Publikationen

Müller-Kozarez I, Sandek A, Edelmann F, Gertler C, Placzek M, Friede T, Licka M, Rieth A, Schunkert H, Akin I, Arnold N, Störk S, Feuerstein A, Herrmann-Lingen C, Hasenfuß G, Wachter R. Baseline characteristics in the TransitionCHF study: asymptomatic patients with heart failure and reduced ejection fraction. ESC Heart Fail. 2026 Feb 3;13(1):xvag012. doi: 0.1093/eschf/xvag012.PMID: 41711737 

Teichgräber U, Ingwersen M, Lehmann T, Platzer S, Kunstmann I, Steiner S, Schmidt A, Wittig T, Zeller T, Thieme M, Krankenberg H, Werner M, Brodmann M, Malyar N, Müller-Hülsbeck S, de Paoli L, Schlager O, Austermann M, Tepe G, Erbel C, Ito W, Waßmer R, Maiwald L, Aschenbach R, Wissgott C, Andrassy M, Wolf F, Beschorner U, Pech M, Katsanos K, Scheinert D; Licka M for SIRONA Study Group. Comparison of Sirolimus- vs Paclitaxel-Coated Balloon Angioplasty for Femoropopliteal Artery Disease: The SIRONA Randomized Noninferiority Trial. J Am Coll Cardiol. 2026 Feb 18:S0735-1097(25)10433-6. doi: 10.1016/j.jacc.2025.12.017. Online ahead of print.PMID: 41706076

Bohula EA, Marston NA, Bhatia AK, De Ferrari GM, Leiter LA, Nicolau JC, Park JG, Kuder JF, Murphy SA, Walsh E, Wang H, Blaha V, Budaj A, Cornel JH, Goudev A, Kiss RG, Lorenzatti AJ, Parkhomenko A, Cyrille M, Paiva da Silva Lima G, Ohman EM, Giugliano RP, Sabatine MS; Licka M for VESALIUS-CV Investigators. Evolocumab in Patients without a Previous Myocardial Infarction or Stroke. N Engl J Med. 2026 Jan 8;394(2):117-127. doi: 10.1056/NEJMoa2514428. Epub 2025 Nov 8.PMID: 41211925 Clinical Trial.

Karakas M, Friede T, Butler J, Talha KM, Placzek M, Asendorf T, Diek M, Nosko A, Stas A, Kluge S, Jarczak D, DeHeer G, Rybczynski M, Bayes-Genis A, Böhm M, Coats AJS, Edelmann F, Filippatos G, Hasenfuß G, Haverkamp W, Lainscak M, Landmesser U, Macdougall IC, Merkely B, Pieske BM, Pinto FJ, Rassaf T, Visser-Rogers JK, Rosano G, Volterrani M, von Haehling S, Anker MS, Doehner W, Ince H, Koehler F, Savarese G, Khan MS, Kröhnert UR, Gori T, Trenkwalder T, Akin I, Paitazoglou C, Kobielusz-Gembala I, Kuthi L, Frey N, Licka M, Kääb S, Laugwitz KL, Ponikowski P, Anker SD. Intravenous ferric carboxymaltose in heart failure with iron deficiency (FAIR-HF2 DZHK05 trial): Sex-specific outcomes. Eur J Heart Fail. 2025 Nov;27(11):2328-2342. doi: 10.1002/ejhf.3742. Epub 2025 Jul 31.PMID: 40740027 

Anker SD, Friede T, Butler J, Talha KM, Placzek M, Diek M, Nosko A, Stas A, Kluge S, Jarczak D, Deheer G, Rybczynski M, Bayes-Genis A, Edelmann F, Filippatos G, Hasenfuß G, Haverkamp W, Lainscak M, Landmesser U, Macdougall IC, Merkely B, Pieske BM, Pinto FJ, Rassaf T, Volterrani M, von Haehling S, Anker MS, Doehner W, Ince H, Koehler F, Savarese G, Rauch-Kröhnert U, Gori T, Trenkwalder T, Akin I, Paitazoglou C, Kobielusz-Gembala I, Zmuda W, Kuthi L, Frey N, Licka M, Kääb S, Laugwitz KL, Ponikowski P, Karakas M. Ferric carboxymaltose assessment of morbidity and mortality in patients with iron deficiency and chronic heart failure (FAIR-HF2-DZHK05) trial: Baseline characteristics and comparison to other relevant clinical trials. Eur J Heart Fail. 2025 Apr, doi: 10.1002/ejhf.3658

Anker SD, Friede T, Butler J, Talha KM, Placzek M, Diek M, Nosko A, Stas A, Kluge S, Jarczak D, deHeer G, Rybczynski M, Bayés-Genís A, Böhm M, Coats AJS, Edelmann F, Filippatos G, Hasenfuß G, Haverkamp W, Lainscak M, Landmesser U, Macdougall IC, Merkely B, Pieske BM, Pinto FJ, Rassaf T, Visser-Rogers JK, Rosano G, Volterrani M, von Haehling S, Anker MS, Doehner W, Ince H, Koehler F, Savarese G, Khan MS, Rauch-Kröhnert U, Gori T, Trenkwalder T, Akin I, Paitazoglou C, Kobielusz-Gembala I, Kuthi L, Frey N, Licka M, Kääb S, Laugwitz KL, Ponikowski P, Karakas M. Intravenous Ferric Carboxymaltose in Heart Failure With Iron Deficiency: The FAIR-HF2 DZHK05 Randomized Clinical Trial. JAMA 2025 March, doi: 10.1001/jama.2025.3833

Laufs U, Licka M, Asprusten E, Cariou B, Jacobsen N, Civeira Murrilo F, Vest J, Kallend D, Stein E. Randomized, open-label, study comparing efficacy and safety of lerodalcibep to inclisiran in patients with CVD or at high risk for CVD requiring additional LDL-cholesterol reduction. Atherosclerosis 2024 August, doi: 10.1016/j.atherosclerosis.2024.118406

Nissen S, Lincoff A, Brennan D, Ray K, Mason D., Kastelein J., Thompson P., Libby P., Cho L., Plutzky J, Bays H., Moriarty P., Menon V., Grobbee D., Louie M., Chen C., Li N., Bloedon L., Robinson P, Horner M., Sasiela W., Mc Cluskey J., Davey D., Fajardo-Campos P., Petrovic P., Fedacko J., Zmuda W., Lukyanow Y., Nicholls S., et. Al. Licka M., for the CLEAR Outcomes Investigators. Bempedoic Acid and Cardiovascular Outcomes in statin-intolerant patients. N Engl J Med 2023 March 4, DOI:10.1056/NEJMoa2215024.

Bauer A, Sappler N, von Stülpnagel L, Klemm M, Schreinlechner M, Wenner F, Schier J, Al Tawil A, Dolejsi T, Krasniqi A, Eiffener E, Bongarth C, Stühlinger M, Huemer M, Gori T, Wakili R, Sahin R, Schwinger R, Lutz M, Luik A, Gessler N, Clemmensen P, Linke A, Maier L, Hinterseer M, Busch M, Blaschke F, Sack S, Lennerz C, Licka M, Tilz R, Ukena C,  Ehrlich J, Zabel M, Schmidt G, Mansmann U, Kääb S, D Rizas K, Massberg S, on behalf of the SMART-MI-DZHK9 investigators. Telemedical cardiac risk assessment by implantable cardiac monitors in patients after myocardial infarction with autonomic dysfunction (SMART-MI-DZHK9): a prospective investigator-initiated, randomised, multicentre, open-label, diagnostic trial. Lancet Digit Health 2022; 4: e105–16. doi: 10.1016/S2589-7500(21)00253-3. Epub 2022 Feb 01. 

Verma S, Dhingra NK, Butler J, Anker SD, Ferreira JP, Filippatos G, Januzzi JL, Lam CSP, Sattar N, Peil B, Nordaby M, Brueckmann M, Pocock SJ, Zannad F, Packer M; Manuela Licka for EMPEROR-Reduced trial committees and investigators. Empagliflozin in the treatment of heart failure with reduced ejection fraction in addition to background therapies and therapeutic combinations (EMPEROR-Reduced): a post-hoc analysis of a randomised, double-blind trial. Lancet Diabetes Endocrinol. 2022 Jan;10(1):35-45. doi: 10.1016/S2213-8587(21)00292-8. Epub 2021 Nov 30. PMID: 34861154.

Nicolas M. Van Mieghem, M.D., Ph.D., Martin Unverdorben, M.D., Ph.D., Christian Hengstenberg, M.D., Helge Möllmann, M.D., Roxana Mehran, M.D., Diego López-Otero, M.D., Ph.D., Luis Nombela-Franco, M.D., Ph.D., Raul Moreno, M.D., Ph.D., Peter Nordbeck, M.D., Holger Thiele, M.D., Irene Lang, M.D., José L. Zamorano, M.D., Manuela Licka for ENVISAGE-TAVI AF Investigators. Edoxaban versus Vitamin K Antagonist for Atrial Fibrillation after TAVR. N Engl J Med. 2021 Aug 28; Online publication; DOI: 10.1056/NEJMoa2111016. Epub 2021 Aug 28.

Stefan D. Anker, M.D., Ph.D., Javed Butler, M.D., Gerasimos Filippatos, M.D., Ph.D., João P. Ferreira, M.D., Edimar Bocchi, M.D., Michael Böhm, M.D., Ph.D., Hans-Peter Brunner–La Rocca, M.D., Dong-Ju Choi, M.D., Vijay Chopra, M.D., Eduardo Chuquiure-Valenzuela, M.D., Nadia Giannetti, M.D., Juan Esteban Gomez-Mesa, M.D., et al., Manuela Licka for the EMPEROR-Preserved Trial Investigators*. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. N Engl J Med. 2021 Oct 14;385(16):1451-1461; N Engl J Med. 2021 Aug 27; Online publication; DOI: 10.1056/NEJMoa2107038. 

Packer M, Anker SD, Butler J, Filippatos G, Pocock SJ, Carson P, Januzzi J, Verma S, Tsutsui H, Brueckmann M, Jamal W, Kimura K, Schnee J, Zeller C, Cotton D, Bocchi E, Böhm M, Choi DJ, Chopra V, Chuquiure E, Giannetti N, Janssens S, Zhang J, Gonzalez Juanatey JR, Kaul S, Brunner-La Rocca HP, Merkely B, Nicholls SJ, Perrone S, Pina I, Ponikowski P, Sattar N, Senni M, Seronde MF, Spinar J, Squire I, Taddei S, Wanner C, Zannad F; LICKA M EMPEROR-Reduced Trial Investigators. Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure. N Engl J Med. 2020 Oct 8;383(15):1413-1424. doi: 10.1056/NEJMoa2022190. Epub 2020 Aug 28. PMID: 32865377.

Ray KK, Wright RS, Kallend D, Koenig W, Leiter LA, Raal FJ, Bisch JA, Richardson T, Jaros M, Wijngaard PLJ, Kastelein JJP; LICKA, M ORION-10 and ORION-11 Investigators.(2020). Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol. N Engl J Med. 2020 Apr 16;382(16):1507-1519. doi: 10.1056/NEJMoa1912387. Epub 2020 Mar 18.

Spyropoulos AC, Ageno W, Albers GW, Elliott CG, Halperin JL, Hiatt WR, Maynard GA, Steg PG, Weitz JI, Suh E, Spiro TE, Barnathan ES, Raskob GE; Licka M (MARINER Investigators). (2018). Rivaroxaban for thromboprophylaxis after hospitalization for medical illness. N Engl J Med. 2018 Sep20; 379(12): 1118-1127. DOI: 10.1056/NEJMoa1805090

Gibson CM1, Korjian S2, Chi G2, Daaboul Y2, Jain P2, Arbetter D2, Goldhaber SZ3, Hull R4, Hernandez AF5, Lopes RD5, Gold A6, Cohen AT7, Harrington RA8; Licka, M (APEX Investigators. (2017). Comparison of Fatal or Irreversible Events With Extended-Duration Betrixaban Versus Standard Dose Enoxaparin in Acutely Ill Medical Patients: An APEX Trial Substudy. J Am Heart Assoc. 2017 Jul 11;6(7). DOI: 10.1161/JAHA.117.006015

Ridker PM, Revkin J, Amarenco P, Brunell R, Curto M, Civeira F, Flather M, Glynn RJ, Gregoire J, Jukema JW, Karpov Y, Kastelein JJP, Koenig W, Lorenzatti A, Manga P, Masiukiewicz U, Miller M, Mosterd A, Murin J, Nicolau JC, Nissen S, Ponikowski P, Santos RD, Schwartz PF, Soran H, White H, Wright RS, Vrablik M, Yunis C, Shear CL, Tardif JC; Licka, M (SPIRE Cardiovascular Outcome Investigators). (2017). Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients. N Engl J Med. 2017 Apr 20;376(16):1527-1539. DOI: 10.1056/NEJMoa1701488

Weitz JI, Lensing AWA, Prins MH, Bauersachs R, Beyer-Westendorf J, Bounameaux H, Brighton TA, Cohen AT, Davidson BL, Decousus H, Freitas MCS, Holberg G, Kakkar AK, Haskell L, van Bellen B, Pap AF, Berkowitz SD, Verhamme P, Wells PS, Prandoni P; Licka M (EINSTEIN CHOICEInvestigators).(2017). Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism. N Engl J Med. 2017 Mar 30; 376 (13): 1211-1222. DOI: 10.1056/NEJMoa1700518

Goette A, Merino JL, Ezekowitz MD, Zamoryakhin D, Melino ,M, Jin J; Licka M (2016). Edoxaban versus enoxaparin-warfarin in patients undergoing cardioversion of atrial fibrillation (ENSURE-AF): a randomised, open-label, phase 3b trial. The Lancet. 2016 Oct 22; 388 (10055): 1995-2003.

Cohen AT, Harrington RA, Goldhaber SZ, Hull RD, Wiens BL, Gold A, Hernandez AF, Gibson CM; Licka M (APEX Investigators). (2016). Extended Thromboprophylaxis with Betrixaban in Acutely Ill Medical Patients. N Engl J Med. 2016 Aug 11; 375 (6): 534-44. DOI: 10.1056/NEJMoa1601747

Weisz G, Généreux P, Iñiguez A, Zurakowski A, Shechter M, Alexander KP, Dressler O, Osmukhina A, James S, Ohman EM, Ben-Yehuda O, Farzaneh-Far R, Stone GW; Licka M (RIVER-PCI investigators). (2016). Ranolazine in patients with incomplete revascularisation after percutaneous coronary intervention (RIVER-PCI): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet. 2016 Jan 9; 387 (10014): 136-45. DOI: 10.1016/S0140-6736(15)00459-6

Hohnloser SH, Halperin JL, Camm AJ, Gao P, Radzik D, Connolly SJ; Licka M (PALLAS investigators). (2014). Interaction between digoxin and dronedarone in the PALLAS trial. Circ Arrhythm Electrophysiol. 2014 Dec; 7 (6): 1019-25. DOI: 10.1161/CIRCEP.114.002046

Diener HC, Eikelboom J, Connolly SJ, Joyner CD, Hart RG, Lip GY, O'Donnell M, Hohnloser SH, Hankey GJ, Shestakovska O, Yusuf S; Licka M (AVERROES Steering Committee and Investigators). (2012). Apixaban versus aspirin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a predefined subgroup analysis from AVERROES, a randomised trial. Lancet Neurol. 2012 Mar; 11 (3): 225-31.

Connolly SJ, Camm AJ, Halperin JL, Joyner C, Alings M, Amerena J, Atar D, Avezum Á, Blomström P, Borggrefe M, Budaj A, Chen SA, Ching CK, Commerford P, Dans A, Davy JM, Delacrétaz E, Di Pasquale G, Diaz R, Dorian P, Flaker G, Golitsyn S, Gonzalez-Hermosillo A, Granger CB, Heidbüchel H, Kautzner J, Kim JS, Lanas F, Lewis BS, Merino JL, Morillo C, Murin J, Narasimhan C, Paolasso E, Parkhomenko A, Peters NS, Sim KH, Stiles MK, Tanomsup S, Toivonen L, Tomcsányi J, Torp-Pedersen C, Tse HF, Vardas P, Vinereanu D, Xavier D, Zhu J, Zhu JR, Baret-Cormel L, Weinling E, Staiger C, Yusuf S, Chrolavicius S, Afzal R, Hohnloser SH; Licka M (PALLAS Investigators). (2011). Dronedarone in high-risk permanent atrial fibrillation. N Engl J Med. 2011 Dec 15; 365 (24): 2268-76.

Licka M, Jahn L, Kelemen K, Voss F, Trappe K, Becker R, Bikou O, Hauck M, Koch M, Katus HA, Bauer A. (2011). Is the determination of the defibrillation threshold in patients with an implantable cardioverter-defibrillator still required? Herzschrittmacherther Elektrophysiol. 2011 Dec; 22(4): 209-13.

Connolly SJ, Eikelboom J, Joyner C, Diener HC, Hart R, Golitsyn S, Flaker G, Avezum A, Hohnloser SH, Diaz R, Talajic M, Zhu J, Pais P, Budaj A, Parkhomenko A, Jansky P, Commerford P, Tan RS, Sim KH, Lewis BS, Van Mieghem W, Lip GY, Kim JH, Lanas-Zanetti F, Gonzalez-Hermosillo A, Dans AL, Munawar M, O'Donnell M, Lawrence J, Lewis G, Afzal R, Yusuf S; Licka M (Averroes Steering Committee and Investigators). (2011). Apixaban in patients with atrial fibrillation. N Engl J Med. 2011 Mar 3; 364 (9): 806-17.

Bikou O*, Licka M*, Kathoefer S, Katus HA, Bauer A. Cost savings and safety of ICD remote control by telephone: a prospective, observational study. J Telemed Telecare. 2010; 16 (7): 403-8. (*: equally contributed).

Thomas D, Khalil M, Alter M, Schweizer PA, Karle CA, Wimmer AB, Licka M, Katus HA, Koenen M, Ulmer HE, Zehelein J. (2010). Biophysical characterization of KCNQ1 P320 mutations linked to long QT syndrome 1. J Mol Cell Cardiol. 2010 Jan; 48 (1):230-7.

Simon T, Becker R, Voss F, Bikoue O, Hauck M, Licka M, Katus HA, Bauer A. (2008). Elevated B-type natriuretic peptide levels in patients with nonischemic cardiomyopathy predict occurrence of arrhythmic events. Clin Res Cardiol. 2008 May; 97 (5): 306-9.

Thomas D, Wimmer AB, Karle CA , Licka M, Alter M, Khalil M, Ulmer HE, Kathöfer S, Kiehn J, Katus HA, Schoels W, Koenen M, Zehelein J. (2005). Dominant-negative I(Ks) suppression by KCNQ1-deltaF339 potassium channels linked to Romano-Ward syndrome. Cardiovasc Res. 2005 Aug 15; 67 (3): 487-97.

Zehelein J, Thomas D, Khalil M, Wimmer AB, Koenen M, Licka M, Wu K, Kiehn J, Brockmeier K, Kreye VA, Karle CA, Katus HA, Ulmer HE, Schoels W. (2004). Identification and characterisation of a novel KCNQ1 mutation in a family with Romano-Ward syndrome. Biochem Biophys Acta. 2004 Nov 5; 1690 (3): 185-92.

Licka M, Zimmermann R, Zehelein J, Dengler TJ, Katus HA, Kübler W. (2002). Troponin T concentrations 72 hours after myocardial infarction as a serological estimate of infarct size. Heart. 2002 Jun; 87 (6): 520-4.

Bauer A, Schnabel PA, Schreiner KD, Becker R, Voss F, Kraft P, Senges J, Licka M, Kübler W, Schoels W. (2001). Effects of propafenone on anisotropic conduction properties within the three-dimensional structure of the canine ventricular wall. Basic Res Cardiol. 2001 Apr; 96 (2): 175-83.

Berthold F, SahinK, Hero B, Christiansen H, Gehring M, Harms D, Horz S, Lampert F, Schwab M, Terpe J. (1997). The current contribution of molecular factors to risk estimation in neuroblastoma patients. Eur J Cancer.1997 Oct; 33 (12): 2092-7

 Gehring M, Berthold F, Edler L, Schwab M, Amler LC. (1995). The 1p deletion is not a reliable marker for the prognosis of patients with neuroblastoma. Cancer Res. 1995 Nov 15; 55 (22): 5366-9.

Corvi R, Amler LC, Savelyeva L, Gehring, M, Schwab M. (1994). MYCN is retained in single copy at chromosome 2 band p23-24 during amplification in human neuroblastoma cells. Proc Natl Acad Sci U S A. 1994 Jun 7; 91 (12): 5523-7.

Gehring M, Berthold F, Schwab M, Amler L. (1994). Genetic stability of microsatellites in human neuroblastomas. Int J Oncol. 1994 May;4 (5): 1043-5.

Kleihues P, Ohgaki H, Eibl RH, Reichel MB, Mariani L, Gehring M, Petersen I, Höll T, von Deimling A, Wiestler OD, et al. (1994). Type and frequency of p53 mutations in tumors of the nervous system and its coverings. Recent Results Cancer Res. 1994; 135: 25-31.

Ohgaki H, Eibl RH, Schwab M, Reichel MB, Mariani L, Gehring M, Petersen I, Höll T, Wiestler OD, Kleihues P. (1993). Mutations of the p53 tumor suppressor gene in neoplasms of the human nervous system. Mol Carcinog.1993; 8 (2): 74-80

Gehring M, Haag D., Goerttler K., Schwab M. (1993). Combined analysis of prognostic parameters in neuroblastoma. Clinical Chemistry and Enzymology Communications. 1993; 5 (4-6): 213-218

Takayama H, Suzuki T, , Mugishima H, Fujisawa T, Ookuni M, Schwab M, Gehring M, Nakamura Y, Sugimura T, Terada M, et al. (1992). Deletion mapping of chromosomes 14q and 1p in human neuroblastoma. Oncogene. 1992 Jun; 7 (6): 1185-9.