2025
 

Systemic Inactivation of TREX1 Induces Selective Inflammation of the Tumor Microenvironment and Invigorated T Cell-Mediated Tumor Control.
Marinkovic E, Chen M, Schubert N, Dogan Dar E, Poth T, Leung JY, Lohre J, Sahni JM, Tun C, Rajeswaran P, Mehlo-Jensen T, Perng O, Hill CM, Sivakumar P, Barnes MJ, Malik R, Behrendt R, Roers A. Cancer Res. 2025 May 12. doi: 10.1158/0008-5472.CAN-24-2262

RNase T2 restricts TLR13-mediated autoinflammation in vivo.
Gomez-Diaz C, Greulich W, Wefers B, Wang M, Bolsega S, Effern M, Varga DP, Han Z, Chen M, Bérouti M, Leonardi N, Schillinger U, Holzmann B, Liesz A, Roers A, Hölzel M, Basic M, Wurst W, Hornung V. J Exp Med. 2025 Mar 3;222(3):e20241424. doi: 10.1084/jem.20241424. Epub 2025 Jan 24.

TGF-β drives differentiation of intraepithelial mast cells in inflamed airway mucosa.
Roers A.J Clin Invest. 2025 Jan 2;135(1):e186337. doi: 10.1172/JCI186337.

Transplant centers' prophylaxis and monitoring strategies: a key determinant of current herpes and polyomavirus incidences - results from the DZIF kidney transplant cohort.
Sommerer C, Schröter I, Gruneberg K, Schindler D, Morath C, Renders L, Einecke G, Guthoff M, Heemann U, Schnitzler P, Zeier M, Giese T; Transplant Cohort of the German Center for Infection Research (DZIF Transplant Cohort) Consortium.BMC Nephrol. 2025 Apr 30;26(1):218. doi: 10.1186/s12882-025-04084-5.PMID: 40307706

Life on the dry side: a roadmap to understanding desiccation tolerance and accelerating translational applications.
Marks RA, Ekwealor JTB, Artur MAS, Bondi L, Boothby TC, Carmo OMS, Centeno DC, Coe KK, Dace HJW, Field S, Hutt A, Porembski S, Thalhammer A, van der Pas L, Wood AJ, Alpert P, Bartels D, Boeynaems S, Datar MN, Giese T, Seidou WI, Kirchner SM, Köhler J, Kumara UGVSS, Kyung J, Lyall R, Mishler BD, Ndongmo JBVT, Otegui MS, Reddy V, Rexroth J, Tebele SM, VanBuren R, Verdier J, Vothknecht UC, Wittenberg MF, Zokov E, Oliver MJ, Rhee SY.Nat Commun. 2025 Apr 6;16(1):3284. doi: 10.1038/s41467-025-58656-y.

Autoinflammatory encephalopathy due to PTPN1 haploinsufficiency: a case series.
Zhu G, Didry-Barca B, Seabra L, Rice GI, Uggenti C, Touimy M, Rodero MP, Trapero RH, Bondet V, Duffy D, Gautier P, Livingstone K, Sutherland FJH, Lebon P, Parisot M, Bole-Feysot C, Masson C, Cagnard N, Nitschké P, Anderson G, Assmann B, Barth M, Boespflug-Tanguy O, D'Arco F, Dorboz I, Giese T, Hacohen Y, Hancarova M, Husson M, Lepine A, Lim M, Mancardi MM, Melki I, Neubauer D, Sa M, Sedlacek Z, Seitz A, Rottman MS, Sanquer S, Straussberg R, Vlčková M, Villéga F, Wagner M, Zerem A, Marsh JA, Frémond ML, Kaliakatsos M, Crow YJ, El-Daher MT, Lepelley A.Lancet Neurol. 2025 Mar;24(3):218-229. doi: 10.1016/S1474-4422(24)00526-X.

Immunoprofiling to guide treatment decision in SAM syndrome.
Bochnig O, Giese T, Fischer J, Komlosi K, Mihalceanu S, Ott H, Schäkel K.J Eur Acad Dermatol Venereol. 2025 Feb 12. doi: 10.1111/jdv.20597.

SARS-CoV-2 Vaccination in Primary Humoral Immunodeficiency: Experience from a German Lung Clinic.
Rosendahl S, Trudzinski FC, Polke M, Herth FJF, Kreuter M, Giese T.Respiration. 2025;104(5):349-359. doi: 10.1159/000543146. Epub 2024 Dec 19.
 

2024

Cre recombinase promotes leukemogenesis in the presence of both homozygous and heterozygous FLT3-ITD. Yang M, Ma Z, Wang C, Agca MC, Liu H, Huang K, Glage S, Rumpel R, Gerbaulet A, Roers A, Liu X, Noyan F, von Neuhoff N, Ganser A, Liu L, Yun H, Li Z. Leukemia. 2024 Jun;38(6):1437-1439. 

Integrin β1-mediated mast cell immune-surveillance of blood vessel content. Link K, Muhandes L, Polikarpova A, Lämmermann T, Sixt M, Fässler R, Roers A. J Allergy Clin Immunol. 2024 Sep;154(3):745-753.

Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity. Luca D, Lee S, Hirota K, Okabe Y, Uehori J, Izawa K, Lanz AL, Schütte V, Sivri B, Tsukamoto Y, Hauck F, Behrendt R, Roers A, Fujita T, Nishikomori R, Lee-Kirsch MA, Kato H. Sci Adv. 2024 Mar;10(9):eadk0820.

A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics. Meyer M, Mahr A, Brewer J, Daniel V, Dell'Aringa J, Goldstone T, Hersey S, Johnston I, Larson P, Loveridge M, MacBeath G, Moyer M, Nagorsen D, Papa S, Peiser L, Ranade K, Rizzi R, Roers A, Schendel D, Sivakumar P, Tran E, Türeci Ö, Weigand L, Wennborg A, Williams D, Yee C, Britten CM. Nat Rev Drug Discov. 2024 Jan;23(1):1-2.

Insights into the metastatic bone marrow niche gained from fibronectin and β1 integrin transgenic mice. Wirth F, Zoeller C, Lubosch A, Schroeder-Braunstein J, Wabnitz G, Nakchbandi IA. Neoplasia. 2024 Oct 15;58:101058. 

2023

High population frequencies of MICA copy number variations originate from independent recombination events. Klussmeier A, Putke K, Klasberg S, Kohler M, Sauter J, Schefzyk D, Schöfl G, Massalski C, Schäfer G, Schmidt AH, Roers A, Lange V. Front Immunol. 2023 Nov 15;14:1297589. doi: 10.3389/fimmu.2023.1297589. 

Induction of Long-Lasting Regulatory B Lymphocytes by Modified Immune Cells in Kidney Transplant Recipients. Morath C, Schaier M, Ibrahim E, Wang L, Kleist C, Opelz G, Süsal C, Ponath G, Aly M, Alvarez CM, Kälble F, Speer C, Benning L, Nusshag C, Pego da Silva L, Sommerer C, Hückelhoven-Krauss A, Czock D, Mehrabi A, Schwab C, Waldherr R, Schnitzler P, Merle U, Tran TH, Scherer S, Böhmig GA, Müller-Tidow C, Reiser J, Zeier M, Schmitt M, Terness P, Schmitt A, Daniel V. J Am Soc Nephrol. 2023 Jan 1;34(1):160-174. 

The Impact of 45S5-Bioactive Glass on Synovial Cells in Knee Osteoarthritis-An In Vitro Study. Platzer H, Marinescu M, Nawaz Q, Tripel E, Gantz S, Horsch A, Daniel V, Boccaccini AR, Hagmann S, Moradi B, Renkawitz T, Westhauser F. Materials (Basel). 2023 Dec 11;16(24):7594.

Five-year follow-up of a phase I trial of donor-derived modified immune cell infusion in kidney transplantation. Schaier M, Morath C, Wang L, Kleist C, Opelz G, Tran TH, Scherer S, Pham L, Ekpoom N, Süsal C, Ponath G, Kälble F, Speer C, Benning L, Nusshag C, Mahler CF, Pego da Silva L, Sommerer C, Hückelhoven-Krauss A, Czock D, Mehrabi A, Schwab C, Waldherr R, Schnitzler P, Merle U, Schwenger V, Krautter M, Kemmner S, Fischereder M, Stangl M, Hauser IA, Kälsch AI, Krämer BK, Böhmig GA, Müller-Tidow C, Reiser J, Zeier M, Schmitt M, Terness P, Schmitt A, Daniel V. Front Immunol. 2023 Jul 11;14:1089664. 

Immune Response to COVID-19 mRNA Vaccination in Previous Nonresponder Kidney Transplant Recipients After Short-term Withdrawal of Mycophenolic Acid 1 and 3 Months After an Additional Vaccine Dose. Kühn T, Speer C, Morath C, Bartenschlager M, Kim H, Beimler J, Buylaert M, Nusshag C, Kälble F, Reineke M, Töllner M, Klein K, Blank A, Parthé S, Schnitzler P, Zeier M, Süsal C, Bartenschlager R, Tran TH, Schaier M, Benning L. Transplantation. 2023 May 1;107(5):1139-1150.

Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury. Hackstein CP, Spitzer J, Symeonidis K, Horvatic H, Bedke T, Steglich B, Klein S, Assmus LM, Odainic A, Szlapa J, Kessler N, Beyer M, Schmithausen R, Latz E, Flavell RA, Garbi N, Kurts C, Kümmerer BM, Trebicka J, Roers A, Huber S, Schmidt SV, Knolle PA, Abdullah Z. J Hepatol. 2023 Jul;79(1):150-166.

IL-10 production by granulocytes promotes Staphylococcus aureus craniotomy infection. Kak G, Van Roy Z, Heim CE, Fallet RW, Shi W, Roers A, Duan B, Kielian T. J Neuroinflammation. 2023 May 13;20(1):114.

Regeneration after blood loss and acute inflammation proceeds without contribution of primitive HSCs. 

Munz CM, Dressel N, Chen M, Grinenko T, Roers A, Gerbaulet A. Blood. 2023 May 18;141(20):2483-2492.

Development of an RNase H2 Activity Assay for Clinical Screening. Schulz MS, Sartorius von Bach CB, Marinkovic E, Günther C, Behrendt R, Roers A. J Clin Med. 2023 Feb 17;12(4):1598.

Myeloid-like B cells boost emergency myelopoiesis through IL-10 production during infection. Kanayama M, Izumi Y, Akiyama M, Hayashi T, Atarashi K, Roers A, Sato T, Ohteki T. J Exp Med. 2023 Apr 3;220(4):e20221221.

Slow integrin-dependent migration organizes networks of tissue-resident mast cells. Kaltenbach L, Martzloff P, Bambach SK, Aizarani N, Mihlan M, Gavrilov A, Glaser KM, Stecher M, Thünauer R, Thiriot A, Heger K, Kierdorf K, Wienert S, von Andrian UH, Schmidt-Supprian M, Nerlov C, Klauschen F, Roers A, Bajénoff M, Grün D, Lämmermann T. Nat Immunol. 2023 Jun;24(6):915-924.

Pharmacodynamic Monitoring of Ciclosporin and Tacrolimus: Insights From Nuclear Factor of Activated T-Cell-Regulated Gene Expression in Healthy Volunteers. Djaelani YA, Giese T, Sommerer C, Czock D. Ther Drug Monit. 2023 Feb 1;45(1):87-94.

Multifunctional IgG/IgM antibodies and cellular cytotoxicity are elicited by the full-length MSP1 SumayaVac-1 malaria vaccine. Rosenkranz M, Fürle K, Hibbert J, Ulmer A, Ali A, Giese T, Blank A, Haefeli WE, Böhnlein E, Lanzer M, Thomson-Luque R. NPJ Vaccines. 2023 Aug 9;8(1):112.

Human and mouse neutrophils share core transcriptional programs in both homeostatic and inflamed contexts. Hackert NS, Radtke FA, Exner T, Lorenz HM, Müller-Tidow C, Nigrovic PA, Wabnitz G, Grieshaber-Bouyer R. Nat Commun. 2023 Dec 8;14(1):8133. 

Molecular HLA mismatching for prediction of primary humoral alloimmunity and graft function deterioration in paediatric kidney transplantation. Kim JJ, Fichtner A, Copley HC, Gragert L, Süsal C, Dello Strologo L, Oh J, Pape L, Weber LT, Weitz M, König J, Krupka K, Tönshoff B, Kosmoliaptsis V. Front Immunol. 2023 Mar 15;14:1092335.

Donor Selection for Allogeneic Hematopoietic Cell Transplantation. Fleischhauer K, Tran TH, Meisel R, Mytilineos J, Dreger P, Kröger N. Dtsch Arztebl Int. 2023 Apr 14;120(15):261-268. 

Donor-Derived Cell-Free DNA (dd-cfDNA) in Kidney Transplant Recipients With Indication Biopsy-Results of a Prospective Single-Center Trial. Benning L, Morath C, Fink A, Rudek M, Speer C, Kälble F, Nusshag C, Beimler J, Schwab C, Waldherr R, Zeier M, Süsal C, Tran TH. Transpl Int. 2023 Nov 3;36:11899. 

A multinational cohort study uncovered sex differences in excess mortality after kidney transplant. Vinson AJ, Zhang X, Dahhou M, Süsal C, Döhler B, Melk A, Sapir-Pichhadze R, Cardinal H, Wong G, Francis A, Pilmore H, Foster BJ. Kidney Int. 2023 Jun;103(6):1131-1143.

Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner. Schumann T, Ramon SC, Schubert N, Mayo MA, Hega M, Maser KI, Ada SR, Sydow L, Hajikazemi M, Badstübner M, Müller P, Ge Y, Shakeri F, Buness A, Rupf B, Lienenklaus S, Utess B, Muhandes L, Haase M, Rupp L, Schmitz M, Gramberg T, Manel N, Hartmann G, Zillinger T, Kato H, Bauer S, Gerbaulet A, Paeschke K, Roers A, Behrendt R. J Exp Med. 2023 Jan 2;220(1):e20220829.

2022

Complementary medicine usage in surgery: a cross-sectional survey in Germany. Lederer AK, Samstag Y, Simmet T, Syrovets T, Huber R. BMC Complement Med Ther. 2022 Oct 11;22(1):263.

Fate mapping of hematopoietic stem cells reveals two pathways of native thrombopoiesis. Morcos MNF, Li C, Munz CM, Greco A, Dressel N, Reinhardt S, Sameith K, Dahl A, Becker NB, Roers A, Höfer T, Gerbaulet A. Nat Commun. 2022 Aug 3;13(1):4504.

Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A. Joulia R, Guerrero-Fonseca IM, Girbl T, Coates JA, Stein M, Vázquez-Martínez L, Lynam E, Whiteford J, Schnoor M, Voehringer D, Roers A, Nourshargh S, Voisin MB.Nat Commun. 2022 Nov 17;13(1):7029.

Genome Replication Is Associated With Release of Immunogenic DNA Waste. Schubert N, Schumann T, Daum E, Flade K, Ge Y, Hagedorn L, Edelmann W, Müller L, Schmitz M, Kuut G, Hornung V, Behrendt R, Roers A. Front Immunol. 2022 May 11;13:880413.

Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner. Schumann T, Ramon SC, Schubert N, Mayo MA, Hega M, Maser KI, Ada SR, Sydow L, Hajikazemi M, Badstübner M, Müller P, Ge Y, Shakeri F, Buness A, Rupf B, Lienenklaus S, Utess B, Muhandes L, Haase M, Rupp L, Schmitz M, Gramberg T, Manel N, Hartmann G, Zillinger T, Kato H, Bauer S, Gerbaulet A, Paeschke K, Roers A, Behrendt R. J Exp Med. 2023 Jan 2;220(1):e20220829.

Heparin is required for the formation of granules in connective tissue mast cells. Herrera-Heredia SA, Hsu HP, Kao CY, Tsai YH, Yamaguchi Y, Roers A, Hsu CL, Dzhagalov IL. Front Immunol. 2022 Nov 9;13:1000405.

Individualised immunosuppression with intravenously administered donor-derived modified immune cells compared with standard of care in living donor kidney transplantation (TOL-2 Study): protocol for a multicentre, open-label, phase II, randomised controlled trial. Morath C, Schmitt A, Schmitt M, Wang L, Kleist C, Opelz G, Süsal C, Tran TH, Scherer S, Schwenger V, Kemmner S, Fischereder M, Stangl M, Hauser IA, Sommerer C, Nusshag C, Kälble F, Speer C, Benning L, Bischofs C, Sauer S, Schubert ML, Kunz A, Hückelhoven-Krauss A, Neuber B, Mehrabi A, Schwab C, Waldherr R, Sander A, Büsch C, Czock D, Böhmig GA, Reiser J, Roers A, Müller-Tidow C, Terness P, Zeier M, Daniel V, Schaier M. BMJ Open. 2022 Nov 11;12(11):e066128.

Deletion of the Natural Killer Cell Receptor NKG2C Encoding KLR2C Gene and Kidney Transplant Outcome. Vietzen H, Döhler B, Tran TH, Süsal C, Halloran PF, Eskandary F, Herz CT, Mayer KA, Kozakowski N, Wahrmann M, Ely S, Haindl S, Puchhammer-Stöckl E, Böhmig GA.Front Immunol. 2022 Mar 24;13:829228.

Induction of Long-Lasting Regulatory B Lymphocytes by Modified Immune Cells in Kidney Transplant Recipients. Morath C, Schaier M, Ibrahim E, Wang L, Kleist C, Opelz G, Süsal C, Ponath G, Aly M, Alvarez CM, Kälble F, Speer C, Benning L, Nusshag C, Pego da Silva L, Sommerer C, Hückelhoven-Krauss A, Czock D, Mehrabi A, Schwab C, Waldherr R, Schnitzler P, Merle U, Tran TH, Scherer S, Böhmig GA, Müller-Tidow C, Reiser J, Zeier M, Schmitt M, Terness P, Schmitt A, Daniel V. J Am Soc Nephrol. 2023 Jan 1;34(1):160-174.

Kynurenine Is the Main Metabolite of Tryptophan Degradation by Tryptophan 2,3-Dioxygenase in HepG2 Tumor Cells. Oweira H, Lahdou I, Mehrle S, Khajeh E, Nikbakhsh R, Ghamarnejad O, Terness P, Reißfelder C, Sadeghi M, Ramouz A. J Clin Med. 2022 Aug 16;11(16):4794. 

Neutralizing antibody response against the B.1.617.2 (delta) and the B.1.1.529 (omicron) variants after a third mRNA SARS-CoV-2 vaccine dose in kidney transplant recipients. Benning L, Morath C, Bartenschlager M, Kim H, Reineke M, Beimler J, Buylaert M, Nusshag C, Kälble F, Reichel P, Töllner M, Schaier M, Klein K, Benes V, Rausch T, Rieger S, Stich M, Tönshoff B, Weidner N, Schnitzler P, Zeier M, Süsal C, Hien Tran T, Bartenschlager R, Speer C. Am J Transplant. 2022 Jul;22(7):1873-1883.

Maternal versus paternal living kidney transplant donation is associated with lower rejection in young pediatric recipients: A Collaborative Transplant Study report. Engels G, Döhler B, Tönshoff B, Oh J, Kruchen A, Müller I, Süsal C. Pediatr Transplant. 2022 Feb;26(1):e14154. 

Neutralizing Antibody Activity Against the B.1.617.2 (delta) Variant Before and After a Third BNT162b2 Vaccine Dose in Hemodialysis Patients. Benning L, Klein K, Morath C, Bartenschlager M, Kim H, Buylaert M, Reineke M, Töllner M, Nusshag C, Kälble F, Reichel P, Schnitzler P, Zeier M, Süsal C, Bartenschlager R, Schaier M, Speer C. Front Immunol. 2022 Mar 4;13:840136.

Association of intraindividual tacrolimus variability with de novo donor-specific HLA antibody development and allograft rejection in pediatric kidney transplant recipients with low immunological risk. Baghai Arassi M, Gauche L, Schmidt J, Höcker B, Rieger S, Süsal C, Tönshoff B, Fichtner A. Pediatr Nephrol. 2022 Oct;37(10):2503-2514.

Influence of Calcineurin Inhibitor Choice on Outcomes in Kidney Transplant Recipients Aged ≥60 Y: A Collaborative Transplant Study Report. Echterdiek F, Döhler B, Latus J, Schwenger V, Süsal C. Transplantation. 2022 Apr 1;106(4):e212-e218.

Neutralizing Antibody Activity Against the B.1.617.2 (delta) Variant Before and After a Third BNT162b2 Vaccine Dose in Hemodialysis Patients. Benning L, Klein K, Morath C, Bartenschlager M, Kim H, Buylaert M, Reineke M, Töllner M, Nusshag C, Kälble F, Reichel P, Schnitzler P, Zeier M, Süsal C, Bartenschlager R, Schaier M, Speer C. Front Immunol. 2022 Mar 4;13:840136. 

Neutralization of SARS-CoV-2 Variants of Concern in Kidney Transplant Recipients after Standard COVID-19 Vaccination. Benning L, Morath C, Bartenschlager M, Nusshag C, Kälble F, Buylaert M, Schaier M, Beimler J, Klein K, Grenz J, Reichel P, Hidmark A, Ponath G, Töllner M, Reineke M, Rieger S, Tönshoff B, Schnitzler P, Zeier M, Süsal C, Bartenschlager R, Speer C. Clin J Am Soc Nephrol. 2022 Jan;17(1):98-106.

Kidney Transplants from Elderly Donors: The Experience of a Reference Center in Croatia. Živčić-Ćosić S, Süsal C, Döhler B, Katalinić N, Markić D, Orlić L, Rački S, Španjol J, Trobonjača Z. Exp Clin Transplant. 2022 Jan;20(1):19-27.

Heart transplantation across preformed donor-specific antibody barriers using a perioperative desensitization protocol. Sommer W, Avsar M, Aburahma K, Salman J, Kaufeld KT, Rojas SV, Meyer AL, Chichelnitskiy E, Süsal C, Kreusser MM, Verboom M, Hallensleben M, Bara C, Blasczyk R, Falk C, Karck M, Haverich A, Ius F, Warnecke G. Am J Transplant. 2022 Aug;22(8):2064-2076.

Soluble Urokinase Receptor and Mortality in Kidney Transplant Recipients. Morath C, Hayek SS, Döhler B, Nusshag C, Sommerer C, Zeier M, Reiser J, Süsal C. Transpl Int. 2022 Feb 3;35:10071.

Age-dependent Sex Differences in Graft Loss After Kidney Transplantation. Vinson AJ, Zhang X, Dahhou M, Süsal C, Döhler B, Sapir-Pichhadze R, Cardinal H, Melk A, Wong G, Francis A, Pilmore H, Foster BJ. Transplantation. 2022 Jul 1;106(7):1473-1484.

Outcome of Extended Right Lobe Liver Transplantations. Lozanovski VJ, Unterrainer C, Döhler B, Süsal C, Mehrabi A. Liver Transpl. 2022 May;28(5):807-818.

The MHC class I MICA gene is a histocompatibility antigen in kidney transplantation. Carapito R, Aouadi I, Verniquet M, Untrau M, Pichot A, Beaudrey T, Bassand X, Meyer S, Faucher L, Posson J, Morlon A, Kotova I, Delbos F, Walencik A, Aarnink A, Kennel A, Suberbielle C, Taupin JL, Matern BM, Spierings E, Congy-Jolivet N, Essaydi A, Perrin P, Blancher A, Charron D, Cereb N, Maumy-Bertrand M, Bertrand F, Garrigue V, Pernin V, Weekers L, Naesens M, Kamar N, Legendre C, Glotz D, Caillard S, Ladrière M, Giral M, Anglicheau D, Süsal C, Bahram S. Nat Med. 2022 May;28(5):989-998. 

Human Leucocyte Antigens as Prognostic Markers in Head and Neck Squamous Cell Carcinoma. Dyckhoff G, Herold-Mende C, Scherer S, Plinkert PK, Warta R. Cancers (Basel). 2022 Aug 7;14(15):3828.

Humoral response to SARS-CoV-2 mRNA vaccination in previous non-responder kidney transplant recipients after short-term withdrawal of mycophenolic acid. Benning L, Morath C, Kühn T, Bartenschlager M, Kim H, Beimler J, Buylaert M, Nusshag C, Kälble F, Reineke M, Töllner M, Schaier M, Klein K, Blank A, Schnitzler P, Zeier M, Süsal C, Bartenschlager R, Tran TH, Speer C.Front Med (Lausanne). 2022 Aug 18;9:958293.

Deletion of the Natural Killer Cell Receptor NKG2C Encoding KLR2C Gene and Kidney Transplant Outcome. 

Vietzen H, Döhler B, Tran TH, Süsal C, Halloran PF, Eskandary F, Herz CT, Mayer KA, Kozakowski N, Wahrmann M, Ely S, Haindl S, Puchhammer-Stöckl E, Böhmig GA. Front Immunol. 2022 Mar 24;13:829228

Induction of Long-Lasting Regulatory B Lymphocytes by Modified Immune Cells in Kidney Transplant Recipients. Morath C, Schaier M, Ibrahim E, Wang L, Kleist C, Opelz G, Süsal C, Ponath G, Aly M, Alvarez CM, Kälble F, Speer C, Benning L, Nusshag C, Pego da Silva L, Sommerer C, Hückelhoven-Krauss A, Czock D, Mehrabi A, Schwab C, Waldherr R, Schnitzler P, Merle U, Tran TH, Scherer S, Böhmig GA, Müller-Tidow C, Reiser J, Zeier M, Schmitt M, Terness P, Schmitt A, Daniel V. J Am Soc Nephrol. 2023 Jan 1;34(1):160-174.

Metabolic Effect of Blocking Sodium-Taurocholate Co-Transporting Polypeptide in Hypercholesterolemic Humans with a Twelve-Week Course of Bulevirtide-An Exploratory Phase I Clinical Trial. Stoll F, Seidel-Glätzer A, Burghaus I, Göring O, Sauter M, Rose P, Daniel V, Haag M, Schwab M, Riffel J, André F, Taylor L, Weiss J, Burhenne J, Cleeves V, Haefeli WE, Blank A. Int J Mol Sci. 2022 Dec 14;23(24):15924.

Ocular and Systemic Complement Activation during Anti-Vascular Endothelial Growth Factor Treatment and Age-Related Eye Disease Study 2 Dietary Supplementation in Neovascular Age-Related Macular Degeneration. Altay L, Lemke J, Schröder-Braunstein J, Gietzelt C, Sitnilska V, Schaub F, Cursiefen C, Enders P, Fauser S. Ophthalmologica. 2022;245(3):258-264.

Effect of JAK Inhibition on the Induction of Proinflammatory HLA-DR+CD90+ Rheumatoid Arthritis Synovial Fibroblasts by Interferon-γ. Zhao S, Grieshaber-Bouyer R, Rao DA, Kolb P, Chen H, Andreeva I, Tretter T, Lorenz HM, Watzl C, Wabnitz G, Tykocinski LO, Merkt W. Arthritis Rheumatol. 2022 Mar;74(3):441-452.

Keratinocyte-induced costimulation of human T cells through CD6 - but not CD2 - activates mTOR and prevents oxidative stress. Orlik C, Berschneider KM, Jahraus B, Niesler B, Balta E, Schäkel K, Schröder-Braunstein J, Souto-Carneiro MM, Samstag Y. Front Immunol. 2022 Oct 24;13:1016112.

Expression of TRX1 optimizes the antitumor functions of human CAR T cells and confers resistance to a pro-oxidative tumor microenvironment. Balta E, Janzen N, Kirchgessner H, Toufaki V, Orlik C, Liang J, Lairikyengbam D, Abken H, Niesler B, Müller-Decker K, Ruppert T, Samstag Y. Front Immunol. 2022 Dec 14;13:1063313.

Ageing and interferon gamma response drive the phenotype of neutrophils in the inflamed joint. 

Grieshaber-Bouyer R, Exner T, Hackert NS, Radtke FA, Jelinsky SA, Halyabar O, Wactor A, Karimizadeh E, Brennan J, Schettini J, Jonsson H, Rao DA, Henderson LA, Müller-Tidow C, Lorenz HM, Wabnitz G, Lederer JA, Hadjipanayis A, Nigrovic PA. Ann Rheum Dis. 2022 Jun;81(6):805-814

Inflammation induces pro-NETotic neutrophils via TNFR2 signaling. Neuenfeldt F, Schumacher JC, Grieshaber-Bouyer R, Habicht J, Schröder-Braunstein J, Gauss A, Merle U, Niesler B, Heineken N, Dalpke A, Gaida MM, Giese T, Meuer S, Samstag Y, Wabnitz G. Cell Rep. 2022 Apr 19;39(3):110710.

The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer. Kennel KB, Burmeister J, Radhakrishnan P, Giese NA, Giese T, Salfenmoser M, Gebhardt JM, Strowitzki MJ, Taylor CT, Wielockx B, Schneider M, Harnoss JM. JCI Insight. 2022 Nov 22;7(22):e153337.

Neutrophil Gene Expression Patterns in Multiple Trauma Patients Indicate Distinct Clinical Outcomes. Bogner-Flatz V, Braunstein M, Bazarian JJ, Keil L, Richter PH, Kusmenkov T, Biberthaler P, Giese T. J Surg Res. 2022 Sep;277:100-109.

Incidences of Infectious Events in a Renal Transplant Cohort of the German Center of Infectious Diseases (DZIF). Sommerer C, Schröter I, Gruneberg K, Schindler D, Behnisch R, Morath C, Renders L, Heemann U, Schnitzler P, Melk A, Della Penna A, Nadalin S, Heeg K, Meuer S, Zeier M, Giese T; Transplant Cohort of the German Center for Infection Research (DZIF Transplant Cohort) Consortium. Open Forum Infect Dis. 2022 May 13;9(7)

Early Development of Ubiquitous Acanthocytosis and Extravascular Hemolysis in Lung Cancer Patients Receiving Alectinib. Kunz J, Wiedemann C, Grosch H, Kriegsmann K, Gryzik S, Felden J, Hundemer M, Seker-Cin H, Stenzinger M, Leo A, Stenzinger A, Thomas M, Christopoulos P. Cancers (Basel). 2022 May 31;14(11):2720.

Natural SARS-CoV-2 infection results in higher neutralization response against variants of concern compared with 2-dose BNT162b2 vaccination in kidney transplant recipients. Benning L, Morath C, Bartenschlager M, Reineke M, Töllner M, Nusshag C, Kälble F, Reichel P, Schaier M, Schnitzler P, Zeier M, Süsal C, Bartenschlager R, Speer C. Kidney Int. 2022 Mar;101(3):639-642

2021

Peptide Vaccination against Cytomegalovirus Induces Specific T Cell Response in Responses in CMV Seronegative End-Stage Renal Disease Patients. Sommerer C, Schmitt A, Hückelhoven-Krauss A, Giese T, Bruckner T, Wang L, Schnitzler P, Meuer S, Zeier M, Schmitt M. Vaccines (Basel). 2021 Feb 6;9(2):133. 

High rate of HSV-1 reactivation in invasively ventilated COVID-19 patients: Immunological findings. Seeßle J, Hippchen T, Schnitzler P, Gsenger J, Giese T, Merle U. PLoS One. 2021 Jul 1;16(7):e0254129

Dysregulated Host Response in Severe Acute Respiratory Syndrome Coronavirus 2-Induced Critical Illness. Tiwari-Heckler S, Rauber C, Longhi MS, Zörnig I, Schnitzler P, Jäger D, Giese T, Merle U. Open Forum Infect Dis. 2021 Jan 18;8(3)

NBAS Variants Are Associated with Quantitative and Qualitative NK and B Cell Deficiency. Lenz D, Pahl J, Hauck F, Alameer S, Balasubramanian M, Baric I, Boy N, Church JA, Crushell E, Dick A, Distelmaier F, Gujar J, Indolfi G, Lurz E, Peters B, Schwerd T, Serranti D, Kölker S, Klein C, Hoffmann GF, Prokisch H, Greil J, Cerwenka A, Giese T, Staufner C. J Clin Immunol. 2021 Nov;41(8):1781-1793.

Selenium-Binding Protein 1 (SELENBP1) as Biomarker for Adverse Clinical Outcome After Traumatic Spinal Cord Injury. Seelig J, Heller RA, Haubruck P, Sun Q, Georg Klingenberg J, Hackler J, Crowell HL, Daniel V, Moghaddam A, Schomburg L, Biglari B. Front Neurosci. 2021 May 28;15:680240. 

CD4+CD25+CD127-Foxp3+ and CD8+CD28- Tregs in Renal Transplant Recipients: Phenotypic Patterns, Association With Immunosuppressive Drugs, and Interaction With Effector CD8+ T Cells and CD19+IL-10+ Bregs. Aly MG, Ibrahim EH, Karakizlis H, Weimer R, Opelz G, Morath C, Zeier M, Ekpoom N, Daniel V. Front Immunol. 2021 Jul 15;12:716559.

Maternal versus paternal living kidney transplant donation is associated with lower rejection in young pediatric recipients: A Collaborative Transplant Study report. Engels G, Döhler B, Tönshoff B, Oh J, Kruchen A, Müller I, Süsal C. Pediatr Transplant. 2022 Feb;26(1):e14154

Natural SARS-CoV-2 infection results in higher neutralization response against variants of concern compared with 2-dose BNT162b2 vaccination in kidney transplant recipients. Benning L, Morath C, Bartenschlager M, Reineke M, Töllner M, Nusshag C, Kälble F, Reichel P, Schaier M, Schnitzler P, Zeier M, Süsal C, Bartenschlager R, Speer C. Kidney Int. 2022 Mar;101(3):639-642. 

Neutralization of SARS-CoV-2 Variants of Concern in Kidney Transplant Recipients after Standard COVID-19 Vaccination. Benning L, Morath C, Bartenschlager M, Nusshag C, Kälble F, Buylaert M, Schaier M, Beimler J, Klein K, Grenz J, Reichel P, Hidmark A, Ponath G, Töllner M, Reineke M, Rieger S, Tönshoff B, Schnitzler P, Zeier M, Süsal C, Bartenschlager R, Speer C. Clin J Am Soc Nephrol. 2022 Jan;17(1):98-106.

Heterologous ChAdOx1 nCoV-19/BNT162b2 Prime-Boost Vaccination Induces Strong Humoral Responses among Health Care Workers. Benning L, Töllner M, Hidmark A, Schaier M, Nusshag C, Kälble F, Reichel P, Buylaert M, Grenz J, Ponath G, Klein K, Zeier M, Süsal C, Schnitzler P, Morath C, Speer C. Vaccines (Basel). 2021 Aug 4;9(8):857. 

Impact of HLA compatibility in recipients of kidneys from expanded criteria donors: A Collaborative Transplant Study Report.  Echterdiek F, Latus J, Döhler B, Schwenger V, Süsal C. Int J Immunogenet. 2021 Apr;48(2):201-210. 

Influence of Cold Ischemia Time on the Outcome of Kidney Transplants from Donors Aged 70 Years and Above-A Collaborative Transplant Study Report. Echterdiek F, Latus J, Döhler B, Schwenger V, Süsal C. Transplantation. 2021 Nov 1;105(11):2461-2469.

Low Pre-Transplant Caveolin-1 Serum Concentrations Are Associated with Acute Cellular Tubulointerstitial Rejection in Kidney Transplantation. Emmerich F, Zschiedrich S, Reichenbach-Braun C, Süsal C, Minguet S, Pauly MC, Seidl M. Molecules. 2021 Apr 30;26(9):2648.

Analysis of de novo donor-specific HLA-DPB1 antibodies in kidney transplantation. Tang C, Unterrainer C, Fink A, Cinca S, Ruhenstroth A, Scherer S, Morath C, Zeier M, Mehrabi A, Süsal C, Tran TH. HLA. 2021 Nov;98(5):423-430.

Longitudinal Humoral Responses after COVID-19 Vaccination in Peritoneal and Hemodialysis Patients over Twelve Weeks. Speer C, Schaier M, Nusshag C, Töllner M, Buylaert M, Kälble F, Reichel P, Grenz J, Süsal C, Zeier M, Schnitzler P, Morath C, Klein K, Benning L. Vaccines (Basel). 2021 Oct 4;9(10):1130. 

Can PIRCHE-II Matching Outmatch Traditional HLA Matching? Unterrainer C, Döhler B, Niemann M, Lachmann N, Süsal C. Front Immunol. 2021 Feb 26;12:631246.

Association of non-HLA antibodies against endothelial targets and donor-specific HLA antibodies with antibody-mediated rejection and graft function in pediatric kidney transplant recipients. Fichtner A, Süsal C, Höcker B, Rieger S, Waldherr R, Westhoff JH, Sander A, Dragun D, Tönshoff B. Pediatr Nephrol. 2021 Aug;36(8):2473-2484.

Kidney re-transplantation in a child across the barrier of persisting angiotensin II type I receptor antibodies. 

Gold A, Fichtner A, Choukair D, Schmitt CP, Süsal C, Dragun D, Tönshoff B. Pediatr Nephrol. 2021 Mar;36(3):725-729. 

Phase 2 Trial of Oncolytic H-1 Parvovirus Therapy Shows Safety and Signs of Immune System Activation in Patients With Metastatic Pancreatic Ductal Adenocarcinoma. Hajda J, Leuchs B, Angelova AL, Frehtman V, Rommelaere J, Mertens M, Pilz M, Kieser M, Krebs O, Dahm M, Huber B, Engeland CE, Mavratzas A, Hohmann N, Schreiber J, Jäger D, Halama N, Sedlaczek O, Gaida MM, Daniel V, Springfeld C, Ungerechts G. Clin Cancer Res. 2021 Oct 15;27(20):5546-5556.

Predicting neurological recovery after traumatic spinal cord injury by time-resolved analysis of monocyte subsets. Heller RA, Seelig J, Crowell HL, Pilz M, Haubruck P, Sun Q, Schomburg L, Daniel V, Moghaddam A, Biglari B. Brain. 2021 Nov 29;144(10):3159-3174. 

Fatal late-onset CAR T-cell-mediated encephalitis after axicabtagene-ciloleucel in a patient with large B-cell lymphoma. Jung S, Greiner J, von Harsdorf S, Popovic P, Moll R, Schittenhelm J, Kandilaris K, Daniel V, Kunz A, Schmitt M, Dreger P. Blood Adv. 2021 Oct 12;5(19):3789-3793.

Relationship of transitional regulatory B and regulatory T cells and immunosuppressive drug doses in stable renal transplant recipients. Ibrahim EH, Aly M, Morath C, Sayed DM, Ekpoom N, Opelz G, Süsal C, Daniel V. Immun Inflamm Dis. 2021 Dec;9(4):1252-1271. 

Higher CD19+CD25⁺ Bregs are independently associated with better graft function in renal transplant recipients. 

Ibrahim EH, Aly MG, Opelz G, Morath C, Zeier M, Süsal C, Sayed DM, Hassan E, Ekpoom N, Daniel V. BMC Nephrol. 2021 May 17;22(1):180. 

Rare Malignant Indications for Liver Transplantation: A Collaborative Transplant Study Report. Houben P, Schimmack S, Unterrainer C, Döhler B, Mehrabi A, Süsal C. Front Surg. 2021 Dec 3;8:678392. 

Living Donor Kidney Transplantation in Patients With Donor-Specific HLA Antibodies After Desensitization With Immunoadsorption. Kälble F, Süsal C, Pego da Silva L, Speer C, Benning L, Nusshag C, Pham L, Tran H, Schaier M, Sommerer C, Beimler J, Mehrabi A, Zeier M, Morath C. Front Med (Lausanne). 2021 Dec 17;8:781491.

The impact of allogeneic hematopoietic cell transplantation on the mortality of poor-risk non-Hodgkin lymphoma: an intent-to-transplant analysis. Selberg L, Stadtherr P, Dietrich S, Tran TH, Luft T, Hegenbart U, Bondong A, Meissner J, Liebers N, Schmitt M, Ho AD, Müller-Tidow C, Dreger P. Bone Marrow Transplant. 2021 Jan;56(1):30-37. 

Functional Fc Gamma Receptor Gene Polymorphisms and Long-Term Kidney Allograft Survival. Wahrmann M, Döhler B, Arnold ML, Scherer S, Mayer KA, Haindl S, Haslacher H, Böhmig GA, Süsal C. Front Immunol. 2021 Aug 23;12:724331.

Early Humoral Responses of Hemodialysis Patients after COVID-19 Vaccination with BNT162b2. Speer C, Göth D, Benning L, Buylaert M, Schaier M, Grenz J, Nusshag C, Kälble F, Kreysing M, Reichel P, Töllner M, Hidmark A, Ponath G, Schnitzler P, Zeier M, Süsal C, Morath C, Klein K. Clin J Am Soc Nephrol. 2021 Jul;16(7):1073-1082. 

Humoral Responses to Single-Dose BNT162b2 mRNA Vaccination in Dialysis Patients Previously Infected With SARS-CoV-2. Speer C, Morath C, Töllner M, Buylaert M, Göth D, Nusshag C, Kälble F, Schaier M, Grenz J, Kreysing M, Reichel P, Hidmark A, Ponath G, Schnitzler P, Zeier M, Süsal C, Klein K, Benning L. Front Med (Lausanne). 2021 Aug 17;8:721286. 

Inhibition of fibronectin accumulation suppresses tumor growth. Ghura H, Keimer M, von Au A, Hackl N, Klemis V, Nakchbandi IA. Neoplasia. 2021 Sep;23(9):837-850. 

Cdc42 in osterix-expressing cells alters osteoblast behavior and myeloid lineage commitment. Wirth F, Huck K, Lubosch A, Zoeller C, Ghura H, Porubsky S, Nakchbandi IA. Bone. 2021 Dec;153:116150. 

Monitoring of gene expression in tacrolimus-treated de novo renal allograft recipients facilitates individualized immunosuppression: Results of the IMAGEN study. Sommerer C, Brunet M, Budde K, Millán O, Guirado Perich L, Glander P, Meuer S, Zeier M, Giese T. Br J Clin Pharmacol. 2021 Oct;87(10):3851-3862.

Human Retrotransposons and the Global Shutdown of Homeostatic Innate Immunity by Oncolytic Parvovirus H-1PV in Pancreatic Cancer. Neulinger-Muñoz M, Schaack D, Grekova SP, Bauer AS, Giese T, Salg GA, Espinet E, Leuchs B, Heller A, Nüesch JPF, Schenk M, Volkmar M, Giese NA. Viruses. 2021 May 28;13(6):1019.

Complementary medicine in Germany: a multi-centre cross-sectional survey on the usage by and the needs of patients hospitalized in university medical centers. Lederer AK, Baginski A, Raab L, Joos S, Valentini J, Klocke C, Samstag Y, Hübner K, Andreeva I, Simmet T, Syrovets T, Hafner S, Freisinger A, Storz MA, Huber R. BMC Complement Med Ther. 2021 Nov 23;21(1):285. 

Hijacked Immune Cells in the Tumor Microenvironment: Molecular Mechanisms of Immunosuppression and Cues to Improve T Cell-Based Immunotherapy of Solid Tumors. Balta E, Wabnitz GH, Samstag Y. Int J Mol Sci. 2021 May 27;22(11):5736.

Redox Regulation of the Actin Cytoskeleton in Cell Migration and Adhesion: On the Way to a Spatiotemporal View. Balta E, Kramer J, Samstag Y. Front Cell Dev Biol. 2021 Jan 28;8:618261. 

The impact of allogeneic hematopoietic cell transplantation on the mortality of poor-risk non-Hodgkin lymphoma: an intent-to-transplant analysis. Selberg L, Stadtherr P, Dietrich S, Tran TH, Luft T, Hegenbart U, Bondong A, Meissner J, Liebers N, Schmitt M, Ho AD, Müller-Tidow C, Dreger P. Bone Marrow Transplant. 2021 Jan;56(1):30-37.

Impact of HLA compatibility in recipients of kidneys from expanded criteria donors: A Collaborative Transplant Study Report. Echterdiek F, Latus J, Döhler B, Schwenger V, Süsal C. Int J Immunogenet. 2021 Apr;48(2):201-210.

Kidney re-transplantation in a child across the barrier of persisting angiotensin II type I receptor antibodies. Gold A, Fichtner A, Choukair D, Schmitt CP, Süsal C, Dragun D, Tönshoff B. Pediatr Nephrol. 2021 Mar;36(3):725-729.

Preprint:
Selective inflammation of the tumor microenvironment and invigorated T cell-mediated tumor control 
upon induced systemic inactivation of TREX1

Emilija Marinkovic, Minyi Chen,
Nadja Schubert,
Elif Dogan Dar, Janet Y. Leung, Jack Lohre,
Jennifer M. Sahni, Christine Tun, Pavithra Rajeswaran,
Tanja Mehlo-Jensen, Olivia Perng, C. Mark Hill,
Pallavur Sivakumar, Michael Barnes, 
Rohit Malik, Rayk Behrendt,Axel Roers
https://doi.org/10.1101/2024.06.09.598086

Integrin β1-mediated mast cell immune-surveillance of blood vessel content. 
Link K, Muhandes L, Polikarpova A, Lämmermann T, Sixt M, Fässler R, Roers A. J Allergy Clin Immunol. 2024 Sep;154(3):745-753.

März: 27.03.2025
Vortrag: Prof. Dr. Florian Leuschner 
(Universitätsklinikum Heidelberg)
Organisator: HD / Prof. Roers

April: 28.04.2025
Vortrag: Prof. Dr. Sonia Tugues 
(Medizinische Fakultät Mannheim)
Organisator: MA / Prof. Cerwenka

June: 16.06.2025
Prof. Luca Gattinoni
(Leibniz Institute for Immunotherapy, Regensburg)
Organisator: MA / Prof. Tugues

November: 03.11.2025
Vortrag: Prof. Dr. Falk Nimmerjahn 
(Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU))
Organisator: HD / Prof. Roers

Lehrsekretariat Immunologie

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• Ausschreibung Masterarbeit