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Trials of the Pediatric Pulmonology and Allergology Unit & Cystic Fibrosis Center

The Pediatric Pulmonology & Allergology Unit and the Cystic Fibrosis Center in Heidelberg conduct clinical trials to improve the diagnosis and therapy of cystic fibrosis and other chronic lung diseases in children and adolescents. Some of these trials were initiated in Heidelberg and are coordinated by us in the German Center for Lung Research (DZL). We also participate in multicentric clinical CF trials within the CF Clinical Trial Network (CF-CTN).


1. Pilot study on preventive inhalation of hypertonic saline in infants with cystic fibrosis NCT01619657 - ClinicalTrials.gov.

Funded by the Dietmar Hopp Foundation and the Federal Ministry of Education and Research (BMBF)


2. Observational study on CF progression after diagnosis in a newborn screening

Funded by the BMBF (82DZL00401)


3. Establishment of a biochemical newborn screening for early CF diagnosis
Funded by the Dietmar Hopp Foundation and the BMBF


4. Use of magnetic resonance tomography (MRT) for a morphological and functional evaluation of lung dysfunction in CF patients.
Funded by Mukoviszidose e.V. and the  BMBF


5. Evaluation of CFTR function in rectal and nasal mucosa as biomarker for CF diagnosis and therapy
Funded by Mukoviszidose e.V. and the  BMBF