Kliniken & Institute ... SFBs SFB TRR156 Research Research Area B: Immune...

B02: Functional analysis of skin subsets of dendritic cells using inducible transgenic mice that allow subset specific antigen expression

Institut für Immunologie der Universitätsmedizin Mainz

The dendritic cell (DC) network of the skin consists of at least five phenotypically distinct subpopulations. There is limited information on the functional specialization of these subsets. We will use inducible transgenic mouse models to target MHC class-I and MHC class-II restricted antigens selectively to DC subsets in the skin, to establish the role of individual subsets in T-cell priming and effector differentiation, T-cell tolerance induction and the establishment of skin resident T-cell memory.

Quelle: Institut für Immunologie der Universitätsmedizin Mainz

Principal investigators

Dr. sc. nat. (ETH Zürich) Hans Christian Probst

Institut für Immunologie der Universitätsmedizin Mainz

Prof. Dr. Hansjörg Schild

Institut für Immunologie der Universitätsmedizin Mainz