Translationale Pneumologie
Translationale Pneumologie
Kliniken &… Interdisziplinäre… Translationale… Forschung Publikationen

Publikationen

  • Gehrig S, Duerr J, Weitnauer M, Wagner CJ, Graeber SY, Schatterny J, Hirtz S, Belaaouaj A, Dalpke AH, Schultz C, Mall MA. Lack of neutrophil elastase reduces inflammation, mucus hypersecretion, and emphysema, but not mucus obstruction, in mice with cystic fibrosis-like lung disease. Am J Respir Crit Care Med 2014;189:1082-1092.
  • Wielpütz MO, Puderbach M, Kopp-Schneider A, Stahl M, Fritzsching E, Sommerburg O, Ley S, Sumkauskaite M, Biederer J, Kauczor HU, Eichinger M, Mall MA. Magnetic resonance imaging detects changes in structure and perfusion, and response to therapy in early cystic fibrosis lung disease. Am J Respir Crit Care Med 2014 Apr 15;189(8):956-65.
  • Hu HY, Gehrig S, Reither G, Subramanian D, Mall MA, Plettenburg O, Schultz C. FRET-based and other fluorescent proteinase probes. Biotechnol J 2014 Feb;9(2):266-81.
  • Sommerburg O, Krulisova V, Hammermann J, Lindner M, Stahl M, Muckenthaler M, Kohlmueller D, Happich M, Kulozik AE, Votava F, Balascakova M, Skalicka V, Stopsack M, Gahr M, Macek M, Jr., Mall MA*, Hoffmann GF*. Comparison of different IRT-PAP protocols to screen newborns for cystic fibrosis in three central European populations. J Cyst Fibros 2014;13:15-23. (*equal contribution)
  • Bauman G, Puderbach M, Heimann T, Kopp-Schneider A, Fritzsching E, Mall MA, Eichinger M. Validation of Fourier decomposition MRI with dynamic contrast-enhanced MRI using visual and automated scoring of pulmonary perfusion in young cystic fibrosis patients. Eur J Radiol 2013;82:2371-2377.
  • Wielputz MO, Weinheimer O, Eichinger M, Wiebel M, Biederer J, Kauczor HU, Heussel CP, Mall MA*, Puderbach M*. Pulmonary emphysema in cystic fibrosis detected by densitometry on chest multidetector computed tomography. PLOS ONE 2013;8:e73142. (*equal contribution)
  • Graeber SY, Zhou-Suckow Z, Schatterny J, Hirtz S, Boucher RC, Mall MA. Hypertonic saline is effective in the prevention and treatment of mucus obstruction, but not airway inflammation, in mice with chronic obstructive lung disease. Am J Respir Cell Mol Biol 2013;49:410-417.
  • Benesova K, Schaefer SM, Mall MA, Muckenthaler MU. Computerized image analysis of iron-stained macrophages. Ann Hematol 2013;92:1195-1199.
  • Geiser M, Quaile O, Wenk A, Wigge C, Eigeldinger-Berthou S, Hirn S, Schaffler M, Schleh C, Moller W, Mall MA, Kreyling WG. Cellular uptake and localization of inhaled gold nanoparticles in lungs of mice with chronic obstructive pulmonary disease. Part Fibre Toxicol 2013;10:19.
  • Wielputz MO, Eichinger M, Weinheimer O, Ley S, Mall MA, Wiebel M, Bischoff A, Kauczor HU, Heussel CP, Puderbach M. Automatic airway analysis on multidetector computed tomography in cystic fibrosis: correlation with pulmonary function testing. J Thorac Imaging 2013;28:104-113.
  • Schmeckebier S, Mauritz C, Katsirntaki K, Sgodda M, Puppe V, Duerr J, Schubert SC, Schmiedl A, Lin Q, Palecek J, Draeger G, Ochs M, Zenke M, Cantz T, Mall MA, Martin U. Keratinocyte growth factor and dexamethasone plus elevated cAMP levels synergistically support pluripotent stem cell differentiation into alveolar epithelial type II cells. Tissue Eng Part A 2013;19:938-951.
  • Bingle L, Wilson K, Musa M, Araujo B, Rassl D, Wallace WA, Leclair EE, Mauad T, Zhou Z, Mall MA, Bingle CD. BPIFB1 (LPLUNC1) is upregulated in cystic fibrosis lung disease. Histochem Cell Biol 2012;138:749-758.
  • Anagnostopoulou P, Riederer B, Duerr J, Michel S, Binia A, Agrawal R, Liu X, Kalitzki K, Xiao F, Chen M, Schatterny J, Hartmann D, Thum T, Kabesch M, Soleimani M, Seidler U, Mall MA. SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation. J Clin Invest 2012;122:3629-3634.
  • Johannesson B, Hirtz S, Schatterny J, Schultz C, Mall MA. CFTR regulates early pathogenesis of chronic obstructive lung disease in βENaC-overexpressing mice. PLoS ONE 2012;7:e44059.
  • Benesova K, Vujic SM, Schaefer SM, Stolte J, Baehr-Ivacevic T, Waldow K, Zhou Z, Klingmueller U, Benes V, Mall MA*, Muckenthaler MU*. Hfe deficiency impairs pulmonary neutrophil recruitment in response to inflammation. PLoS ONE 2012;7:e39363. (*equal contribution)
  • Gehrig S, Mall MA*, Schultz C*. Spatially resolved monitoring of neutrophil elastase activity with ratiometric fluorescent reporters. Angew Chem Int Ed Engl 2012;51:6258-6261. (*equal contribution)
  • Mundhenk L, Johannesson B, Anagnostopoulou P, Braun J, Bothe MK, Schultz C, Mall MA*, Gruber AD*. mCLCA3 Does Not Contribute to Calcium-Activated Chloride Conductance in Murine Airways. Am J Respir Cell Mol Biol 2012;47:87-93. (*equal contribution)
  • Hentschel J, Riesener G, Nelle H, Stuhrmann M, Schoner A, Sommerburg O, Fritzsching E, Mall MA, von Eggeling F, Mainz JG. Homozygous CFTR mutation M348K in a boy with respiratory symptoms and failure to thrive. Disease-causing mutation or benign alteration? Eur J Pediatr 2012;171:1039-1046.
  • Eichinger M, Optazaite DE, Kopp-Schneider A, Hintze C, Biederer J, Niemann A, Mall MA, Wielputz MO, Kauczor HU, Puderbach M. Morphologic and functional scoring of cystic fibrosis lung disease using MRI. Eur J Radiol 2012;81:1321-1329.
  • Hartl D, Gaggar A, Bruscia E, Hector A, Marcos V, Jung A, Greene C, McElvaney G, Mall M, Doring G. Innate immunity in cystic fibrosis lung disease. J Cyst Fibros 2012;11:363-382.
  • Seeger W, Welte T, Eickelberg O, Mall M, Rabe KF, Keller B, Winkler S, Koller U. The German Centre for Lung Research - Translational Research for the Prevention, Diagnosis and Treatment of Respiratory Diseases. Pneumologie 2012;66:464-469.
  • Wielputz MO, Eichinger M, Zhou Z, Leotta K, Hirtz S, Bartling SH, Semmler W, Kauczor HU, Puderbach M, Mall MA. In vivo monitoring of cystic fibrosis-like lung disease in mice by volumetric computed tomography. Eur Respir J 2011;38:1060-1070.
  • Roth EK, Hirtz S, Duerr J, Wenning D, Eichler I, Seydewitz HH, Amaral MD, Mall MA. The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients. PLoS ONE 2011;6:e24445.
  • Hector A, Kormann MS, Mack I, Latzin P, Casaulta C, Kieninger E, Zhou Z, Yildirim AO, Bohla A, Rieber N, Kappler M, Koller B, Eber E, Eickmeier O, Zielen S, Eickelberg O, Griese M, Mall MA, Hartl D. The chitinase-like protein YKL-40 modulates cystic fibrosis lung disease. PLoS ONE 2011;6:e24399.
  • Bonora M, Riffault L, Marie S, Mall M, Clement A, Tabary O. Morphological analysis of the trachea and pattern of breathing in βENaC-Tg mice. Respir Physiol Neurobiol 2011;178:346-348.
  • Duerr J, Gruner M, Schubert SC, Haberkorn U, Bujard H, Mall MA. Use of a new-generation reverse tetracycline transactivator system for quantitative control of conditional gene expression in the murine lung. Am J Respir Cell Mol Biol 2011;44:244-254.
  • Moog U, Okun PM, Bettendorf M, Gorenflo M, Kölker S, Krämer A, Lorenz HM, Mall MA, Muckenthaler MU, Schaefer FS, Schönland SO, Hoffmann GF. Zentrum für Seltene Erkrankungen Universitätsmedizin Heidelberg. Medizinische Genetik 2011;4:493-504
  • Gaggar A, Hector A, Bratcher PE, Mall MA, Griese M, Hartl D. The role of matrix metalloproteinases in cystic fibrosis lung disease. Eur Respir J 2011;38:721-727
  • Zhou Z, Duerr J, Johannesson B, Schubert SC, Treis D, Harm M, Graeber SY, Dalpke A, Schultz C, Mall MA. The ENaC-overexpressing mouse as a model of cystic fibrosis lung disease. J Cyst Fibros 2011;10 Suppl 2:S172-S182.
  • Becq F, Mall MA, Sheppard DN, Conese M, Zegarra-Moran O. Pharmacological therapy for cystic fibrosis: from bench to bedside. J Cyst Fibros 2011;10 Suppl 2:S129-S145.
  • Sheppard DN, Liu J, Zhou Z, Mall MA. Treatment of cystic fibrosis lung disease - the development of drugs targeting cystic fibrosis transmembrane conductance regulator dysfunction. European Respiratory Disease 2011;7:12-17.
  • Anagnostopoulou P, Dai L, Schatterny J, Hirtz S, Duerr J, Mall MA. Allergic airway inflammation induces a pro-secretory epithelial ion transport phenotype in mice. Eur Respir J 2010;36:1436-1447.
  • Sommerburg O, Lindner M, Muckenthaler M, Kohlmueller D, Leible S, Feneberg R, Kulozik AE, Mall MA*, Hoffmann GF*. Initial evaluation of a biochemical cystic fibrosis newborn screening by sequential analysis of immunoreactive trypsinogen and pancreatitis-associated protein (IRT/PAP) as a strategy that does not involve DNA testing in a Northern European population. J Inherit Metab Dis 2010;33:S263-S271. (*equal contribution).
  • Mall MA, Button B, Johannesson B, Zhou Z, Livraghi A, Caldwell RA, Schubert SC, Schultz C, O'Neal WK, Pradervand S, Hummler E, Rossier BC, Grubb BR, Boucher RC. Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with βENaC-overexpressing mice. J Biol Chem 2010;285:26945-26955.
  • Cobos-Correa A, Mall MA, Schultz C. Reporters to monitor cellular MMP12 activity. Proc of SPIE 2010;7576:1-10. doi:10.1117/12.842113.
  • Cobos-Correa A, Trojanek JB, Diemer S, Mall MA*, Schultz C*. Membrane-bound FRET probe visualizes MMP12 activity in pulmonary inflammation. Nat Chem Biol 2009;5:628-630. (*equal contribution)
  • Livraghi A, Grubb BR, Hudson EJ, Wilkinson KJ, Sheehan JK, Mall MA, O'Neal WK, Boucher RC, Randell SH. Airway and lung pathology due to mucosal surface dehydration in β-epithelial Na+ channel-overexpressing mice: role of TNF-α and IL-4Rα signaling, influence of neonatal development, and limited efficacy of glucocorticoid treatment. J Immunol 2009;182:4357-4367.
  • Mall MA. Role of the amiloride-sensitive epithelial Na+ channel in the pathogenesis and as a therapeutic target for cystic fibrosis lung disease. Exp Physiol 2009;94:171-174.
  • Zhou Z, Treis D, Schubert S, Harm M, Schatterny J, Hirtz S, Duerr J, Boucher RC, Mall MA. Preventive but not late amiloride therapy reduces morbidity and mortality of lung disease in βENaC-overexpressing mice. Am J Respir Crit Care Med 2008; 178: 1245-1256
  • Mall MA, Harkema JR, Trojanek JB, Treis D, Livraghi A, Schubert S, Zhou Z, Kreda SM, Tilley SL, Hudson EJ, O'Neal WK, Boucher RC. Development of chronic bronchitis and emphysema in βENaC-overexpressing mice. Am J Respir Crit Care Med 2008; 177(7): 730-42
  • Livraghi A, Mall M, Paradiso AM, Boucher RC, Pedrosa Ribeiro CM. Modelling Dysregulated Na+ Absorption in Airway Epithelial Cells with Mucosal Nystatin Treatment. Am J Respir Cell Mol Biol 2008; 38(4)
  • Mall MA. Role of cilia, mucus and airway surface liqiud in mucociliary dysfunction: lessons from mouse models. J Aerosol Med 2008;21:13-24.
  • Mall M. Hypertones Kochsalz: Therapie der Lungenerkrankung bei Mukoviszidose - Mechanismen und Langzeitwirkung. Monatsschr Kinderheilkd 2006;154:907-909.
  • Kreda SM, Mall M, Mengos A, Rochelle L, Yankaskas J, Riordan JR, Boucher RC. Characterization of wild-type and deltaF508 cystic fibrosis transmembrane regulator in human respiratory epithelia. Mol Biol Cell 2005;16:2154-2167
  • Kunzelmann K, Sun J, Markovich D, Konig J, Murle B, Mall M, Schreiber R. Control of ion transport in mammalian airways by protease activated receptors type 2 (PAR-2). FASEB J 2005;19:969-976
  • Mall M, Kunzelmann K. Correction of the CF defect by curcumin: hypes and disappointments. Bioessays 2005;27:9-13
  • Mall M, Grubb BR, Harkema JR, O'Neal WK, Boucher RC. Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice. Nat Med 2004;10:487-493
  • Hirtz S, Gonska T, Seydewitz HH, Thomas J, Greiner P, Kuehr J, Brandis M, Eichler I, Rocha H, Lopes AI, Barreto C, Ramalho A, Amaral MD, Kunzelmann K, Mall M. CFTR Cl- channel function in native human colon correlates with the genotype and phenotype in cystic fibrosis. Gastroenterology 2004;127:1085-1095
  • Mall M, Kreda SM, Mengos A, Jensen TJ, Hirtz S, Seydewitz HH, Yankaskas J, Kunzelmann K, Riordan JR, Boucher RC. The DeltaF508 mutation results in loss of CFTR function and mature protein in native human colon. Gastroenterology 2004;126:32-41
  • Mall M, Hirtz S, Gonska T, Kunzelmann K. Assessment of CFTR function in rectal biopsies for the diagnosis of cystic fibrosis. J Cyst Fibros 2004;3 Suppl 2:165-169
  • Mall M, Gonska T, Thomas J, Schreiber R, Seydewitz HH, Kuehr J, Brandis M, Kunzelmann K. Modulation of Ca2+-activated Cl- secretion by basolateral K+ channels in human normal and cystic fibrosis airway epithelia. Pediatr Res 2003;53:608-618
  • Ramalho AS, Beck S, Penque D, Gonska T, Seydewitz HH, Mall M, Amaral MD. Transcript analysis of the cystic fibrosis splicing mutation 1525-1G>A shows use of multiple alternative splicing sites and suggests a putative role of exonic splicing enhancers. J Med Genet, 40:e88, 2003
  • Kunzelmann K, Mall M. Pharmacotherapy of the ion transport defect in cystic fibrosis: role of purinergic receptor agonists and other potential therapeutics. Am J Respir Med 2003;2:299-309.
  • Mall M, Gonska T, Thomas J, Hirtz S, Schreiber R, Kunzelmann K. Activation of ion secretion via proteinase-activated receptor-2 in human colon. Am J Physiol Gastrointest Liver Physiol 2002;282:G200-G210
  • Konig J, Schreiber R, Mall M, Kunzelmann K. No evidence for inhibition of ENaC through CFTR-mediated release of ATP. Biochim Biophys Acta 2002;1565:17
  • Kunzelmann K, Mall M. Electrolyte transport in the mammalian colon: mechanisms and implications for disease. Physiol Rev 2002;82:245-289
  • Kunzelmann K, Schreiber R, Konig J, Mall M. Ion transport induced by proteinase-activated receptors (PAR2) in colon and airways. Cell Biochem Biophys 2002;36:209-214
  • Konig J, Schreiber R, Voelcker T, Mall M, Kunzelmann K. The cystic fibrosis transmembrane conductance regulator (CFTR) inhibits ENaC through an increase in the intracellular Cl- concentration. EMBO Rep 2001;2:1047-1051
  • Kunzelmann K, Mall M. Pharmacotherapy of the ion transport defect in cystic fibrosis. Clin Exp Pharmacol Physiol 2001;28:857-867
  • Greger R, Schreiber R, Mall M, Wissner A, Hopf A, Briel M, Bleich M, Warth R, Kunzelmann K. Cystic fibrosis and CFTR. Eur J Physiol - Pflügers Arch 2001;443:S3-S7
  • Ballmann M, Griese M, Hebestreit A, Hofmann T, Kersting U, Lindemann H, Mall M, Schüler D, Reinhardt D. Klinischer Stellenwert der modernen elektrophysiologischen Diagnostik bei Mukoviszidose (Zystischer Fibrose). Monatsschr Kinderheilkd 2001;149:258-264.
  • Mall M, Wissner A, Seydewitz HH, Kuehr J, Brandis M, Greger R, Kunzelmann K. Defective cholinergic Cl- secretion and detection of K+ secretion in rectal biopsies from cystic fibrosis patients. Am J Physiol Gastrointest Liver Physiol 2000;278:G617-G624
  • Seydewitz HH, Mall M, Kuehr J. A novel missense mutation, S1159F, in exon 19 of the CFTR gene. Hum Mutat, 15:390, 2000
  • Mall M, Wissner A, Schreiber R, Kuehr J, Seydewitz HH, Brandis M, Greger R, Kunzelmann K. Role of KVLQT1 in cAMP-mediated Cl- secretion in human airway epithelia. Am J Respir Cell Molec Biol 2000;23:283-289
  • Mall M, Wissner A, Seydewitz HH, Hübner M, Kuehr J, Brandis M, Greger R, Kunzelmann K. Effect of genistein on native epithelial tissue from normal individuals and CF patients and on ion channels expressed in Xenopus oocytes. Br J Pharmacol 2000;130:1884-1892
  • Seydewitz HH, Gonska T, Mall M, Kuehr J. A novel frameshift mutation, 1870delG, in exon 12 of the CFTR gene. Hum Mutat, 16:277, 2000
  • Mall M, Wissner A, Gonska T, Calenborn D, Kuehr J, Brandis M, Kunzelmann K. Inhibition of amiloride-sensitive epithelial Na+ absorption by extracellular nucleotides in human normal and cystic fibrosis airways. Am J Respir Cell Mol Biol 2000;23:755-761
  • Kunzelmann K, Schreiber R, Nitschke R, Mall M. Control of the epithelial Na+ conductance by the cystic fibrosis transmembrane regulator. Eur J Physiol -Pflügers Arch 2000;440:193-201
  • Hopf A, Schreiber R, Mall M, Greger R, Kunzelmann K. Cystic fibrosis transmembrane conductance regulator inhibits epithelial Na+ channels carrying Liddle`s syndrome mutations. J Biol Chem 1999;274:13894-13899
  • Schreiber R, Hopf A, Mall M, Greger R, Kunzelmann K. The first nucleotide binding domain of the cystic fibrosis transmembrane conductance regulator is important for inhibition of the epithelial Na+ channel. Proc Natl Acad Sci USA 1999;96:5310-5315
  • Mall M, Bleich M, Kuehr J, Brandis M, Greger R, Kunzelmann K. CFTR-mediated inhibition of epithelial Na+ conductance in human colon is defective in cystic fibrosis. Am J Physiol Gastrointest Liver Physiol 1999;277:G709-G716
  • Mall M, Bleich M, Greger R, Schreiber R, Kunzelmann K. The amiloride inhibitable Na+ conductance is reduced by CFTR in normal but not in cystic fibrosis airways. J Clin Invest 1998;102:15-21
  • Mall M, Bleich M, Greger R, Schürlein M, Kühr J, Seydewitz HH, Brandis M, Kunzelmann K. Cholinergic ion secretion in human colon requires co-activation by cAMP. Am J Physiol 1998;275:G1274-G1281
  • Kunzelmann K, Mall M, Briel M, Hipper A, Nitschke R, Ricken S, Greger R. The cystic fibrosis transmembrane conductance regulator attenuates the endogenous Ca2+ activated Cl- conductance in Xenopus ooyctes. Eur J Physiol -Pflügers Arch 1997;434:178-181
  • Greger R, Bleich M, Leipziger J, Ecke D, Mall M, Kunzelmann K. Regulation of ion transport in colonic crypts. News Physiol Sci 1997;12:62-66
  • Mall M, Hipper A, Greger R, Kunzelmann K. Wild type but not F508 CFTR inhibits Na+ conductance when coexpressed in Xenopus oocytes. FEBS Lett 1996;381:47-52
  • Mall M, Kunzelmann K, Hipper A, Busch AE, Greger R. cAMP stimulation of CFTR expressing xenopus oocytes activates a chromanol inhibitable K+ conductance. Eur J Physiol -Pflügers Arch 1996;432:516-522
  • Greger R, Mall M, Bleich M, Ecke D, Warth R, Riedemann N, Kunzelmann K. Regulation of epithelial ion channels by the cystic fibrosis transmembrane conductance regulator (CFTR). J Mol Med 1996;74:527-534
  • Hipper A, Mall M, Greger R, Kunzelmann K. Mutations in the putative pore forming domain of CFTR do not change anion selectivity of the cAMP activated Cl- conductance. FEBS Lett 1995;374:312-316
  • Gehrig S, Duerr J, Weitnauer M, Wagner CJ, Graeber SY, Schatterny J, Hirtz S, Belaaouaj A, Dalpke AH, Schultz C, Mall MA. Lack of neutrophil elastase reduces inflammation, mucus hypersecretion, and emphysema, but not mucus obstruction, in mice with cystic fibrosis-like lung disease. Am J Respir Crit Care Med 2014;189:1082-1092.
  • Wielputz MO, Puderbach M, Kopp-Schneider A, Stahl M, Fritzsching E, Sommerburg O, Ley S, Sumkauskaite M, Biederer J, Kauczor HU, Eichinger M, Mall MA. Magnetic resonance imaging detects changes in structure and perfusion, and response to therapy in early cystic fibrosis lung disease. Am J Respir Crit Care Med 2014;189:956-965.
  • Anagnostopoulou P, Riederer B, Duerr J, Michel S, Binia A, Agrawal R, Liu X, Kalitzki K, Xiao F, Chen M, Schatterny J, Hartmann D, Thum T, Kabesch M, Soleimani M, Seidler U, Mall MA. SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation. J Clin Invest 2012;122:3629-3634.
  • Gehrig S, Mall MA*, Schultz C*. Spatially resolved monitoring of neutrophil elastase activity with ratiometric fluorescent reporters. Angew Chem Int Ed Engl 2012;51:6258-6261. (*equal contribution)
  • Cobos-Correa A, Trojanek JB, Diemer S, Mall MA*, Schultz C*. Membrane-bound FRET probe visualizes MMP12 activity in pulmonary inflammation. Nat Chem Biol 2009;5:628-630. (*equal contribution)
  • Zhou Z, Treis D, Schubert S, Harm M, Schatterny J, Hirtz S, Duerr J, Boucher RC, Mall MA. Preventive but not late amiloride therapy reduces morbidity and mortality of lung disease in βENaC-overexpressing mice. Am J Respir Crit Care Med 2008; 178: 1245-1256.
  • Mall MA, Harkema JR, Trojanek JB, Treis D, Livraghi A, Schubert S, Zhou Z, Kreda SM, Tilley SL, Hudson EJ, O'Neal WK, Boucher RC. Development of chronic bronchitis and emphysema in βENaC-overexpressing mice. Am J Respir Crit Care Med 2008; 177(7): 730-42.
  • Mall M, Grubb BR, Harkema JR, O'Neal WK, Boucher RC. Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice. Nat Med 2004;10:487-493.
  • Hirtz S, Gonska T, Seydewitz HH, Thomas J, Greiner P, Kuehr J, Brandis M, Eichler I, Rocha H, Lopes AI, Barreto C, Ramalho A, Amaral MD, Kunzelmann K, Mall M. CFTR Cl- channel function in native human colon correlates with the genotype and phenotype in cystic fibrosis. Gastroenterology 2004;127:1085-1095.
  • Mall M, Bleich M, Greger R, Schreiber R, Kunzelmann K. The amiloride inhibitable Na+ conductance is reduced by CFTR in normal but not in cystic fibrosis airways. J Clin Invest 1998;102:15-21.