Working Groups
Translational Transplantation Research
The overarching goal of the working group is to research methods for improving short- and long-term outcomes following visceral organ transplantation (liver, kidney, pancreas). Various techniques and ex vivo and in vivo models are employed in the lab to assess and improve organ preservation through innovative techniques such as machine perfusion. The aim is to better preserve, evaluate, and recondition or modify organs for transplantation. In the clinical setting, the research group also employs various study designs, conducting both retrospective and prospective studies to identify clinical and paraclinical factors influencing patient and graft survival post-transplantation. Another important clinical focus is the investigation of nutritional status and body composition as potentially modifiable risk factors in patients after organ transplantation and in major surgical procedures. The working group is assigned to the Section of Liver Surgery and Visceral Transplantation Surgery (lead by Prof. Dr. A. Mehrabi).
Most relevant publications
Jiang D, Mantas A, Studier-Fischer A, Fuchs J, Uluk D, Loos M, Mieth M, Zeier M, Husen P, Golriz M, Kahlert C, Ryschich E, Mehrabi A, Pratschke J, Michalski CW, and Czigany Z (2024). Clinical Research in Renal Transplantation: A Bibliometric Perspective on a Half-century of Innovation and Progress. Transplantation.
Reichelt S, Pratschke J, Engelmann C, Neumann UP, Lurje G, and Czigany Z (2022). Body composition and the skeletal muscle compartment in liver transplantation: Turning challenges into opportunities. Am J Transplant 22, 1943-1957.
Czigany Z, Pratschke J, Fronek J, Guba M, Schoning W, Raptis DA, Andrassy J, Kramer M, Strnad P, Tolba RH, Liu W, Keller T, Miller H, Pavicevic S, Uluk D, Kocik M, Lurje I, Trautwein C, Mehrabi A, Popescu I, Vondran FWR, Ju C, Tacke F, Neumann UP, and Lurje G (2021). Hypothermic Oxygenated Machine Perfusion Reduces Early Allograft Injury and Improves Post-transplant Outcomes in Extended Criteria Donation Liver Transplantation From Donation After Brain Death: Results From a Multicenter Randomized Controlled Trial (HOPE ECD-DBD). Ann Surg 274, 705-712.