Kliniken & Institute … Institute Zentrum für… Parasitology Unit Research Frischknecht Lab Publications

Selected publications of the Frischknecht group

=> Books etc.

F. Frischknecht, Malaria - Tödliche Parasiten, spannende Forschung und kein ImpfstoffSpringer Essentials, 2018

J. Baum, and F. Frischknecht, Motorizing Pathogens, Semin Cell Dev Biol, 46, 78-81, 2015.

F. Frischknecht, M. M. Mota, A. Scherf and A. P. Waters (eds), Malaria, a special themed issue of Cellular Microbiology, 16 (5), 599-795, 2014.

F. Frischknecht and S.L. Shorte (eds), Imaging host-pathogen interactions, Biotechnology Journal, Wiley-Blackwell, 4 (6), 773-948, 2009.

S. L. Shorte, F. Frischknecht (eds), Imaging Cellular and Molecular Biological Functions, Springer Verlag, 2007.

=> Reviews

M. De Niz, F. Spadin, M. Marti, J.V. Stein, M. Frenz, F. FrischknechtToolbox for In Vivo Imaging of Host-Parasite Interactions at Multiple Scales. Trends Parasitol, doi: 10.1016/j.pt.2019.01.002, 2019.

J. M. MuthinjaJ. Ripp, T. Kruger, A. Imle, T. Haraszti, O. T. Fackler, J. P. Spatz, M. Engstler, and F. Frischknecht, Tailored Environments to Study Motile Cells and Pathogens, Cell Microbiol, 20, 2018.

M. CyrklaffF. Frischknecht, and M. Kudryashev, Functional Insights into Pathogen Biology from 3d Electron Microscopy, FEMS Microbiol Rev, 41, 828-53,  2017.

M. De Niz, P. C. Burda, G. Kaiser, H. A. Del Portillo, T. Spielmann, F. Frischknecht, and V. T. Heussler, Progress in Imaging Methods: Insights Gained into Plasmodium Biology, Nat Rev Microbiol, 15, 37-54, 2017.

F. Frischknecht, and K. Matuschewski, Plasmodium Sporozoite Biology, Cold Spring Harb Perspect Med, 7, 2017.

M. Singer, and F. Frischknecht, Time for Genome Editing: Next-Generation Attenuated Malaria Parasites, Trends Parasitol, 33, 202-13, 2017.

R. G. Douglas, R. Amino, P. Sinnis, and F. Frischknecht, Active Migration and Passive Transport of Malaria Parasites, Trends Parasitol, 31, 357-62, 2015.

F. Frischknecht, Biological warfare: from history to current affairs, eLS, 2014.

M. Meissner, D. Fergusson and F. Frischknecht, Invasion factors of apicomplexan parasites: Essential or redundant? Current Opinion in Microbiology, 16, 438-444, 2013.

M. Singer and F. Frischknecht, Challenges of imaging parasite transmission, Methods in Enzymology, 506, 19-33, 2012.

F. Frischknecht, Imaging parasites at different scales, Cell Host & Microbe, 8, 16-21, 2010.

F. Frischknecht, M. Gunzer and S.L. Shorte, Birth of the cool: Imaging and microbiology from lbn al-Haytham to Leewenhoek and Comandon, Biotechnology Journal, 4, 787-790, 2009.

S. Lepper, S. Münter, Spotlight on pathogens: Imaging Host-pathogen Interactions, Cellular Microbiology, 11, 855-862, 2009.

F. Frischknecht, The skin as interface in the transmission of arthropod-borne pathogens, Cellular Microbiology, 7, 1630-1640, 2007.

F. Frischknecht, O. Renaud, and S. L. Shorte, Imaging today's infectious animalcules, Current Opinion in Microbiology, 9, 297-306, 2006.

S. Münter, M. Way, and F. Frischknecht, Signaling during pathogen infection, Science STKE, re5, 2006.

R. Amino, R. Menard and F. FrischknechtIn vivo imaging of malaria parasites - recent advances and future perspectives, Current Opinion in Microbiology, 8, 407-414, 2005.

F. Frischknecht, and M. Way, Surfing pathogens and the lessons learned for actin polymerization, Trends in Cell Biology, 11, 30-38, 2001.

=> Articles

D. Klug, J. Kehrer, F. Frischknecht, M. Singer, A synthetic promoter for multi-stage expression to probe complementary functions of PlasmodiumadhesinsJournal of Cell Science 131, 20, 2018.

R.G. Douglas, M. Reinig, M. Neale, F. Frischknecht, Screening for potential prophylactics targeting sporozoite motility through the skinMalaria Journal. 17, 319, 2018.

R.G. Douglas, P. Nandekar, J.E. Aktories, H. Kumar, R. Weber, J.M. Sattler, M. Singer, S. Lepper, S.K. Sadiq, R.C. Wade, F. Frischknecht, Inter-subunit interactions drive divergent dynamics in mammalian and Plasmodium actin filamentsPLoS Biology 16, e2005345, 2018.

H. Prinz, J.M. Sattler, A. Roth, J. Ripp, J.H. Adams, F. FrischknechtImmunization efficacy of cryopreserved genetically attenuated Plasmodium berghei sporozoitesParasitology Research117, 2487-249, 2018.

C. A. MoreauS. P. BhargavH. KumarK. A. Quadt, H. Piirainen, L. StraussJ. KehrerM. Streichfuss, J.P. Spatz, R. C. Wade, I. Kursula, and F. Frischknecht, A Unique Profilin-Actin Interface Is Important for Malaria Parasite Motility, PLoS Pathog, 13 e1006412, 2017.

J. M. Santos, S. Egarter, V. Zuzarte-Luis, H. KumarC. A. MoreauJ. Kehrer, A. Pinto, M. D. Costa, B. Franke-Fayard, C. J. Janse, F. Frischknecht, and G. R. Mair, Malaria Parasite Limp Protein Regulates Sporozoite Gliding Motility and Infectivity in Mosquito and Mammalian Hosts, Elife, 6, 2017.

D. Klug, and F. Frischknecht, Motility Precedes Egress of Malaria Parasites from Oocysts, Elife, 6, 2017.

M. J. MuthinjaJ. Ripp, J. K. Hellmann, T. Haraszti, N. Dahan, L. Lemgruber, A. Battista, L. Schutz, O. T. Fackler, U. S. Schwarz, J. P. Spatz, and F. Frischknecht, Microstructured Blood Vessel Surrogates Reveal Structural Tropism of Motile Malaria Parasites, Adv Healthc Mater, 6, 2017.

K. S. Bane, S. Lepper, J. KehrerJ. M. SattlerM. SingerM. ReinigD. Klug, K. Heiss, J. Baum, A. K. Mueller, and F. Frischknecht, The Actin Filament-Binding Protein Coronin Regulates Motility in Plasmodium Sporozoites, PLoS Pathog, 12, 2016.

J. Kehrer, M. Singer, L. Lemgruber, P. A. Silva, F. Frischknecht, and G. R. Mair, A Putative Small SoluteTransporter Is Responsible for the Secretion of G377 and Trap-Containing Secretory Vesicles During Plasmodium Gamete Egress and Sporozoite Motility, PLoS Pathog, 12 (2016), e1005734.

J.Kehrer, F. Frischknecht and G. R. Mair, Proteomic analysis of the Plasmodium berghei gametocyte egressome and vesicular bioID of osmiophilic body proteins identifies MTRAP as an essential factor for parasite transmission, Mol Cell Proteomics, 2016.

H.KumarJ.M. SattlerM. Singer, K. Heiss, M. Reinig, C. Hammerschmidt-Kamper, V. Heussler, A.K. Mueller and F. Frischknecht, Protective efficacy and safety of liver stage attenuated malaria parasites, Sci Reports, 6, 2016.

D. KlugG. R. MairF. Frischknecht, and R. G. Douglas, A Small Mitochondrial Protein Present in Myzozoans Is Essential for Malaria Transmission, Open Biol, 6, 2016.

K. A. Quadt, M. Streichfuss, C. A. Moreau, J. P. Spatz, and F. Frischknecht, Coupling of Retrograde Flow to Force Production During Malaria Parasite Migration, ACS Nano, 10, 2091-102, 2016.

M. Singer, J. Marshall, K. Heiss, G. R. Mair, D. Grimm, A. K. Mueller, and F. Frischknecht, Zinc Finger Nuclease-Based Double-Strand Breaks Attenuate Malaria Parasites and Reveal Rare Microhomology-Mediated End Joining, Genome Biol, 16, 249, 2015.

A.C. Carey, M. Singer, D. Barigieri, F. Frischknecht, R. Menard and R. Amino, Calcium dynamics of Plasmodium berghei sporozoite motility, Cellular Microbiology, 16, 768-783, 2014.

J. K. Hellmann, N. Perschmann, J. P. Spatz and F. Frischknecht, Tunable substrates unveil chemical complementation of a genetic cell migration defect, Advanced Healthcare Materials, 2, 1162-1169, 2013.

L. Lemgruber, M. Kudryashev, C. Dekiwadia, D. Riglar, J. Baum, H. Stahlberg, S. A. Ralph and F. Frischknecht, Cryo-electron tomography reveals four membrane architecture of the Plasmodium apicoplast. Malaria Journal 12, 25, 2013.

K. Kühni, M. Ma, L. Lemgruber, M. Cyrklaff, F. Frischknecht, V. Gaschen, M. Stoffel and M. Baumgartner, Actin-mediated plasma membrane plasticity of the intracellular parasite Theileria annulata, Cellular Microbiology, 14, 1867-1879, 2012.

M. Kudryashev, S. Münter, L. Lemgruber, G. Montagna, K. Matuschewski, H. Stahlberg, M. Meissner, M. Cyrklaff, F. Frischknecht, Structural basis for chirality and directed Plasmodium sporozoite migration, Cellular Microbiology, 14, 1757-1768, 2012.

S. Hegge, K. Uhrig, M. Streichfuss, G. Kynast-Wolf, K. Matuschewski, J.P. Spatz and F. Frischknecht, Direct manipulation of malaria parasites with optical tweezers reveals distinct functions of Plasmodium surface proteins, ACS Nano, 6. 4648-4662, 2012.

C. S. S. Gomes-Santos, M. A. Itoe, C. Afonso, R. Henriques, R. Gardner, P. D. Simoes, H. Raquel, P. Almeida, L. F. Moita, F. Frischknecht and M. M. Mota, Heptocyte actin polymerization around developing Plasmodium, PLoS One e29408, 2012.

M. Cyrklaff, J. Simpore, C. P. Sanchez, C. Biseye, F. Frischknecht, and M. Lanzer, Hemoglobins S and C interfere with actin remodeling in Plasmodium falciparum-infected erythrocytes. Science334, 1283-1286, 2011.

N. Perschmann, J.K. HellmannF. Frischknecht, and J.P. Spatz, Induction of malaria parasite migration by synthetically tunable microenvironments, Nano Letters, 11, 4468-4474, 2011.

J. K. Hellmann, S. Münter, M. Kudryashev, S. Schulz, K. Heiss, A. K. Müller, K. Matuschewski, J. P. Spatz, U. S. Schwarz and F. Frischknecht, Environental constraints guide migration of malaria parasites during transmission, PLoS Pathogens, 7, e1002080, 2011.

M. Kudryashev, M. Cyrklaff, B. Alex, L. Lemgruber, W. Baumeister, R. Wallich and F. Frischknecht, Evidence of direct cell-cell fusion in Borrelia by cryogenic electron tomography, Cellular Microbiology, 13, 731-741, 2011.

S. HeggeM. KudryashevA. Smith and F. Frischknecht, Key factors regulating Plasmodium berghei sporozoite survival and transformation revealed by an automated visual assay, FASEB Journal, 24, 5003-5012, 2010.

S. Hegge, S. Münter, M. Steinbrüchel, K. Heiss, U. Engel, K. Matuschewski and F. Frischknecht, Multi-step adhesion of Plasmodium sporozoites, FASEB Journal, 24, 2222-2234, 2010.

M. Kudryashev, S. Lepper, R. Stanway, S. Bohn, W. Baumeister, M. Cyrklaff and F. Frischknecht, Positioning of large organelles by a membrane associated cytoskeleton in Plasmodium sporozoites, Cellular Microbiology, 12, 362-371, 2010.

M. Kudryashev, M. Cyrklaff, R. Wallich, W. Baumeister and F. Frischknecht, Distinct in situstructures of the Borrelia flagella motor, Journal of Structural Biology, 169, 54-61, 2010.

S. Münter, B. Sabass, C. Selhuber-Unkel, M. Kudryashev, S. Hegge, U. Engel, J. P. Spatz, K. Matuschewski, U. S. Schwarz and F. Frischknecht, Plasmodium sporozoite motility is modulated by the turnover of discrete adhesion sites, Cell Host & Microbe, 6, 551-562, 2009.

S. Hegge, M. KudryashevA. Smith, F. Frischknecht, Automated classification of Plasmodiumsporozoite movement patterns reveals a shift towards productive motility during salivary gland infection, Biotechnology Journal, 4, 903-913, 2009.

M. Kudryashev, M. Cyrklaff, W. Baumeister, M.M. Simon, R. Wallich, F. Frischknecht, Comparative cryo-electron tomography of pathogenic Lyme disease spirochetes, Molecular Microbiology, 71, 1415- 1434, 2009.

A. Herm-Götz, C. Agop-Nersesian, S. Münter, J. S. Grimley, T. J. Wandless, F. Frischknecht & M. Meissner, Rapid control of protein level in the apicomplexan Toxoplasma gondiiNature Methods, 4, 1003 - 1005, 2007.1

M. Cyrklaff, M. Kudryashev, A. Leis, K. Leonard, W. Baumeister, R. Menard, M. Meissner, F. Frischknecht, Cryoelectron tomography reveals periodic material at the inner side of subpellicular microtubules in apicomplexan parasites, Journal of Experimental Medicine, 204, 1281-1287, 2007.

R. Amino, S. Thiberge, B. Martin, S. Celli, S. L. Shorte, F. Frischknecht and R. Ménard, Quantitative imaging of malaria parasite transmission to the mammalian host, Nature Medicine12, 220-224, 2006.

F. Valderrama, J. V. Cordeiro, S. Schleich, F. Frischknecht and M. Way, Vaccinia induced migration and viral morphogenesis requires F11L-mediated inhibition of RhoA signalling, Science 311, 377-381, 2006.

F. Frischknecht, P. Baldacci, B. Martin, C. Zimmer, S. Thiberge, J.-C. Olivo-Marin, S. L. Shorte, and R. Ménard, Imaging movement of malaria parasites during transmission by Anopheles mosquitoes, Cellular Microbiology 6, 687-694, 2004.

F. Frischknecht, V. Moreau, S. Röttger, S. Gonfloni, I. Reckmann, G. Superti-Furga, and M. Way, Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signalling, Nature, 401, 926-929, 1999.

F. Frischknecht, and A. Randall, Voltage- and ligand-gated ion channels in floor plate neuroepithelia of the rat, Neuroscience, 85, 1135-1149, 1998.

=> Science and Society

F. Frischknecht, Infectious entertainment, Biotechnology Journal, 4, 944-946, 2009.

F. Frischknecht, Small countries are unexpected winners in ERC grant tables, Nature, 454, 690, 2008.

F. Frischknecht, The history of biological warfare, EMBO Reports, 4, 47-52, 2003.

==> Conference EMBL 2002: Infectious Diseases; Session IV, F. Frischknecht, Biological Weapons: Uses and Abuses of Infectious Agents.