Kliniken & Institute ... Kliniken Zentrum für Innere... Innere Medizin III:... Forschung Section of Molecular... Publikationen

Publikationen

Publication list / Original research articles (2000 to 2019)

El-Battrawy I, Zhao Z, Lan H, Li X, Yücel G, Lang S, Sattler K, Schünemann JD, Zimmermann WH, Cyganek L, Utikal J, Wieland T, Bieback K, Bauer R, Ratte A, Pribe-Wolferts R, Rapti K, Nowak D, Wittig J, Thomas D, Most P, Katus HA, Ravens U, Schmidt C, Borggrefe M, Zhou XB, Müller OJ, Akin I.
Ion Channel Dysfunctions in Dilated Cardiomyopathy in Limb-Girdle Muscular Dystrophy.
Circ Genom Precis Med. 11(3):e001893, 2018

Lehmann LH, Jebessa ZH, Kreusser MM, Horsch A, He T, Kronlage M, Dewenter M, Sramek V, Oehl U, Krebs-Haupenthal J, von der Lieth AH, Schmidt A, Sun Q, Ritterhoff J, Finke D, Völkers M, Jungmann A, Sauer SW, Thiel C, Nickel A, Kohlhaas M, Schäfer M, Sticht C, Maack C, Gretz N, Wagner M, El- Armouche A, Maier LS, Londoño JEC, Meder B, Freichel M, Gröne HJ, Most P, Müller OJ, Herzig S, Furlong EEM, Katus HA, Backs J.
A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway.
Nat Med. 1, 62-72, 2018

Müller I, Vogl T, Pappritz K, Miteva K, Savvatis K, Rohde D, Most P, Lassner D, Pieske B, Kühl U, Van Linthout S, Tschöpe C.
Pathogenic Role of the Damage-Associated Molecular Patterns S100A8 and S100A9 in Coxsackievirus B3-Induced Myocarditis. Circ Heart Fail. 11, pii: e004125 2017 .

Kossack M, Hein S, Juergensen L, Siragusa M, Benz A, Katus HA, Most P*, Hassel D.
Induction  of  cardiac  dysfunction  in  developing  and  adult  zebrafish  by  chronic  isoproterenol stimulation.
J Mol Cell Cardiol. 108, 95-105, 2017 (*co-corresponding and co-senior author)

Schlegel P, Reinkober J, Meinhardt E, Tscheschner H, Gao E, Schumacher SM, Yuan A, Backs J, Most P, Wieland T, Koch WJ, Katus HA, Raake PW.
G protein-coupled receptor kinase 2 promotes cardiac hypertrophy.
PLoS One. 12:e0182110, 2017

Lerchemüller  C.,  Heißenberg  J.,  Damilano  F.,  Bezzeridis  V.J.,  Krämer  I.,  Bochaton-Piallat  M.L., Hirschberg K., Busch M., Katus H.A., Peppel K., Rosenzweig A., Busch H., Börries M., Most P.
S100A6   regulates   endothelial   cell   cycle   progression   by   attenuating   antiproliferative   signal transducers and activators of transcription 1 signaling.
Arterioscler Thromb Vasc Biol, 39, 1854-1867, 2016

Eden M., Meder B., Völkers M., Poomvanicha M., Domes K., Branchereau M., Marck P., Will R., Bernt A., Rangez A., Hrabe de Angelis M., Heymes C., Rottbauer W., Most P., Hoffmann F., Frey N.
Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.
Nature Communications, 7, 11317, 2016

Korkmaz-Icöz S, Al Said S, Radovits T, Li S, Brune M, Hegedűs P, Atmanli A, Ruppert M, Brlecic P, Lehmann LH, Lahrmann B, Grabe N, Yoshikawa Y, Yasui H, Most P, Karck M, Szabó G.
Oral treatment with a zinc complex of acetylsalicylic acid prevents diabetic cardiomyopathy in a rat model of type-2 diabetes: activation of the Akt pathway.
Cardiovasc Diabetol. 6, 15:75 2016

Rebbeck RT, Nitu FR, Rohde D, Most P, Bers DM, Thomas DD, Cornea RL.
S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor•Calmodulin Complex.Journal of Biological Chemistry, 291, 15896-907, 2016

Ritterhoff J., Völkers M., Seitz A., Spaich K., Gao E., Peppel K. Pleger S.T., Zimmermann W., Friederich O., Fink R., Koch W.J., Katus H.A., Most P.
S100A1  DNA-based  inotropic  therapy  protects  against  proarrhythmogenic  ryanodine  receptor  2 dysfunction.
Molecular Therapy, 23, 1320-1330, 2015

Buss S., Krautz B., Hofmann N., Sander Y., Rust L., Giuca S., Galuschky C., Seitz S., Giannitsis E., Pleger S., Raake P., Most P., Katus H.A., Korosoglu G.
Prediction of functional recovery by cardiac magnetic resonance feature tracking imaging in first time ST-elevation myocardial infarction. Comparison to infarct size and transmurality by late gadolinium enhancement.
International Journal of Cardiology, 183, 162-170, 2015

Rohde D., Schön C., Börries M., Didrihisone I., Ritterhoff J., Kubatzky K.F., Völkers M., Herzog N., Mähler M., Tsoporis J., Parker T.G., Linke B., Giannitsis E., Gao E., Peppel K., Most, P.
S100A1  is  released  from  ischemic  cardiomyocytes  and  signals  myocardial  damage  via  Toll-like receptor 4.
EMBO Molecular Medicine, 6, 778-794, 2014

Friedrich O., Yi B., Edwards J., Reischl B., Wirth-Hücking A., Buttgereit A., Lang R., Weber C., Polyak F., Liu I., von Wegner F., Cully T., Lee A., Most P., Völkers M.
IL-1a reversibly inhibits skeletal muscle ryanodine receptor: a novel mechanism for critical illness myopathy.
Am J Respir Cell Mol Biol., 50, 1096-1106, 2014

Brinks H., Giraud M., Segiser A., Ferrie C., Longnus S., Ullrich N., Koch W.J., Most P., Carrel T.P. Tevaerai H. Dynamic patterns of ventricular remodelling and apoptosis in hearts unloaded by heterotopic transplantation.
J Heart Lung Transplantation, 33, 203-210, 2014

Weber C., Neascu I., Krautz B., Schlegel C., Sauer S., Raake P., Ritterhoff J., Jungmann A., Remppis A., Stangassinger M., Koch W.J., Katus H.A. Most P., Pleger S.T.
Therapeutic  safety  of  high  myocardial  expression  levels  of  the  molecular  inotrope  S100A1  in  a preclinical heart failure model.
Gene Therapy, 21, 131-138, 2014

Sen A., Most P., Peppel K.
Induction of microRNA-138 by proinflammatory cytokines causes endothelial dysfunction.
FEBS Letters, 518, 906-914, 2014

Sen A., Ren S., Lerchenmüller C., Sun J., Most P., Peppel K.
miRNA-138 regulates hypoxia-induced endothelial cell dysfunction by targeting S100A1. Plos One, 8, e78648, 2013

Most P., Lerchenmüller C., Rengo G., Mahlmann A., Ritterhoff J., Rohde D., Goodman C., Busch C.J., Laube F., Heissenberg J., Pleger S.T., Weiss N., Katus H.A., Koch W.J., Peppel K.
S100A1 deficiency impairs post-ischemic angiogenesis via compromised proangiogenic endothelial cell function and nitric oxide synthase regulation.
Circulation Research 112:66-78, 2013

Raake P.W.J., Schlegel P., Ksienzyk J., Reinkober J., Barthelmes J., Schinckel S., Pleger S.T., Mier W., Haberkorn U., Koch W.J., Katus H.A., *,#Most P., *Müller O.J.
AAV6-BARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model. (*shared last authorship and #corresponding authors) European Heart Journal, 34, 1437-1447, 2013

Raake P., Zhang X., Vinge L.E., Brinks H., Gao E., Jaleel N., Li Y., Tang M., Most P., Dorn G.W. 2nd, Houser S.R., Katus H.A., Chen X., Koch W.J.
Cardiac  G-protein-coupled receptor  kinase 2  ablation  induces  a  novel  Ca2+ handling phenotype resistant to adverse alterations and remodeling after myocardial infarction.
Circulation, 125, 2108-18, 2012

Völkers M., Dolatabadi N., Gude N., Most P., Sussman M.A., Hassel D.
Orai defieciency leads to heart failure and skeletal myopathy in zebrafish.
Journal of Cell Science, 125, 287-94, 2012

Pleger S.T., Shan C., Kszienzk J., Bekeredjian R., Boekstegers P., Hinkel R., Schinckel S., Leuchs B., Ludwig. J, Qiu G., Weber C., Raake P., Koch W.J., Katus H.A., Müller O.J., Most P.
Cardiac AAV9-S100A1 gene therapy rescues postischemic heart failure and reverses remodelling in a preclinical large animal model.
Science Translational Medicine, 3, 92ra64, 2011

Brinks H., Rohde D., Völkers M., Qiu G., Pleger S.T., Herzog N., Rabinowitz J., Ruhparwar A., Silvestry S., Lerchenmüller C., Mather P.J., Eckhart A.D., Katus H.A., Carrel T., Koch W.J., Most P. S100A1 genetically-targeted therapy reverses dysfunction of human failing cardiomyocytes. Journal of the American College of Cardiology, 58, 966-973, 2011

Völkers M., Weidenhammer C., Herzog N., Qiu G., Spaich K., v.Wegner F., Peppel K., Müller O., Schinkel S., Rabinowitz J., Hippe H.J., Brinks H., Katus H.A., Koch W.J., Eckhart A., Friedrich O., Most P. The inotropic peptide βARKct improves βAR Responsiveness in normal and failing cardiomyocytes-mediated L-type calcium current disinhibition.
Circulation Research, 108, 27-39, 2011

Völkers, M., Salz, M., Herzog, N., Frank, D., Dolatabati, N., Frey, N., Gude, N., Friedrich, O., Koch, W.J., Katus, H.A., Sussman, M.A., Most, P.
Orai1 and Stim-1 regulate normal and hypertrophic growth in cardiomyocytes. Journal of Molecular and Cellular Cardiology, 48, 1329-34, 2010

Brinks H., Boucher M., Gao E., Chuprun J.K., Pesant S., Raake P.W., Huang Z.M., Wang X., Qiu G., Gumpert A., Harris D.M., Eckhart A.D., Most P., Koch W.J.
Level of G protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via pro- and anti-apoptotic mechanisms.
Circulation Research, 107, 1140-9, 2010

Luedde, M., Floegel, U., Knorr, M., Grundt, C., Hippe, H.J., Brors, B., Frank, D., Haselmann, U., Antony, C., Voelkers, M., Schrader, J., Most, P., Lemmer, B., Katus, H.A., Frey, N.
Decreased  contractility  due  to  energy  deprivation  in  a  transgenic  rat  model  of  hypertrophic cardiomyopathy.
Journal of Molecular Medicine, 87, 411-422, 2009

Harris, D.M., Chen, X., Pesant, S., Cohn, H.I., McDonnel, S.M., Boucher, M., Vinge, L.E., Raake, P., Moraca, S.R., Li, D., Most, P., Houser, R. H., Koch, W. J., Eckhart, A.D.
-adrenergic receptor mediated effects in a renal artery stenosis model of high blood pressure.
Journal of Cellular and Molecular Cardiology, 46, 100-107, 2009

deGeorge Jr., B., Rosenberg, M., Eckstein, V., Gao, E., Herzog, N., Katus, H.A., Koch, W.J., Frey, N.,
Most, P.
BMP-2 and FGF-2 synergistically facilitate adoption of a cardiac phenotype in somatic bone marrow
c-kit+/sca-1+ stem cells.
Clinical and Translational Science, 2, 116-125, 2008

Pleger, S.T., Harris, D.H., Shan, C., Vinge, L.E., Chuprun, J.K., Berzins, B., Pleger, W., Druckman, C., Voelkers, M., Heierhorst, J., Oie,. E, Remppis, A., Katus, H.A., Scalia, R., Eckhart, A.D. Koch, W.J., Most. P.
Endothelial S100A1 modulates vascular function via nitric oxide.
Circulation Research, 102, 786-794, 2008

Völkers, M., Loughrey, C.M., MacQuaide, N., Remppis, A., deGeorge, B., Koch, W.J., v.Wegner, F., Friederich, O., Katus, H.A., Fink, R.H.A., Smith, G.L., Most, P.
S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized ventricular cardiomyocytes.
Cell Calcium, 41, 135-143, 2007

Most, P.*, Börries, M.*, Gledhill, J.R., Walker, J.E., Katus, H.A., Koch, W.J., Ueli, A., Schoenenberger, C.A.
The Ca2+-dependent interaction of S100A1 with the F1-ATPase leads to an increased ATP content in cardiomyocytes.
Molecular and Cellular Biology, 27, 4365-4373, 2007 (*shared first authorship)

Pleger,  S.T.*,  Most,  P.*,  Boucher,  M.,  Soltys,  S.,  Chuprun,  J.K.,  Pleger,  W.,  Gao,  E.,  Rengo,  G., Remppis, A., Katus, H.A., Eckhart, A.D., Rabinowitz, J.E., Koch, W.J.
Stable myocardial specific AAV6-S100A1 gene therapy results in chronical functional heart failure rescue.
Circulation, 115, 2506-2515, 2007 (*shared first authorship)

Ehlermann, P., Eggers, K., Bierhaus, A., Most, P., Weichenhan, D., Greten, J., Nawroth, P.P., Katus, H.A., Remppis, A.
Increased  proinflammatory  endothelial  response  to  S100A8/S100A9  after  preactivation  through advanced glycation end products.
Cardiovascular Diabetology, 5, 1-9, 2006                                                                                                  I

Most, P., Seifert, H., Gao, E.G., Funakoshi, H., Völkers, M., Heierhorst, J., Remppis, A., Pleger, S.T., deGeorge, B., Eckhart, A.D., Katus, H.A., Feldman, A.M., Koch, W.J.
Cardiac  S100A1  protein  levels  determine  contractile  performance  and propensity  towards  heart failure after myocardial infarction.
Circulation, 114, 1258-1268, 2006

Most, P.*, Pleger, S.T.*, Heidt, B., Völkers, M., Hata J.A., Katus, H.A., Remppis, A., Koch, W.J. S100A1 gene transfer to myocardium.
European Journal Medical Research, 11, 418-422, 2006 (*shared first authorship)

Pleger, S.T., Remppis, A., Heidt, B., Völkers, M., Gao, E., Chaprun, J.K., Szabo, G., Weichenhan, D., Müller, O., Eckhart, A.D., Katus, H.A., Koch, W.J., Most, P.
S100A1 gene therapy preserves in vivo cardiac function after myocardial infarction. Molecular Therapy, 12, 1120-1129, 2005

Most,  P.,  Boerries,  M.,  Eicher,  C.,  Schweda,  C.,  Völkers,  M.,  Wedel,  T.,  Söllner,  S.,  Katus,  H.A., Remppis, A., Aebi, U., Koch, W.J., Schoenenberger, C.
Distinct subcellular location of the Ca2+-binding protein S100A1 differentially modulates Ca2+-cycling in ventricular rat cardiomyocytes.
Journal of Cell Science, 118, 421-431, 2005

Liu, H.R., Gao, E., Hu, A., Tao, L., Qu, Y., Most, P., Koch, W.J., Christopher, T.A., Lopez, B.L., Alnemri, E.S., Zervos, A.S., Ma, X.L.
Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion. Circulation, 111, 90-96, 2004

Rottbauer, W., Just, S., Trano, N., Wessels, G., Most, P., Katus, H.A., Fishman, M.C. VEGF-
Genes and Development, 19, 1624-1634, 2005

Kettlewell, S.*, Most, P.*, Currie, S., Koch, W.J., Smith, G.L.
S100A1   increases   the   gain   of   excitation-contraction   coupling   in   isolated   rabbit   ventricular
cardiomyocytes.
Journal of Molecular and Cellular Cardiology, 39, 900-910, 2005 (*shared first authorship)

Most, P., Pleger, S.T., Völkers, M., Heidt, B., Börries, M., Weichenhan, D., Löffler, E., Janssen, P.M.L., Williams, M.L., Katus, H.A., Remppis, A., Koch, W.J.
Cardiac adenoviral S100A1 gene delivery rescues failing myocardium. Journal of Clinical Investigation, 114, 1550-1563, 2004

Remppis,  A.,  Pleger,  S.T.,  Most,  P.,  Lindenkamp,  J.,  Ehlermann,  P.,  Schweda,  C.,  Löffler,  E., Weichenhan, D., Zimmermann, W., Eschenhagen, T., Koch, W.J., Katus, H.A.
S100A1 gene transfer: A strategy to strengthen engineered cardiac grafts. Journal of Gene Medicine, 6, 387-394, 2004

Most, P., Börries, M., Eicher, C., Schweda, C., Löffler, E., Ehlermann, P., Pleger, S.T., Koch, W.J., Katus, H.A., Remppis, A.
Extracellular S100A1 protein inhibits apoptosis of ventricular rat cardiac myocytes via activation of the ERK1/2 pathway.
Journal of Biological Chemistry, 278, 48404-48412, 2003

Most, P., Remppis, A., Pleger, S.T., Loffler, E., Ehlermann, P., Bernotat, J., Kleuss, C., Heierhorst, J., Ruiz, P., Witt, H., Karczewski, P., Mao, L., Rockman, H.A., Duncan, S.J., Katus, H.A., Koch, W.J. Transgenic overexpression of the Ca2+ binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance.
Journal of Biological Chemistry, 278, 33809-33817, 2003

Most, P., Remppis, A., Weber, C., Bernotat, J., Ehlermann, P., Pleger, S.T., Kirsch, W., Weber, M., Uttenweiler, D., Smith, G.L., Katus, H.A., Fink, R.H.
The C-terminus (aa 75-94) and the linker region (aa 42-54) of the Ca2+ binding protein S100A1 differentially enhance sarcoplasmic Ca2+ release in murine skinned skeletal muscle fibres.
Journal of Biological Chemistry, 278, 26356-26364, 2003

Remppis, A., Most, P., Löffler, E., Ehlermann, P., Bernotat, J., Pleger, S., Börries, M., Reppel, M., Fischer, J., Koch, W.J., Smith, G.L., Katus, H.A.
The small EF-hand Ca2+ binding protein S100A1 increases contractility and Ca2+ cycling in rat cardiac myocytes.
Basic Res Cardiol 97, I/56-I/62, 2002

Most, P., Bernotat, J., Ehlermann, P., Pleger, S.T., Reppel, M., Börries, M., Niroomand, F., Pieske, B., Janssen, P.M.L., Eschenhagen, T., Karczewski, P., Smith, G.L., Koch, W.J., Katus, H.A., Remppis, A.
S100A1: A regulator of myocardial contractility. Proc Natl Acad Sci U S A, 98, 13889-13894, 2001

Remppis, A., Ehlermann, P., Giannitsis, E., Greten, T., Most, P., Müller-Bardorff, M., Katus, H.A. Cardiac Troponin T Levels at 96 Hours Reflect Myocardial Infarct Size: a Pathoanatomical Study. Cardiology, 93, 249-253, 2000

Ehlermann, P., Remppis, A., Most, P., Bernotat, J., Heizmann, C.W., Katus, H. A.
Purification of the Ca2+ binding protein S100A1 from myocardium and recombinant Escherichia coli.
J Chromatogr B Biomed Sci App, 737, 39-45, 2000