Personen

Prof. Dr. med. Raffaele De Simone

Senior physician (Klinik für Herzchirurgie)
Head of research group (B01: Wissensbasiertes Assistenzsystem für die rekonstruktive Herzklappenchirurgie)

Bereichsleiter Rhythmuschirurgie


Commendations

2014

BVM-Award Best Talk 2014 “Vermessung des Mitralapparats mit einem optisch getrackten Zeigeinstrument für die virtuelle Annuloplastie” (Sandy Engelhardt) 

2014

MICCAI AE-CAI 1st Place Best Paper Award 2014 „Augmented Reality-Enhanced Endoscopic Images for Annuloplasty Ring Sizing” (Sandy Engelhardt)

2nd Place conHIT Nachwuchspreis für die beste Abschlussarbeit (Bachelorarbeit Silvio Kolb) 

Bücher und CD-ROMs

seit 2002

De Simone R, Glombitza G, Wolf I, Vahl CF, Meinzer HP, Hagl S. (2002)
Three-Dimensional Color Doppler Imaging.
In Atlas of 3D-Echocardiography edited by N. Nanda and Sorrell VL. Chapter 11, p. 227-238. Futura Publishing Company - Armonk - New York 2002. ISBN 0-87993-486-7

seit 2000

De Simone R, Glombitza G. (2000)
Three-Dimensional Color Doppler. Visualization and Quantification of Intracardiac Blood Flow.
In Three-Dimensional Echocardiography edited by J. Roelandt. Chapter 5, p. 59-68 - The Netherlands 2000. ISBN 90-75141-83-1

seit 1999

De Simone R. (1999)
Three-Dimensional Color Doppler. An Atlas of Intracardiac Flow Imaging.
Futura Publishing Company - Armonk - New York 1999. ISBN 0-87993-429-8
 
De Simone R, Glombitza G. (1999)
CD-ROM: Three-Dimensional Color Doppler. An Atlas of Intracardiac Flow Imaging.
Futura Publishing Company - Armonk - New York 1999. ISBN 0-87993-429-8

seit 1997

De Simone R. (1997)
CD-ROM: Interactive Atlas of Transesophageal Color Doppler Echocardiography (II Edition).
Springer-Verlag Berlin, Heidelberg, New York 1997. ISBN 3-540-14532-X

seit 1994

De Simone R. (1994)
Atlas of Transesophageal Color Doppler Echocardiography and Intraoperative Imaging.
Springer-Verlag Berlin, Heidelberg, New York 1994. ISBN 3-540-57938-9
 
De Simone R. (1994)
CD-ROM: Interactive Atlas of Transesophageal Color Doppler Echocardiography and Intraoperative Imaging.
Springer-Verlag Berlin, Heidelberg, New York 1994. ISBN 3-540-14179-0

Arbeitsschwerpunkte

  • Koronarrevaskularisierung ohne Einsatz der Herz-Lungen-Maschine (OPCAB)
  • Komplett arterielle Revaskularisation der Herzkranzgefäße
  • Mitral- und Aortenklappen-Chirurgie unter Berücksichtigung rekonstruktiver und minimal-invasiver Operationstechniken
  • Sondenexplantation mit Excimer-Laser. Transvenöse und epimyokardiale Schrittmacher- und Defibrillator-Implantation (inkl. biventrikulären und komplexeren Systemen).
  • Projekt B01: Wissensbasiertes Assistenzsystem für die rekonstruktive Herzklappenchirurgie.
  • Entwicklung einer computergestützten Operationsumgebung zur rekonstruktiven Chirurgie der Herzklappen und der großen Gefäße.
    Durch die Verknüpfung von modernen 3D diagnostischen Verfahren mit Wissen zur Pathophysiologie wird ein prädiktives Feedback über die operativen Ergebnisse ermöglicht.
  • Die rekonstruktive Herzklappenchirurgie erfordert die präzise Erfassung und Interpretation der komplexen Geometrie und Funktion der Herzklappe. Ziel des Projekts ist ein wissensbasiertes Assistenzsystems, das dem Chirurgen ständig relevantes geometrisches und funktionelles Wissen als neue, quantitativ fundierte Entscheidungshilfe zur Verfügung stellt. Hierzu werden 3D-Parameter zusammen mit klinischen Parametern prä- und intraoperativ erfasst, mit den postoperativen Ergebnissen korreliert, in die Wissensbasis des SFB überführt und von dem Assistenzsystem interpretiert.

Publikationen

2019

Engelhardt S, Sauerzapf S, Preim B, Karck M, Wolf I, De Simone R (2019)

Flexible and comprehensive patient-specific mitral valve silicone models with chordae tendineae made from 3D-printable molds.

Int J Comput Assist Radiol Surg. 2019 Jul;14(7):1177-1186. doi: 10.1007/s11548-019-01971-9. Epub 2019 Apr 17.

 

Engelhardt S, Sauerzapf S, Brcic A, Karck M, Wolf I, De Simone R (2019)

Replicated mitral valve models from real patients offer training opportunities for minimally invasive mitral valve repair.

Interact Cardiovasc Thorac Surg. 2019 Jul 1;29(1):43-50. doi: 10.1093/icvts/ivz008.

 

Al-Maisary SSA, Romano G, Karck M, De Simone R (2019)

Epicardial pacemaker as a bridge for pacemaker-dependent patients undergoing explantation of infected cardiac implantable electronic devices.

J Card Surg. 2019 Jun;34(6):424-427. doi: 10.1111/jocs.14058. Epub 2019 Apr 24.

 

2017

Al-Maisary S, Graser B, Engelhardt S, Wolf I, Karck M, De Simone R (2016)

The geometrical effect of different annuloplasty rings on mitral valve annulus.

J Cardiovasc Surg (Torino). 2017 Jun;58(3):481-488. doi: 10.23736/S0021-9509.16.09314-9. Epub 2016 May 6.

 

Schmidt C, Wiedmann F, Zhou XB, Heijman J, Voigt N, Ratte A, Lang S, Kallenberger SM, Campana C, Weymann A, De Simone R, Szabo G, Ruhparwar A, Kallenbach K, Karck M, Ehrlich JR, Baczkó I, Borggrefe M, Ravens U, Dobrev D, Katus HA, Thomas D (2017)

Inverse remodelling of K2P3.1 K+ channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific antiarrhythmic drug therapy.

Eur Heart J. 2017 Jun 7;38(22):1764-1774. doi: 10.1093/eurheartj/ehw559.

 

Al-Maisary S, Engelhardt S, Graser B, Wolf I, Karck M, De Simone R (2017)

Computer-based comparison of different methods for selecting mitral annuloplasty ring size.

J Cardiothorac Surg. 2017 Jan 30;12(1):8. doi: 10.1186/s13019-017-0571-y.

 

2016

Engelhardt S, De Simone R, Al-Maisary S, Kolb S, Karck M, Meinzer HP, Wolf I (2016)

Accuracy Evaluation of a Mitral Valve Surgery Assistance System Based On Optical Tracking.

Int J Comput Assist Radiol Surg. 2016 Oct;11(10):1891-904. doi: 10.1007/s11548-016-1353-z. Epub 2016 Feb 25.

 

Schoch N, Kißler F, Stoll M, Engelhardt S, de Simone R, Wolf I, Bendl R, Heuveline V (2016)

Comprehensive patient-specific information preprocessing for cardiac surgery simulations.

Int J Comput Assist Radiol Surg. 2016 Jun;11(6):1051-9. doi: 10.1007/s11548-016-1397-0. Epub 2016 Apr 12.

 

Engelhardt S, Wolf I, Al-Maisary S, Schmidt H, Meinzer HP, Karck M, De Simone R (2016)

Intraoperative Quantitative Mitral Valve Analysis Using Optical Tracking Technology.

Ann Thorac Surg. 2016 May;101(5):1950-6. doi: 10.1016/j.athoracsur.2016.01.018

 

Arif R, De Simone R, Karck M, Auch-Schwelk W (2016)

Coronary Stenosis Associated with a Giant Coronary Aneurysm.

J Card Surg. 2016 Feb;31(2):98-9. doi: 10.1111/jocs.12658. Epub 2015 Dec 2

 

2014

Graser B, Al-Maisary S, Zimmermann N, Nabers D, Meinzer HP, Wolf I, Karck M, De Simone R (2014)

Computerunterstütztes „ring sizing“ für die Anuloplastie.

Z Herz-,Thorax- Gefäßchir, Oct 2014, 28, (5):347-351

 

Graser B, Wald D, Al-Maisary S, Grossgasteiger M, de Simone R, Meinzer HP, Wolf I (2014)

Using a shape prior for robust modeling of the mitral annulus on 4D ultrasound data.

Int J Comput Assist Radiol Surg. 2014 Jul;9(4):635-44.

 

2013

Hien MD, Rauch H, Lichtenberg A, De Simone R, Weimer M, Ponta OA, Rosendal C (2012)

Real-Time Three-Dimensional Transesophageal Echocardiography: Improvements in Intraoperative Mitral Valve Imaging.

Anesth Analg. 2013 Feb;116(2):287-95. doi: 10.1213/ANE.0b013e318262e154. Epub 2012 Jul 13.

 

2012

Rosendal C, Almamat Uulu K, De Simone R, Wolf I, Deckert A, Martin EO, Böttiger BW, Rauch H (2012)

Right ventricular function during orthotopic liver transplantation: Three-dimensional transesophageal echocardiography and thermodilution.

Ann Transplant. 2012 Mar 31;17(1):21-30

 

2009

Bergmeir C, Seitel M, Frank C, De Simone R, Meinzer HP, Wolf I (2009):

Comparing calibration approaches for 3D ultrasound probes.

Int J Comput Assist Radiol Surg. 2009 Mar;4(2):203-13. Epub 2008 Nov 4.

 

Osswald BR, De Simone R, Most S, Tochtermann U, Tanzeem A, Karck M (2009):

High defibrillation threshold in patients with implantable defibrillator: how effective is the subcutaneous finger lead?

Eur J Cardiothorac Surg. 2009 Mar;35(3):489-92. Epub 2009 Jan 14]

 

Seitel M, Maier-Hein L, Rietdorf U, Nikoloff S, Seitel A, Franz A, Kenngott H, Karck M, De Simone R, Wolf I, Meinzer HP (2009):

Towards a mixed reality environment for preoperative planning of cardiac surgery.

Stud Health Technol Inform. 2009;142:307-9

 

2008

Mottl-Link S, Hübler M, Kühne T, Rietdorf U, Krueger JJ, Schnackenburg B, De Simone R, Berger F, Juraszek A, Meinzer HP, Karck M, Hetzer R, Wolf I (2008):

Physical models aiding in complex congenital heart surgery.

Ann Thorac Surg. 2008 Jul;86(1):273-7

 

2007

Hoda MR, Schwarz T, Wolf I, Mottl-Link S, Meinzer HP, Karck M, De Simone R (2007):

[Three-dimensional echocardiography in cardiac surgery : Current status and perspectives.][Article in German].

Chirurg. 2007 May;78(5):435-42.

 

2006

De Simone R, Glombitza G, Wolf I, Hoda R, Ambrus J, Woo YR, Meinzer HP, Hagl S (2006):

Das Regurgitationsjetvolumen zur Quantifizierung der Mitralklappeninsuffizienz.

Z Herz-, Thorax- und Gefäßchirurgie, Aug; 20(4): 144-150

 

De Simone R, Wolf I, Hoda R, Mikhail B, Mottl-Link S, Meinzer HP, Hagl S. (2006):

Three-Dimensional Assessment of Left Ventricular Geometry and Annular Dilatation Provides new Mechanistic Insights into Asymmetrical Ring Annuloplasty.

Thorac Cardiovasc Surg. 2006 Oct;54(7):452-8

 

De Simone R, Wolf I, Mottl-Link S, Hoda R, Mikhail B, Sack FU, Meinzer HP, Hagl S (2006)

A clinical study of annular geometry and dynamics in patients with ischemic mitral regurgitation: new insights into asymmetrical ring annuloplasty.

Eur J Cardiothorac Surg 29(3):355-61.

 

Hoda MR, El-Achkar H, Schmitz E, Scheffold T, Vetter HO, De Simone R (2006)

Systemic stress hormone response in patients undergoing open heart surgery with or without cardiopulmonary bypass.

Ann Thorac Surg. 82(6):2179-86

 

2005

De Simone R, Mottl-Link S, Wolf I, Böttiger T, Rauch H, Meinzer HP, Hagl S. (2005):

Intraoperative assessment of right ventricular volume and function.

Eur J Cardio-thorac Surg; (6):988-93

 

Koch A, Sebening C, De Simone R, Jahn L, Sack FU, Hagl S (2005)

Coronary fistula of right coronary artery to vena cava superior and ectasia of pulmonary artery.

Z Kardiol Dec 94(12): 813-816

 

Mottl-Link S, Wolf I, Hastenteufel M, Witte S, Meinzer H-P, Hagl S, De Simone R (2005).

Non-invasive assessment of differences between bileaflet and tilting disc aortic valve prostheses by 3D-Doppler flow profiles.

Interactive Cardiovascular and Thoracic Surgery 4: 383-387

 

2004

Albers J, Nitsche T, Boese J, De Simone R, Wolf I, Schroeder A, Vahl CF (2004):

Regurgitant jet evaluation using three-dimensional echocardiography and magnetic resonance.

Ann Thorac Surg 78(1):96-102.

 

2003

Wolf I, Hastenteufel M, Mottl-Link S, De Simone R, Vahl CF, Meinzer HP (2003):

Clinical application of new 3D and 4D visualization and quanification tools for cardiac diagnosis and therapy.

Int Congr Ser (Proceedings of Comp Ass Radiol Surg) 1256: 735-740

 

2002

Mottl-Link S, Wolf I, Hastenteufel M, Vahl CF, Hagl S, Meinzer HP, De Simone R (2002): 

Klinische Applikationen von 3D- und 4D- Visualisierungsverfahren in der Echocardiographie 

Biomed Tech;47 Suppl 1 Pt 2:923-6

 

Wolf I, De Simone R, Hastenteufel M, Kunert T, Link S, Meinzer HP (2002): 

Virtual reality in 3D echocardiography: dynamic visualization of qatrioventricular annuli surface models and volume rendered Doppler-ultrasound. 

Stud Health Technol Inform 85: 580-585 

 

Wolf I, Hastenteufel M, De Simone R, Vetter M, Glombitza G, Mottl-Link S, Vahl CF, Meinzer HP (2002): 

ROPES: a semiautomated segmentation method for accelerated analysis of three-imensional echocardiographic data

IEEE Trans Med Imaging 21(9): 1091-1104 

 

2001

Albers J, Schroeder A, De Simone R, Möckel R, Vahl CF, Hagl S (2001): 

3D Evaluation of Myocardial Edema: Experimental Study on 22 Pigs Using Magnetic Resonance and Tissue Analysis. 

Thorac Cardiovasc Surg 49: 1-5

 

De Simone R, Wolf I, Hastenteufel M, Glombitza G, Link S, Meinzer HP, Hagl S, Vahl CF (2001): 

Neue dreidimensionale diagnostische Verfahren in der Herzchirurgie. 

Proceedings: Rechner- und sensorgestützte Chirurgie, S. 298-305

 

De Simone R, Rodrian J, Osswald B, Sack FU, De Simone E, Hagl S (2001): 

Initial experience with a new communication tool: the 'Digital Interactive Poster Presentation'. 

Eur J Cardiothorac Surg 19: 953-5 

 

2000

De Simone R, Glombitza G, Vahl CF, Meinzer HP, Hagl S (2000): 

Three-dimensional color doppler flow reconstruction and its clinical applications. 

Echocardiography 17: 765-771

 

De Simone R, Glombitza G, Vahl CF, Meinzer HP, Hagl S (2000): 

Three-dimensional color Doppler reconstruction of intracardiac blood flow in patients with different heart valve diseases. 

Am J Cardiol 86: 1343-8

 

Glombitza G, De Simone R, Wolf I, Heid V, Hagl S, Meinzer HP (2000): 

Volumetric analysis and visualization of cardiologic ultrasound data 

Radiologe 40: 168-75 

 

1999

De Simone R, Glombitza G, Vahl CF, Albers J, Meinzer HP, Hagl S (1999): 

Three-dimensional color-doppler: a new approach for quantitative assessment of mitral regurgitant jets. 

Am Soc Echocardiogr 12: 173-185

 

De Simone R, Glombitza G, Vahl CF, Albers J, Meinzer HP, Hagl S (1999): 

Three-dimensional color-doppler for assessing mitral regurgitation during valvuloplasty. 

Eur J Cardio-Thoracic Surg 15: 127-133

 

De Simone R, Glombitza G, Vahl CF, Albers J, Meinzer HP, Hagl S (1999): 

Three-dimensional color-doppler: a clinical study in patients with mitral regurgitation. 

J Am Coll Cardiol 33: 1646-1654

 

De Simone R, Glombitza G, Vahl CF, Albers J, Meinzer HP, Hagl S (1999): 

Assessment of mitral regurgitant jets by three-dimensional color-doppler. 

Ann Thorac Surg 67: 494-499

 

De Simone R, Glombitza G, Vahl CF, Meinzer HP, Hagl S (1999): 

A new diagnostic procedure for assessing intracardiac flow disturbances in patients with heart valve disease. 

Thorac Cardiovasc Surg 47: 369-375

 

De Simone R, Glombitza G, Vahl CF, Meinzer HP, Hagl S (1999): 

Three-dimensional doppler. Techniques and clinical applications. 

Eur Heart J 20: 619-627

 

Glombitza G, De Simone R, Mende U, Merdes M, Krempien R, Zerfoski D, Vahl CF, Meinzer HP, Hagl S (1999): 

Neue klinische Anwendungen der dreidimensionalen Rekonstruktion in der echocardiographischen Diagnostik. 

Informatik Forsch Entw 14: 16-23

 

Vahl CF, Kloss T, Yang X, Castell M, Mehrkens A, De Simone R, Schäffer L, Hagl S (1999): 

Surgical treatment of oligosymptomatic mitral valve incompetence? 

Eur J Cardio-Thorac Surg 16: 524-532 

 

1998

Albers J, Schroeder A, Makabe M, Gaa J, De Simone R, Vahl CF, Hagl S (1998): 

Validierung digitaler Volumetrie und dreidimensionale Rekonstruktion kardialer magnetresonanz- und computertomographischer Bilddaten: Studie an explantierten Schweineherzen. 

Kardiovask Med 2: 79-87

 

Bauernschmitt R, De Simone R, Lange R, Vahl CF, Thomas G, Hagl S (1998):

[Surgery of acute aortic valve endocarditis: prognosis in paravalvular abscess]

Z Kardiol. 1998 Apr; 87(4): 276-82

 

De Simone R, Glombitza G, Vahl CF, Albers J, Meinzer HP, Hagl S (1998) 

Three dimensional doppler for the assessment of mitral regurgitation. 

Computers in Cardiology 25: 617-620 

 

1997

Bauernschmitt R, Lange R, De Simone R, Hagl S (1997):

[Surgical treatment of acute endocarditis--which preoperative diagnosis does the surgeon need?]

Langenbecks Arch Chir Suppl Kongressbd. 1997; 114: 1370-2

 

Thielmann M, Lange R, Bauernschmitt R, De Simone R, Richter G, Hagl S (1997): 

["Necessary" diagnostic procedures in traumatic aortic rupture, acute dissecting and chronic aortic aneurysms] 

Langenbecks Arch Chir Suppl Kongressbd. 1997; 114: 449-53

 

Vahl CF, Carl I, De Simone R, Meinzer HP, Thomas G, Hagl S (1997):

[Calibration of clinical databanks with "virtual patients"]

Z Kardiol. 1997 Jan; 86(1): 35-41

 

Vahl CF, Osswald BR, Meinzer HP, De Simone R, Thomas G, Hagl S (1997):

[Internal quality assurance or Hawthorne effect?]

Langenbecks Arch Chir Suppl Kongressbd. 1997; 114: 260-6 

 

1996

Lange R, De Simone R, Bauernschmitt R, Tanzeem A, Schmidt C, Hagl S (1996):

Tricuspid valve reconstruction, a treatment option in acute endocarditis

Eur J Cardiothorac Surg. 1996; 10(5): 320-6 

 

1995

De Simone R, Lange R, Sack RU, Mehmanesh H, Hagl S (1995):

Atrioventricular valve insufficiency and atrial geometry after orthotopic heart transplantation

Ann Thorac Surg. 1995 Dec; 60(6): 1686-93

 

De Simone R, Lange R, Tanzeem A, Hagl S (1995): 

Adjustable De Vega tricuspid valve annuloplasty guided by transesophageal echocardiography [letter; comment] 

Ann Thorac Surg. 1995 May; 59(5): 1272 

 

Lange R, De Simone R, Bauernschmitt R, Tanzeem A, Schmidt C, Hagl S (1995):

[Surgical therapy of acute tricuspid valve endocarditis: indications, technique and results]

Z Kardiol. 1995 Nov; 84(11): 921-9 

 

Lange R, Sack FU, Voss B, De Simone R, Nair A, Thielmann M, Brachmann J, Fleischer F, Hagl S (1995):

Dynamic cardiomyoplasty: indication, surgical technique, and results

Thorac Cardiovasc Surg. 1995 Oct; 43(5): 243-51 

 

Lange R, Sack FU, Voss B, De Simone R, Thielmann M, Nair A, Brachmann J, Haussmann R, Fleischer F, Hagl S (1995):

Treatment of dilated cardiomyopathy with dynamic cardiomyoplasty: the Heidelberg experience

Ann Thorac Surg. 1995 Nov; 60(5): 1219-25 

 

1994

De Simone R, Lange R, Iacono A, Hagl S (1994):

[Role of transesophageal echocardiography in tricuspid valve repair]

Cardiologia. 1994 Dec; 39(12 Suppl 1): 87-101 

 

De Simone R, Lange R, Sack FU, Mehmanesh H, Hagl S (1994):

[Atrioventricular valve insufficiency and atrial geometry in orthotopic heart transplantation]

Cardiologia. 1994 May; 39(5): 325-34 

 

1993

De Simone R, Lange R, Tanzeem A, Gams E, Hagl S (1993):

Adjustable tricuspid valve annuloplasty assisted by intraoperative

transesophageal color Doppler echocardiography [see comments]

Am J Cardiol. 1993 Apr 15; 71(11): 926-31 

 

1992

De Simone R, Lange R, Saggau W, Gams E, Tanzeem A, Hagl S (1992):

Intraoperative transesophageal echocardiography for the evaluation of mitral,

aortic and tricuspid valve repair. A tool to optimize surgical outcome

Eur J Cardiothorac Surg. 1992; 6(12): 665-73

 

De Simone R, Lange R, Saggau W, Tanzeem A, Hagl S (1992):

[Intraoperative evaluation of tricuspid valve annuloplasty with transesophageal echocardiography]

Cardiologia. 1992 Mar; 37(3): 195-201

 

Saggau W, Sack FU, Lange R, Werling C, De Simone R, Brachmann J, Hagl S (1992):

Superiority of endocardial versus epicardial implantation of the implantable cardioverter defibrillator (ICD)

Eur J Cardiothorac Surg. 1992; 6(4): 195-200 

 

1991

Lange R, Sack FU, Saggau W, Vahl CF, De Simone R, Hagl S (1991):

Performance of dynamic cardiomyoplasty related to the functional state of the heart

J Card Surg. 1991 Mar; 6(1 Suppl): 225-35 

Publikationen, Kongressbeiträge und Preise, SFB/Transregio 125, Proj. 01