Eulat Eradicate GBC

Cada año, son demasiadas personas las que reciben un diagnóstico de cáncer de vesícula biliar. El proyecto EULAT Eradicate GBC tiene como objetivo mejorar la prevención, la detección precoz y el tratamiento de esta enfermedad. Investigadores de Alemania, Argentina, Bolivia, Chile, Francia, Perú, Noruega y Reino Unido trabajamos juntos en este proyecto para identificar factores de riesgo y biomarcadores que permitan mejorar la prevención y el tratamiento del cáncer de vesícula biliar.

Too many people are diagnosed with gallbladder cancer each year. The research project EULAT Eradicate GBC  aims to improve the prevention, early detection and treatment of this aggressive disease. Researchers from Argentina, Bolivia, Chile, France, Germany, Peru, Norway and UK collaborate in this project to identify risk factors and biomarkers that translate into a better prevention and treatment.

Gallbladder cancer (GBC) is a neglected disease with huge potential for prevention. This project aims at significantly improving the accuracy of risk estimation and early detection of GBC by identifying and adequately considering geographical, environmental, lifestyle, ethnic, gender and molecular differences. We plan to generate the information needed to establish and refine current prevention programmes, including the primary, secondary and tertiary prevention of GBC. We will (1) build a unique European–Latin American GBC biorepository integrated into a tailored IT platform, (2) identify, validate and functionally characterize novel GBC biomarkers, (3) develop a multifactorial risk score that integrates established and newly identified epidemiological and molecular risk factors, (4) improve the understanding of the causal mechanisms that link lifestyle, cultural and behavioural factors to GBC development, (5) unravel novel opportunities for the targeted therapy of incidental GBC, (6) exploit existing and newly generated epidemiological and multi-omics data to improve the accuracy of GBC risk prediction and (7) contribute to the training of the next generation of Latin American researchers in precision medicine for GBC. The generated information will permit identification of individuals at high GBC risk, guiding surveillance and individual decisions on the possible benefit of preventive gallbladder removal in regions of low and high GBC incidence. Novel data on genomic alterations in incidental GBC will pave the way towards implementation of future clinical trials. The planned European–Latin American GBC biorepository and IT platform will constitute a prime resource for translational research on individualized prevention, personalized early detection and targeted therapy of GBC. The participation in our project of representatives of health authorities, patients and the industry guarantees the efficient incorporation of project results into national health policies.

Funding

This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 825741

Kontakt

Project Coordinator
Prof. Justo Lorenzo Bermejo
+49 6221 56 4180

Project Management Latin America
Carol Barahona Ponce
+49 6221 56 7616

Project Management Europe
Dominique Scherer
+49 6221 56 7302

EULAT_Eradicate_GBC@imbi.uni-heidelberg.de