Roers Lab
We address mechanisms of induction and regulation of beneficial and pathogenic immune responses
Focus 1: Innate immune signals as drivers of tumor immune control and autoimmunity
Mammalian cells sense virus infection by detection of viral nucleic acids. Several sensor pathways of the innate immune system specialize in detection of viral RNA and DNA to induce antiviral type I-interferon (IFN) responses. These responses are essential to control virus infection and prevent e.g. severe courses of SARS-CoV2 infection. Uncontrolled activity of this arm of the immune system, however, can cause massive damage to host tissues, a principle dubbed ‘autoinflammation’. Inappropriate chronic activation of innate antiviral immunity can also result in a break-down of self-tolerance in the adaptive immune system and constitutes a major cause of autoimmunity in Systemic Lupus (SLE) and related conditions.
We focus on molecular mechanisms of chronic activation of the cGAS/STING pathway that senses DNA in the cytosol. As the sensor cGAS does not discriminate between endogenous and microbial DNA, pathogenic activation can result from failure to keep the cytosol free of endogenous DNA. This is a situation that can ensue from defects of cytosolic DNA waste disposal which is primarily a function of the cytosolic DNase TREX1. We address nature and source of TREX1 DNA substrates, the regulation of the immune response in TREX1-deficient cells, and how the lack of TREX1 leads to autoimmunity.
While inherited defects of TREX1 result in fatal disease, we also explore whether cGAS/STING activation by temporary and partial pharmacologic inhibition of TREX1 can be leveraged to invigorate anti-tumor immunity. Impact of STING responses on T cell immunity can enhance, but also compromise T cell responses, depending on intensity and context. Our results in preclinical models indicate that STING activation through induced loss of TREX1 in the adult massively improves T cell-mediated tumor control and synergizes with immune checkpoint inhibition, but does not trigger rapid onset of autoimmunity. We investigate the impact of TREX1 inactivation on DC function and T cell exhaustion.
Funding
DFG: TRR SFB 237 ‚Nucleic Acid Immunity’, Project B17: Molecular and cellular dynamics of nucleic acid-driven immune responses and immunopathology
German Cancer Aid: Project 70116421 Induction of anti-tumor immunity by systemic low-level cGAS/STING signaling
Focus 2: Biology of mast cells and principles of activation of type 2 immunity
Mast cells are tissue resident hematopoietic cells. They are best known for their pathogenic functions as the major effector cells of allergic, IgE-mediated immune responses. Physiological mast cell functions are less clear and much debate. Mast cell activation can occur through innate immune sensors and other surface receptors, but they are also innate effector cells of humoral adaptive immunity equipped with polyclonal IgE antigen receptors, which they acquire from the circulation by means of their high affinity Fce receptor. Their IgE enables mast cells to sensitively and rapidly respond to antigen. Upon activation, they release the content of their secretory granules that contain histamine and other proinflammatory mediators, as well as large amounts of proteases. Degranulation occurs within seconds to minutes after crosslinking of IgE by antigen. This ultra-fast response protects against environmental hazards, e.g. by proteolytic degradation of animal venoms, expulsion of inhaled toxins from the airways and avoidance behaviour preventing intake of harmful food. However, these mast cell functions are also responsible for key manifestations of allergic diseases. Factors determining whether a MC response is protective or rather results in life-threatening allergy are subject to discussion.
We have generated tools allowing study of mast cell in vivo functions, including transgenic mice expressing Cre-recombinase in mast cells, mast cell reporters and mast cell-deficiency models. We search for novel mast cell functions and currently focus on a subset of mast cells intimately associated with blood vessels that we found are capable of sampling blood vessel content and may provide alarm signals or protection upon detection of circulating hazards.
Principles of activation of type 2 immunity
Allergies, asthma and atopic dermatitis are summarized as ‘atopic diseases’, share a common genetic predisposition, but are also driven by environmental factors. Atopy is associated with deregulated type 2 immunity and overproduction of IgE. We are interested in mechanisms driving pathogenic type 2 responses.
Funding
DFG project RO 2133/12-1 Immunosurveillance of the blood stream by mast cells: Protection against circulating microorganisms, microbial toxins and animal venoms?
DFG: TRR SFB 156 ‚The Skin as Sensor and Effector Organ Orchestrating Local and Systemic Immune Responses’, Project C11N: Immune cell crosstalk in barrier-defective skin driving systemic atopic disease
DFG: FOR 2599 ‚Tissue Type 2 Immunity‘, Project 8: Control of high-affinity IgE responses to animal venoms by skin innate type 2 immunity
People
Dr. Emilija Marinkovic, postdoc
Dr. Lena Krämer, project coordinator
Dr. Minyi Chen, postdoc
Dr. Michael Persicke, postdoc
Han Gao, fellow
Yunchen Wu, fellow
Kristina Link, PhD student
Zeina Salloum, PhD student
Katariana Bezakova, MD student
Cagil Yetis, MD student
Antje Heidtmann, MTA
Sabine Ulbricht, BTA & lab manager
Publications
Publications Axel Roers 2025 – 2017
Marinkovic E*, Chen M*, Schubert N, Dogan Dar E, Poth T, Leung JY, Lohre J, Sahni JM, Tun C, Rajeswaran P, Mehlo-Jensen T, Perng O, Hill CM, Sivakumar P, Barnes MJ, Malik R, Behrendt R, Roers A. Systemic Inactivation of TREX1 Induces Selective Inflammation of the Tumor Microenvironment and Invigorated T Cell-Mediated Tumor Control. Cancer Res. 2025;85(15):2876-2889.
doi: 10.1158/0008-5472. *equal contribution
Kovacs D, Heger K, Giansanti P, Iuliano C, Meissner F, Mann M, Böttcher J, Öllinger R, Rad R, Tammer F, Gölling V, Zeng T, Masjedi A, Dr Med Vet TG, Roers A, Babina M, Robles MS, Moser M, Kaesler S, Dr Med Vet KS, Biedermann T, Schmidt-Supprian M. Mast cells modulate macrophage biology through release of pre-stored CSF1. J Allergy Clin Immunol. 2025;S0091-6749(25)00617-7.
doi: 10.1016/j.jaci.2025.05.022 Online ahead of print. Open access
Gomez-Diaz C, Greulich W, Wefers B, Wang M, Bolsega S, Effern M, Varga DP, Han Z, Chen M, Bérouti M, Leonardi N, Schillinger U, Holzmann B, Liesz A, Roers A, Hölzel M, Basic M, Wurst W, Hornung V. RNase T2 restricts TLR13-mediated autoinflammation in vivo. J Exp Med. 2025;222(3):e20241424.
Roers A. TGF-β drives differentiation of intraepithelial mast cells in inflamed airway mucosa. J Clin Invest. 2025;135(1):e186337.
doi: 10.1172/JCI186337 Open access
Link K, Muhandes L, Polikarpova A, Lämmermann T, Sixt M, Fässler R, Roers A. Integrin β1-mediated mast cell immune-surveillance of blood vessel content, J Allergy Clin Immunol. 2024;154(3):745-753.
doi: 10.1016/j.jaci.2024.03.022 Open access
Yang M, Ma Z, Wang C, Agca MC, Liu H, Huang K, Glage S, Rumpel R, Gerbaulet A, Roers A, Liu X, Noyan F, von Neuhoff N, Ganser A, Liu L, Yun H, Li Z. Cre recombinase promotes leukemogenesis in the presence of both homozygous and heterozygous FLT3-ITD. Leukemia 2024;38(6):1437-1439.
doi: 10.1038/s41375-024-02259-x Open access
Luca D, Lee S, Hirota K, Okabe Y, Uehori J, Izawa K, Lanz AL, Schütte V, Sivri B, Tsukamoto Y, Hauck F, Behrendt R, Roers A, Fujita T, Nishikomori R, Lee-Kirsch MA, Kato H. Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity. Sci Adv. 2024;10(9):eadk0820.
doi: 10.1126/sciadv.adk0820 Open access
Meyer M, Mahr A, Brewer J, Daniel V, Dell'Aringa J, Goldstone T, Hersey S, Johnston I, Larson P, Loveridge M, MacBeath G, Moyer M, Nagorsen D, Papa S, Peiser L, Ranade K, Rizzi R, Roers A, Schendel D, Sivakumar P, Tran E, Türeci Ö, Weigand L, Wennborg A, Williams D, Yee C, Britten CM. A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics. Nat Rev Drug Discov. 2024;23(1):1-2.
doi: 10.1038/d41573-023-00189-4
Klussmeier A, Putke K, Klasberg S, Kohler M, Sauter J, Schefzyk D, Schöfl G, Massalski C, Schäfer G, Schmidt AH, Roers A, Lange V. High population frequencies of MICA copy number variations originate from independent recombination events. Front Immunol. 2023;14:1297589.
doi: 10.3389/fimmu.2023.1297589 Open access
Suk G, Kwon DH, Roers A, Abraham SN, Choi HW. Stabilization of activated mast cells by ORAI1 inhibitor suppresses peanut-induced anaphylaxis and acute diarrhea. Pharmacol Res. 2023;196:106887.
doi: 10.1016/j.phrs.2023.106887 Open access
Dressel N, Natusch L, Munz CM, Costas Ramon S, Morcos MNF, Loff A, Hiller B, Haase C, Schulze L, Müller P, Lesche M, Dahl A, Luksch H, Rösen-Wolff A, Roers A, Behrendt R, Gerbaulet A. Activation of the cGAS/STING Axis in Genome-Damaged Hematopoietic Cells Does Not Impact Blood Cell Formation or Leukemogenesis. Cancer Res. 2023;83:2858-2872.
doi: 10.1158/0008-5472.CAN-22-3860
Hackstein CP, Spitzer J, Symeonidis K, Horvatic H, Bedke T, Steglich B, Klein S, Assmus LM, Odainic A, Szlapa J, Kessler N, Beyer M, Schmithausen R, Latz E, Flavell RA, Garbi N, Kurts C, Kümmerer BM, Trebicka J, Roers A, Huber S, Schmidt SV, Knolle PA, Abdullah Z.J. Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury. Hepatol. 2023;79:150-166.
doi: 10.1016/j.jhep.2023.02.026 Open access
Kaltenbach L, Martzloff P, Bambach SK, Aizarani N, Mihlan M, Gavrilov A, Glaser KM, Stecher M, Thünauer R, Thiriot A, Heger K, Kierdorf K, Wienert S, von Andrian UH, Schmidt-Supprian M, Nerlov C, Klauschen F, Roers A, Bajénoff M, Grün D, Lämmermann T. Slow integrin-dependent migration organizes networks of tissue-resident mast cells. Nat Immunol. 2023;24:915-924.
doi: 10.1038/s41590-023-01493 Open access
Munz CM, Dressel N, Chen M, Grinenko T, Roers A, Gerbaulet A. Regeneration after blood loss and acute inflammation proceeds without contribution of primitive HSCs. Blood 2023;141:2483-2492.
doi: 10.1182/blood.2022018996 Open access
Kak G, Van Roy Z, Heim CE, Fallet RW, Shi W, Roers A, Duan B, Kielian T. IL-10 production by granulocytes promotes Staphylococcus aureus craniotomy infection. J Neuroinflammation2023;20:114.
doi: 10.1186/s12974-023-02798-7 Open access
Kanayama M, Izumi Y, Akiyama M, Hayashi T, Atarashi K, Roers A, Sato T, Ohteki T. Myeloid-like B cells boost emergency myelopoiesis through IL-10 production during infection. J Exp Med. 2023;220:e20221221.
doi: 10.1084/jem.20221221 Open access
Körholz J, Gabrielyan A, Sczakiel HL, Schulze L, Rejzek M, Laass MW, Leuchten N, Tiebel O, Aust D, Conrad K, Röber N, Jacobsen EM, Ehmke N, Berner R, Lucas N, Lee-Kirsch MA, Wiedemuth R, Roesler J, Roers A, Amendt T, Schuetz C. Novel mutation and expanding phenotype in IRF2BP2 deficiency Rheumatology (Oxford) 2023;62:1699-1705.
doi: 10.1093/rheumatology/keac575
Schulz MS, Sartorius von Bach CB, Marinkovic E, Günther C, Behrendt R, Roers A. Development of an RNase H2 Activity Assay for Clinical Screening. J Clin Med. 2023;12:1598.
doi: 10.3390/jcm12041598. Open access
Schumann T, Ramon SC, Schubert N, Mayo MA, Hega M, Maser KI, Ada SR, Sydow L, Hajikazemi M, Badstübner M, Müller P, Ge Y, Shakeri F, Buness A, Rupf B, Lienenklaus S, Utess B, Muhandes L, Haase M, Rupp L, Schmitz M, Gramberg T, Manel N, Hartmann G, Zillinger T, Kato H, Bauer S, Gerbaulet A, Paeschke K, Roers A, Behrendt R.J. Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner. J.Exp Med. 2023;220:e20220829.
doi: 10.1084/jem.20220829 Open access
Joulia R, Guerrero-Fonseca IM, Girbl T, Coates JA, Stein M, Vázquez-Martínez L, Lynam E, Whiteford J, Schnoor M, Voehringer D, Roers A, Nourshargh S, Voisin MB. Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A. Nat Commun. 2022;13:7029.
doi: 10.1038/s41467-022-34695-7 Open access
Morath C, Schmitt A, Schmitt M, Wang L, Kleist C, Opelz G, Süsal C, Tran TH, Scherer S, Schwenger V, Kemmner S, Fischereder M, Stangl M, Hauser IA, Sommerer C, Nusshag C, Kälble F, Speer C, Benning L, Bischofs C, Sauer S, Schubert ML, Kunz A, Hückelhoven-Krauss A, Neuber B, Mehrabi A, Schwab C, Waldherr R, Sander A, Büsch C, Czock D, Böhmig GA, Reiser J, Roers A, Müller-Tidow C, Terness P, Zeier M, Daniel V, Schaier M. Individualised immunosuppression with intravenously administered donor-derived modified immune cells compared with standard of care in living donor kidney transplantation (TOL-2 Study): protocol for a multicentre, open-label, phase II, randomised controlled trial. BMJ Open. 2022;12:e066128.
doi: 10.1136/bmjopen-2022-066128 Open access
Herrera-Heredia SA, Hsu HP, Kao CY, Tsai YH, Yamaguchi Y, Roers A, Hsu CL, Dzhagalov IL. Heparin is required for the formation of granules in connective tissue mast cells. Front Immunol. 2022;13:1000405.
doi: 10.3389/fimmu.2022.1000405 Open access
Willenborg S, Roscito JG, Gerbaulet A, Roers A, Dahl A, Eming SA, Reinhardt S. Isolation of macrophages from mouse skin wounds for single-cell RNA sequencing.STAR Protoc. 2022;3:101488.
doi: 10.1016/j.xpro.2022.101488 Open access
Morcos MNF, Li C, Munz CM, Greco A, Dressel N, Reinhardt S, Sameith K, Dahl A, Becker NB, Roers A, Höfer T, Gerbaulet A. Fate mapping of hematopoietic stem cells reveals two pathways of native thrombopoiesis. Nat Commun. 2022;13:4504.
doi: 10.1038/s41467-022-31914-z Open access
Schubert N, Schumann T, Daum E, Flade K, Ge Y, Hagedorn L, Edelmann W, Müller L, Schmitz M, Kuut G, Hornung V, Behrendt R, Roers A. Genome Replication Is Associated With Release of Immunogenic DNA Waste. Front Immunol. 2022;13:880413.
doi: 10.3389/fimmu.2022.880413 Open access
Willenborg S, Roscito JG, Gerbaulet A, Roers A, Dahl A, Eming SA, Reinhardt S. Isolation of macrophages from mouse skin wounds for single-cell RNA sequencing. STAR Protoc. 2022;3:101337.
10.1016/j.xpro.2022.101337doi: https://www.sciencedirect.com/science/article/pii/S2666166722002179?via=ihub. Open access
Sanin DE, Ge Y, Marinkovic E, Kabat AM, Castoldi A, Caputa G, Grzes KM, Curtis JD, Thompson EA, Willenborg S, Dichtl S, Reinhardt S, Dahl A, Pearce EL, Eming SA, Gerbaulet A, Roers A, Murray PJ, Pearce EJ. A common framework of monocyte-derived macrophage activation. Sci Immunol. 2022;7:eabl7482.
doi: 10.1126/sciimmunol.abl7482
Dichtl S, Sanin DE, Koss CK, Willenborg S, Petzold A, Tanzer MC, Dahl A, Kabat AM, Lindenthal L, Zeitler L, Satzinger S, Strasser A, Mann M, Roers A, Eming SA, El Kasmi KC, Pearce EJ, Murray PJ. Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF. Life Sci Alliance. 2022;5:e202101315.
doi: 10.26508/lsa.202101315 Open access
Barrett B, Nguyen DH, Xu J, Guo K, Shetty S, Jones ST, Mickens KL, Shepard C, Roers A, Behrendt R, Wu L, Kim B, Santiago ML. SAMHD1 Promotes the Antiretroviral Adaptive Immune Response in Mice Exposed to Lipopolysaccharide. J Immunol. 2022;208:444-453.
doi: 10.4049/jimmunol.200138 Open access
Klewer T, Bakic L, Müller-Reichert T, Kiewisz R, Jessberger G, Kiessling N, Roers A, Jessberger R. E-Cadherin restricts mast cell degranulation in mice. Eur J Immunol. 2022;52:44-53.
doi: 10.1002/eji.202049087 Open access
Willenborg S, Sanin DE, Jais A, Ding X, Ulas T, Nüchel J, Popović M, MacVicar T, Langer T, Schultze JL, Gerbaulet A, Roers A, Pearce EJ, Brüning JC, Trifunovic A, Eming SA. Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing. Cell Metab. 2021;33:2398-2414.e9.
doi: 10.1016/j.cmet.2021.10.004 Open access
Muhandes L, Chapsa M, Pippel M, Behrendt R, Ge Y, Dahl A, Yi B, Dalpke A, Winkler S, Hiller M, Boutin S, Beissert S, Jessberger R, Fallon PG, Roers A. Low Threshold for Cutaneous Allergen Sensitization but No Spontaneous Dermatitis or Atopy in FLG-Deficient Mice. J Invest Dermatol. 2021;141:2611-2619.e2.
doi: 10.1016/j.jid.2021.02.763 Open access
Stackowicz J, Gaudenzio N, Serhan N, Conde E, Godon O, Marichal T, Starkl P, Balbino B, Roers A, Bruhns P, Jönsson F, Moguelet P, Georgin-Lavialle S, Broderick L, Hoffman HM, Galli SJ, Reber LL. Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome. J Exp Med. 2021;218:e20201466.
doi: 10.1084/jem.20201466 Open access
Schetelig J, Heidenreich F, Baldauf H, Trost S, Falk B, Hoßbach C, Real R, Roers A, Lindemann D, Dalpke A, Kolditz M, de With K, Bornhäuser M, Bonifacio EE, Rücker-Braun E, Lange V, Markert J, Barth R, Hofmann JA, Sauter J, Bernas SN, Schmidt AH. Individual HLA-A, -B, -C, and -DRB1 Genotypes Are No Major Factors Which Determine COVID-19 Severity. Front Immunol. 2021;12:698193.
doi: 10.3389/fimmu.2021.698193 Open access
Barkaway A, Rolas L, Joulia R, Bodkin J, Lenn T, Owen-Woods C, Reglero-Real N, Stein M, Vázquez-Martínez L, Girbl T, Poston RN, Golding M, Saleeb RS, Thiriot A, von Andrian UH, Duchene J, Voisin MB, Bishop CL, Voehringer D, Roers A, Rot A, Lämmermann T, Nourshargh S. Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage. Immunity 2021;54:1494-1510.e7.
doi: 10.1016/j.immuni.2021.04.025 Open access
Weitzmann A, Naumann R, Dudeck A, Zerjatke T, Gerbaulet A, Roers A. Mast Cells Occupy Stable Clonal Territories in Adult Steady-State Skin. J Invest Dermatol. 2020;140:2433-2441.
doi: 10.1016/j.jid.2020.03.963 Open access
Wasielewska JM, Grönnert L, Rund N, Donix L, Rust R, Sykes AM, Hoppe A, Roers A, Kempermann G, Walker TL. Author Correction: Mast cells increase adult neural precursor proliferation and differentiation but this potential is not realized in vivo under physiological conditions. Sci Rep. 2020;10(1):19816.
doi: 10.1038/s41598-020-76589-y Open access
Minshawi F, Lanvermann S, McKenzie E, Jeffery R, Couper K, Papoutsopoulou S, Roers A, Muller W. The Generation of an Engineered Interleukin-10 Protein With Improved Stability and Biological Function. Front Immunol. 2020;11:1794.
doi: 10.3389/fimmu.2020.01794 Open access
Siedel H, Roers A, Rösen-Wolff A, Luksch H. Type I interferon-independent T cell impairment in a Tmem173 N153S/WT mouse model of STING associated vasculopathy with onset in infancy (SAVI). Clin Immunol. 2020;216:108466. doi: doi: 10.1016/j.clim.2020.108466
Morcos MNF, Zerjatke T, Glauche I, Munz CM, Ge Y, Petzold A, Reinhardt S, Dahl A, Anstee NS, Bogeska R, Milsom MD, Säwén P, Wan H, Bryder D, Roers A, Gerbaulet A. Continuous mitotic activity of primitive hematopoietic stem cells in adult mice. J Exp Med. 2020;217:e20191284.
doi: 10.1084/jem.20191284 Open access
Izawa K, Kaitani A, Ando T, Maehara A, Nagamine M, Yamada H, Ando T, Ide T, Matsuzawa M, Okamoto Y, Yin E, Fukase S, Wang H, Kamei A, Uchida S, Maeda K, Nakano N, Uchida K, Tamura N, Ikeda K, Ebihara N, Shimizu T, Voehringer D, Roers A, Ogawa H, Okumura K, Kitaura J. Differential Lipid Recognition by Mouse versus Human CD300f, Inhibiting Passive Cutaneous Anaphylaxis, Depends on a Single Amino Acid Substitution in its Immunoglobulin-Like Domain. J Invest Dermatol. 2020;140:710-713.e3.
doi: 10.1016/j.jid.2019.08.439 Open access
Reinke S, Linge M, Diebner HH, Luksch H, Glage S, Gocht A, Robertson AAB, Cooper MA, Hofmann SR, Naumann R, Sarov M, Behrendt R, Roers A, Pessler F, Roesler J, Rösen-Wolff A, Winkler S. Non-canonical Caspase-1 Signaling Drives RIP2-Dependent and TNF-α-Mediated Inflammation In Vivo. Cell Rep. 2020 Feb 25;30(8):2501-2511.e5.
doi: 10.1016/j.celrep.2020.01.090 Open access
Ding X, Willenborg S, Bloch W, Wickström SA, Wagle P, Brodesser S, Roers A, Jais A, Brüning JC, Hall MN, Rüegg MA, Eming SA. Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation. J Allergy Clin Immunol. 2020;145:283-300.e8.
doi: 10.1016/j.jaci.2019.07.033
Maurer M, Taube C, Schröder NWJ, Ebmeyer J, Siebenhaar F, Geldmacher A, Schubert N, Roers A. Mast cells drive IgE-mediated disease but might be bystanders in many other inflammatory and neoplastic conditions. J Allergy Clin Immunol. 2019;144:S19-S30.
doi: 10.1016/j.jaci.2019.07.017
Dolch A, Kunz S, Dorn B, Alessandrini F, Müller W, Jack RS, Martin SF, Roers A, Jakob T. IL-10 signaling in dendritic cells is required for tolerance induction in a murine model of allergic airway inflammation. Eur J Immunol. 2019;49:302-312.
doi: 10.1002/eji.201847883 Open access
Wei Y, Chhiba KD, Zhang F, Ye X, Wang L, Zhang L, Robida PA, Moreno-Vinasco L, Schnaar RL, Roers A, Hartmann K, Lee CM, Demers D, Zheng T, Bochner BS, Zhu Z. Mast Cell-Specific Expression of Human Siglec-8 in Conditional Knock-in Mice. Int J Mol Sci. 2018;20(1):19.
doi: 10.3390/ijms20010019 Open access
Stein K, Lysson M, Schumak B, Vilz T, Specht S, Heesemann J, Roers A, Kalff JC, Wehner S. Leukocyte-Derived Interleukin-10 Aggravates Postoperative Ileus.
Front Immunol. 2018;9:2599.
doi: 10.3389/fimmu.2018.02599 Open access
Hiller B, Hoppe A, Haase C, Hiller C, Schubert N, Müller W, Reijns MAM, Jackson AP, Kunkel TA, Wenzel J, Behrendt R, Roers A. Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin.
Cancer Res. 2018;78(20):5917-5926
doi: 10.1158/0008-5472.CAN-18-1099 Open access
Li Y, Liu B, Harmacek L, Long Z, Liang J, Lukin K, Leach SM, O'Connor B, Gerber AN, Hagman J, Roers A, Finkelman FD, Huang H. The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis. J Allergy Clin Immunol. 2018;142(4):1173-1184.
doi: 10.1016/j.jaci.2017.10.043 Open access
Schubert N, Lisenko K, Auerbach C, Weitzmann A, Ghouse SM, Muhandes L, Haase C, Häring T, Schulze L, Voehringer D, Gunzer F, Müller W, Feyerabend TB, Rodewald HR, Dudeck A, Roers A. Unimpaired Responses to Vaccination With Protein Antigen Plus Adjuvant in Mice With Kit-Independent Mast Cell Deficiency. Front Immunol. 2018;9:1870.
doi: 10.3389/fimmu.2018.01870 Open access
Tsvilovskyy V, Solís-López A, Schumacher D, Medert R, Roers A, Kriebs U, Freichel M. Deletion of Orai2 augments endogenous CRAC currents and degranulation in mast cells leading to enhanced anaphylaxis.Cell Calcium. 2018;71:24-33.
doi: 10.1016/j.ceca.2017.11.004
Maehara A, Kaitani A, Izawa K, Shiba E, Nagamine M, Takamori A, Isobe M, Uchida S, Uchida K, Ando T, Maeda K, Nakano N, Voehringer D, Roers A, Shimizu T, Ogawa H, Okumura K, Kitamura T, Kitaura J. Role of the Ceramide-CD300f Interaction in Gram-Negative Bacterial Skin Infections. J Invest Dermatol. 2018;138(5):1221-1224.
doi: 10.1016/j.jid.2017.11.025 Open access
Palam LR, Mali RS, Ramdas B, Srivatsan SN, Visconte V, Tiu RV, Vanhaesebroeck B, Roers A, Gerbaulet A, Xu M, Janga SC, Takemoto CM, Paczesny S, Kapur R. Loss of epigenetic regulator TET2 and oncogenic KIT regulate myeloid cell transformation via PI3K pathway. JCI Insight. 2018;3(4):e94679.
doi: 10.1172/jci.insight.94679 Open access
Ghouse SM, Polikarpova A, Muhandes L, Dudeck J, Tantcheva-Poór I, Hartmann K, Lesche M, Dahl A, Eming S, Müller W, Behrendt R, Roers A. Although Abundant in Tumor Tissue, Mast Cells Have No Effect on Immunological Micro-milieu or Growth of HPV-Induced or Transplanted Tumors. Cell Rep. 2018;22(1):27-35.
doi: 10.1016/j.celrep.2017.12.010 Open access
Magnúsdóttir EI, Grujic M, Roers A, Hartmann K, Pejler G, Lagerström MC. Mouse mast cells and mast cell proteases do not play a significant role in acute tissue injury pain induced by formalin. Mol Pain. 2018;14:1744806918808161. doi: 10.1177/1744806918808161 Open access
Wasielewska JM, Grönnert L, Rund N, Donix L, Rust R, Sykes AM, Hoppe A, Roers A, Kempermann G, Walker TL. Mast cells increase adult neural precursor proliferation and differentiation but this potential is not realized in vivo under physiological conditions. Sci Rep. 2017;7(1):17859.
doi: 10.1038/s41598-017-18184-2 Open access
Achleitner M, Kleefisch M, Hennig A, Peschke K, Polikarpova A, Oertel R, Gabriel B, Schulze L, Lindeman D, Gerbaulet A, Fiebig U, Lee-Kirsch MA, Roers A, Behrendt R. Lack of Trex1 Causes Systemic Autoimmunity despite the Presence of Antiretroviral Drugs. J Immunol. 2017;199(7):2261-2269.
doi: 10.4049/jimmunol.1700714 Open access
Nakamura T, Fujiwara Y, Yamada R, Fujii W, Hamabata T, Lee MY, Maeda S, Aritake K, Roers A, Sessa WC, Nakamura M, Urade Y, Murata T. Mast cell-derived prostaglandin D2 attenuates anaphylactic reactions in mice. J Allergy Clin Immunol. 2017;140(2):630-632.e9.
doi: 10.1016/j.jaci.2017.02.030
Izawa K, Maehara A, Isobe M, Yasuda Y, Urai M, Hoshino Y, Ueno K, Matsukawa T, Takahashi M, Kaitani A, Shiba E, Takamori A, Uchida S, Uchida K, Maeda K, Nakano N, Yamanishi Y, Oki T, Voehringer D, Roers A, Nakae S, Ishikawa J, Kinjo Y, Shimizu T, Ogawa H, Okumura K, Kitamura T, Kitaura J. Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment. Sci Rep. 2017;7(1):4298.
doi: 10.1038/s41598-017-04647-z Open access
Morcos MNF, Schoedel KB, Hoppe A, Behrendt R, Basak O, Clevers HC, Roers A, Gerbaulet A. SCA-1 Expression Level Identifies Quiescent Hematopoietic Stem and Progenitor Cells.Stem Cell Reports. 2017;8(6):1472-1478.
doi: 10.1016/j.stemcr.2017.04.012 Open access
Reber LL, Sibilano R, Starkl P, Roers A, Grimbaldeston MA, Tsai M, Gaudenzio N, Galli SJ. Imaging protective mast cells in living mice during severe contact hypersensitivity.
JCI Insight. 2017;2(9):e92900.
doi: 10.1172/jci.insight.92900 Open access
Dolch A, Kunz S, Dorn B, Roers A, Martin SF, Jakob T. Contact allergens induce CD8+ T cell-derived interleukin 10 that appears dispensable for regulation of contact hypersensitivity. Exp Dermatol. 2017;26(5):449-451.
Reitz M, Brunn ML, Rodewald HR, Feyerabend TB, Roers A, Dudeck A, Voehringer D, Jönsson F, Kühl AA, Breloer M. Mucosal mast cells are indispensable for the timely termination of Strongyloides ratti infection. Mucosal Immunol. 2017;10(2):481-492.
doi: 10.1038/mi.2016.56 Open access
Weidemann RR, Behrendt R, Schoedel KB, Müller W, Roers A, Gerbaulet A. Constitutive Kit activity triggers B-cell acute lymphoblastic leukemia-like disease in mice.
Exp Hematol. 2017;45:45-55.e6.
doi: 10.1016/j.exphem.2016.09.005 Open access