Research Group Lusic
The studies of the Lusic laboratory focus on deciphering the cellular mechanisms used by the virus to either promote or repress viral gene expression. We investigate which parameters control integration of the viral genome and subsequent gene expression, with a strong focus on reactivation of viral gene expression after a silent phase of latency.
While an overall goal of our laboratory is to explore the specific contributions of nuclear topology and chromatin factors to HIV integration site selection and establishment of latency, we are specifically interested in determining the role of nuclear pore complex proteins in integration site selection. Moreover, we would like to focus on the interactions between nucleoporins with proteins that we previously found to contribute to proviral latency such as TRIM proteins.
Our methodology comprises the visualization of integrated HIV DNA in host cells by using a combination of 3D Immuno DNA FISH and Chromatin Immunoprecipitation technology.
Marina Lusic, PhD
Bojana Lucic, PhD
Mia Stanic, MSc
Chiara Valentini, MSc