Kliniken & Institute … SFBs SFB TRR156 Research 1. Funding Period Research Area B: Immune…

B03: Influence of ATP metabolites on contact hypersensitivity reactions in skin

Universitäts-Hautklinik Heidelberg

The balance of pro-inflammatory adenosine triphosphate (ATP) and it’s immunosuppressive metabolite adenosine (ADO) in skin affects contact hypersensitivity (CHS) reactions. But as to how this balance of ATP and ADO in skin regulates skin immune cell functions is not clear. We will test mice that are deficient for the ATP-degrading enzymes CD39 and CD73 in hapten-induced CHS models and (i) analyze the phenotype and function of skin derived dendritic cells (DC), (ii) assess the signal transduction events and (iii) monitor molecular interactions between cells during CHS induction. These data will reveal major mechanisms how ATP/ADO turnover in skin affects CHS responses.

Quelle: Universitäts-Hautklinik Heidelberg

Principal investigators

Prof. Dr. Karsten Mahnke

Arbeitsgruppenleiter (AG Prof. Dr. K. Mahnke)

06221 56-8170
06221 56-1617