Applied Tumor Biology … Overview


The department of Applied Tumor Biology investigates the molecular mechanisms of tumor development and progression. In patients’ diagnostics, analyses are performed for tumor classification and cancer early detection. In research, novel diagnostic markers and antigens, which are relevant for immunotherapy, are identified. Based on these markers, clinical studies are planned and performed. There is a close collaboration with different clinical and theoretical institutions as well as the National Center for Tumor Diseases (NCT), the German Cancer Research Center (DKFZ) and the European Molecular Biological Laboratory (EMBL), and several industrial partners. Our teaching activity comprises lectures, seminars, and colloquia in the field of applied tumor biology.

Laboratory services

  • Diagnostics of hereditary tumor diseases (familial colorectal cancer, HNPCC)
    • Microsatellite instability analysis
    • Immunohistochemistry
  • Diagnostics of virus-associated tumors
    • Diagnostics of human papillomavirus (HPV) infections
    • Biomarker analysis in premalignant lesions


Research and Innovation

  • Molecular pathogenesis of microsatellite unstable neoplasia
  • Molecular pathogenesis of HPV-associated tumors
  • Development of novel diagnostical tools for the early detection and diagnosis of cancer
  • Development of tumor antigen-based cancer vaccines
  • Characterization of antitumoral immune responses (ELISA, ELISpot, cytotoxicity assays)
  • Glycobiology of cancer


Special technology

  • Genetic Analyzers ABI 3100 and 310, Laser Capture Microdissection Microscope (LCM), FACS, preparative and analytical ultra-centrifuge, liquid scintillation spectrometer, phosphoimager, FPLC, lyophylization, 2D-protein-gelelektrophoresis, isotope laboratory



Prof. M. von Knebel Doeberitz, MD

Im Neuenheimer Feld 224

69120 Heidelberg


Phone.: +49-6221-56-4220



A. Klingmann (Monday-Friday, 8:30 a.m. - 1:00 p.m.)

Phone.: 0049-6221-56-4221

Fax: 0049-6221-56-5981

Email: andrea.klingmann(at)