Kliniken & Institute … Institute Zentrum für… Parasitology Unit Research Malaria 3: Mueller … Publications

Selected publications of the Mueller group

Book chapters

 Hafalla, J.C.R, Matuschewski K. and Mueller AK (2007) Encyclopedia of Life Sciences. Malaria: Immunity (A20183).

Pradel, G., Mueller AK. (2009) Parasitology Research Trends. New Insights into Liver Stages of Malaria Parasites. Nova Science Publishers, Hauppauge.

 Mueller AK., Hammerschmidt-Kamper C. and Kaiser A (2014) RNAi in Plasmodium. Curr Pharm Des. 20(2):278-83.

Mendes AM, Scholzen A, Mueller AK, Khan SM, Sauerwein RW, and Prudêncio M (2017) Malaria – Immune Response to Infection and Vaccination: Whole-Sporozoite Malaria Vaccines. Springer International Publishing. DOI 10.1007/978-3-319-45210-4.


Matuschewski K., Mueller AK (2007) Vaccines against malaria- an update. FEBS J. 274 (18): 4680-7.

Mueller, AK., Kohlhepp, F., Hammerschmidt, C. and Michel, K. (2010) Invasion of mosquito salivary glands by malaria parasites: Prerequisites and defense strategies, Int J Parasitol. 40 (11):1229-35.

Hentzschel F., Herrmann AK., Mueller AK., Grimm D (2016) Plasmodium meets AAV - the (un)likely marriage of parasitology and virology, and how to make the match. FEBS Lett. doi: 10.1002/1873-3468.12187


Mueller AK, Labaied M, Kappe SH, Matuschewski K. (2005) Genetically modified Plasmodium parasites as a protective experimental malaria vaccine. Nature. 433(7022):164-7.

Schuler H, Mueller AK, Matuschewski K. (2005) Unusual properties of Plasmodium falciparum actin: new insights into microfilament dynamics of apicomplexan parasites. FEBS Lett. 579(3):655-60.

Mueller AK, Camargo N, Kaiser K, Andorfer C, Frevert U, Matuschewski K, Kappe SH. (2005) Plasmodium liver stage developmental arrest by depletion of a protein at the parasite-host interface. Proc Natl Acad Sci U S A. 102(8):3022-7.

Schuler H, Mueller AK, Matuschewski K. (2005) A Plasmodium Actin-depolymerizing Factor That Binds Exclusively to Actin Monomers. Mol Biol Cell. 16(9):4013-23.

Mueller AK, Deckert M, Heiss K, Goetz K, Matuschewski K, Schluter D. (2007) Genetically Attenuated Plasmodium berghei Liver Stages Persist and Elicit Sterile Protection Primarily via CD8 T Cells. Am J Pathol. 171(1): 107-115.

Jobe O., Lumsden J., Mueller AK., Williams J., Silva-Rivera H., Kappe S.H., Schwenk R.J., Matuschewski K., Krzych U. (2007) Genetically Attenuated Plasmodium berghei Liver Stages Induce Sterile Protracted Protection that Is Mediated by Major Histocompatibility Complex Class I-Dependent Interferon-gamma-Producing CD8+ T Cells. J Infect Dis. 196(4): 599-607.

Hellmann JK., Münter S., Kudryashev M., Schulz S., Heiss K., Mueller AK, Matuschewski K., Spatz JP., Schwarz US., Frischknecht F. (2011) Environmental constraints guide migration of malaria parasites during transmission. PLoS Pathog. 7(6):e1002080.

Lewis MD., Pfeil J., Mueller AK. (2011) Continuous oral chloroquine as a novel route for Plasmodium prophylaxis and cure in experimental murine models. BMC Res Notes. 28;4:262.

Schwentke A., Krepstakies M, Mueller AK., Hammerschmidt-Kamper C., Motaal BA., Bernhard T., Hauber J., Kaiser A. (2012) In vitro and in vivo silencing of Plasmodial DHS and EIF-5A genes in a putative, non-canonical RNAi-related pathway. BMC Microbiol. 12(1):107.

Mueller AK., Behrends J., Hagens K., Mahlo J., Schaible UE., Schneider BE. (2012) Natural transmission of Plasmodium berghei exacerbates chronic tuberculosis in an experimental co-infection model. PLOS One.7(10):e48110.

Schrader FC., Glinca S., Sattler JM., Dahse HM., Afanador GA., Prigge ST., Lanzer M., Mueller AK., Klebe G., Schlitzer M. (2013) Novel FASII inhibitors as multistage antimalarials. ChemMedChem. 8(3):442-61. doi: 10.1002/cmdc.201200407.

Lödige M, Lewis MD, Paulsen E, Esch H., Pradel G, Lehmann L, Brun R, Bringmann G, Mueller AK, (2013) An antiplasmodial hybrid agent with a dual mode of action: Innovative advancement of aproved drugs. Int J Med Microbiol. doi:pii: S1438-4221(13)00101-X. 10.1016/j.ijmm.2013.07.005. [Epub ahead of print]

Mueller AK., Behrends J., Blank J., Schaible U., Schneider BE.  (2014) An experimental model to study tuberculosis-malaria co-infection upon natural transmission of Mycobacterium tuberculosis and Plasmodium berghei. J Vis Exp (84):e50829. doi: 10.3791/50829.

Lewis MD., Pfeil J., Heiss K., Mueller AK. (2014) CD8+ T cells mediate robust stage-specific immunity to P.berghei under chemoprophylaxis and this protective environment is not downregulated by blood-stage infection. PLoS One. 9(2):e88117. doi: 10.1371/journal.pone.0088117. eCollection 2014.

Grützke J., Rindte K., Goosmann C., Silvie O., Rauch C., Heuer D., Lehmann MJ., Mueller AK., Brinkmann V., Matuschewski K., Ingmundson A. (2014) The spatiotemporal dynamics and membranous features of the Plasmodium liver stage tubovesicular network. Traffic. 15(4):362-82. doi: 10.1111/tra.12151. Epub 2014 Feb 13

Pfeil J., Sepp K., Heiss K., Meister M., Mueller AK*., Borrmann S*. (2014) Protection against malaria by immunization with non-attenuated sporozoites under single-dose piperaquine tetraphosphate chmoprophylaxis. Vaccine. pii: S0264-410X(14)01197-9. doi: 10.1016/j.vaccine.2014.07.112. [Epub ahead of print] (*co-corresponding authors)

Hentzschel F., Hammerschmidt-Kamper C., Börner K., Heiss K., Knapp B., Sattler JM.,  Kaderali L., Castoldi M., Bindman JG., Malato Y., Willenbring H., Mueller AK*., Grimm D*. (2013) AAV8-mediated in vivo overexpression of miR-155 improved vaccination against experimental malaria Mol Ther.  doi: 10.1038/mt.2014.172. [Epub ahead of print] (*co-corresponding authors).

Senís E., Fatouros C., Große S., Wiedtke E., Niopek D., Mueller AK., Börner K., Grimm D. (2014) An adeno-associated viral (AAV) vector toolbox for CRISPR/Cas9-mediated genome engineering. Biotechnol J. doi: 10.1002/biot.201400046.

Lentz CS., Sattler JM., Fendler M., Gottwalt S., Strassel S., Halls VS., Arriens S., Hannam JS., Specht S., Famulok M., Mueller AK., Hoerauf A., Pfarr KM. (2014) In vitro activity of wALADin-benzimidazoles against different life-cycle stages of Plasmodium parasites. Antimicrob. Agents & Chemoth. pii: AAC.02383-14.

Pfeil J., Heine JF., Mueller AK (2015) Addition of histamine to subcutaneously injected Plasmodium berghei sporozoites increases the parasite liver load and could facilitate whole-parasite vaccination. Malar J. 28;14(1):36. 

Lewis MD., Behrends J., Sa e Cunha C., Mendes A., Lasitschka F., Sattler JM., Heiss K., Kooij T.,  Prudendcio M., Bringmann G., Frischknecht F., Mueller AK. (2015) Chemical attenuation of Plasmodium in the liver modulates severe malaria disease progression. J Immunol. Apr 10. pii: 1400863. 

Singer M., Marshall J., Heiss K., Mair G., Grimm D., Mueller AK., Frischknecht F. (2015) Zinc finger nuclease-based double strand breaks attenuate malaria parasites and reveal rare microhomology-mediated end joining. Genome Biology Nov 17;16:249. doi: 10.1186/s13059-015-0811-1.

Hoffmann A., Pfeil J., Alfonso J., Kurz FT., Sahm F., Heiland S., Monyer H., Bendszus M., Mueller AK., Helluy X, Pham M. (2016) Experimental cerebral malaria spreads along the rostral migratory stream. PLOS Pathog 12(3):e1005470. doi: 10.1371/journal.ppat.1005470. eCollection 2016 Mar.

Bane K., Lepper S., Kehrer J., Sattler JM., Singer M., Ester M., Klug D., Heiss K., Baum J., Mueller AK., Frischknecht F. (2016) The actin filament-binding protein coronin regulates motility in Plasmodium sporozoites. PLOS Pathog. 13;12(7):e1005710. doi: 10.1371/journal.ppat.1005710.

Kumar H., Sattler JM., Singer M., Heiss K., Reinig M., Hammerschmidt-Kamper C., Heussler V., Mueller AK., Frischknecht F. (2016) Protective efficacy and safety of liver stage attenuated malaria parasites. Sci Rep. 6:26824. doi: 10.1038/srep26824.

Kersting D, Krüger M, Sattler JM, Mueller AK, Kaiser A. (2016) A suggested vital function for eIF-5A and dhs genes during murine malaria blood-stage infection. FEBS Open Bio 6(8):860-72. doi: 10.1002/2211-5463.12093. eCollection 2016 Aug

Cyrklaff M, Srismith S, Nyboer B, Burda K, Hoffmann A, Lasitschka F, Adjalley S, Bisseye C, Simpore J, Mueller AK, Sanchez CP, Frischknecht F, Lanzer M. (2016) Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes. Nat Commun 8;7:13401. doi: 10.1038/ncomms13401

Sá E Cunha C, Nyboer B, Heiss K, Sanches-Vaz M, Fontinha D, Wiedtke E, Grimm D, Przyborski JM, Mota MM, Prudêncio M, Mueller AK. (2017) Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development. Proc Natl Acad Sci U S A pii: 201606419. doi: 10.1073/pnas.1606419114

Science and Society

 Niopek D, Berrens R, Mockenhaupt S, Lewis MD, Mueller AK, Grimm D. (2011) To go, or not to go, that is the question - Six personal reflections on how geographic mobility may affect your career and life. Bioessays. doi: 10.1002/bies.201100083.

Lewis MD. (2011) Malaria: connecting reality with research. Eur J Immunol. 41(4):882-4.