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Here you will find important publications made by the members of our workgroup.


Publications to therapy with local anesthetics from Heidelberg University

  • The first public lecture to local anesthetics in 1884 in Heidelberg [1]


Original papers to basic research

  • Modification of the gate control theory [2]
  • Effects of local anesthetics at Gq protein receptors [3]
  • Effects of local anesthetics at NMDA receptors [4]
  • Effects of local anesthetics at muscarinic receptors [5-7]
  • Immune modulation through local anesthetics [8-9]


Original paper to clinical effects

  • Improvement of perioperative parameters through infusion of local anesthetics [10]


Original papers to healthcare research

  • Frequency of use of neural therapy in family practices in Germany [11]
  • Integration of neural therapy into the curriculum of medical studies [12]



  • TLA for musculoskeletal disorders [13]
  • Opens external link in new windowReview: Therapy with Local Anesthetics [14]
  • Review, expanded and updated German version (DZA) in two parts: [15-16]


Case Report

  • Successful neural therapy for vulvodynia [17]



  • Effect of neural therapy on heart rate variability (HRV) [18]


Overview papers

  • Short-acting local anesthetics for chronic pain [19]
  • Textbook contributions and textbooks
  • Manual to Neural Therapy [20]
  • Neural therapy and treatment of tissue, spec. osteopathy [21]



1. Koller C: Über die Verwendung des Cocains zur Anästhesierung am Auge. Wien Klin Wochenschr 1884, 34:1276.

2. Zimmermann M: Dorsal root potentials after C-fiber stimulation. Science 1968, 160(3830):896-898.

3. Hollmann MW, Difazio CA, Durieux ME: Ca-signaling G-protein-coupled receptors: a new site of local anesthetic action? Reg Anesth Pain Med 2001, 26(6):565-571.

4. Hahnenkamp K, Durieux ME, Hahnenkamp A, Schauerte SK, Hoenemann CW, Vegh V, Theilmeier G, Hollmann MW: Local anaesthetics inhibit signalling of human NMDA receptors recombinantly expressed in Xenopus laevis oocytes: role of protein kinase C. Br J Anaesth 2006, 96(1):77-87.

5. Hollmann MW, Fischer LG, Byford AM, Durieux ME: Local anesthetic inhibition of m1 muscarinic acetylcholine signaling. Anesthesiology 2000, 93(2):497-509.

6. Picardi S, Stevens MF, Hahnenkamp K, Durieux ME, Lirk P, Hollmann MW: Time-dependent modulation of muscarinic m1/m3 receptor signalling by local anaesthetics. Br J Anaesth 2014, 112(2):370-379.

7. Hollmann MW, Ritter CH, Henle P, de Klaver M, Kamatchi GL, Durieux ME: Inhibition of m3 muscarinic acetylcholine receptors by local anaesthetics. Br J Pharmacol 2001, 133(1):207-216.

8. Herroeder S, Reichardt P, Sassmann A, Zimmermann B, Jaeneke D, Hoeckner J, Hollmann MW, Fischer KD, Vogt S, Grosse R et al: Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility. Immunity 2009, 30(5):708-720.

9. Hollmann MW, Durieux ME: Local anesthetics and the inflammatory response: a new therapeutic indication? Anesthesiology 2000, 93:858-875.

10. Herroeder S, Pecher S, Schonherr ME, Kaulitz G, Hahnenkamp K, Friess H, Bottiger BW, Bauer H, Dijkgraaf MG, Durieux ME et al: Systemic lidocaine shortens length of hospital stay after colorectal surgery: a double-blinded, randomized, placebo-controlled trial. Ann Surg 2007, 246(2):192-200.

11. Joos S, Musselmann B, Szecsenyi J: Integration of Complementary and Alternative Medicine into Family Practices in Germany: Results of a National Survey. Evid Based Complement Alternat Med 2009.

12. Joos S, Eicher C, Musselmann B, Kadmon M: [Development and implementation of a 'curriculum complementary and alternative medicine' at the Heidelberg Medical School]. Forsch Komplementmed 2008, 15(5):251-260.

13. Mosshammer D, Mayer B, Joos S: Local anesthetics injection therapy for musculoskeletal disorders: a systematic review and meta-analysis. Clin J Pain 2013, 29(6):540-550.

14. Weinschenk S: Neural Therapy - A review of the therapeutic use of local anaesthetics. Acupunct Rel Ther 2012, 4(1):25-29.

15. Weinschenk S: Neuraltherapie - die Therapie mit Lokalanästhetika. Teil 2: Klinische Anwendung. Dtsch Zschr Akupunktur 2013, 56(3):6-9.

16. Weinschenk S: Neuraltherapie - die Therapie mit Lokalanästhetika. Teil 1: Grundlagen. Dtsch Zschr Akupunktur 2013, 54(1):6-9.

17. Weinschenk S, Brocker K, Hotz L, Strowitzki T, Joos S: Successful therapy of vulvodynia with local anaesthetics. A Case report. Forsch Komplementmed 2013, 20(2):138-143.

18. Wisseler H: [Change of Heart Rate Variability during different Medical Interventions in a CAM practice in Germany]. Doctoral Thesis. Heidelberg: University of Heidelberg; 2012.

19. Hollmann MW, Durieux ME: Prolonged actions of short-acting drugs: local anesthetics and chronic pain. Reg Anesth Pain Med 2000, 25(4):337-339.

20. Weinschenk S: Handbuch Neuraltherapie - Diagnostik und Therapie mit Lokalanästhetika; Stefan Weinschenk (Hrsg.), 1. edn. edn. München: Elsevier Urban & Fischer; 2010.

21. Wander R, Weinschenk S: Neural Therapy [as a fascia-oriented therapy]. In: The tensional network of the human body. Edited by Schleip R, Findley T, Chaitow L, Huijing PA. Edinburgh: Churchill Livingstone; 2012: 375-382.

22. Weinschenk S, Hollmann MW, Strowitzki T.: New perineal injection technique for pudendal nerve infiltration in diagnostic and therapeutic procedures. Arch Gynecol Obstet. 2015 Sep 15, PMID: 26374644

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