Kliniken &… Institute Zentrum für… Abteilung… Forschung Forschungsgruppen Schnitzler Lab

Research Group Schnitzler

Projects

Herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) are wide spread human pathogens which cause epidermal lesions. Several drugs are currently available for the management of HSV infections. Natural products like the Australian tea tree oil and peppermint oil are also quite effective against HSV as shown in plaque reduction assays. We analyse the mechanism of the virucidal effect of several essential oils on HSV in vitro. Since esssential oils are mixtures of many different natural compounds, we try to isolate the active virucidal compound against herpes simplex virus.

  • Salwender H., Weinhold N., Benner A., Miah K., Merz M., Haenel M., Jehn C., Mai E.K., Menis E., Blau I.W., Scheid C., Hose D., Seckinger A., Luntz S.P., Besemer B., Munder M., Brossart P., Glass B., Lindemann H.-W., Weisel K., Hanoun C., Schnitzler P., Klemm S., Goldschmidt H., Raab M.S., Elmaagacli A. (2024). Cytomegalovirus immunoglobulin serology prevalence in newly diagnosed multiple myeloma treated within the GMMG-MM5 Phase III Trial.Hematology, 29, 2320006
  • Benning L., Bartenschlager M., Kim H., Kälble F., Nusshag C., Buylaert M., Reichel P., Schaier M., Morath C., Zeier M., Schnitzler P., Bartenschlager R., Speer C. (2023) Live-virus serum neutralization after bivalent SARS-CoV-2 mRNA vaccination in hemodialysis patients. J. Med. Virol., e29303
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  • Cizmic A., Eichel V., Weidner N., Wise P.A., Müller F., Rompen I., Bartenschlager R., Schnitzler P., Nickel F., Müller-Stich B.-P. (2023) Viral load of SARS-CoV-2 in surgical smoke in minimally invasive and open surgery – a single-center prospective clinical trial. Sci. Rep., 13:20299
  • Speer C., Töllner M., Benning L., Bartenschlager M., Kim H., Nusshag C., Kälble F., Reineke M., Reichel P., Schnitzler P., Zeier M., Morath C., Schmitt W., Bergner R., Bartenschlager R., Lorenz H.-M., Schaier M. (2023) BA.1/BA.5 immunogenicity, reactogenicity, and disease activity after COVID-19 vaccination in patients with ANCA-associated vasculitis: a prospective observational cohort study
  • Viruses, 15, 1778Benning L., Reineke M., Bundschuh C., Kühn T., Zeier M., Bartenschlager R., Schnitzler P., Morath C., Speer C. (2023) Quantification of torque teno viral load to monitor changes in immunosuppressive therapy in kidney transplant recipients. Transplantation, 107: e363
  • Schaier M., Morath C., Wang L., Kleist C., Opelz G., Tran T.H., Scherer S., Pham L., Ekpoom N., Süsal C., Ponath G., Kälble F., Speer C., Benning L., Nusshag C., Mahler C.F., Pego da Silva L., Sommerer C., Hückelhoven-Krauss A., Czock D., Mehrabi A., Schwab C., Waldherr R., Schnitzler P., Merle U., Schwenger V., Kemmner S., Fischereder M., Stangl M., Hauser I.A., Böhmig G.A., Müller-Tidow C., Reiser J., Zeier M., Schmitt M., Terness P.,     Schmitt A., Daniel V. (2023). Five-year follow-up of a phase I trial of donor-derived modified immune cell infusion in kidney transplantation. Frontiers Immunol., 14:1089664
  • Deckert A., Anders S., Morales I., De Allegri M., Nguyen H.T., Souares A., McMahon S., Meurer M., Burk R., Sand M., Koeppel L., Maier Hein L., Roß T., Adler T., Brugnara L., Brenner S., Herbst K., Kirrmaier D., Duan Y., Ovchinnikova S., Marx M., Schnitzler P., Kräusslich H.-G., Knop M., Bärnighausen T., Denkinger C.M. (2023) Comparison of four active SARS-CoV-2 surveillance strategies in representative population sample points: two-factor randomized controlled trial. JMIR Pub. Health Surv., 9, c44204
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  • Ünal S., Schnitzler P., Giesen N., Wedde M., Dürrwald R., Tabatabai J. (2023) Molecular epidemiology and disease severity of influenza virus infection in patients with haematological disorders. J. Med. Virol., 95:e28835
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  • Dubler S., Etringer M., Weigand M.A., Brenner Th., Zimmermann S., Schnitzler P., Budeus B., Rengier F., Kalinowska P., Lih Hoo Y., Lichtenstern C. (2023). Impact of invasive pulmonary aspergillosis in critically ill patients with or without immunosuppression. J. Clin. Med., 12, 3282
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  • Lou D., Meurer M., Ovchinnikova S., Burk R., Denzler A., Herbst K., Papaioannou I., Yuanqiang   D., Jacobs M., Witte V., Uerge D., Kirrmaier D., Krogemann M., Gubiczka K., Boerner K., Bundschuh C., Weidner N., Merle U., Knorr B., Welker A., Denkinger C., Schnitzler P., Kräusslich H.-G., Dao Thi V.L., De Allegri M., Nguyen H.T., Deckert A., Anders S., Knop M. (2023) Scalable RT-LAMP-based SARS-CoV-2 testing for infection surveillance with applications in pandemic preparedness. EMBO reports, e57162
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  • Tabatabai J., Ihling C.M., Manuel B., Rehbein R.M., Schnee S.V., Hoos J., Pfeil J., Grulich-Henn    J., Schnitzler P. (2023) Viral aetiology and clinical characteristics of acute respiratory tract infections in hospitalized children in Southern Germany (2014-2018) Open Forum Inf. Dis., 10.1093/ofid/ofad110
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  • Kühn T., Speer C., Morath C., Bartenschlager M., Kim H., Beimler J., Buylaert M., Nusshag C., Kälble F., Reineke M., Töllner M., Klein K., Blank A., Parthé S., Schnitzler P., Zeier M., Süsal C., Bartenschlager R., Tran H., Schaier M., Benning L. (2023). Immune response to COVID-19 mRNA vaccination in previous non-responder kidney     transplant recipients after short-term withdrawal of mycophenolic acid one- and three-months after an additional vaccine dose. Transplantation, 107, 1139-1150
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  • Gsenger J., Bruckner T., Ihling C.M., Rehbein R.M., Schnee S.V., Hoos J., Pfeil J., Schnitzler P., Tabatabai J. (2023) RSV-CLASS  - Clinical Assessment Severity Score: an easy-to-use clinical disease severity score for respiratory syncytial virus (RSV) infection in hospitalized children. J. Med. Virol., 95:e28541
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  • Schindler H., Lusky F., Daniello L., Elshiaty M., Gaissmaier L., Benesova K., Souto-Carneiro M., Angeles A., Janke F., Kazdal D., Schneider M., Liersch S., Klemm S., Schnitzler P., Stenzinger A., Sültmann H., Thomas M., Christopoulos P. (2022). Serum cytokines predict efficacy and toxicity, but are not useful for disease monitoring in lung cancer treated with PD-(L)1 inhibitors. Front. Oncol., 12:1010660
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  • Denkinger C.M., Janssen M., Schäkel U., Gall J., Leo A., Stelmach P., Weber S.F., Krisam J.,    Baumann L., Stermann J., Merle U., Zeier M., Weigand M.A., Bullinger L., Schrezenmeier J.-F., Bornhäuser M., Alakel N., Witzke O., Wolf T., Vehreschild M.J.G.T., Schmiedel S.,      Addo M.M., Herth F., Kreutner M., Tepasse P.-R., Hertenstein B., Hänel M., Morgner A.,       Kiehl M., Hopfer O., Wattad M.-A., Schimanski C.C., Celik C., Pohle T., Ruhe M., Kern W.V., Schmitt A., Loren H.-M., Souto-Carneiro M., Gaeddert M., Halama N., Meuer S., Kräusslich H.-G., Müller B., Schnitzler P., Parthé S., Bartenschlager R., Gronkowski M., Klemmer J., Schmitt M., Dreger P., Kriegsmann K., Schlenk R.F., Müller-Tidow C. (2023). Benefit of anti-SARS-Cov2 antibody containing plasma in patients with            hematological/solid cancer or other risk factors and severe COVID-19 - a randomized controlled trial. Nature Cancer, 4, 96-107
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  • Morath C., Schaier M., Ibrahim E., Wang L., Kleist C., Opelz G., Süsal C., Aly M., Kälble F., Speer C., Benning L., Nusshag C., da Silva L.P., Sommerer C., Hückelhoven-Krauss A., Czock D., Mehrabi A., Schwab C., Waldherr R., Schnitzler P., Merle U., Tran H., Scherer S., Roers A., Böhmig G., Halloran P., Müller-Tidow C., Reiser J., Zeier M., Schmitt M., Terness P., Schmitt A., Daniel V. (2023). Induction of long-lasting regulatory B lymphocytes by modified immune cells (MIC) in kidney transplant recipients. J. Am. Soc. Nephrol, 34, 160-174
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  • Benning L., Morath C., Kühn T., Bartenschlager M., Kim H., Beimler J., Buylaert M., Nusshag C., Kälble F., Reineke M., Töllner M., Schaier M., Klein K., Blank A., Schnitzler P., Zeier M., Süsal C., Bartenschlager R., Tran T.H., Speer C. (2022). Humoral response to SARS-CoV-2 mRNA vaccination in previous non-responder kidney transplant recipients after short-term withdrawal of mycophenolic acid. Frontiers Med., 9:958293
  •  Stich M., Benning L., Speer C., Garbade S.F., Bartenschlager M., Kim H., Gleich F., Jeltsch K., Haase B., Grulich-Henn J., Janda A., Renk H., Elling R., Schnitzler P., Waterboer T., Hoffmann G.F., Kräusslich H.-G., Müller B., Bartenschlager R., Tönshoff B. (2022) Waning immunity 14 months after SARS-CoV-2 infection. Pediatrics, 150, e2022057151
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  • Krüger L.J., Lindner A.K., Gaeddert M., Tobian F., Steinke S., Lainati F., Schnitzler P., Nikolai O., Mockenhaupt F.P., Seybold J., Corman V.M., Jones T.C., Pollock N.R., Knorr B., Welker A., Weber S., de Vos M., Ongarello S., Sacks J.A., Escadafal C., Denkinger C.M. (2022). A multi-center clinical diagnostic accuracy study of SureStatus - an affordable, WHO emergency-use-listed, rapid, point-of-care, antigen-detecting diagnostic test for SARS-CoV-2. Spectrum, 10.1128
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  • Tabatabai J., Schnitzler P., Prifert C., Schiller M., Weissbrich B., von Lilienfeld-Toal M., Teschner D., Jordan K., Müller-Tidow C., Egerer G., Giesen N. (2022) Parainfluenza virus infections in patients with hematological malignancies or stem cell transplantation: analysis of clinical characteristics, nosocomial transmission and viral shedding. PLoS ONE, 17: e0271756              
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  • Denzler A., Jacobs M.L., Witte V., Schnitzler P., Denkinger C.M., Knop M. (2022) Rapid comparative evaluation of SARS-CoV-2 rapid point-of-care antigen tests. Infection, 50, 1281-1293
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  • Heuss C., Rothhaar P., Burm R., Lee J.-Y., Ralfs P., Haselmann U., Ströh L.J., Colasanti O., Tran C.S., Schäfer N., Schnitzler P., Merle U., Bartenschlager R., Patel A.H., Graw F., Krey T., Laketa V., Meuleman P., Lohmann V. (2022) A Hepatitis C virus genotype 1b post-transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo. PLoS Pathogens, 18: e1010472
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  • Sommerer C., Schröter I., Wagner K., Schindler D., Behnisch R., Morath C., Heemann U., Schnitzler P., Heeg K., Meuer S., Zeier M., Giese T. and the Transplant Cohort of the German Center for Infection Research (DZIF Transplant Cohort) Consortium (2022). Incidences of infectious events in a renal transplant cohort of the German Center of Infectious Diseases (DZIF). Open Forum Inf. Dis., 10.1093
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  • Benning L., Morath C., Bartenschlager M., Reineke M., Beimler J., Buylaert M., Nusshag C., Kälble F., Reichel P., Töllner M., Schaier M., Rieger S., Stich M., Tönshoff B., Schnitzler P., Zeier M., Süsal C., Tran T.H., Bartenschlager R., Speer C. (2022) Neutralizing antibody response against the B.1.617.2 (delta) and the B.1.1.529.1 (omicron) variant after a third mRNA SARS-CoV-2 vaccine dose in kidney transplant recipients. Am. J. Transplant., 22, 1873 - 1883
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  • Töllner M., Speer C., Benning L., Bartenschlager M., Nusshag C., Morath C., Zeier M., Süsal C., Schnitzler P., Schmitt W., Bergner R., Bartenschlager R., Lorenz H.-M., Schaier M. (2022). Impaired neutralizing antibody activity against B.1.617.2 (delta) after anti-SARS-CoV-2 vaccination in patients receiving anti-CD20 therapy. J. Clin. Med., 11, 1739
  • Nkongolo S., Mohr I., Wenzel J.J., Khalid D., Mieth M., Mehrabi A., Weiss K.H., Schnitzler P. (2022) Hepatitis E seroprevalence, cases and management in a large German centre for liver transplantation. Liver Cancer Int., 3, 72-81
  • Benning L., Morath C., Bartenschlager M., Reineke M., Töllner M., Nusshag C., Kälble F., Reichel P., Schaier M., Schnitzler P., Zeier M., Süsal C., Bartenschlager R., Speer C. (2022) Neutralizing antibody activity against B.1.617.2 (delta) 8 months after two-dose vaccination with BNT162b2 in health care workers. Clin. Microbiol. Inf., 28, 1024.e7 – 1024.e12
  • Pabst C., Benning L., Liebers N., Janssen M., Caille L., Speer C., He L., Schubert M.-L., Simons L., Hegenbart U., Schönland S., Radujkovic A., Schmitt M., Schnitzler P., Müller-Tidow C., Dietrich S., Dreger P., Luft T. (2022) Humoral responses and chronic GVHD exacerbation after COVID-19 vaccination post allogeneic stem cell transplantation Vaccines, 10, 330
  • Benning L., Klein K., Morath C., Bartenschlager M. Buylaert M., Töllner M., Nusshag C., Kälble F., Reichel P., Schnitzler P., Zeier M., Süsal C., Bartenschlager R., Schaier M., Speer C. (2022) Neutralizing antibody activity against B.1.617.2 (delta) before and after a third BNT162b2 mRNA vaccine dose in hemodialysis patients. Front. Immunol., 13:840136

 

Krüger L.J., Klein J.A.F., Tobian F., Gaeddert M., Lainati F., Klemm S., Schnitzler P., Bartenschlager R., Cerikan B., Neufeldt C.J., Nikolai O., Lindner A.K., Mockenhaupt F.P., Seybold J., Corman V.M., Drosten C., Pollock N.R., Knorr B., Welker A., de Vos M., Sacks J.A., Denkinger C.M.  (2022) Evaluation of the accuracy, exclusivity, limit-of-detection and ease-of-use of LumiraDx™; an antigen-detecting point-of-care device for SARS-CoV-2. Infection, 50, 395-406

 

  • Liebers N., Schönland S.O., Speer C., Schnitzler P., Kräusslich H.-G., Mueller-Tidow C., Hegenbart U., Dietrich S. (2022) Seroconversion rates after the second COVID-19 vaccination in patients with systemic light chain (AL) amyloidosis. HemaSphere, 6:3(e688)
  • Benning L., Morath C., Bartenschlager M., Reineke M., Töllner M., Nusshag C., Kälble F., Reichel P., Schaier M., Schnitzler P., Zeier M., Süsal C., Bartenschlager R., Speer C. (2022). Natural SARS-CoV-2 infection results in higher neutralization response against variants of concern compared to two-dose BNT162b2 vaccination in kidney transplant recipients. Kidney Int., 101, 639-642
  • Tabatabai J., Ihling C.M., Rehbein R.M., Schnee S.V., Hoos J., Pfeil J., Grulich-Henn J., Schnitzler P. (2022). Molecular epidemiology of respiratory syncytial virus in hospitalised children in Heidelberg, Southern Germany, 2014 – 2017. Inf. Gen. Evol., 98, 105209
  • Speer C., Töllner M., Benning L., Klein K., Bartenschlager M., Nusshag C., Kälble F., Reichel P., Schnitzler P., Zeier M., Morath C., Schmitt W., Bergne R., Bartenschlager R., Schaier M. (2022). A third COVID-19 vaccine dose with BNT162b2 in patients with ANCA-associated vasculitis. Ann. Rheum. Dis., 81, 593-595
  • Benning L., Morath C., Bartenschlager M., Reineke M., Töllner M., Nusshag C., Kälble F., Reichel P., Schaier M., Schnitzler P., Zeier M., Süsal C., Bartenschlager R., Speer C. (2022). Natural SARS-CoV-2 infection results in higher neutralization response against variants of concern compared to two-dose BNT162b2 vaccination in kidney transplant recipients. Kidney Int., 101, 639-642 
  • Lindner A.K., Krüger L.J., Nikolai O., Klein J.A.F., Rössig H., Schnitzler P., Corman V.M., Jones T.C., Tobian F., Gaeddert M., Burock S., Sacks J.A., Seybold J., Mockenhaupt F.P., Denkinger C.M. (2022). SARS-CoV-2 variant of concern B.1.1.7: diagnostic sensitivity of three antigen-detecting rapid tests. Microbiol. Spect., e00763-21
  • Krüger L.J., Tanuri A., Lindner A.K., Gaeddert M., Köppel L., Tobian F., Brümmer L.E., Klein J.A.F., Lainati F., Schnitzler P., Nikolai O., Mockenhaupt F.P., Seybold J., Corman V.M., Jones             T.C., Drosten C., Gottschalk C., Weber S.F., Weber  S., Ferreira O.C. Jr., Mariani D., Ramos dos Santos Nascimento E., Pereira Pinto Castineiras T.M., Mello Galliez R., Souza Faffe D., de Carvalho Leitão I., dos Santos Rodrigues C., Silva Frauches T., Chagas Vilela Nocchi K.J., Martins Feitosa N., Santana Ribeiro S., Pollock N.R., Knorr B., Welker A., de Vos M., Sacks J.A., Ongarello S., Denkinger C.M. (2022). Accuracy and ease-of-use of seven point-of-care SARS-CoV-2 antigen-detecting tests: a multi-centre clinical evaluation. EBioMedicine, 75: 103774
  • Lempp F.A., Roggenbach I., Nkongolo S., Sakin V., Schlund F., Schnitzler P., Wedemeyer H., Le   Gal F., Gordien E., Yurdaydin C., Urban S. (2021). A rapid point-of-care test for the serodiagnosis of hepatitis delta virus infection. Viruses, 13, 2371
  • Wildemann B., Jarius S., Lehmann L., André F., Frey N., Schnitzler P., Jäger L., Gumbinger C., Viehöver A., (2022). Covid-19 related severe MS exacerbation with life-threatening Takotsubo cardiomyopathy in a previously stable patient and interference of MS therapy with long-term immunity against SARS-CoV-2, J. Neurol., 269, 1138-1141
  • Giannakis A., Móré D., Erdmann S., Kintzelé L., Fischer R.M., Vogel M., Mangold D.L., Schnitzler P., Zimmermann S., Heussel C.P., Kauczor H.U., Hellbach K. (2021) COVID-19 pneumonia and its lookalikes: How radiologists perform in differentiating atypical pneumonias. Eur. J. Radiol. 144, 110002
  • Speer C., Schaier M., Nusshag C., Buylaert M., Töllner M., Kälble F., Reichel P., Grenz J., Süsal C., Zeier M., Schnitzler P., Morath C., Klein K., Benning L. (2021). Longitudinal humoral responses after COVID-19 vaccination in peritoneal and hemodialysis patients over twelve weeks. Vaccines, 9, 1130

 

  • Liebers N., Speer C., Benning L., Bruch P.-M., Kraemer I., Meissner J., Schnitzler P., Kräusslich H.-G., Dreger P., Mueller-Tidow C., Poschke I., Dietrich S. (2021) Humoral and cellular responses after COVID-19 vaccination in anti-CD20 treated lymphoma patients. Blood, 139, 142-147
  • Roggenbach I., Chi X., Lempp F.A., Qu B., Walter L., Wu R., Gao X., Schnitzler P., Ding Y., Urban S., Niu J. (2021). HDV seroprevalence in HBsAg-positive patients in China occurs in hotspots and is not associated with HCV mono-infection.Viruses, 13, 1799
  • Joachim A., Dewald F., Suarez I., Zemlin M., Lang I., Stutz R., Marthaler A., Bosse H.M., Lübke     N., Münch J., Bernard M.-A., Jeltsch K., Tönshoff B., Weidner N., Kräusslich H.-G., Birzele L., Hübner J., Schmied P., Meyer-Bühn M., Horemheb-Rubio G., Cornely O.A., Haverkamp H., Wiesmüller G., Fätkenheuer G., Hero B., Kaiser R., Dötsch J., Rybniker J., for the B-FAST study group (2021) Pooled RT-qPCR testing for SARS-CoV-2 surveillance in schools – a cluster randomized   trial. EClinicalMedicine 39, 101082 
  • Wachinger J., I.D. Olaru, Horner S., Schnitzler P., Kihm L., Heeg K., C.M. Denkinger (2021). The potential of SARS-CoV-2 antigen-detection tests in the screening of asymptomatic persons. Clin. Micro. Inf., 1700.e1-1700.e3
  • Benning L., Töllner M., Hidmark A., Schaier M., Nusshag C., Kälble F., Reichel P., Buylaert M., Grenz J., Ponath G., Klein K., Zeier M., Süsal C., Schnitzler P., Morath C., Speer C. (2021). Heterologous ChAdOx-nCoV19/BNT162b2 prime-boost vaccination induces strong humoral responses among health care workers (2021). Vaccines, 9, 857
  • Speer C., Morath C., Töllner M., Buylaert M., Göth D., Schaier M., Grenz J., Nusshag C., Kälble F., Kreysing M., Reichel P., Hidmark A., Ponath G., Schnitzler P., Zeier M., Süsal C., Klein K., Benning L. (2021). Humoral responses to single-dose BNT162b2 mRNA vaccination in dialysis patients previously infected with SARS-CoV-2. Frontiers Med., 8:721286
  • Speer C., Benning L., Töllner M., Nusshag C., Kälble F., Reichel P., Schaier M., Bartenschlager M., Schnitzler P., Zeier M., Süsal C., Morath C., Bartenschlager R. (2021). Neutralizing antibody response against variants of concern after vaccination of dialysis patients with BNT162b2. Kidney Int., 100, 700-702
  • Salbach C., Mueller-Hennessen M., Biener M., Stoyanov K., Preusch M., Kihm L., Merle U., Schnitzler P., Katus H.A., Giannitsis E. (2021). Interpretation of myocardial injury subtypes in COVID-19 disease per fourth version of Universal Definition of Myocardial Infarction. Biomarkers, 26, 401-409
  • Seeßle J., Hippchen T., Schnitzler P., Gsenger J., Giese T., Merle U. (2021). High rate of HSV-1 reactivation in invasively ventilated COVID-19 patients: immunological findings. PLoS ONE, e0254129
  • Klein J.A.F., Krüger L.J., Tobian F., Gaeddert M., Lainati F., Schnitzler P., Lindner A.K., Nikolai O., Knorr B., Welker A., de Vos M., Sacks J.A., Escadafal C., Denkinger C.M. for the study team (2021). Head-to-head performance comparison of self-collected nasal versus professional- collected nasopharyngeal swab for a WHO-listed SARS-CoV-2 antigen detecting rapid-diagnostic test. Med. Microb. Imm., 210, 181-18
  • Korell F., Schubert M.-L., Sauer T., Schmitt A., Derigs P., Weber T., Schnitzler P., Müller-Tidow C., Dreger P., Schmitt M. (2021). Infection complications after lymphodepletion and dosing of chimeric antigen receptor T (CAR-T) cell therapy in patients with relapsed/refractory acute lymphoblastic leukemia (ALL) or B-cell non-Hodgkin’s lymphoma (NHL). Cancers 13, 1684
  • Ihling C.M., Schnitzler P., Heinrich N., Mangu C., Sudi L., Souares A., Gies S., Sié A., Coulibaly B., Ouédraogo A.T., Mordmüller B., Held J., Adegnika A.A., Fernandez J.F., Eckerle I., May J., Hogan B., Eibach D., Owusu-Dabo E., Tabatabai J. (2021) Molecular epidemiology of respiratory syncytial virus (RSV) in children in sub-Saharan Africa. Trop. Med Int. Hyg., 26, 810-822
  • Krüger L.J., Gaeddert M., Tobian F., Lainati F., Gottschalk C., Klein J., Schnitzler P., Kräusslich H.-G., Lindner A.K., Nikolai O., Mockenhaupt F.P., Seybold J., Corman V.M., Drosten C., Pollock N.R., Knorr B., Welker A., de Vos M., Sacks J.A., Denkinger C.M. The Abbott PanBio A WHO emergency use listed, rapid, antigen-detecting point-of-care diagnostic for SARS-CoV-2 - Evaluation of the accuracy and ease-of-use. PLoS ONE, e0247918
  • Tiwari-Heckler S., Rauber C., Serena Longhi M., Zörnig I., Schnitzler P., Jäger D., Giese T., Merle U. (2021). Dysregulated host response in severe acute respiratory syndrome coronavirus 2 induced critical illness. Open For. Infect. Dis., 8, ofab19
  • Hornuss D., Rudi A., Koerner L., Mohr I., Merle U., Wehling C., Rupp C., Dill M., Golriz M.,Schnitzler P., Brenner T.H., Mehrabi A., Weiss K.H., Mieth M. (2021) HBV-infection rate and long-term outcome after liver-transplantation of anti-HBc-positive liver-grafts to HBV-naïve recipients: a retrospective study. Clin. Res. Hepatol. Gastroenterol., 45, 10149
  • Salbach C., Mueller-Hennessen M., Biener M., Stoyanov K.M., Vafaie M., Preusch M.R., Kihm L.P., Merle U., Schnitzler P., Katus H.A., Giannitsis E. (2021) Validation of two severity scores as predictors for outcome in coronavirus disease 2019 (COVID-19) PLoS ONE, 16, e0247488
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  • Sommerer C., Schmitt A., Green E.W., Bunse L., Hückelhoven A., Tan C.L., Bruckner T., Schnitzler P., Platten M., Zeier M., Schmitt M. (2021) Peptide vaccination against cytomegalovirus (CMV) induces specific T cell responses in CMV seronegative end-stage renal disease patients. Vaccines, 9, 133
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  • Pape C., Remme R., Wolny A., Olberg S., Wolf S., Cerrone L., Cortese M., Klaus S., Lucic B., Ullrich S., Anders-Össwein M., Berati C., Neufeld C., Schnitzler P., Merle U., Lusic M., Boulant S., Stanifer M., Bartenschlager R., Tischer C., Kreshuk A., Hamprecht F.A., Kräusslich H.-G., Müller B., Laketa V. (2021) Microscopy-based assay for semi-quantitative detection of SARS-CoV-2 specific antibodies in human sera. BioEssays, e2000257
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  • Hoffmann P., Behnisch R., Gsenger J., Schnitzler P., Gauss A. (2020) Hepatitis E seroprevalence in a German cohort of patients with inflammatory bowel diseases. PLoS ONE, 15(10): e0239825
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  • Dao Thi V.L., Herbst K., Boerner K., Meurer M., Kremer L.P., Kirrmaier D., Freistaedter A., Papagiannidis D., Galmozzi C., Stanifer M.L., Boulant S., Klein S., Chlanda P., Khalid D., Barreto Miranda I., Schnitzler P., Kräusslich H.G., Knop M., Anders S. (2020) A colorimetric RT-LAMP assay and LAMP-sequencing for detecting SARS-CoV-2 RNA in clinical samples. Sci. Transl. Med., eabc707
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  • Klein S., Müller T.G., Khalid D., Sonntag-Buck V., Heuser A.M., Glass B., Meurer M., Morales I., Schillak A., Freistaedter A., Ambiel I., Winter S.L., Zimmermann L., Naumoska T., Bubeck                F., Kirrmaier D., Ullrich S., Barreto Miranda I., Anders S., Grimm D., Schnitzler P., Knop M., Kräusslich H.G., Dao Thi V.L., Börner K., Chlanda P. (2020). SARS-CoV-2 RNA extraction using magnetic beads for rapid large-scale testing by RT-qPCR and RT-LAMP. Viruses, E863
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  • Fakhiri J., Linse K.P., Mietzsch M., Xu M., Schneider M.A., Meister M., Schildgen O., Schnitzler P., Söderlund-Venermo M., Agbandje-McKenna M., Grimm D. (2020). Impact of natural or synthetic singletons in the capsid of human bocavirus 1 on particle infectivity and immunoreactivity. J. Virol., e00170-20.
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  • Delecluse S., Poirey R., Zeier M., Schnitzler P., Behrends U., Tsai M.H., Delecluse H.J. (2020). Identification and cloning of a new western Epstein Barr virus strain that efficiently replicates in primary B cells. J. Virol., e01918-19
  • Domingo C., Lamerz J., Cadar D., Stojkovic M., Eisermann P., Merle U., Nitsche A., Schnitzler P. (2020) Severe multiorgan failure following yellow fever vaccination. Vaccines 26, 249
     
  • Morath C., Schmitt A., Kleist C., Daniel V., Opelz G., Süsal C., Kälble F., Speer C., Nusshag C., Pego da Silva L., Sommerer C., Wang L., Ni M., Hückelhoven-Krauss A., Czock D., Merle U., Mehrabi A., Sander A., Hackbusch M., Eckert C., Waldherr R., Schnitzler P., Dreger P., Müller-Tidow C., Hoheisel J.D., Mustafa S., Alhamdani M.S.S., Zeier M., Schmitt M.,Schaier M., Terness P. (2020) mPhase I trial of donor-derived modified immune cell infusion in kidney transplantationJ. Clin. Invest., 130, 2364-2376
  • Schmack I., Ballikaya S., Erber B., Voehringer I., Burkhardt U., Auffarth G.U., Schnitzler P. Validation of spiked post-mortem blood samples from cornea donors on the Abbott   ARCHITECT and m2000 system for viral infections (2020) Transf. Med. Hemother., 47, 236-242
     
  • Delecluse S., Yu J., Bernhardt K., Haar J., Poirey R., Tsai M.-H., Kiblawi R., Kopp-Schneider A., Schnitzler P., Zeier M., Dreger P., Wuchter P., Bulut O.C., Behrends U., Delecluse H.-J. (2019) Spontaneous lymphoblastoid cell lines from patients with Epstein-Barr virus infection show highly variable proliferation characteristics that correlate with the expression levels of viral microRNAs
     
  • Mertz D., Ka-Fung Lo C., Lytvyn L., Ortiz J.R., Loeb M., for the FLURISK-INVESTIGATORS Pregnancy as a risk factor for severe influenza infection: an individual participant data meta-analysis (2019) BMC Infect. Dis. 19:683
     
  • Rauber C., Bartelheimer K., Zhou T., Rupp C., Schnitzler P., Schemmer P., Sauer P., Weiss K.H., Gotthardt D.N. (2019) Prevalence of human herpesviruses in biliary fluid and their association with biliary complications after liver transplantation. BMC Gastroenterol. 19: 110
     
  • Schnitzler P. (2019) Essential oils for the treatment of herpes simplex virus infections. Chemotherapy, 64, 1-7
     
  • Meyding-Lamadé U., Craemer E., Schnitzler P. (2019). Emerging and re-emerging viruses affecting the nervous system.Neurol. Res. Prac., 1: 20
     
  • von Felden J., Alric L., Pischke S., Aitken C., Schlabe S., Spengler U., Giordani M.T., Schnitzler P., Bettinger D., Thimme R., Binder M., Ayuk F., Lohse A.W., Cornelissen J.J., Man R.A., Mallet V. (2019). The burden of hepatitis E virus infection among patients with haematological malignancy: a retrospective European cohort study. J. Hepatol. 71, 465-472
     
  • Oweira H.,Khajeh E., Mohammadi S., Ghamarnejad O., Daniel V., Schnitzler P., Golriz M., Mieth M., Morath C., Zeier M., Mehrabi A., Sadeghi M. (2019) Pre-transplant CD200 and CD200R1 are associated with post-transplant events in kidney transplant recipients. Medicine 98:37 e17006
     
  • Manuel B., Hackbusch M., Tabatabai J., Hoos J., Peters R., Schnee S.V., Ihling C.M., Schnitzler P., Pfeil J. (2019) RSVpredict: An online tool to calculate the likelihood of respiratory syncytial virus infection in children hospitalized with acute respiratory disease Pediatric Inf. Dis. J., 38, 678-681
     
  • Tabatabai J., Fakhiri J., Meyburg J., Linse K.-P., Xu M., Söderlund-Venermo M., Grimm D., Schnitzler P. (2019) Severe human bocavirus-1 respiratory tract infection in an immunodeficient child with fatal outcome Pediatric Inf. Dis. J., 38, e219-e222
     
  • Brenner N., Mentzer A.J., Butt J., Braband K.L., Michel A., Jeffery K., Klenerman P., Gärtner B., Schnitzler P., Hill A., Taylor G., Demontis M.A., Guy E., Hadfield S.J., Almond R., Allen N., Pawlita M., Tim Waterboer T. (2019) Validation of multiplex serology for human hepatitis viruses B and C, human T-lymphotropic virus 1 and Toxoplasma gondii
     
  • Brenner N., Butt J., Bomfim I.L., Tabatabai J., Pawlita M., Schnitzler P., Waterboer T. (2019) Validation of monoplex assays detecting antibodies against Corynebacterium diphtheriae and Clostridium tetani toxins, rubella virus and parvovirus B19 for incorporation into multiplex serology Methods 158, 44-53
     
  • Höcker B., Tabatabai J., Schneble L., Oh J., Thiel F., Pape L., Rusai K., Topaloglu R., Kranz B., Klaus G., Printza N., Yavascan O., Fichtner A., Krupka K., Bruckner T., Waldherr R., Pawlita M., Schnitzler P., Hirsch H.H., Tönshoff B. (2018) JC polyomavirus replication and associated morbidity in pediatric renal transplantation: an international CERTAIN registry study Ped. Nephrol. 33, 2343-2352
     
  • Höcker B., Schneble L., Murer L., Carraro A., Pape L., Kranz B., Oh J., Zirngibl M., Dello Strologo L., Büscher A., Weber L.T., Awan A., Pohl M., Bald M., Printza N., Rusai K., Peruzzi L., Topaloglu R., Fichtner A., Krupka K., Köster L., Bruckner T., Schnitzler P., Hirsch H.H., Tönshoff B. (2019). Epidemiology of and risk factors for BK polyomavirus replication and nephropathy in   pediatric renal transplant recipients: an international CERTAIN registry study. Transplantation, 103, 1224-1233
     
  • Grünvogel O., Colasanti O., Lee J.-Y., Klöss V., Belouzard S., Reustle A., Esser-Nobis K., Hesebeck-Brinckmann J., Mutz P., Hoffmann K., Mehrabi A., Koschny R., Vondran F.W.R., Gotthardt D., Schnitzler P., Neumann-Haefelin C., Thimme R., Binder M., Bartenschlager R., Dubuisson J., Dalpke A.H., Lohmann V. (2018). Secretion of hepatitis C virus replication intermediates dampens toll-like receptor 3 activation in hepatocytes. Gastroenterol. 154, 2237-2251
     
  • Cordts S.E., Schneble L., Schnitzler P., Wenzel J.J., Vinke T., Rieger S., Fichtner A., Tönshoff B., Höcker B. (2018) Prevalence, morbidity and therapy of hepatitis E virus infection in pediatric renal allograft recipients Ped. Nephrol. 33, 1215-1225
     
  • Höcker B., Aguilar M., Schnitzler P., Pape L., Bald M., König J., Marks S.D., Genc G., Büscher A., Kemper M.J., Billing H., Pohl M., Rieger S., Mankertz A., Krupka K., Bruckner T., Fichtner A., Tönshoff B. (2018) Vaccination titres pre- and post-transplant in paediatric renal transplant recipients and the impact of immunosuppressive therapyPed. Nephrol., 33, 897-910
     
  • Schnee S.V., Pfeil J., Ihling C.M., Tabatabai J., Schnitzler P. (2017). Performance of the Alere i RSV assay for point-of-care detection of respiratory syncytial virus in children. BMC Infect. Dis, 17: 767
     
  • Tabatabai J., Thielen A., Lehners N., Daeumer M., Schnitzler P. (2018) Respiratory syncytial virus A in haematological patients with prolonged shedding: premature stop codons and deletion of the genotype ON1 72-nucleotide-duplication in the attachment G gene J. Clin. Virol., 98, 10-17.
     
  • Höcker B., Aguilar M., Schnitzler P., Pape L., Dello Strologo L., Webb N.J.A. Bald M., Genc G.,   Billing H., König J., Büscher A., Kemper M.J., Marks S.D., Pohl M., Wigger M., Topaloglu R., Rieger S., Krupka K., Bruckne T., Fichtner A., Tönshoff B. (2018)Incomplete vaccination coverage in European children with end-stage kidney disease prior to renal transplantation. Ped. Nephrol., 33, 341-350
     
  • Sharifi-Rad J., Salehi B., Schnitzler P., Ayatollahi S.A., Kobarfard F., Fathi M., Eisazadeh M., Sharifi-Rad M. (2017) Susceptibility of herpes simplex virus type 1 to monoterpenes thymol, carvacrol, p-cymene and essential oils of Sinapis arvensis L., Lallemantia royleana Benth., and Pulicaria vulgaris Gaertn. Cell. Mol. Biol. 63, 42-47
     
  • Nusshag C., Osberghaus A., Baumann A., Schnitzler P., Zeier M., Krautkrämer E. (2017) Deregulation of levels of angiopoietin-1 and angiopoietin-2 is associated with severe courses of hantavirus infection (2017)J. Clin. Virol. 94, 33-36
     
  • Schmitt M., Schmitt A., Wiesneth M., Hückelhoven A., Wu Z., Kuball J., Wang L., Schauwecker P., Hofmann S., Götz M., Michels B., Maccari B., Wuchter P., Mertens T., Schnitzler P.,    Döhner H., Ho A.D., Bunjes D.W., Dreger P., Schrezenmeier H., Greiner J. (2017)Peptide vaccination against cytomegalovirus (CMV) elicits both cellular and humoral    immune responses clearing the virus load after allogeneic stem cell transplantation even from a CMV seronegative donor. Theranostics, 7, 1705-1718
     
  • Peters R.M., Schnee S.V., Tabatabai J., Schnitzler P., Pfeil J. (2017)Evaluation of Alere™ i RSV for rapid detection of respiratory syncytial virus in children hospitalized with acute respiratory tract infection J. Clin. Microbiol, 55, 1032-1036
     
  • Hoos J., Peters R.M., Tabatabai J., Grulich-Henn J., Schnitzler P., Pfeil J. (2017)Reverse-transcription isothermal loop-mediated amplification for rapid detection of respiratory syncytial virus directly from nasopharyngeal swabs. J. Virol. Meth., 242, 53-5
     
  • Radujkovic A., Schnitzler P., Ho A.D., Dreger P., Luft T. (2017)Low Vitamin D serum levels predict shorter survival following first-line azacitidine treatment in myelodysplastic Syndrome Clin. Nutrition, 36, 542-551
     
  • Fink S., Tsai M.-H., Schnitzler P., Zeier M., Dreger P., Wuchter P., Bulut O.C., Behrends U., Delecluse H.-J. (2017)The Epstein-Barr virus DNA load in the peripheral blood of transplant recipients does not accurately reflect the burden of infected cellsTransplant Intern., 30, 57-67
     
  • Harak C., Meyrath M., Romero-Brey I., Schenk C., Gondeau C., Schult P., Esser-Nobis K., Saeed       M., Neddermann P., Schnitzler P., Gotthardt D., Perez-del-Pulgar S., Neumann-Haefelin C., Thimme R., Meuleman P., De Francesco R., Rice C.M., Bartenschlager R., Lohmann V. (2016) Tuning a cellular lipid kinase adapts hepatitis C virus to cell culture. Nature Microbiol., 19: 16247
     
  • Dörflinger S., Tabatabai J., Schnitzler P., Farah C., Rameil S., Sander P., Koromyslova A., Hansman GS (2016)Development of a nanobody-based lateral flow immunoassay for the detection of human norovirus mSphere, 1, e00219-16
     
  • Dalpke A., Zimmermann S., Schnitzler P. (2016) Underdiagnosing of Mycoplasma pneumoniae infections as revealed by use of a respiratory multiplex PCR panel. Diagn. Microbiol. Infect. Dis, 86, 50-52
     
  • Krautkrämer E., Nusshag C., Baumann A., Schäfer J., Hofmann J., Schnitzler P., Klempa B., Witkowski P.T., Krüger D.H., Zeier M. (2016) Clinical characterization of two severe cases of hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses Puumala and Dobrava-Belgrade genotype Sochi BMC Infect. Dis. 16: 67
     
  • Sadeghi M., Lahdou I., Opelz G., Mehrabi A., Zeier M., Schnitzler P., Daniel V. (2016) IL-23 plasma level is strongly associated with CMV status and reactivation of CMV in renal transplant recipients. BMC Immunology, 17:35
     
  • Dubler S., Hofer S., Fischer M., Zimmermann S., Schnitzler P., Bruckner T., Weigand M.A., Frank U., Heininger A. (2016)Bacterial and viral contamination of breathing circuits after extended use – an aspect of patient safety?Acta Anaesthes. Scand., 60, 1251-1260
     
  • Lehners N., Tabatabai J., Prifert C., Wedde W., Puthenparambil J., Weissbrich B., Biere, B., Schweiger B., Egerer G., Schnitzler P. (2016) Long-term shedding of influenza virus, parainfluenza virus, respiratory syncytial virus and nosocomial epidemiology in patients with hematological disorders PLoS ONE, 11, e0148258.
     
  • Höcker B., Zencke S., Pape L., Krupka K., Köster L., Fichtner A., Dello Strologo L., Guzzo I., Topaloglu R., Kranz B., König J., BaldM.,Webb N.J.A., Noyan A., Dursun H., Marks S., Yalcinkaya F., Thiel F., Billing H., Pohl M., Fehrenbach H., Schnitzler P., Bruckner T., Ahlenstiel-Grunow T., Tönshoff B. (2016) Impact of everolimus-based immunosuppressive therapy on cytomegalovirus replication and disease in pediatric renal transplantation. Am. J. Transplant., 16, 921-929
     
  • Poelman R., Schuffenecker I., van Leer-Buter C., Josset L., Niesters H.G.M., Lina B., and the ESCV-ECDC EV-D68 studygroup (2015) European surveillance for enterovirus D68 during the emerging North-American outbreak in 2014 J. Clin. Virol., 71, 1-9
     
  • Dondog B., Schnitzler P., Michael K.M., Clifford G., Franceschi S., Pawlita M., Waterboer T. (2015) Hepatitis C Virus seroprevalence in Mongolian women assessed by a novel multiplex antibody detection assayCancer Epidemiol. Biomarkers Prev., 24, 1360-1365.