, Vehreschild MJGT, Schmiedel S, Addo MM, Herth F, Kreuter M, Tepasse PR, Hertenstein B, Hänel M, Morgner A, Kiehl M, Hopfer O, Wattad MA, Schimanski CC, Celik C, Pohle T, Ruhe M, Kern WV, Schmitt A, Lorenz HM, Souto-Carneiro M, Gaeddert M, Halama N, Meuer S, Kräusslich HG, Müller B, Schnitzler P, Parthé S, Bartenschlager R, Gronkowski M, Klemmer J, Schmitt M, Dreger P, Kriegsmann K, Schlenk RF, Müller-Tidow C. Anti-SARS-CoV-2 antibody-containing plasma improves outcome in patients with hematologic or solid cancer and severe COVID-19: a randomized clinical trial. Nat Cancer. 2023 Jan;4(1):96-107. doi: 10.1038/s43018-022-00503-w. Epub 2022 Dec 29. PMID: 36581734; PMCID: PMC9886549. 

7: Schindler H, Lusky F, Daniello L, Elshiaty M, Gaissmaier L, Benesova K, Souto-Carneiro M, Angeles AK, Janke F, Eichhorn F, Kazdal D, Schneider M, Liersch S, Klemm S, Schnitzler P, Stenzinger A, Sültmann H, Thomas M, Christopoulos P. Serum cytokines predict efficacy and toxicity, but are not useful for disease monitoring in lung cancer treated with PD-(L)1 inhibitors. Front Oncol. 2022 Oct 31;12:1010660. doi: 10.3389/fonc.2022.1010660. PMID: 36387148; PMCID: PMC9662790. 

8: Orlik C, Berschneider KM, Jahraus B, Niesler B, Balta E, Schäkel K, Schröder- Braunstein J, Souto-Carneiro MM, Samstag Y. Keratinocyte-induced costimulation of human T cells through CD6 - but not CD2 - activates mTOR and prevents oxidative stress. Front Immunol. 2022 Oct 24;13:1016112. doi: 10.3389/fimmu.2022.1016112. PMID: 36353616; PMCID: PMC9639098. 

9: Benesova K, Kraus FV, Carvalho RA, Lorenz H, Hörth CH, Günther J, Klika KD, Graf J, Diekmann L, Schank T, Christopoulos P, Hassel JC, Lorenz HM, Souto- Carneiro M. Distinct immune-effector and metabolic profile of CD8+ T cells in patients with autoimmune polyarthritis induced by therapy with immune checkpoint inhibitors. Ann Rheum Dis. 2022 Aug 3;81(12):1730–41. doi: 10.1136/ard-2022-222451. Epub ahead of print. PMID: 35922125; PMCID: PMC9664113.