Kliniken & Institute ... Kliniken Zentrum für Innere... Innere Medizin III:... Research Grundlagenforschung ... Molecular Genetics... Publications


Haas J, Mester S, Lai A, Frese KS, Sedaghat-Hamedani F, Kayvanpour E, Rausch T, Nietsch R, Boeckel JN, Carstensen A, Völkers M, Dietrich C, Pils D, Amr A, Holzer DB, Martins Bordalo D, Oehler D, Weis T, Mereles D, Buss S, Riechert E, Wirsz E, Wuerstle M, Korbel JO, Keller A, Katus HA, Posch AE, Meder B. Genomic structural variations lead to dysregulation of important coding and non-coding RNA species in dilated cardiomyopathy.


EMBO Mol Med. 2017 Nov 14. pii: e201707838.


Sedaghat-Hamedani F, Haas J, Zhu F, Geier C, Kayvanpour E, Liss M, Lai A, Frese K, Pribe-Wolferts R, Amr A, Li DT, Samani OS, Carstensen A, Bordalo DM, Müller M, Fischer C, Shao J, Wang J, Nie M, Yuan L, Haßfeld S, Schwartz C, Zhou M, Zhou Z, Shu Y, Wang M, Huang K, Zeng Q, Cheng L, Fehlmann T, Ehlermann P, Keller A, Dieterich C, Streckfuß-Bömeke K, Liao Y, Gotthardt M, Katus HA, Meder B. Clinical genetics and outcome of left ventricular non-compaction cardiomyopathy.

Eur Heart J. 2017 Oct 6. doi: 10.1093/eurheartj/ehx545.


Meder B, Haas J, Sedaghat-Hamedani F, Kayvanpour E, Frese K, Lai A, Nietsch R, Scheiner C, Mester S, Martins Bordalo D, Amr A, Dietrich C, Pils D, Siede D, Hund H, Bauer AS, Holzer DB, Ruhparwar A, Mueller-Hennessen M, Weichenhan D, Plass C, Weis TM, Backs J, Wuerstle ML, Keller A, Katus HA, Posch AE. Epigenome-Wide Association Study Identifies Cardiac Gene Patterning and A Novel Class of Biomarkers for Heart Failure.

Circulation. 2017 Aug 24. doi: 10.1161/CIRCULATIONAHA.117.027355.


Fehlmann T, Backes C, Kahraman M, Haas J, Ludwig N, Posch AE, Würstle ML, Hübenthal M, Franke A, Meder B, Meese E, Keller A. Web-based NGS data analysis using miRMaster: a large-scale meta-analysis of human miRNAs.

Nucleic Acids Res. 2017 Sep 6;45(15):8731-8744. doi: 10.1093/nar/gkx595.


Heinig M, Adriaens ME, Schafer S, van Deutekom HWM, Lodder EM, Ware JS, Schneider V, Felkin LE, Creemers EE, Meder B, Katus HA, Rühle F, Stoll M, Cambien F, Villard E, Charron P, Varro A, Bishopric NH, George AL Jr, Dos Remedios C, Moreno-Moral A, Pesce F, Bauerfeind A, Rüschendorf F, Rintisch C, Petretto E, Barton PJ, Cook SA, Pinto YM, Bezzina CR, Hubner N. Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy.

Genome Biol. 2017 Sep 14;18(1):170. doi: 10.1186/s13059-017-1286-z.


Sedaghat-Hamedani F, Kayvanpour E, Tugrul OF, Lai A, Amr A, Haas J, Proctor T, Ehlermann P, Jensen K, Katus HA, Meder B. Clinical outcomes associated with sarcomere mutations in hypertrophic cardiomyopathy: a meta-analysis on 7675 individuals.

Clin Res Cardiol. 2017 Aug 24. doi: 10.1007/s00392-017-1155-5.


Keller A, Kreis S, Leidinger P, Maixner F, Ludwig N, Backes C, Galata V, Guerriero G, Fehlmann T, Franke A, Meder B, Zink A, Meese E. miRNAs in ancient tissue specimens of the Tyrolean Iceman.

Mol Biol Evol. 2016 Dec 26. pii: msw291. doi: 10.1093/molbev/msw291. [Epub ahead of print]


Abu-Taha IH, Heijman J, Hippe HJ, Wolf NM, El-Armouche A, Nikolaev VO, Schäfer M, Würtz C, Neef S, Voigt N, Baczkó I, Varró A, Müller M, Meder B, Katus HA, Spiger K, Vettel C, Lehmann LH, Backs J, Skolnik EY, Lutz S, Dobrev D, Wieland T. Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure.

Circulation. 2016 Dec 7. pii: CIRCULATIONAHA.116.022852. [Epub ahead of print]


Gomes B, Geis NA, Chorianopoulos E, Meder B, Leuschner F, Katus HA, Bekeredjian R. Improvements of Procedural Results With a New-Generation Self-Expanding Transfemoral Aortic Valve Prosthesis in Comparison to the Old-Generation Device.

J Interv Cardiol. 2016 Nov 24. doi: 10.1111/joic.12356. [Epub ahead of print]


Jarr KU, Leuschner F, Meder B, Katus HA, Bekeredjian R, Chorianopoulos E. Initial Single-Center Experience With the Fully Repositionable Transfemoral Lotus Aortic Valve System.

J Invasive Cardiol. 2017 Jan;29(1):30-35.


Beqqali A, Bollen IA, Rasmussen TB, van den Hoogenhof MM, van Deutekom HW, Schafer S, Haas J, Meder B, Sørensen KE, van Oort RJ, Mogensen J, Hubner N, Creemers EE, van der Velden J, Pinto YM. A mutation in the glutamate-rich region of RNA-binding motif protein 20 causes dilated cardiomyopathy through missplicing of titin and impaired Frank-Starling mechanism.

Cardiovasc Res. 2016 Oct;112(1):452-63. doi: 10.1093/cvr/cvw192.


Hecksteden A, Leidinger P, Backes C, Rheinheimer S, Pfeiffer M, Ferrauti A, Kellmann M, Sedaghat F, Meder B, Meese E, Meyer T, Keller A. miRNAs and sports: tracking training status and potentially confounding diagnoses.

J Transl Med. 2016 Jul 26;14(1):219. doi: 10.1186/s12967-016-0974-x.


Riffel JH, Keller MG, Rost F, Arenja N, Andre F, Aus dem Siepen F, Fritz T, Ehlermann P, Taeger T, Frankenstein L, Meder B, Katus HA, Buss SJ. Left ventricular long axis strain: a new prognosticator in non-ischemic dilated cardiomyopathy?

J Cardiovasc Magn Reson. 2016 Jun 7;18(1):36. doi: 10.1186/s12968-016-0255-0.


Neumann D, Mansi T, Itu L, Georgescu B, Kayvanpour E, Sedaghat-Hamedani F, Amr A, Haas J, Katus H, Meder B, Steidl S, Hornegger J, Comaniciu D. A self-taught artificial agent for multi-physics computational model personalization.

Med Image Anal. 2016 Dec;34:52-64. doi: 10.1016/j.media.2016.04.003.


Eden M, Meder B, Völkers M, Poomvanicha M, Domes K, Branchereau M, Marck P, Will R, Bernt A, Rangrez A, Busch M; German Mouse Clinic Consortium., Hrabě de Angelis M, Heymes C, Rottbauer W, Most P, Hofmann F, Frey N. Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.

Nat Commun. 2016 Apr 28;7:11317. doi: 15.13155/ncomms11317.


Hamberg M, Backes C, Fehlmann T, Hart M, Meder B, Meese E, Keller A. MiRTargetLink--miRNAs, Genes and Interaction Networks.

Int J Mol Sci. 2016 Apr 14;17(4):564. doi: 10.3390/ijms17040564.


Scheid LM, Mosqueira M, Hein S, Kossack M, Juergensen L, Mueller M, Meder B, Fink RH, Katus HA, Hassel D. Essential light chain S195 phosphorylation is required for cardiac adaptation under physical stress.

Cardiovasc Res. 2016 Jul 1;111(1):44-55. doi: 10.1093/cvr/cvw066.


Ludwig N, Leidinger P, Becker K, Backes C, Fehlmann T, Pallasch C, Rheinheimer S, Meder B, Stähler C, Meese E, Keller A. Distribution of miRNA expression across human tissues.

Nucleic Acids Res. 2016 May 5;44(8):3865-77. doi: 10.1093/nar/gkw116.


Schwarz EC, Backes C, Knörck A, Ludwig N, Leidinger P, Hoxha C, Schwär G, Grossmann T, Müller SC, Hart M, Haas J, Galata V, Müller I, Fehlmann T, Eichler H, Franke A, Meder B, Meese E, Hoth M, Keller A. Deep characterization of blood cell miRNomes by NGS.

Cell Mol Life Sci. 2016 Aug;73(16):3169-81. doi: 10.1007/s00018-016-2154-9.


Amr A, Kayvanpour E, Sedaghat-Hamedani F, Passerini T, Mihalef V, Lai A, Neumann D, Georgescu B, Buss S, Mereles D, Zitron E, Posch AE, Würstle M, Mansi T, Katus HA, Meder B. Personalized Computer Simulation of Diastolic Function in Heart Failure.

Genomics Proteomics Bioinformatics. 2016 Aug;14(4):244-52. doi: 10.1016/j.gpb.2016.04.006.


Nietsch R, Haas J, Lai A, Oehler D, Mester S, Frese KS, Sedaghat-Hamedani F, Kayvanpour E, Keller A, Meder B. The Role of Quality Control in Targeted Next-generation Sequencing Library Preparation. Genomics Proteomics Bioinformatics. 2016 Aug;14(4):200-6. doi: 10.1016/j.gpb.2016.04.007.


Gast M, Schroen B, Voigt A, Haas J, Kuehl U, Lassner D, Skurk C, Escher F, Wang X, Kratzer A, Michalik K, Papageorgiou A, Peters T, Loebel M, Wilk S, Althof N, Prasanth KV, Katus H, Meder B, Nakagawa S, Scheibenbogen C, Schultheiss HP, Landmesser U, Dimmeler S, Heymans S, Poller W. Long noncoding RNA MALAT1-derived mascRNA is involved in cardiovascular innate immunity.

J Mol Cell Biol. 2016 Jan 27. pii: mjw003.


Sedaghat-Hamedani F, Kayvanpour E, Frankenstein L, Mereles D, Amr A, Buss S, Keller A, Giannitsis E, Jensen K, Katus HA, Meder B. Biomarker Changes after Strenuous Exercise Can Mimic Pulmonary Embolism and Cardiac Injury-A Metaanalysis of 45 Studies.

Clin Chem. 2015 Aug 3. pii: clinchem.2015.240796. [Epub ahead of print] Review.


Kayvanpour E, Katus HA, Meder B. Determined to Fail-the Role of Genetic Mechanisms in Heart Failure.

Curr Heart Fail Rep. 2015 Aug 2. [Epub ahead of print]


Schuol S, Schickhardt C, Wiemann S, Bartram CR, Tanner K, Eils R, Meder B, Richter D, Glimm H, von Kalle C, Winkler EC. So rare we need to hunt for them: reframing the ethical debate on incidental findings.

Genome Med. 2015 Jul 30;7(1):83. doi: 10.1186/s13073-015-0198-3. eCollection 2015.


Backes C, Leidinger P, Altmann G, Würstle M, Meder B, Galata V, Müller SC, Sickert D, Stähler C, Meese E, Keller A. The influence of Next-Generation Sequencing and storage conditions on miRNA patterns generated from PAXgene blood.

Anal Chem. 2015 Jul 24. [Epub ahead of print]


Backes C, Haas J, Leidinger P, Frese K, Großmann T, Ruprecht K, Meder B, Meese E, Keller A. miFRame: analysis and visualization of miRNA sequencing data in neurological disorders.

J Transl Med. 2015 Jul 14;13:224. doi: 10.1186/s12967-015-0594-x.


Mueller SC, Backes C, Kalinina OV, Meder B, Stöckel D, Lenhof HP, Meese E, Keller A. BALL-SNP: combining genetic and structural information to identify candidate non-synonymous single nucleotide polymorphisms.

Genome Med. 2015 Jul 1;7(1):65. doi: 10.1186/s13073-015-0190-y. eCollection 2015.


Kayvanpour E, Mansi T, Sedaghat-Hamedani F, Amr A, Neumann D, Georgescu B, Seegerer P, Kamen A, Haas J, Frese KS, Irawati M, Wirsz E, King V, Buss S, Mereles D, Zitron E, Keller A6, Katus HA, Comaniciu D, Meder B. Towards Personalized Cardiology: Multi-Scale Modeling of the Failing Heart.

PLoS One. 2015 Jul 31;10(7):e0134869. doi: 10.1371/journal.pone.0134869.


Karen S. Frese*, Benjamin Meder*, Andreas Keller, Steffen Just, Jan Haas, Britta Vogel, Simon Fischer, Christina Backes, Mark Matzas, Doreen Köhler,Vladimir Benes, Hugo A. Katus, Wolfgang Rottbauer. RNA splicing regulated by RBFOX1 is essential for cardiac function in zebrafish.

J Cell Sci 2015 (contributed equally)


Mogensen J, van Tintelen JP, Fokstuen S, Elliott P, van Langen IM, Meder B, Richard P, Syrris P, Caforio AL, Adler Y, Anastasakis A, Gimeno JR, Klingel K, Linhart A, Imazio M, Pinto Y, Newbery-Ecob R, Schmidtke J, Charron P. The current role of next-generation DNA sequencing in routine care of patients with hereditary cardiovascular conditions: a viewpoint paper of the European Society of Cardiology working group on myocardial and pericardial diseases and members of the European Society of Human Genetics.

Eur Heart J. 2015 Apr 5. pii: ehv122.


Sophie Garnier, Christian Hengstenberg, Nicolas Lamblin, Olivier Dubourg, Pascal De Groote e, Laurent Fauchier, Jean-Noël Trochu, Eloisa Arbustini, Ulrike Esslinger, Paul J. Barton, Benjamin Meder, Hugo Katus, Karen Frese, Michel Komajda, Stuart A. Cook, Richard Isnard, Laurence Tiret, Eric Villard, Philippe Charron. Involvement of BAG3 and HSPB7 loci in various etiologies of systolic heart failure: Results of a European collaboration assembling more than 2000 patients.

International Journal of Cardiology 189 (2015) 105–107


Kappel A, Backes C, Huang Y, Zafari S, Leidinger P, Meder B, Schwarz H, Gumbrecht W, Meese E, Stähler C, Keller A. MicroRNA In Vitro Diagnostics by Use of Immunoassay Analyzers.

Clin Chem. 2015 Jan 23. pii: clinchem.2014.232165. [Epub ahead of print]


Backes C, Harz C, Fischer U, Schmitt J, Ludwig N, Petersen B, Mueller SC, Kim Y, Wolf NM, Katus HA, Meder B, Furtwängler R, Franke A, Bohle R, Henn W, Graf N, Keller A, Meese E. New insights into the genetics of glioblastoma multiforme by familial exome sequencing.

Oncotarget. 2014 Dec 10. [Epub ahead of print]


Haas J, Barb I, Katus HA, Meder B. Targeted next-generation sequencing: the clinician’s stethoscope for genetic disorders.

Personalized Medicine, Vol. 11, No. 6, Pages 581-592.


Neumann D, Mansi T, Georgescu B, Kamen A, Kayvanpour E, Amr A, Sedaghat-Hamedani F, Haas J, Katus H, Meder B, Hornegger J, Comaniciu D. Robust image-based estimation of cardiac tissue parameters and their uncertainty from noisy data.

Med Image Comput Comput Assist Interv. 2014;17(Pt 2):9-16.


Keller A, Leidinger P, Vogel B, Backes C, ElSharawy A, Galata V, Müller SC, Marquart S, Schrauder MG, Strick R, Bauer A, Wischhusen J, Beier M, Kohlhaas J, Katus HA, Hoheisel J, Franke A, Meder B, Meese E. miRNAs can be generally associated with human pathologies as exemplified for miR-144*

BMC Med. 2014 Dec 3;12(1):224. [Epub ahead of print]


Li J, Franke J, Pribe-Wolferts R, Meder B, Ehlermann P, Mereles D, Andre F, Abdelrazek MA, Merten C, Schweizer PA, Becker R, Katus HA, Thomas D. Effects of β-blocker therapy on electrocardiographic and echocardiographic characteristics of left ventricular noncompaction.

Clin Res Cardiol. 2014 Oct 21.


Buss SJ, Breuninger K, Lehrke S, Voss A, Galuschky C, Lossnitzer D, Andre F, Ehlermann P, Franke J, Taeger T, Frankenstein L, Steen H, Meder B, Giannitsis E, Katus HA, Korosoglou G. Assessment of myocardial deformation with cardiac magnetic resonance strain imaging improves risk stratification in patients with dilated cardiomyopathy.

Eur Heart J Cardiovasc Imaging. 2014 Sep 21.


Schweizer PA, Schröter J, Greiner S, Haas J, Yampolsky P, Mereles D, Buss SJ, Seyler C, Bruehl C, Draguhn A, Koenen M, Meder B, Katus HA, Thomas D. The Symptom Complex of Familial Sinus Node Dysfunction and Myocardial Noncompaction Is Associated With Mutations in the HCN4 Channel.

J Am Coll Cardiol. 2014 Aug 26;64(8):757-67. doi: 10.1016/j.jacc.2014.06.1155.


Backes C, Rühle F, Stoll M, Haas J, Frese K, Franke A, Lieb W, Wichmann HE, Weis T, Kloos W, Lenhof HP, Meese E, Katus H, Meder B, Keller A. Systematic permutation testing in GWAS pathway analyses: identification of genetic networks in dilated cardiomyopathy and ulcerative colitis.

BMC Genomics. 2014 Jul 22;15(1):622. [Epub ahead of print]


Haas J, Frese KS, Peil B, Kloos W, Keller A, Nietsch R, Feng Z, Müller S, Kayvanpour E, Vogel B, Sedaghat-Hamedani F, Lim WK, Zhao X, Fradkin D, Köhler D, Fischer S, Franke J, Marquart S, Barb I, Li DT, Amr A, Ehlermann P, Mereles D, Weis T, Hassel S, Kremer A, King V, Wirsz E, Isnard R, Komajda M, Serio A, Grasso M, Syrris P, Wicks E, Plagnol V, Lopes L, Gadgaard T, Eiskjær H, Jørgensen M, Garcia-Giustiniani D, Ortiz-Genga M, Crespo-Leiro MG, Deprez RH, Christiaans I, van Rijsingen IA, Wilde AA, Waldenstrom A, Bolognesi M, Bellazzi R, Mörner S, Bermejo JL, Monserrat L, Villard E, Mogensen J, Pinto YM, Charron P, Elliott P, Arbustini E, Katus HA, Meder B. Atlas of the clinical genetics of human dilated cardiomyopathy.

Eur Heart J. 2014 Aug 27. pii: ehu301. [Epub ahead of print]


Meder B, Backes C, Haas J, Leidinger P, Stähler C, Großmann T, Vogel B, Frese K, Giannitsis E, Katus HA, Meese E, Keller A. Influence of the Confounding Factors Age and Sex on MicroRNA Profiles from Peripheral Blood.

Clin Chem. 2014 Jun 30. pii: clinchem.2014.224238. [Epub ahead of print]


Leidinger P, Backes C, Meder B, Meese E, Keller A. The human miRNA repertoire of different blood compounds.

BMC Genomics. 2014 Jun 14;15(1):474. [Epub ahead of print]


Zettinig O, Mansi T, Neumann D, Georgescu B, Rapaka S, Seegerer P, Kayvanpour E, Sedaghat-Hamedani F, Amr A, Haas J, Steen H, Katus H, Meder B, Navab N, Kamen A, Comaniciu D. Data-driven estimation of cardiac electrical diffusivity from 12-lead ECG signals.

Med Image Anal. 2014 Apr 26. pii: S1361-8415(14)00065-6. doi: 10.1016/j.media.2014.04.011. [Epub ahead of print]


Sedaghat-Hamedani F, Zitron E, Kayvanpour E, Lorenz HM, Katus HA, Meder B. Post cardiac injury syndrome after initially uncomplicated CRT-D implantation: a case report and a systematic review. Clin Res Cardiol. 2014 Apr 29. [Epub ahead of print]


Vogel B, Kirchberger M, Zeier M, Stoll F, Meder B, Saure D, Andrassy M, Mueller OJ, Hardt S, Schwenger V, Strothmeyer A, Katus HA, Blessing E. Renal sympathetic denervation therapy in the real world: results from the Heidelberg registry.

Clin Res Cardiol. 2014 Feb;103(2):117-24. doi: 10.1007/s00392-013-0627-5. Epub 2013 Oct 15.


Leidinger P, Backes C, Deutscher S, Schmitt K, Mueller SC, Frese K, Haas J, Ruprecht K, Paul F, Stähler C, Lang CJ, Meder B, Bartfai T, Meese E, Keller A. A blood based 12-miRNA signature of Alzheimer disease patients.

Genome Biol. 2013 Jul 29;14(7):R78. [Epub ahead of print]


Vogel B, Keller A, Frese KS, Leidinger P, Sedaghat-Hamedani F, Kayvanpour E, Kloos W, Backe C, Thanaraj A, Brefort T, Beier M, Hardt S, Meese E, Katus HA, Meder B. Multivariate miRNA signatures as biomarkers for non-ischaemic systolic heart failure.

Eur Heart J. 2013 Sep;34(36):2812-22. doi: 10.1093/eurheartj/eht256. Epub 2013 Jul 17.


Keller A, Leidinger P, Steinmeyer F, Stähler C, Franke A, Hemmrich-Stanisak G, Kappel A, Wright I, Dörr J, Paul F, Diem R, Tocariu-Krick B, Meder B, Backes C, Meese E, Ruprecht K. Comprehensive analysis of microRNA profiles in multiple sclerosis including next-generation sequencing.

Mult Scler. 2014 Mar;20(3):295-303. doi: 10.1177/1352458513496343. Epub 2013 Jul 8.


Zettinig O, Mansi T, Georgescu B, Kayvanpour E, Sedaghat-Hamedani F, Amr A, Haas J, Steen H, Meder B, Katus H, Navab N, Kamen A, Comaniciul D. Fast data-driven calibration of a cardiac electrophysiology model from images and ECG.

Med Image Comput Comput Assist Interv. 2013;16(Pt 1):1-8.


Maixner F, Overath T, Linke D, Janko M, Guerriero G, van den Berg BH, Stade B, Leidinger P, Backes C, Jaremek M, Kneissl B, Meder B, Franke A, Egarter-Vigl E, Meese E, Schwarz A, Tholey A, Zink A, Keller A. Paleoproteomic study of the Iceman's brain tissue.

Cell Mol Life Sci. 2013 Jun 6. [Epub ahead of print]


Thanaraj A, Meder B. Genetic testing is superior to biopsy of the myocardium in cardiomyopathy - yes.

Dtsch Med Wochenschr. 2013 Mar;138(12):598. Epub 2013 Mar 12.


Benjamin Meder, Frank Rühle, Tanja Weis, Georg Homuth, Andreas Keller, Jennifer Franke, Barbara Peil, Justo Lorenzo Bermejo, Karen Frese, Andreas Huge, Anika Witten, Britta Vogel, Jan Haas, Uwe Völker, Florian Ernst, Alexander Teumer, Philipp Ehlermann, Christian Zugck, Frauke Friedrichs, Heyo Kroemer, Marcus Dörr, Wolfgang Hoffmann, Bernhard Maisch, Sabine Pankuweit, Volker Ruppert, Thomas Scheffold, Uwe Kühl, Hans-Peter Schultheiss, Reinhold Kreutz, Georg Ertl, Christiane Angermann, Philippe Charron, Eric Villard, Françoise Gary, Richard Isnard, Michel Komajda, Matthias Lutz, Thomas Meitinger, Moritz F. Sinner, H.-Erich Wichmann, Michael Krawczak, Boris Ivandic, Dieter Weichenhan, Goetz Gelbrich, Nour-Eddine El-Mokhtari, Stefan Schreiber, Stephan B. Felix, Gerd Hasenfuß, Arne Pfeufer, Norbert Hübner, Stefan Kääb, Eloisa Arbustini, Wolfgang Rottbauer, Norbert Frey, Monika Stoll, Hugo A. Katus. A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy.

Eur Heart J. 2014 Apr;35(16):1069-77. doi: 10.1093/eurheartj/eht251. Epub 2013 Jul 12.


Frese KS, Katus HA, Meder B. Next-Generation Sequencing: From Understanding Biology to Personalized Medicine.

Biology 2013, 2(1), 378-398; doi:10.3390/biology2010378


Haverslag RT, de Groot D, Grundmann S, Meder B, Goumans MJ, Pasterkamp G, Hoefer IE, de Kleijn DP. CD26 Inhibition Enhances Perfusion Recovery in ApoE-/-Mice.

Curr Vasc Pharmacol. 2013 Jan 1;11(1):21-8.


Haas J, Frese KS, Park YJ, Keller A, Vogel B, Lindroth AM, Weichenhan D, Franke J, Fischer S, Bauer A, Marquart S, Sedaghat-Hamedani F, Kayvanpour E, Köhler D, Wolf NM, Hassel S, Nietsch R, Wieland T, Ehlermann P, Schultz JH, Dösch A, Mereles D, Hardt S, Backs J, Hoheisel JD, Plass C, Katus HA, Meder B. Alterations in cardiac DNA methylation in human dilated cardiomyopathy. EMBO Mol Med. 2013 Jan 22. doi: 10.1002/emmm.201201553. [Epub ahead of print]


Vogel B, Keller A, Frese K, Kloos W, Kayvanpour E, Sedaghat-Hamedani F, Hassel S, Marquart S, Beier M, Giannitis E, Hardt S, Katus HA, Meder B. Refining Diagnostic MicroRNA Signatures by Whole-miRNome Kinetic Analysis in Acute Myocardial Infarction.

Clin Chem. 2013 Feb;59(2):410-8.


Stäehler CF, Keller A, Leidinger P, Backes C, Chandran A, Wischhusen J, Meder B, Meese E. Whole miRNome-wide Differential Co-expression of MicroRNAs.

Genomics Proteomics Bioinformatics. 2012 Oct;10(5):285-94. doi: 10.1016/j.gpb.2012.08.003. Epub 2012 Aug 23.


Narula N, Favalli V, Tarantino P, Grasso M, Pilotto A, Bellazzi R, Serio A, Gambarin FI, Charron P, Meder B, Pinto Y, Elliott PM, Mogensen J, Bolognesi M, Bollati M, Arbustini E. Quantitative Expression of the Mutated Lamin A/C Gene in Patients With Cardiolaminopathy.

J Am Coll Cardiol. 2012 Sep 28. pii: S0735-1097(12)04113-7.


Meder B, Frese KS, Katus HA. Die dilatative Kardiomyopathie – Ein Update.

Aktuelle Kardiologie. 2012


Kloos W, Katus HA, Meder B. Genetic cardiomyopathies: Lessons learned from humans, mice, and zebrafish.

Herz. 2012 Jul 7. [Epub ahead of print]


Meder B, Katus HA. Clinical and genetic aspects of hypertrophic and dilated cardiomyopathy.

Der Internist 2012 [Epub ahead of print].


Laczny C, Leidinger P, Haas J, Ludwig N, Backes C, Gerasch A, Kaufmann M, Vogel B, Katus HA, Meder B, Stähler C, Meese E, Lenhof HP, Keller A. miRTrail – a comprehensive webserver for analyzing gene and miRNA patterns to enhance the understanding of regulatory mechanisms in diseases.

BMC Bioinformatics 2012,13:56 (epub ahead)


Keller A, Graefen A, Ball M, Matzas M, Boisguerin V, Maixner F, Leidinger P, Backes C, Khairat R, Forster M, Stade B, Franke A, Mayer J, Spangler J, McLaughlin S, Shah M, Lee C, Harkins TT, Sartori A, Moreno-Estrada A, Henn B, Sikora M, Semino O, Chiaroni J, Rootsi S, Myres NM, Cabrera VM, Underhill PA, Bustamante CD, Vigl EE, Samadelli M, Cipollini G, Haas J, Katus H, O'Connor BD, Carlson MR, Meder B, Blin N, Meese E, Pusch CM, Zink A. New insights into the Tyrolean Iceman’s origin and phenotype as inferred by whole-genome sequencing.

Nature Communications 2012 (epub ahead)


Andreas Keller, Christina Backes, Petra Leidinger, Nathalie Kefer, Valesca Boisguerin, Catalin Barbacioru, Britta Vogel, Mark Matzas, Hanno Huwer, Hugo A.Katus, Cord Stähler, Benjamin Meder*, Eckart Meese*. Next-generation sequencing identifies novel microRNAs in peripheral blood of lung cancer patients.

Molecular Biosystems. 2011 (epub ahead). (*contributed equally as senior authors)


Haas J, Katus HA, Meder B. Next-generation sequencing entering the clinical arena.

Mol Cell Probes. 2011 Sep 8. [Epub ahead of print].


Keller A, Leidinger P, Bauer A, ElSharawy A, Haas J, Backes C, Wendschlag A, Giese N, Tjaden C, Ott K, Werner J, Hackert T, Ruprecht K, Huwer H, Huebers J, Jacobs G, Rosenstiel P, Dommisch H, Schaefer A, Müller-Quernheim J, Wullich B, Keck B, Graf N, Reichrath J, Vogel B, Nebel A, Jager S, Staehler P, Amarantos I, Boisguerin V, Staehler C, Beier M, Scheffler M, Büchler MW, Wischhusen J, Haeusler S, Dietl J, Hofmann S, Lenhof HP, Schreiber S, Katus HA, Rottbauer W, Meder B, Hoheisel J, Franke A, Meese E. Towards discovering the blood-born miRNome of human diseases.

Nature Methods 2011.


Meder B, Huttner IG, Sedaghat-Hamedani F, Just S, Dahme T, Frese KS, Vogel B, Köhler D, Kloos W, Rudloff J, Marquart S, Katus HA, Rottbauer W. PINCH proteins regulate cardiac contractility by modulating ILK-PKB signaling.

Molecular and Cellular Biology 2011 (epub ahead of print).


Just S, Berger IM, Meder B, Backs J, Marquart S, Eva Patzel, Gerd-Jörg Rauch; Tübingen 2000 Screen Consortium; Hugo A. Katus; Wolfgang Rottbauer. Protein kinase D2 controls cardiac valve formation in zebrafish by regulating HDAC5 activity.

Circulation 2011 (epub ahead of print).


Meder B, Bergmann CE, Keller A, Just S, Katus HA, Hoefer IE, Buschmann IR. Quantification of Collateral Artery Growth by Automated Fluorescent Microsphere Perfusion.

International Journal of Cardiology 2011 (epub ahead of print)


Just S*, Meder B*, Ina M. Berger, Christelle Etard, Nicole Trano, David Hassel, Sabine Marquart, Tillman Dahme, Alexander Hess, Britta Vogel, Mark C. Fishman, Uwe Strähle, Hugo A. Katus, Wolfgang Rottbauer. The myosin-interacting protein SMYD1 is essential for sarcomere organization.

Journal of Cell Science 2011 (epub ahead of print) (*first and second author contributed equally)


Meder B, Scholz EP, Hassel D, Wolff C, Just S, Berger IM, Patzel E, Karle C, Katus HA, Rottbauer W. Reconstitution of Defective Protein Trafficking Rescues Long-QT Syndrome in Zebrafish.

Biochem. Biophys. Res. Commun. 2011 (epub ahead of print)


Ehlermann P, Lehrke S, Papavassiliu T, Meder B, Borggrefe M, Katus HA, Schimpf R. Sudden cardiac death in a patient with lamin A/C mutation in the absence of dilated cardiomyopathy or conduction disease.

Clin Res Cardiol. 2011 Feb 16. (epub ahead of print)


Meder B. MicroRNA Signaturen als neue Biomarker kardiovaskulärer Erkrankungen - Winzige Moleküle zeigen Herzinfarkt an.

Lebendige Wissenschaft – Spitzenforschung Herz-Kreislauf-Medizin 2011


Keller A, Harz C, Matzas M, Meder B, Katus HA, Ludwig N, Fischer U, Meese E. Identification of novel SNPs in glioblastoma using targeted resequencing.

PLoS One 2011


Meder B, Haas J, Keller A, Heid C, Just S, Borries A, Boisguerin V, Scharfenberger-Schmeer M, Stähler P, Beier M, Weichenhan D, Strom T, Pfeufer A, Korn B, Katus HA, Rottbauer W. Targeted Next-Generation Sequencing for the Molecular Genetic Diagnostics of Cardiomyopathies.

Circulation Cardiovascular Genetics 2011 (epub ahead of print)


Meder B, Keller A, Vogel B, Haas J, Sedaghat F, Kayvanpour E, Just S, Borries A, Rudloff J, Leidinger P, Meese E, Katus HA, Rottbauer W. MicroRNA Signatures in Total Peripheral Blood as Novel Biomarkers for Acute Myocardial Infarction.

Basic Res Cardiol. 2010 (online first, DOI 10.1007/s00395-010-0123-2)


Meder B, Just S, Vogel B, Rudloff J, Gartner L, Dahme T, Huttner I, Zankl A, Katus HA, Rottbauer W. JunB-CBFß Signaling is essential to maintain sarcomeric Z-disc structure and when defective leads to heart failure.

J Cell Sci. 2010; 10.1242/jcs.067967


Hassel D*, Dahme T*, Erdmann J*, Meder B, Huge A, Stoll M, Just S, Hess A, Ehlermann P, Weichenhan D, Grimmler M, Liptau H, Hetzer R, Regitz-Zagrosek V, Fischer C, Nürnberg P, Schunkert H, Katus HA, Rottbauer W. Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy.

Nature Med 2009;15:1281-8


Meder B, Laufer C, Hassel D, Just S, Marquart S, Vogel B, Hess A, Fishman MC, Katus HA, Rottbauer W. A single serine in the carboxyl terminus of cardiac essential myosin light chain-1 controls cardiomyocyte contractility in vivo.

Circ Res 2009;104:650-659


Vogel B*, Meder B*, Just S, Laufer C, Berger I, Weber S, Katus HA, Rottbauer W. In Vivo Characterization of Human Dilated Cardiomyopathy Genes in Zebrafish.

Biochem. Biophys. Res. Commun. 2009, doi:10.1016/j.bbrc.2009.09.129 (*contributed equally)


Meder B, Katus HA, Rottbauer W. Leichte Kette mit schweren Folgen - Der Zebrafish als Modell genetischer Herzschwäche.

GenomXpress 2009;3.09


Friedrichs F, Zugck C, Rauch GJ, Ivandic B, Weichenhan D, Müller-Bardorff M, Meder B, El Mokhtari NE, Regitz-Zagrosek V, Hetzer R, Schäfer A, Schreiber S, Chen J, Neuhaus I, Ji R, Siemers NO, Frey N, Rottbauer W, Katus HA, Stoll M. HBEGF, SRA1, and IK: Three cosegregating genes as determinants of cardiomyopathy.

Genome Res 2009;19:395-403


Meder B, Katus HA, Rottbauer, W. Genetik der hypertrophischen Kardiomyopathie.

Journal für Kardiologie 2009;16 (7-8), 274-278


Hassel D, Scholz EP, Trano N, Friedrich O, Just S, Meder B, Weiss DL, Zitron E, Marquart S, Vogel B, Karle CA, Seemann G, Fishman MC, Katus HA, Rottbauer W. Deficient zebrafish ether-à-go-go-related gene channel gating causes short-QT syndrome in zebrafish reggae mutants.

Circulation. 2008;117:866-875


Meder B, Katus HA, Rottbauer W. Right into the heart of microRNA-133a.

Genes Dev 2008;22:3227-3231


Bergmann C, Hoefer I, Meder B, Roth H, van Royen N, Breit SM, Jost MM, Aharinejad S, Hartmann S, Buschmann IR. Arteriogenesis depends on circulating monocytes and macrophage accumulation and is severely depressed in op/op mice.

J Leukoc Biol 2006;80:59-65


Hoefer I, Grundmann S, Schirmer S, van Royen N, Meder B, Bode C, Piek JJ, Buschmann IR. Aspirin, but not clopidogrel, reduces collateral conductance in a rabbit model of femoral artery occlusion.

J Am Coll Cardiol 2005;46:994-1001


Jost MM*, Ninci E*, Meder B, Kempf C, van Royen N, Hua J, Berger B, Hoefer I, Modolell M, Buschmann I. Divergent effects of GM-CSF and TGFbeta1 on bone marrow-derived macrophage arginase-1 activity, MCP-1 expression, and matrix metalloproteinase-12: a potential role during arteriogenesis.

FASEB J 2003;17:2281-2283