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SFB 938

Projekt N – Schäkel

Vermi W, Micheletti A, Lonardi S, Costantini C, Calzetti F, Nascimbeni R, Bugatti M, Codazzi M, Pinter PC, Schäkel K, Tamassia N, Cassatella MA: slanDCs selectively accumulate in carcinoma-draining lymph nodes and marginate metastatic cells.
Nat Commun. 2014;5:3029.1-16 DOI: 10.1038/ncomms4029
Döbel T, Kunze A, Babatz J, Tränkner K, Ludwig A, Schmitz M, Enk A, Schäkel K:
FcγRIII (CD16) equips immature 6-sulfo LacNAc-expressing dendritic cells (slanDCs) with a unique capacity to handle IgG-complexed antigens.
Blood. 2013 (18) 3609-18.
Klug F, Prakash P, Huber PE, Seibel T, Bender N, Halama N, Pfirschke C, Voss RH, Timke C, Umansky L, Klapproth K, Schäkel K, Garbi N, Jäger D, Weitz J, Schmitz-Winnenthal H, Hämmerling GJ, Beckhove P: Low-dose irradiation programs macrophage differentiation to an iNOS+/M1 phenotype that orchestrates effective T cell immunotherapy.
Cancer Cell. 2013, 24(5):589-602
Hänsel A, Günther C, Baran W, Bidier M, Lorenz HM, Schmitz M, Bachmann M, Döbel T, Enk AH, Schäkel K: Human 6-sulfo LacNAc (slan) dendritic cells have molecular and functional features of an important pro-inflammatory cell type in lupus erythematosus.
J Autoimmun. 2013 (40) 1-8.
Günther C, Blau K, Förster U, Viehweg A, Wozel G, Schäkel K. Reduction of inflammatory slan (6-sulfo LacNAc) dendritic cells in psoriatic skin of patients treated with etanercept.
Exp Dermatol. 2013 (22) 535-40.
Günther C, Starke J, Zimmermann N, Schäkel K: Human 6-sulfo LacNAc (slan) dendritic cells are a major population of dermal dendritic cells in steady state and inflammation.
Clin Exp Dermatol. 2012 (37)169-76.
Hänsel A, Günther C, Ingwersen J, Starke J, Schmitz M, Bachmann M, Meurer M, Rieber EP, Schäkel K: Human slan (6-sulfo LacNAc) dendritic cells are inflammatory dermal dendritic cells in psoriasis and drive strong TH 17/TH 1 T-cell responses.
J. Allergy Clin. Immunol. 2011 (127) 787-794.
Bippes CC, Feldmann A, Stamova S, Cartellieri M, Schwarzer A, Wehner R, Schmitz M, Rieber EP, Zhao S, Schäkel K, Temme A, Scofield HR, Kurien BT, Bartsch H, Bachmann M:
A novel modular antigen delivery system for immuno targeting of human 6-sulfo LacNAc-positive blood dendritic cells (slanDCs).
PloS One. 2011 (6). e16315. doi: 10.1371/journal.pone.0016315.
Costantini C, Calzetti F, Perbellini O, Micheletti A, Scarponi C, Lonardi S, Pelletier M, Schäkel K, Pizzolo G, Facchetti F, Vermi W, Albanesi C, Cassatella MA:
Human neutrophils interact with both 6-sulfo LacNAc+ DC and NK cells to amplify NK-derived IFN{gamma}: role of CD18, ICAM-1, and ICAM-3.
Blood. 2011 (117) 1677-1686.




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