Function of the Erythropoietin Receptor in anti-inflammatory Signalling:
While it has been known for several decades that the EpoR plays an important role in erythropoiesis, it is now becoming clear that this receptor is also involved in inflammatory processes. Epo has been found to down-regulate the production of pro-inflammatory cytokines, but the mechanistic details of its signalling pathways in immune cells have not been fully discovered yet. We aim to unravel these pathways on a molecular level and to determine its significance in inflammatory signalling.
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Kubatzky, K.F., W. Liu, K. Goldgraben, C. Simmerling, S.O. Smith, S.N. Constantinescu. Structural requirements of the extracellular to transmembrane domain junction for erythropoietin receptor function. J Biol Chem 280(15): 14844-14854
Seubert, N., Y. Royer, J. Staerk, K.F. Kubatzky, V. Moucadel, S. Krishnakumar, S.O. Smith, S.N. Constantinescu. Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer. Mol Cell 12(5): 1239-1250
Constantinescu, S.N., T. Keren, W.P. Russ, I. Ubarretxena-Belandia, Y. Malka, K.F. Kubatzky, D.M. Engelmann, H.F. Lodish, Y.I. Henis. J Biol Chem 278(44): 43744-43763
Kubatzky, K.F., W. Ruan, R. Gurezka, J. Cohen, R. Ketteler, S.S. Watowich, D. Neumann, D. Langosch, U. Klingmüller. Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor. Curr Biol 11(2): 110-115