Kliniken &… HiDC 2017 HiDC 2016

3rd Heidelberg International Symposium on Diabetic Complications

06. - 08.10.2016

The conference will highlight recent exciting developments in key areas of diabetic (long-term) complications, covering a wide range from vascular biology and neuropathology to epigenetics and clinical studies.
We envision contributions allowing the audience to gain an overview of the recent exciting progress on these fundamental topics.

Francesco Beguinot University of Naples Naples Italy
Neil Docherty University College Dublin Dublin Ireland
Phillipe Froguel Imperial College London University/
Lille University
London /Lille UK / France
Anthony Heagerty University of Manchester Manchester UK
Stephan Herzig Helmholtz Zentrum München, Institute for Diabetes and Cancer Munich Germany
Martin Hrabe de Angelis Helmholtz Zentrum München Munich/Neuherberg Germany
Berend Isermann Otto-von-Guericke-University Magdeburg Magdeburg Germany
Rohit N Kulkarni Harvard Medical School Boston USA
George Kunos National Institutes of Health (NIH) - NIAAA Bethesda USA
Tony Lam Toronto General Research Institute and Department of Medicine Toronto Canada
Susanne Mandrup University of Southern Denmark Odense Denmark
Alexander Pfeifer University of Bonn Bonn Germany
Michael Potente Max Planck Institute for Heart and Lung Research Bad Nauheim Germany
Matthew Poy Max-Delbrück-Center for Molecular Medicine (MDC) Berlin Germany
Michael Ristow ETH Zurich Zurich Switzerland
Alan Saltiel University of California La Jolla USA
Aurelio Teleman German Cancer Research Center (DKFZ) Heidelberg Germany
Frederic Tessier Lille 2 University Lille France
Paul Thornalley University of Warwick Coventry UK
Emmanuel van Obberghen University of Nice Nice France
Erwin Wagner CNIO - Centro Nacional de Investigaciones Oncologicas Madrid Spain
Siu Ling Wong Harvard Medical School Boston USA
Giles Yeo University of Cambridge Cambridge UK

Thursday, October 6

08.00 - 08.50 Registration
08.50 Welcome
Stephan Herzig, Helmholtz Zentrum München, Institute for Diabetes and Cancer, Munich
09.00 - 12.30 Session I: Novel concepts derived from clinical studies
09.00 Essential role of peripheral cannabinoid-1 receptors in type-2 diabetes and diabetic nephropathy
George Kunos, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda

Prenatal environment and diabetes: possible role of microRNAs
Emmanuel Van Obberghen, Department of Medical Research IRCAN Medical School, Nice

10.00 Inflammatory links between obesity and diabetes
Alan Saltiel, UC San Diego Institute for Diabetes and Metabolic Health (IDMH), La Jolla
10.30 Coffee break
11.00 Using iPS cells to interrogate diabetes complications
Rohit N Kulkarni, Joslin Diabetes Center- Harvard Medical School, Boston
11.30 Targeting BAT as a new approach to tackle diabetes
Alexander Pfeifer, University of  Bonn, Bonn
12.00 - 12.30 Short Talks I
12.00 Reduced glyoxalase 1 activity in carotid artery plaques of non-diabetic patients with increased HbA1c
Andreas Peters, University of Heidelberg, Heidelberg
12.15 Impact of the glyoxalase system on organ development and function under diabetic conditions in zebrafish
Elisabeth Lodd, Medical Faculty Mannheim, Heidelberg University, Mannheim
12.30 - 14.30 Lunch break and poster session
Posters are displayed in Foyer
14.30 - 18.00 Session II: Genetics and Epigenetics of diabetic complications
14.30 Genetic susceptibility to diabetes
Philippe Froguel, Imperial College London, London/ Lille University, Lille
15.00 New Genetic and Epigenetic insights into Metabolism and Diabetes
Martin Hrabe de Angelis, Helmholtz Zentrum München, Institute of Experimental Genetics, Munich/ Neuherberg
15.30 Genetics of obesity: Can an old dog teach us new tricks?
Giles Yeo, University of Cambridge, Cambridge
16.00 Coffee break
16.30 Transcriptional networks regulation adipocyte differentiation and function
Susanne Mandrup, University of Southern Denmark, Odense
17.00 The regulatory role of Argonaute2 in glucose and lipid metabolism
Matthew Poy, Max Delbrueck Center for Molecular Medicine, Berlin
17.30 - 18.00 Short Talks II  
17.30 Transforming Growth Factor Beta-like stimulated clone 22 D4 promotes diabetic hyperglycemia and insulin resistance
Bilgen E. Uestuenel, Heidelberg – IDC Translational Diabetes Program, Heidelberg University Hospital, Heidelberg
17.45 Crosstalk of fatty liver with renal sinus fat impairs renal function and glomerular cell integrity
Erwin Schleicher, University of Tuebingen, Tuebingen
18.00 End of Session  


Friday, October 7

08.00 - 08.50 Registration
09.00 - 12.30 Session III: Emerging concepts in vascular dysfunction
09.00 Regulation of endothelial quiescence by metabolites
Michael Potente, Max Planck Institute for Heart and Lung Research, Bad Nauheim
09.30 Delayed wound healing in diabetes: The impact of NETs
Siu Ling Wong, Harvard Medical School, Boston
10.00 Perivascular Adipose Tissue and Arterial Function in Health and Obesity
Anthony Heagerty, University of Manchester , Manchester
10.30 Coffee break
11.00 Metabolic Stress in the Control of Healthspan
Michael Ristow, ETH Zurich, Zurich
11.30 Proteostasis in diabetic nephropathy
Berend Isermann, Otto-von-Guericke-University Magdeburg, Magdeburg
12.00 - 12.30 Short Talks III
12.00 Vascular complications associated with gestational diabetic mothers and their newborn
Halime Kenar, Kocaeli University, Kocaeli
12.15 Oxidative stress and biochemical markers of vascular disease in Type 1 diabetes mellitus
Jan Skrha, Charles University, Prague
12.30 - 14.30 Lunch break and poster session
Posters are displayed in Foyer
14.30 - 16.00 Session IV: Organ-Metabolism Crosstalk
14.30 Impaired methylglyoxal detoxification recapitulates progression of Type 2 Diabetes
Aurelio Teleman, German Cancer Research Center (DKFZ), Heidelberg
15.00 Brain-Liver Axis
Tony Lam, Toronto General Research Institute (TGRI), Toronto
15.30 Inflammation and metabolic dysfunction
Erwin Wagner, Spanish National Cancer Research Center, Madrid
16.00 End of Sessions
16.00 – 16.30 Coffee break
16.30 – 17.00 EASD Business Meeting


Saturday, October 8

08.00 - 08.50 Registration
09.00 - 12.30 Session V: EASD
09.00 Glyoxalase 1 inducers - a new treatment for diabetic complications?
Paul Thornalley,  University of Warwick, Coventry
09.30 The liver as a regulator of diabetic complications
Stephan Herzig, Helmholtz Zentrum München, Institute for Diabetes and Cancer, Munich
10.00 Effect of Gastric Bypass Surgery on Experimental Diabetic Kidney Disease
Neil Docherty, University College Dublin, Dublin
10.30 - 11.00 Short  Talk  EASD
  Dicarbonyl stress in periodontitis – the fifth complication of diabetes
Naila Rabbani, University of Warwick, Coventry

10.45 - 11.00

Coffee break
10.30 - 11.30 Poster Session EASD
Posters are displayed in Foyer
11.30 AGEs, can we eat diabetes?
Frederic Tessier, Lille 2 University, Lille
12.00 Does Epigenetics account for Diabetes (and Comorbidity) Risk?
Francesco Beguinot, Federico II University of  Naples, Naples
12.30 - 13.30 Farewell


Uniklinikum Heidelberg
Prof. Nawroth

Institute for Diabetes and Cancer IDC Munich
Prof. Herzig

Uniklinikum Mannheim
Prof. Hammes

University of Warwick
Prof. Thornalley

CRC 1118 - Reactive metabolites as a cause of diabetic complications

the graduate school DIAMICOM

Department of Internal Medicine (Krehl Clinic)
Lecture hall
Heidelberg University Hospital
Im Neuenheimer Feld 410
69120 Heidelberg