Kliniken & Institute … Institute Zentrum für… Abteilung Virologie … Forschung Schnitzler Lab

Research Group Schnitzler

Projects

Herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) are wide spread human pathogens which cause epidermal lesions. Several drugs are currently available for the management of HSV infections. Natural products like the Australian tea tree oil and peppermint oil are also quite effective against HSV as shown in plaque reduction assays. We analyse the mechanism of the virucidal effect of several essential oils on HSV in vitro. Since esssential oils are mixtures of many different natural compounds, we try to isolate the active virucidal compound against herpes simplex virus.

Selected Publications

Complete Publication List (PubMed)

  • Hoffmann P., Behnisch R., Gsenger J., Schnitzler P., Gauss A. (2020) Hepatitis E seroprevalence in a German cohort of patients with inflammatory bowel diseases. PLoS ONE, 15(10): e0239825
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  • Dao Thi V.L., Herbst K., Boerner K., Meurer M., Kremer L.P., Kirrmaier D., Freistaedter A., Papagiannidis D., Galmozzi C., Stanifer M.L., Boulant S., Klein S., Chlanda P., Khalid D., Barreto Miranda I., Schnitzler P., Kräusslich H.G., Knop M., Anders S. (2020) A colorimetric RT-LAMP assay and LAMP-sequencing for detecting SARS-CoV-2 RNA in clinical samples. Sci. Transl. Med., eabc707
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  • Klein S., Müller T.G., Khalid D., Sonntag-Buck V., Heuser A.M., Glass B., Meurer M., Morales I., Schillak A., Freistaedter A., Ambiel I., Winter S.L., Zimmermann L., Naumoska T., Bubeck                F., Kirrmaier D., Ullrich S., Barreto Miranda I., Anders S., Grimm D., Schnitzler P., Knop M., Kräusslich H.G., Dao Thi V.L., Börner K., Chlanda P. (2020). SARS-CoV-2 RNA extraction using magnetic beads for rapid large-scale testing by RT-qPCR and RT-LAMP. Viruses, E863
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  • Fakhiri J., Linse K.P., Mietzsch M., Xu M., Schneider M.A., Meister M., Schildgen O., Schnitzler P., Söderlund-Venermo M., Agbandje-McKenna M., Grimm D. (2020). Impact of natural or synthetic singletons in the capsid of human bocavirus 1 on particle infectivity and immunoreactivity. J. Virol., e00170-20.
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  • Delecluse S., Poirey R., Zeier M., Schnitzler P., Behrends U., Tsai M.H., Delecluse H.J. (2020). Identification and cloning of a new western Epstein Barr virus strain that efficiently replicates in primary B cells. J. Virol., e01918-19
  • Domingo C., Lamerz J., Cadar D., Stojkovic M., Eisermann P., Merle U., Nitsche A., Schnitzler P. (2020) Severe multiorgan failure following yellow fever vaccination. Vaccines 26, 249
     
  • Morath C., Schmitt A., Kleist C., Daniel V., Opelz G., Süsal C., Kälble F., Speer C., Nusshag C., Pego da Silva L., Sommerer C., Wang L., Ni M., Hückelhoven-Krauss A., Czock D., Merle U., Mehrabi A., Sander A., Hackbusch M., Eckert C., Waldherr R., Schnitzler P., Dreger P., Müller-Tidow C., Hoheisel J.D., Mustafa S., Alhamdani M.S.S., Zeier M., Schmitt M.,Schaier M., Terness P. (2020) mPhase I trial of donor-derived modified immune cell infusion in kidney transplantationJ. Clin. Invest., 130, 2364-2376
  • Schmack I., Ballikaya S., Erber B., Voehringer I., Burkhardt U., Auffarth G.U., Schnitzler P. Validation of spiked post-mortem blood samples from cornea donors on the Abbott   ARCHITECT and m2000 system for viral infections (2020) Transf. Med. Hemother., 47, 236-242
     
  • Delecluse S., Yu J., Bernhardt K., Haar J., Poirey R., Tsai M.-H., Kiblawi R., Kopp-Schneider A., Schnitzler P., Zeier M., Dreger P., Wuchter P., Bulut O.C., Behrends U., Delecluse H.-J. (2019) Spontaneous lymphoblastoid cell lines from patients with Epstein-Barr virus infection show highly variable proliferation characteristics that correlate with the expression levels of viral microRNAs
     
  • Mertz D., Ka-Fung Lo C., Lytvyn L., Ortiz J.R., Loeb M., for the FLURISK-INVESTIGATORS Pregnancy as a risk factor for severe influenza infection: an individual participant data meta-analysis (2019) BMC Infect. Dis. 19:683
     
  • Rauber C., Bartelheimer K., Zhou T., Rupp C., Schnitzler P., Schemmer P., Sauer P., Weiss K.H., Gotthardt D.N. (2019) Prevalence of human herpesviruses in biliary fluid and their association with biliary complications after liver transplantation. BMC Gastroenterol. 19: 110
     
  • Schnitzler P. (2019) Essential oils for the treatment of herpes simplex virus infections. Chemotherapy, 64, 1-7
     
  • Meyding-Lamadé U., Craemer E., Schnitzler P. (2019). Emerging and re-emerging viruses affecting the nervous system.Neurol. Res. Prac., 1: 20
     
  • von Felden J., Alric L., Pischke S., Aitken C., Schlabe S., Spengler U., Giordani M.T., Schnitzler P., Bettinger D., Thimme R., Binder M., Ayuk F., Lohse A.W., Cornelissen J.J., Man R.A., Mallet V. (2019). The burden of hepatitis E virus infection among patients with haematological malignancy: a retrospective European cohort study. J. Hepatol. 71, 465-472
     
  • Oweira H.,Khajeh E., Mohammadi S., Ghamarnejad O., Daniel V., Schnitzler P., Golriz M., Mieth M., Morath C., Zeier M., Mehrabi A., Sadeghi M. (2019) Pre-transplant CD200 and CD200R1 are associated with post-transplant events in kidney transplant recipients. Medicine 98:37 e17006
     
  • Manuel B., Hackbusch M., Tabatabai J., Hoos J., Peters R., Schnee S.V., Ihling C.M., Schnitzler P., Pfeil J. (2019) RSVpredict: An online tool to calculate the likelihood of respiratory syncytial virus infection in children hospitalized with acute respiratory disease Pediatric Inf. Dis. J., 38, 678-681
     
  • Tabatabai J., Fakhiri J., Meyburg J., Linse K.-P., Xu M., Söderlund-Venermo M., Grimm D., Schnitzler P. (2019) Severe human bocavirus-1 respiratory tract infection in an immunodeficient child with fatal outcome Pediatric Inf. Dis. J., 38, e219-e222
     
  • Brenner N., Mentzer A.J., Butt J., Braband K.L., Michel A., Jeffery K., Klenerman P., Gärtner B., Schnitzler P., Hill A., Taylor G., Demontis M.A., Guy E., Hadfield S.J., Almond R., Allen N., Pawlita M., Tim Waterboer T. (2019) Validation of multiplex serology for human hepatitis viruses B and C, human T-lymphotropic virus 1 and Toxoplasma gondii
     
  • Brenner N., Butt J., Bomfim I.L., Tabatabai J., Pawlita M., Schnitzler P., Waterboer T. (2019) Validation of monoplex assays detecting antibodies against Corynebacterium diphtheriae and Clostridium tetani toxins, rubella virus and parvovirus B19 for incorporation into multiplex serology Methods 158, 44-53
     
  • Höcker B., Tabatabai J., Schneble L., Oh J., Thiel F., Pape L., Rusai K., Topaloglu R., Kranz B., Klaus G., Printza N., Yavascan O., Fichtner A., Krupka K., Bruckner T., Waldherr R., Pawlita M., Schnitzler P., Hirsch H.H., Tönshoff B. (2018) JC polyomavirus replication and associated morbidity in pediatric renal transplantation: an international CERTAIN registry study Ped. Nephrol. 33, 2343-2352
     
  • Höcker B., Schneble L., Murer L., Carraro A., Pape L., Kranz B., Oh J., Zirngibl M., Dello Strologo L., Büscher A., Weber L.T., Awan A., Pohl M., Bald M., Printza N., Rusai K., Peruzzi L., Topaloglu R., Fichtner A., Krupka K., Köster L., Bruckner T., Schnitzler P., Hirsch H.H., Tönshoff B. (2019). Epidemiology of and risk factors for BK polyomavirus replication and nephropathy in   pediatric renal transplant recipients: an international CERTAIN registry study. Transplantation, 103, 1224-1233
     
  • Grünvogel O., Colasanti O., Lee J.-Y., Klöss V., Belouzard S., Reustle A., Esser-Nobis K., Hesebeck-Brinckmann J., Mutz P., Hoffmann K., Mehrabi A., Koschny R., Vondran F.W.R., Gotthardt D., Schnitzler P., Neumann-Haefelin C., Thimme R., Binder M., Bartenschlager R., Dubuisson J., Dalpke A.H., Lohmann V. (2018). Secretion of hepatitis C virus replication intermediates dampens toll-like receptor 3 activation in hepatocytes. Gastroenterol. 154, 2237-2251
     
  • Cordts S.E., Schneble L., Schnitzler P., Wenzel J.J., Vinke T., Rieger S., Fichtner A., Tönshoff B., Höcker B. (2018) Prevalence, morbidity and therapy of hepatitis E virus infection in pediatric renal allograft recipients Ped. Nephrol. 33, 1215-1225
     
  • Höcker B., Aguilar M., Schnitzler P., Pape L., Bald M., König J., Marks S.D., Genc G., Büscher A., Kemper M.J., Billing H., Pohl M., Rieger S., Mankertz A., Krupka K., Bruckner T., Fichtner A., Tönshoff B. (2018) Vaccination titres pre- and post-transplant in paediatric renal transplant recipients and the impact of immunosuppressive therapyPed. Nephrol., 33, 897-910
     
  • Schnee S.V., Pfeil J., Ihling C.M., Tabatabai J., Schnitzler P. (2017). Performance of the Alere i RSV assay for point-of-care detection of respiratory syncytial virus in children. BMC Infect. Dis, 17: 767
     
  • Tabatabai J., Thielen A., Lehners N., Daeumer M., Schnitzler P. (2018) Respiratory syncytial virus A in haematological patients with prolonged shedding: premature stop codons and deletion of the genotype ON1 72-nucleotide-duplication in the attachment G gene J. Clin. Virol., 98, 10-17.
     
  • Höcker B., Aguilar M., Schnitzler P., Pape L., Dello Strologo L., Webb N.J.A. Bald M., Genc G.,   Billing H., König J., Büscher A., Kemper M.J., Marks S.D., Pohl M., Wigger M., Topaloglu R., Rieger S., Krupka K., Bruckne T., Fichtner A., Tönshoff B. (2018)Incomplete vaccination coverage in European children with end-stage kidney disease prior to renal transplantation. Ped. Nephrol., 33, 341-350
     
  • Sharifi-Rad J., Salehi B., Schnitzler P., Ayatollahi S.A., Kobarfard F., Fathi M., Eisazadeh M., Sharifi-Rad M. (2017) Susceptibility of herpes simplex virus type 1 to monoterpenes thymol, carvacrol, p-cymene and essential oils of Sinapis arvensis L., Lallemantia royleana Benth., and Pulicaria vulgaris Gaertn. Cell. Mol. Biol. 63, 42-47
     
  • Nusshag C., Osberghaus A., Baumann A., Schnitzler P., Zeier M., Krautkrämer E. (2017) Deregulation of levels of angiopoietin-1 and angiopoietin-2 is associated with severe courses of hantavirus infection (2017)J. Clin. Virol. 94, 33-36
     
  • Schmitt M., Schmitt A., Wiesneth M., Hückelhoven A., Wu Z., Kuball J., Wang L., Schauwecker P., Hofmann S., Götz M., Michels B., Maccari B., Wuchter P., Mertens T., Schnitzler P.,    Döhner H., Ho A.D., Bunjes D.W., Dreger P., Schrezenmeier H., Greiner J. (2017)Peptide vaccination against cytomegalovirus (CMV) elicits both cellular and humoral    immune responses clearing the virus load after allogeneic stem cell transplantation even from a CMV seronegative donor. Theranostics, 7, 1705-1718
     
  • Peters R.M., Schnee S.V., Tabatabai J., Schnitzler P., Pfeil J. (2017)Evaluation of Alere™ i RSV for rapid detection of respiratory syncytial virus in children hospitalized with acute respiratory tract infection J. Clin. Microbiol, 55, 1032-1036
     
  • Hoos J., Peters R.M., Tabatabai J., Grulich-Henn J., Schnitzler P., Pfeil J. (2017)Reverse-transcription isothermal loop-mediated amplification for rapid detection of respiratory syncytial virus directly from nasopharyngeal swabs. J. Virol. Meth., 242, 53-5
     
  • Radujkovic A., Schnitzler P., Ho A.D., Dreger P., Luft T. (2017)Low Vitamin D serum levels predict shorter survival following first-line azacitidine treatment in myelodysplastic Syndrome Clin. Nutrition, 36, 542-551
     
  • Fink S., Tsai M.-H., Schnitzler P., Zeier M., Dreger P., Wuchter P., Bulut O.C., Behrends U., Delecluse H.-J. (2017)The Epstein-Barr virus DNA load in the peripheral blood of transplant recipients does not accurately reflect the burden of infected cellsTransplant Intern., 30, 57-67
     
  • Harak C., Meyrath M., Romero-Brey I., Schenk C., Gondeau C., Schult P., Esser-Nobis K., Saeed       M., Neddermann P., Schnitzler P., Gotthardt D., Perez-del-Pulgar S., Neumann-Haefelin C., Thimme R., Meuleman P., De Francesco R., Rice C.M., Bartenschlager R., Lohmann V. (2016) Tuning a cellular lipid kinase adapts hepatitis C virus to cell culture. Nature Microbiol., 19: 16247
     
  • Dörflinger S., Tabatabai J., Schnitzler P., Farah C., Rameil S., Sander P., Koromyslova A., Hansman GS (2016)Development of a nanobody-based lateral flow immunoassay for the detection of human norovirus mSphere, 1, e00219-16
     
  • Dalpke A., Zimmermann S., Schnitzler P. (2016) Underdiagnosing of Mycoplasma pneumoniae infections as revealed by use of a respiratory multiplex PCR panel. Diagn. Microbiol. Infect. Dis, 86, 50-52
     
  • Krautkrämer E., Nusshag C., Baumann A., Schäfer J., Hofmann J., Schnitzler P., Klempa B., Witkowski P.T., Krüger D.H., Zeier M. (2016) Clinical characterization of two severe cases of hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses Puumala and Dobrava-Belgrade genotype Sochi BMC Infect. Dis. 16: 67
     
  • Sadeghi M., Lahdou I., Opelz G., Mehrabi A., Zeier M., Schnitzler P., Daniel V. (2016) IL-23 plasma level is strongly associated with CMV status and reactivation of CMV in renal transplant recipients. BMC Immunology, 17:35
     
  • Dubler S., Hofer S., Fischer M., Zimmermann S., Schnitzler P., Bruckner T., Weigand M.A., Frank U., Heininger A. (2016)Bacterial and viral contamination of breathing circuits after extended use – an aspect of patient safety?Acta Anaesthes. Scand., 60, 1251-1260
     
  • Lehners N., Tabatabai J., Prifert C., Wedde W., Puthenparambil J., Weissbrich B., Biere, B., Schweiger B., Egerer G., Schnitzler P. (2016) Long-term shedding of influenza virus, parainfluenza virus, respiratory syncytial virus and nosocomial epidemiology in patients with hematological disorders PLoS ONE, 11, e0148258.
     
  • Höcker B., Zencke S., Pape L., Krupka K., Köster L., Fichtner A., Dello Strologo L., Guzzo I., Topaloglu R., Kranz B., König J., BaldM.,Webb N.J.A., Noyan A., Dursun H., Marks S., Yalcinkaya F., Thiel F., Billing H., Pohl M., Fehrenbach H., Schnitzler P., Bruckner T., Ahlenstiel-Grunow T., Tönshoff B. (2016) Impact of everolimus-based immunosuppressive therapy on cytomegalovirus replication and disease in pediatric renal transplantation. Am. J. Transplant., 16, 921-929
     
  • Poelman R., Schuffenecker I., van Leer-Buter C., Josset L., Niesters H.G.M., Lina B., and the ESCV-ECDC EV-D68 studygroup (2015) European surveillance for enterovirus D68 during the emerging North-American outbreak in 2014 J. Clin. Virol., 71, 1-9
     
  • Dondog B., Schnitzler P., Michael K.M., Clifford G., Franceschi S., Pawlita M., Waterboer T. (2015) Hepatitis C Virus seroprevalence in Mongolian women assessed by a novel multiplex antibody detection assayCancer Epidemiol. Biomarkers Prev., 24, 1360-1365.
     
  • Sadeghi M., Lahdou I., Ettinger J., Heidary Navid M., Daniel V., Zeier M., Hofmann J., Opelz G., Schnitzler P. (2015)Association of low serum TGF-β level in hantavirus infected patients with severe disease BMC Immunol., 16:19
     
  • Hahn M., Schnitzler P., Schweiger B., Kunz C., Ho A.D., Goldschmidt H., Schmitt M. (2015) Efficacy of single versus boost vaccination against influenza virus in patients with multiple myeloma Haematologica, 100: e285
     
  • Gauss A., Rosenstiel S., Schnitzler P., Hinz U., Rehlen T., Kadmon M., Ehehalt R., Stremmel W.,  Zawierucha A. (2015)Intestinal cytomegalovirus infection in patients hospitalized for exacerbation of inflammatory bowel disease: a 10-year tertiary referral center experience Eur. J. Gastroenterol. Hepatol., 27, 712-720
     
  • Tappe D., Nachtigall S., Kapaun A., Schnitzler P., Günther S., Schmidt-Chanasit J. (2015) Acute Zika virus infection after travel to Malaysian Borneo, September 2014 Emerg. Infect. Dis., 21, 911-913
     
  • Astani A., Albrecht U., Schnitzler P. (2015) Piroxicam inhibits herpes simplex virus type 1 infection in vitro Pharmazie, 70, 331-336
     
  • Eckerle I., Kapaun A., Junghanss T., Schnitzler P., Drosten C., Jänisch T. (2015) Dengue virus serotype 3 infection in traveler returning from West Africa to Germany Emerg. Infect. Dis., 21, 175-177.
     
  • Aichinger E., Schnitzler P., Heeg K., Dederer W., Benz M., Buda S., Dreger P., Egerer G., Eisenbach C., Geis S., Haas W., Ho A.D., Lehners N., Neben K., Pfaff G., Schwertz R., Thalheimer M., Wagner-Wiening C., Weißbrich B., Buchholz U. (2014) Contributing and terminating factors of a large outbreak of respiratory syncytial virus infections in an adult hematology unit Plos Current Outbreaks, doi: 10.1371/currents.outbreaks.3bc85b2a508d205ecc4a5534ecb1f9be
     
  • Sadeghi M., Lahdou I., Mehrle S., Heidary Navid M., Daniel V., Zeier M., Schnitzler P., Opelz G., Terness P. (2014) Increased serum kynurenine level is associated with severity of kidney injury in Puumala hantavirus infection J. Virol. Antivir. Res., 3: 4, doi: 10.4172/2324-8955.1000130.
     
  • Protzer U., Böhm F., Longerich T., Seebach J., Heidary Navid M., Friemel J., Marques-Maggio E., Bawohl M., Heikenwalder M., Schirmacher P., Dutkowski P., ClavienP.-A., Schemmer P., Schnitzler P., Gotthardt D., Müllhaupt B., Weber A. (2014) Molecular detection of hepatitis E-Virus (HEV) in liver biopsies after liver transplantation Mod. Pathol., 214, 1-10.
     
  • Tabatabai J., Prifert C., Pfeil J., Grulich-Henn J., Schnitzler P. (2014) Novel respiratory syncytial virus (RSV) genotype ON1 predominates in Germany during winter season 2012-13 Plos ONE, 9, e109191
     
  • Pfeil J., Tabatabai J., Sander A., Ries M., Grulich-Henn J., Schnitzler P. Screening for respiratory syncytial virus and isolation strategies in children hospitalized with acute respiratory tract infection Medicine, 93, e144
     
  • Astani A., Heidary Navid M., Schnitzler P. (2014) Attachment and penetration of acyclovir-resistant herpes simplex virus are inhibited by Melissa officinalis extract Phytother. Res., 28, 1547-1552.
     
  • Tabatabai J., Namakhoma I., Tweya H., Phiri S., Schnitzler P., Neuhann F. (2014) Understanding reasons for treatment interruption amongst patients on antiretroviral therapy - a qualitative study at Lighthouse Clinic Lilongwe/Malawi Glob. Health Action, 7, 24795
     
  • Roos K., Gotthardt D., Giese T., Schnitzler P., Stremmel W., Czock D., Eisenbach C. (2014) Pharmacodynamic monitoring of immunosuppressive effects indicates reduced cyclosporine activity during telaprevir therapy Liver Transplant., 20, 1106-1117
     
  • Tabatabai J., Wenzel J.J., Soboletzki M., Flux C., Heidary Navid M., Schnitzler P. (2014) First case report of an acute hepatitis E subgenotype 3c infection during pregnancy in Germany J. Clin. Virol., 61, 170-172