Kliniken &… SFB / DZG SFB TRR 156 Research 1. Funding Period Research Area A: Skin…

A06: Regulation of Th17-mediated skin inflammation by heme oxygenase 1 and inflammasome activation

Universitäts-Hautklinik Tübingen

During skin inflammation the generation of reactive oxygen species (ROS) can influence keratinocytes and myeloid cells. On the one hand ROS affect inflammasome activation, IL-1 production and subsequent Th17 responses. On the other hand ROS-inducing conditions in antigen presenting cells induce oxidative stress-response genes, prevent the development of pathogenic Th17 cells and related inflammation. By using conditional mice and models of Th17-skin inflammation we want to decipher the interplay between oxidative stress and the inflammasome complex in myeloid cells and keratinocytes and their consequences for Th17 responses.

Quelle: Universitäts-Hautklinik Tübingen

Principal investigators

PD Dr. med. Amir Yazdi

Universitäts-Hautklinik Tübingen

PD Dr. med. Kamran Ghoreschi

Universitäts-Hautklinik Tübingen