2nd Heidelberg International Symposium on Diabetic Complications

16. - 17.10.2015

The conference will highlight recent exciting developments in key areas of vascular biology and diabetes, including current progress in vascular-metabolic aspects and clinical perspectives in the treatment of diabetes and its long-term complications. We envision contributions allowing the audience to gain an overview of the recent progress on these fundamental topics in biomedicine.

Speakers

Sven Enerbäck	University of Gothenburg	Gothenburg	Sweden
Per-Henrik Groop	Helsinki University	Helsinki	Finland
Katerina Kankova	Masaryk University	Brno	Czech Republic
Georg Kunos	National Institutes of Health (NIH) - NIAAA	Rockville	USA
Eckhard Lammert	Heinrich-Heine-Universität	Dusseldorf	Germany
Michael Potente	Max Planck Institute for Heart and Lung Research	Bad Nauheim	Germany
Klaus Preissner	Justus-Liebig-University	Giessen	Germany
Peter Rossing	Aarhus University/ Steno Diabetes Center A/S	Gentofte	Denmark
Christiana Ruhrberg	University College London	London	UK
Alan Stitt	Queen's University Belfast	Belfast	UK
Paul Thornalley	University of Warwick	Coventry	UK
Karl Tryggvason	Karolinska Institut & Duke-NUS	Stockholm & Singapore	Sweden & Singapore
Antonio Vidal-Puig	University of Cambridge	Cambridge	UK
Kenneth Walsh	Boston University School of Medicine	Boston	USA
Christian Weber	Ludwig-Maximilians-University	Munich	Germany

Program

08.00 - 08.50	Registration
08.50	Welcome Stephan Herzig
09.00 - 12.30	Session I: Emerging molecular concepts in diabetic vascular dysfunction
09.00	Neuropilin signaling in vascular eye pathology Christiana Ruhrberg
09.30	Innate immune responses and Diabetic Retinopathy Alan Stitt
10.00	Metabolic regulation of endothelial growth and quiescence Michael Potente
10.30	Coffee break
11.00	Diabetic nephropathy susceptibility genes Karl Tryggvason
11.30	New treatment options in diabetic nephropathy Peter Rossing
12.00 - 12.30	Poster Talks I
12.00	Cation channels of the TRPC family contribute to development of nephropathy and retinopathy in the STZ model Dagmar Schumacher
12.10	Hyperglycemic memory - Mechanisms relevant to the diabetic retina Patrick Friedrichs
12.20	Anks6^(p.R823W) overexpression in kidney affects retinal degeneration Jihong Lin
12.30 - 14.30	Lunch break and poster session Posters are displayed in Foyer
14.30 - 18.00	Session II: Stress signaling pathways in diabetic complications
14.30	Alarming news and views of extracellular RNA in inflammation and vascular remodeling Klaus T. Preissner
15.00	Novel antifibrotic treatment strategy using peripheral CB1 receptor inhibitors with secondary targets Georg Kunos
15.30	Dicarbonyl stress and glyoxalase 1 in the development of vascular complications of diabetes Paul Thornalley
16.00	Coffee break
16.30	Glyoxalase system in clinically relevant metabolic stresses in diabetes: hyperglycemia, high glucose variability, lipotoxicity and uremia Katerina Kankova
17.00	Adipokine links between metabolic and cardiovascular disease Kenneth Walsh
17.30 - 18.00	Poster Talks II
17.30	Age-related carbonylation in glomeruli of diabetic mice influences anti-oxidative defense mechanisms Tanja Wiedenmann
17.40	Microvascular reactivity relates to the skin autofluorescence but not to soluble receptor for advanced glycation endproducts in patients with diabetes Jan Škrha jr.
17.50	Post-glucose load plasma α-dicarbonyl concentrations are increased in individuals with impaired glucose metabolism and type 2 diabetes: The CODAM study Dionne Maessen

08.00 - 08.50	Registration
09.00 - 12.30	Session III: Beyond complications
09.00	Diabetic nephropathy – genes or the environment? Per-Henrik Groop
09.30	Brown adipose tissue - of mice and men Sven Enerbäck
10.00	Adipose tissue expandibility, lipotoxicity and the metabolic syndrome Antonio Vidal-Puig
10.30	Coffee break
11.00	Novel targets for vascular protection Christian Weber
11.30	NMDA-receptors - novel drug targets for diabetes treatment Eckhard Lammert
12.00 - 12.30	Poster Talks III
12.00	Hypoxia plays a key role in the accumulation of carbonyl stress in obese adipose tissue Katrien Gaens
12.10	The association between dietary intake of advanced glycation endproducts and plasma levels of advanced glycation endproducts: THE CODAM STUDY Jean Scheijen
12.20	Advanced glycation end-products as long-term retrospective indicators of glycemic balance in children with non-complicated type 1 diabetes mellitus Stéphane Jaisson
12.30	Concluding remarks Peter Nawroth
12.40 - 14.30	Lunch break and poster session Posters are displayed in Foyer
14.30 - 16.00	EASD Study Group Talks
14.30	Skin AGEs and skin fluorescence in the progression of micro- and macrovascular complications in Type 1 diabetes: The plot thickens Vincent Monnier
14.50	Methylglyoxal modification of low density lipoprotein – a novel route to the pro-atherogenic, small dense LDL with increased arterial proteoglycan binding and aortal retention Naila Rabbani
15.10	Over-expression of the AGE receptor (AGE-R1) during high age feeding results in hepatic fibrosis and exacerbates glucose intolerance Josephine Forbes
15.30	Centrally obese women present low sRAGE but unaltered SSAO/sVAP-1 levels regardless of presence/absence of additional cardiometabolic risk factors Katerina Šebeková
16.00 - 16.30	Coffee break
16.30 - 17.30	EASD Business Meeting