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Angewandte Tumorbiologie

Current projects related to MMR deficient cancers (MSI-H)

Microsatellite-unstable (MSI-H) cancers are caused by loss of the DNA mismatch repair function. This mechanism is responsible for a significant number of human cancers.  Approximately 15% of colorectal cancers are trigged by the loss of DNA mismatch repair (MMR) functions. The most frequent inherited tumor syndrome, hereditary non-polyposis colorectal cancer (HNPCC) or Lynch syndrome, is associated with a high lifetime risk of developing MSI-H cancers in the colorectum and other organs.


Our research on MSI-H cancers is focused on the development of new approaches for prevention and therapy. Central part of our activities is to understand the immune biology of MSI-H cancers and to establish a vaccine, which could be used for adjuvant therapy of MSI-H cancers and for cancer prevention in Lynch syndrome.


Details of our research on MSI-H cancers are outlined for four of our main research directions Opens internal link in current windowMSI pathogenesis, Opens internal link in current windowMSI vaccines, Opens internal link in current windowMSI diagnostics, and Opens internal link in current windowMSI glycobiology.

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