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Publikationen der AG

Originalarbeiten (aktuelle Auswahl)

Bikou O*, Thomas D*, Trappe K, Lugenbiel P, Kelemen K, Koch M, Soucek R, Voss F, Becker R, Katus HA, Bauer A (2011) Connexin 43 gene therapy prevents persistent atrial fibrillation in a porcine model. Cardiovasc Res 92: 218-225

Duhme N*, Schweizer PA*, Thomas D, Becker R, Schröter J, Barends TR, Schlichting I, Draguhn A, Bruehl C, Katus HA, Koenen M (2013) Altered HCN4 channel C-linker interaction is associated with familial tachycardia-bradycardia syndrome and atrial fibrillation. Eur Heart J 34: 2768-2775

Li J, Seyler C, Wiedmann F, Schmidt C, Schweizer PA, Becker R, Katus HA, Thomas D (2013) Anti-KCNQ1 K+ channel autoantibodies increase IKs current and are associated with QT interval shortening in dilated cardiomyopathy. Cardiovasc Res 98: 496-503

Li J, Franke J, Pribe-Wolferts R, Meder B, Ehlermann P, Mereles D, Andre F, Abdelrazek MA, Merten C, Schweizer PA, Becker R, Katus HA, Thomas D (2015) Effects of β-blocker therapy on electrocardiographic and echocardiographic characteristics of left ventricular noncompaction. Clin Res Cardiol 104: 241-249

Lugenbiel P, Bauer A, Kelemen K, Schweizer PA, Becker R, Katus HA, Thomas D (2012) Biological heart rate reduction through genetic suppression of Gαs protein in the sinoatrial node. J Am Heart Assoc 1: jah3-e000372

Lugenbiel P*, Thomas D*, Kelemen K, Trappe K, Bikou O, Schweizer PA, Voss F, Becker R, Katus HA, Bauer A (2012) Genetic suppression of Gαs protein provides rate control in atrial fibrillation. Basic Res Cardiol 107: 1-12

Schmidt C, Wiedmann F, Langer C, Tristram F, Anand P, Wenzel W, Lugenbiel P, Schweizer PA, Katus HA, Thomas D (2014) Cloning, functional characterization and remodeling of K2P3.1 (TASK-1) potassium channels in a porcine model of atrial fibrillation and heart failure. Heart Rhythm 11: 1798-1805

Schweizer PA*, Duhme N*, Thomas D, Becker R, Zehelein J, Draguhn A, Bruehl C, Katus HA, Koenen M (2010) cAMP sensitivity of HCN pacemaker channels determines basal heart rate but is not critical for autonomic rate control. Circ Arrhythm Electrophysiol 3: 542-552

Schweizer PA, Schröter J, Greiner S, Haas J, Yampolsky P, Mereles D, Buss SJ, Seyler C, Bruehl C, Draguhn A, Koenen M, Meder B, Katus HA, Thomas D (2014) The symptom complex of familial sinus node dysfunction and myocardial non-compaction is associated with mutations in the HCN4 channel. J Am Coll Cardiol 64: 757-767

Schmidt C, Wiedmann F, Voigt N, Zhou XB, Heijman J, Lang S, Albert V, Kallenberger S, Ruhparwar A, Szabo G, Kallenbach K, Karck M, Borggrefe M, Biliczki P, Ehrlich JR, Baczko I, Lugenbiel P, Schweizer PA, Donner B, Katus HA, Dobrev D, Thomas D (2015) Upregulation of K2P3.1 K+ current causes action potential shortening in patients with chronic atrial fibrillation. Circulation 132: 82-92

Soucek R*, Thomas D*, Kelemen K, Bikou O, Seyler C, Voss F, Becker R, Koenen M, Katus HA, Bauer A (2012) Genetic suppression of atrial fibrillation using a dominant-negative ether-a-go-go-related gene mutant. Heart Rhythm 9: 265-272

Thomas D, Plant LD, Wilkens CM, McCrossan ZA, Goldstein SAN (2008) Alternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodium. Neuron 58: 859-870

Trappe K*, Thomas D*, Bikou O, Kelemen K, Lugenbiel P, Voss F, Becker R, Katus HA, Bauer A (2013) Suppression of persistent atrial fibrillation by genetic knockdown of caspase 3 – a preclinical pilot study. Eur Heart J 34: 147-157

Zylla MM, Pohlmeier M, Hess A, Mereles D, Kieser M, Bruckner T, Scholz E, Zitron E, Schweizer PA, Katus HA, Thomas D (2015) Prevalence of intracardiac thrombi under phenprocoumon, direct oral anticoagulants (dabigatran, rivaroxaban) and bridging therapy in patients with atrial fibrillation and flutter. Am J Cardiol 115: 635-640 

Übersichtsartikel (aktuelle Auswahl)

Hancox JC, James AF, Marrion NV, Zhang H, Thomas D (2016) Novel ion channel targets in atrial fibrillation. Expert Opin Ther Targets, doi: 10.1517/14728222.2016.1159300

Schmidt C*, Kisselbach J*, Schweizer PA, Katus HA, Thomas D (2011) The pathology and treatment of cardiac arrhythmias: Focus on atrial fibrillation. Vasc Health Risk Manag 7: 193-202

Schmidt C, Wiedmann F, Schweizer PA, Katus HA, Thomas D (2012) Kardiale Zwei-Porendomänen-Kaliumkanäle (K2P): Physiologie, Pharmakologie und therapeutisches Potenzial. Dtsch Med Wochenschr 137: 1654-1658

Schmidt C, Wiedmann F, Schweizer PA, Katus HA, Thomas D (2014) Inhibition of cardiac two-pore-domain K+ (K2P) channels – an emerging antiarrhythmic concept. Eur J Pharmacol 738: 250-255

Thomas D, Eckardt L, Estner HL, Kuniss M, Meyer C, Neuberger HR, Sommer P, Steven D, Voss F, Bonnemeier H (2016) Typisches Vorhofflattern - Diagnostik und Therapie. Herzschrittmacherther Elektrophysiol, doi: 10.1007/s00399-016-0413-y