Kliniken &… HiDC 2017 HiDC 2015

2nd Heidelberg International Symposium on Diabetic Complications

16. - 17.10.2015

The conference will highlight recent exciting developments in key areas of vascular biology and diabetes, including current progress in vascular-metabolic aspects and clinical perspectives in the treatment of diabetes and its long-term complications. We envision contributions allowing the audience to gain an overview of the recent progress on these fundamental topics in biomedicine.

Sven Enerbäck University of Gothenburg Gothenburg Sweden
Per-Henrik Groop Helsinki University Helsinki Finland
Katerina Kankova Masaryk University Brno Czech Republic
Georg Kunos National Institutes of Health (NIH) - NIAAA Rockville USA
Eckhard Lammert Heinrich-Heine-Universität Dusseldorf Germany
Michael Potente Max Planck Institute for Heart and Lung Research Bad Nauheim Germany
Klaus Preissner Justus-Liebig-University Giessen Germany
Peter Rossing Aarhus University/ Steno Diabetes Center A/S Gentofte Denmark
Christiana Ruhrberg University College London London UK
Alan Stitt Queen's University Belfast Belfast UK
Paul Thornalley

University of Warwick

Coventry UK
Karl Tryggvason Karolinska Institut & Duke-NUS Stockholm & Singapore Sweden & Singapore
Antonio Vidal-Puig University of Cambridge Cambridge UK
Kenneth Walsh Boston University School of Medicine Boston USA
Christian Weber Ludwig-Maximilians-University Munich Germany

Friday, October 16

08.00 - 08.50 Registration
08.50 Welcome
Stephan Herzig
09.00 - 12.30 Session I: Emerging molecular concepts in diabetic vascular dysfunction
09.00 Neuropilin signaling in vascular eye pathology
Christiana Ruhrberg
09.30 Innate immune responses and Diabetic Retinopathy
Alan Stitt
10.00 Metabolic regulation of endothelial growth and quiescence
Michael Potente
10.30 Coffee break
11.00 Diabetic nephropathy susceptibility genes
Karl Tryggvason
11.30 New treatment options in diabetic nephropathy
Peter Rossing
12.00 - 12.30 Poster Talks I
12.00 Cation channels of the TRPC family contribute to development of nephropathy and retinopathy in the STZ model
Dagmar Schumacher
12.10 Hyperglycemic memory - Mechanisms relevant to the diabetic retina
Patrick Friedrichs
12.20 Anks6(p.R823W)  overexpression in kidney affects retinal degeneration
Jihong Lin
12.30 - 14.30 Lunch break and poster session
Posters are displayed in Foyer
14.30 - 18.00 Session II: Stress signaling pathways in diabetic complications
14.30 Alarming news and views of extracellular RNA in inflammation and vascular remodeling
Klaus T. Preissner
15.00 Novel antifibrotic treatment strategy using peripheral CB1 receptor inhibitors with secondary targets
Georg Kunos
15.30 Dicarbonyl stress and glyoxalase 1 in the development of vascular complications of diabetes
Paul Thornalley
16.00 Coffee break
16.30 Glyoxalase system in clinically relevant metabolic stresses in diabetes: hyperglycemia, high glucose variability, lipotoxicity and uremia
Katerina Kankova
17.00 Adipokine links between metabolic and cardiovascular disease
Kenneth Walsh
17.30 - 18.00 Poster Talks II  
17.30 Age-related carbonylation in glomeruli of diabetic mice influences anti-oxidative defense mechanisms
Tanja Wiedenmann
17.40 Microvascular reactivity relates to the skin autofluorescence but not to soluble receptor for advanced glycation endproducts in patients with diabetes
Jan Škrha jr.
17.50 Post-glucose load plasma α-dicarbonyl concentrations are increased in individuals with impaired glucose metabolism and type 2 diabetes: The CODAM study
Dionne Maessen


Saturday, October 17

08.00 - 08.50 Registration
09.00 - 12.30 Session III: Beyond complications
09.00 Diabetic nephropathy – genes or the environment?
Per-Henrik Groop
09.30 Brown adipose tissue - of mice and men
Sven Enerbäck
10.00 Adipose tissue expandibility, lipotoxicity and the metabolic syndrome 
Antonio Vidal-Puig
10.30 Coffee break
11.00 Novel targets for vascular protection
Christian Weber
11.30 NMDA-receptors - novel drug targets for diabetes treatment
Eckhard Lammert
12.00 - 12.30 Poster Talks III
12.00 Hypoxia plays a key role in the accumulation of carbonyl stress in obese adipose tissue
Katrien Gaens
12.10 The association between dietary intake of advanced glycation endproducts and plasma levels of advanced glycation endproducts: THE CODAM STUDY
Jean Scheijen
12.20 Advanced glycation end-products as long-term retrospective indicators of glycemic balance in children with non-complicated type 1 diabetes mellitus
Stéphane Jaisson
12.30 Concluding remarks
Peter Nawroth
12.40 - 14.30 Lunch break and poster session
Posters are displayed in Foyer
14.30 - 16.00 EASD Study Group Talks
14.30 Skin AGEs and skin fluorescence in the progression of micro- and macrovascular complications in Type 1 diabetes: The plot thickens
Vincent Monnier
14.50 Methylglyoxal modification of low density lipoprotein – a novel route to the pro-atherogenic, small dense LDL with increased arterial proteoglycan binding and aortal retention
Naila Rabbani
15.10 Over-expression of the AGE receptor (AGE-R1) during high age feeding results in hepatic fibrosis and exacerbates glucose intolerance
Josephine Forbes
15.30 Centrally obese women present low sRAGE but unaltered SSAO/sVAP-1 levels regardless of presence/absence of additional cardiometabolic risk factors
Katerina Šebeková
16.00 - 16.30 Coffee break
16.30 - 17.30 EASD Business Meeting


Uniklinikum Heidelberg
Prof. Nawroth

Institute for Diabetes and Cancer IDC Munich
Prof. Herzig

Uniklinikum Mannheim
Prof. Hammes

University of Warwick
Prof. Thornalley

CRC 1118 - Reactive metabolites as a cause of diabetic complications

the graduate school DIAMICOM

Department of Internal Medicine (Krehl Clinic)
Lecture hall
Heidelberg University Hospital
Im Neuenheimer Feld 410
69120 Heidelberg