Kliniken & Institute … Institute Zentrum für… Parasitology Unit Research Malaria 8: Guizetti … Projects

Current projects of the Guizetti group

The Guizetti lab studies the unusual cell division mechanisms of the malaria parasite Plasmodium falciparum. Rapid mitotic divisions enable proliferation of the parasite in the human blood cells and contribute to disease severity. Even though mitosis in this parasite shows significant differences to what has been described in classical model organisms, it is poorly studied so far. We use super-resolution, electron, and live cell microscopy technologies combined with CRISPR/Cas9 genome editing to describe the dynamics and regulation of chromosomes, centromeres, and the nuclear envelope during division. Thereby we hope to uncover new targets within this essential pathway and contribute to the fight against malaria.