Kliniken & Institute ... Kliniken Zentrum für Innere... Innere Medizin III:... Forschung Grundlagenforschung ... Cardiac Proteostasis ...

AG Cardiac Proteostasis

We aim to understand age- and disease-linked changes in proteostasis (protein homeostasis) in the heart that underlie cardiac dysfunction and disease.

The overarching hypothesis that guides our research is that the levels and functions of key proteins in the heart are altered by cellular responses to age- and disease-linked changes in the intracellular environment that affect protein synthesis, protein folding, protein secretion, and protein degradation, i.e. protein homeostasis, and that these effects contribute to cardiac dysfunction. This hypothesis was developed as a result of our past and current research and it serves as the underpinning of our ongoing and future studies.

Funding from the German Center for Cardiovascular Research (Deutsche Zentrum für Herz-Kreislauf-Forschung e. V.; DZHK) provides support for our studies of protein stability in the heart.

These publications reflect our current interests:  

Doroudgar S, Völkers M, Thuerauf DJ, Khan M, Mohsin K, Wang W, Respress JL, Gude N, Müller OJ, Wehrens XHT, Sussman MA, Glembotski CC. (2015) Hrd1 is a Critical Element of the Sarcoplasmic/Endoplasmic Reticulum Quality Control in the Heart. Circ Res. 2015;117:536-546.
(link to pdf)

A commentary on this article appears as follows:
Sun H, Gao C, Wang Y. A H(a)rd Way to Adapt in Cardiac Hypertrophy. (2015) Circ Res. 2015;117:484-486.
(link to pdf)

Doroudgar S, Glembotski CC. (2013) New Concepts of Endoplasmic Reticulum Function in the Heart: Programmed to Conserve. J Mol Cell Cardiol. 2013 Feb;55:85-91.
(link to pdf)

Doroudgar S, Glembotski CC. (2011) The Cardiokine Story Unfolds: Ischemic Stress-induced Protein Secretion in the Heart. Trends Mol Med. 17(4):207-14.
(link to pdf)

Doroudgar S, Thuerauf DJ, Marcinko MC, Belmont PJ, Glembotski CC. (2009) Ischemia Activates the ATF6 Branch of the Endoplasmic Reticulum (ER) Stress Response. J. Biol. Chem. 284: 29735-29745.
(link to pdf)



  • Mojdeh Talebi Darestani

Technische Assistenten/-innen

Open Positions

Post-doctoral Scientist

We are currently searching for a post-doctoral scientist with experience in protein quality and quantity control for a DZHK-funded position in our team. The project will be focused on regulation of protein stability in cellular growth in the heart. 

Please send inquiries the head of our research group

Collaborating Scientists

Prof. Dr. Oliver Müller, Ruprecht-Karls-Universität Heidelberg

Prof. Dr. Bernd Bukau, Ruprecht-Karls-Universität Heidelberg

Dr. Marius Lemberg, Ruprecht-Karls-Universität Heidelberg

Prof. Dr. Wolfram-Hubertus Zimmermann, Georg-August University Göttingen

Prof. Dr. Lucie Carrier, Universitätsklinikum Hamburg-Eppendorf

Dr. Mirko Völkers, Ruprecht-Karls-Universität Heidelberg

Prof. Dr. Christopher C. Glembotski, San Diego State University

Im Neuenheimer Feld 410
69669 Heidelberg

06221 56-34412
06221 56-5372

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Shirin Doroudgar, Ph.D.
Im Neuenheimer Feld 410
69669 Heidelberg
Gebäude 6669

06221 56-34412
06221 56-5372