Portrait von Prof. Dr. med. Tsvetomir Loukanov

Prof. Dr. med. Tsvetomir Loukanov

Head of Division (Sektion Kinderherzchirurgie)

Facharzt für Herzchirurgie, Facharzt für Chirurgie, zertifizierter Kinderherzchirurg

Medical/Professional background

since 2014

Leiter der Sektion Kinderherzchirurgie, Klinik für Herzchirurgie, Universitätsklinikum Heidelberg

2011 – 2013

Oberarzt Sektion Kinderherzchirurgie, Klinik für Herzchirurgie, Universitätsklinikum Heidelberg

2004 – 2011

Assistenzarzt, Klinik für Herzchirurgie, Universitätsklinikum Heidelberg

1994 – 1998

Assistenzarzt, Abteilung für Chirurgie, Nationales Onkologisches Zentrum Sofia

1998 – 2004

Assistenzarzt, Abteilung Kinderherzchirurgie, Nationales Herzzentrum, Sofia, Bulgarien

Scientific background


Ernennung zum außerplanmäßigen Professor an der Rupprecht–Karls Universität Heidelberg


Habilitation mit Erteilung der Venia legendi für das Fach Chirurgie an der Rupprecht–Karls Universität Heidelberg


Harvard Medical University, Boston, Congenital Heart Surgery Training Course


Rupprecht–Karls Universität Heidelberg, Zertifikat für Kinderherzchirurgie der Deutschen Gesellschaft für Thorax-, Herz- und Gefäßchirurgie


Rupprecht–Karls Universität Heidelberg, Facharzt für Herzchirurgie, Ärztekammer Nordbaden


Rupprecht–Karls Universität Heidelberg, Promotion: Tracheal Stenosis and Congenital Heart Defects


Rupprecht–Karls Universität Heidelberg, Approbation als Arzt (Deutschland) nach Staatsexamen


Medizinische Universität Sofia, Facharzt für Allgemeine Chirurgie


Approbation als Arzt, Golden Hippokrates Preis

1988 – 1994

Studium der Humanmedizin an der Medizinischen Universität Pleven, Bulgarien 


Europäische Akademie für Herzchirurgie, Bergamo, Italien


2002 – 2004

EACTS Stipendium (Prof. H. G. Borst) - Chirurgische Klinik, Herzchirurgie Uiversität Heidelberg


DKFZ Heidelberg Stipendium (Prof. Harald zur Hausen)


DKFZ Heidelberg Stipendium (Prof. Harald zur Hausen)


Europäische Gemeinschaft Chirurgische Onkologie Stipendium, Chirurgische Klinik–Heidelberg (Prof. Herfarth)


DKFZ Heidelberg Stipendium (Prof. Harald zur Hausen)

Professional memberships

Mitglied Europäische Assoziation Herz-und Thorax Chirurgie EACTS

Mitglied Deutsche Gesellschaft Thorax-, Herz-und Gefäß Chirurgie DGTHG

Mitglied Bulgarische Akademie der Wissenschaften

Mitglied Europäische Gemeinschaft Chirurgische Onkologie ESSO

Zusätzliche Zertifikation

Zertifikat für Kinderherzchirurgie der Deutschen Gesellschaft für Thorax-, Herz- und Gefäßchirurgie

Congenital Heart Surgery Training Course, Harvard Medical University, Boston

Klinische Schwerpunkte

Herzchirurgische Eingriffe im Hybridverfahren

Operation am schlagenden Herzen

Vaskuläre Kompressionsyndrome der intrathorakalen Trachea, Assoziation mit Herzvitien

Klappenrekonstruktion; Extracorporale Membran – Oxygenierung (ECMO)

Univentrikuläres Herz, Aortenbogen- und Trachealchirurgie, Pulmonale Hypertonie, Cerebrale Perfusion, Herzoperationen bei frühgeborenen Kindern, Psychosozialer Einfluss angeborener Herzfehler, Vergleich von OP-Techniken, Intraoperative Videodokumentation



Beckmann A, Dittrich S, Arenz C, Krogmann ON, Horke A, Tengler A, Meyer R, Bauer UMM, Hofbeck M; German Quality Assurance / Competence Network for Congenital Heart Defects Investigators (2021)

German Registry for Cardiac Operations and Interventions in Patients with Congenital Heart Disease: Report 2020-Comprehensive Data from 6 Years of Experience.

Thorac Cardiovasc Surg. 2021 Dec;69(S 03):e21-e31. doi: 10.1055/s-0041-1722978. Epub 2021 Feb 26. PMID: 33638137 Free PMC article.




Plaschke K, Weiskircher A, Benner L, Klein B, Loukanov T, Gorenflo M, Weigand MA, Rauch H (2020)

Depth of anesthesia by Narcotrend® and postoperative characteristics in children undergoing cardiac surgery under extracorporeal circulation: a retrospective comparison of two anesthetic regimens.

Perfusion. 2020 Jan 11:267659119895447. doi: 10.1177/0267659119895447. [Epub ahead of print]


Jaschinski C, Cussigh C, Fonseca E, Bruckner T, Karck M, Loukanov T (2020)

A Wide Comparison of Techniques for Repair of PAPVCs: One Institution's 20-Year Experience.

Thorac Cardiovasc Surg. 2020 Jan;68(1):15-23. doi: 10.1055/s-0039-1693655. Epub 2019 Aug 6.



Eichhorn JG, Ley S, Kropp F, Fink C, Brockmeier K, Loukanov T, Ley-Zaporozhan J (2019)

Aortic Coarctation a Systemic Vessel Disease-Insights from Magnetic Resonance Imaging.

Thorac Cardiovasc Surg. 2019 Dec;67(S 04):e1-e10. doi: 10.1055/s-0039-1697915. Epub 2019 Nov 1.


Gerrah R, Fonseca Escalante E, Gorenflo M, Loukanov T (2019)

The Cavoatrial Anastomosis Procedure in Anomalous Connection of Superior Vena Cava to Left Atrium.

World J Pediatr Congenit Heart Surg. 2019 Nov;10(6):803-805. doi: 10.1177/2150135119878102.


Jaschinski C, Uzdenov M, Loukanov T (2019)

Cor triatriatum sinister with left anomalous pulmonary venous return to innominate vein.

Cardiol Young. 2019 Mar;29(3):428-430. doi: 10.1017/S1047951118002305. Epub 2019 Jan 24.


Imle R, Tosev G, Behnisch W, Schenk JP, Rauch H, Mueller A, Gorenflo M, Loukanov T, Kulozik A, Nyarangi-Dix J (2019)

Intracardiac Extension of Wilms Tumor: A Case of a 2.5-Year-Old Girl Presenting with Upper Venous Congestion Caused by Tumor Growth into the Right Cardiac Ventricle.

Case Rep Oncol. 2019 Jan 4;12(1):33-38. doi: 10.1159/000496020. eCollection 2019 Jan-Apr.


Sommburg O, Helling-Bakki A, Alrajab A, Schenk JP, Springer W, Mall MA, Loukanov T, Eichhorn JG (2019)

Assessment of Suspected Vascular Rings and Slings and/or Airway Pathologies Using Magnetic Resonance Imaging Rather Than Computed Tomography.

Respiration. 2019;97(2):108-118. doi: 10.1159/000492080. Epub 2018 Oct 5.



Szczechowicz M, Mkalaluh S, Farag M, Mashhour A, Loukanov T, Kolcz J, Karck M, Weymann A (2018)

Pulmonary valve and right ventricular outflow tract surgery in adults: 23-year experience.

Kardiol Pol. 2018;76(3):602-610. doi: 10.5603/KP.a2017.0260. Epub 2018 Jan 3.



Ziesenitz VC, Gorenflo M, Loukanov T (2016)

Repair of an aorto-right ventricular tunnel in a newborn.

Cardiol Young. 2016 Jan;26(1):147-8. doi: 10.1017/S1047951115001572. Epub 2015 Sep 3.


Ziesenitz VC, Loukanov T, Gläser C, Gorenflo M (2016)

Variable expression of Alagille syndrome in a family with a new JAG1 gene mutation.

Cardiol Young. 2016 Jan;26(1):164-7. doi: 10.1017/S1047951114002753. Epub 2015 Jan 23.



Arnold RR, Loukanov T, Gorenflo M (2014)

Hypoplastic left heart syndrome - unresolved issues.

Front Pediatr. 2014 Nov 10;2:125. doi: 10.3389/fped.2014.00125. eCollection 2014. Review.


Sandrio S, Springer W, Karck M, Gorenflo M, Weymann A, Ruhparwar A, Loukanov T (2014)

Extracorporeal life support with an integrated left ventricular vent in children with a low cardiac output.

Cardiol Young. 2014 Aug;24(4):654-60. doi: 10.1017/S1047951113001017. Epub 2013 Aug 6.


Fonseca E, Georgiev SG, Gorenflo M, Loukanov TS (2014)

Patent ductus arteriosus in preterm infants: benefits of early surgical closure.

Asian Cardiovasc Thorac Ann. 2014 May;22(4):391-6. doi: 10.1177/0218492313480051. Epub 2013 Nov 5.


Sandrio S, Karck M, Gorenflo M, Loukanov T (2014)

Results of using cardiopulmonary bypass for spinal cord protection during surgical repair of complex aortic coarctation.

Cardiol Young. 2014 Feb;24(1):113-9. doi: 10.1017/S1047951113000115. Epub 2013 Feb 6.



Köhler D, Arnold R, Loukanov T, Gorenflo M (2013)

Right ventricular failure and pathobiology in patients with congenital heart disease - implications for long-term follow-up.

Front Pediatr. 2013 Nov 19;1:37. doi: 10.3389/fped.2013.00037. Review.


Loukanov T, Jaschinski C, Kirilov M, Klimpel H, Karck M, Gorenflo M (2013)

Cyclooxygenase-2 expression in lung in patients with congenital heart malformations and pulmonary arterial hypertension.

Thorac Cardiovasc Surg. 2013 Jun;61(4):307-11. doi: 10.1055/s-0033-1337446. Epub 2013 May 16.


Weymann A, Georgiev S, Vogelsang C, Ivad A, Karck M, Gorenflo M, Loukanov T (2013)

Temporary tricuspid valve detachment for ventricular septal defect closure: is it worth doing it?

Heart Surg Forum. 2013 Apr;16(2):E99-102. doi: 10.1532/HSF98.20121111.



Loukanov T, Takahashi H, Tonchev P, Gross J, Bettendorf M, Gorenflo M (2011)

Plasma cyclic 3',5'-adenosine monophosphate in patients with elevated pulmonary pressure due to left-to-right shunt.

Can J Cardiol. 2011 Jul-Aug;27(4):523.e25-9. doi: 10.1016/j.cjca.2010.12.063. Epub 2011 Jun 8. English, French.


Loukanov T, Bucsenez D, Springer W, Sebening C, Rauch H, Roesch E, Karck M, Gorenflo M (2011)

Comparison of inhaled nitric oxide with aerosolized iloprost for treatment of pulmonary hypertension in children after cardiopulmonary bypass surgery.

Clin Res Cardiol. 2011 Jul;100(7):595-602. doi: 10.1007/s00392-011-0284-5. Epub 2011 Feb 13.


Loukanov T, Hoss K, Tonchev P, Klimpel H, Arnold R, Sebening C, Karck M, Gorenflo M (2011)

Endothelial nitric oxide synthase gene polymorphism (Glu298Asp) and acute pulmonary hypertension post cardiopulmonary bypass in children with congenital cardiac diseases.

Cardiol Young. 2011 Apr;21(2):161-9. doi: 10.1017/S1047951110001630. Epub 2010 Dec 10.



Ley S, Loukanov T, Ley-Zaporozhan J, Springer W, Sebening C, Sommerburg O, Hagl S, Gorenflo M (2010)

Long-term outcome after external tracheal stabilization due to congenital tracheal instability.

Ann Thorac Surg. 2010 Mar;89(3):918-25. doi: 10.1016/j.athoracsur.2009.11.066.


Loukanov Ts, Kirilov M, Fürstenberger G, Müller-Decker K (2010)

Localization of cyclo-oxygenase-2 in human recurrent colorectal cancer.

Clin Invest Med. 2010 Feb 1;33(1):E22-9.


Loukanov T, Geiger R, Agrawal R (2010)

Animal models related to congenital heart disease and clinical research in pulmonary hypertension.

Cardiology. 2010;116(1):18-25. doi: 10.1159/000313865. Epub 2010 Apr 24.



Loukanov TS, Sebening C, Springer W, Hagl S, Karck M, Gorenflo M (2009)

The evolution of the pulmonary arterial sling syndrome, with particular reference to the need for reoperations because of untreated tracheal stenosis.

Cardiol Young. 2009 Sep;19(5):446-50. doi: 10.1017/S1047951109990576. Epub 2009 Aug 7.



Loukanov T, Arnold R, Gross J, Sebening C, Klimpel H, Eichhorn J, Hoss K, Ulmer HE, Kark M, Gorenflo M (2008)

Endothelin-1 and asymmetric dimethylarginine in children with left-to-right shunt after intracardiac repair.

Clin Res Cardiol. 2008 Jun;97(6):383-8. doi: 10.1007/s00392-008-0645-x. Epub 2008 Feb 22.


Hagl S, Sebening C, Springer W, Loukanov T (2008)

Modified sliding tracheal plasty using the bridging bronchus for repair of long-segment tracheal stenosis.

Ann Thorac Surg. 2008 Mar;85(3):1118-20. doi: 10.1016/j.athoracsur.2007.08.003.


Loukanov T, Sebening C, Springer W, Khalil M, Ulmer HE, Hagl S, Karck M, Gorenflo M (2008)

Replacement of valved right ventricular to pulmonary artery conduits: an observational study with focus on right ventricular geometry.

Clin Res Cardiol. 2008 Mar;97(3):169-75. Epub 2007 Nov 28.



Loukanov T, Gorenflo M, Sebening C, Springer W, Eichhorn J, Ulmer H, Hagl S (2007)

Surgical treatment of long-segment tracheal anomalies in infants and children.

Thorac Cardiovasc Surg. 2007 Sep;55(6):375-9.



Loukanov T, Sebening C, Springer W, Ulmer H, Hagl S (2005)

Simultaneous management of congenital tracheal stenosis and cardiac anomalies in infants.

J Thorac Cardiovasc Surg. 2005 Dec;130(6):1537-41.



Loukanov T, Marinov S, Lazarov S, Pilossoff V (2003):

Cardiopulmonary bypass – principles, effect on organism and possible mechanisms for decreasing of the complications. II. Inflammatory response to CPB.

Pediatrics 4: 11-17


Loukanov T, Marinov S, Lazarov S, Pilossoff V (2003):

Cardiopulmonary bypass – principles, effect on organism and possible mechanisms for decreasing of the complications. I. Mechanism and principles.

Pediatrics 4: 7-11



Loukanov T, Lazarov S, Lacheva A, Pilossoff V (2002):

Extracorporeal Memebrane Oxygenation (ECMO).

Bulg. Cardiology 4:31-36


Loukanov T, Lazarov S, Pilossoff V (2002):

Myocardial protection in pediatric heart surgery.

Bulg. Cardiology 2: 15-24



Loukanov T (2001):

Cyclooxygenase-2 (COX-2) Selective Inhibitors and Potential Mechanisms for Colorectal Cancer Chemopreventetion.

Hepatogastroenterology 67: 152-155


Loukanov T, Loukanova S, Kolchakov W, Markova E, Krastev Z (2001):

Cyclo- oxygenase 2 (COX-2) expression in preneoplastic diseases and epithelial colon cancer.

Hepatogastroenterology 67:23-27



Loukanov T (2000):

Angiogenic therapy of the malignant diseases.

In: Chernozemsky I, Shipkov T, editors. Oncology 2001. 1st ed. Ciela- Soft and Publishing; 2000. p. 199- 205.


Loukanov T (2000):

Gene therapy of the malignant diseases.

In: Chernozemsky I, Shipkov T, editors. Oncology 2001. 1st ed. Ciela- Soft and Publishing; 2000. p. 190-199



Mueller-Decker K, Albert C, Loukanov T , Winde F, Marks G, Fuerstenberger G(1999):

Cellular localisation of cyclooxygenase isoenzymes in Crohn’s colitis and colorectal cancer.

Int. Journal of Colorectal Diseases 14:212-218



Loukanov T, Botev C, Markov N, Djongov L, Dimitrov V (1998):

Fibrin tissue adhesives in surgical oncology.

Journal of B.U.ON.4: 297- 300


29. March 2000

Patent N: 62679: Method for transfer of the distal part of the minor pectoral muscle in axillary fossa.

28. April 2000

Patent N: 62638: Autologous fibrin glue.