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SFB 938


Welcome to the homepage of the Collaborative Research Program “SFB 938” entitled „Environment specific control of immune reactivity“ that was founded at the Ruprecht-Karls-University Heidelberg in 2011.

SFB 938 represents a joint effort by scientists working at the Medical Schools of Heidelberg and Mannheim and at the Helmholtz-Institute „German Cancer Research Center (DKFZ)“ aimed at elucidating  the regulation of immune reactivity in health and disease in a comprehensive fashion.

Immune responses result from complex interactions between different microenvironments of the organism with the various discrete cellular subpopulations of the immune-organ. At the molecular level these involve metabolic conditions, soluble mediators such as cytokines, chemokines and their receptors as well as cell-cell interaction molecules. Given that cells of the immune organ recirculate throughout each individual organism it follows that they have to be able to adjust their phenotypes and functions according to respective microenviromental demands. Immune mediated disease, therefore, likely results from an impaired interplay between microenvironment and immunocompetent cells.

16 individual projects and 2 central projects range from the analysis of contemporary animal models, novel experimental in vitro systems, and investigations on characteristic features of different human microenvironments involving genomics, proteomics, and metabolomics.

An attractive seminar program with internationally renowned speakers connects the SFB 938 with the scientific community worldwide.

Since decades immunologists of the University of Heidelberg have proven their joint abilities to develop and support successfully science and academic careers. Therefore, if you are interested in both, please be invited to visit our website regularly which provides contemporary information on achievements, initiatives, events and job opportunities.

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Prof. Dr. med.
Stefan Meuer