Department of General… About us Section Cognitive… Recent publications …

Recent publications

Cognitive neuropsychiatry section


1.     Northoff G, Hirjak D, Wolf RC, Magioncalda P, Martino M (2020) Why is there symptom coupling of psychological and motor changes in psychomotor mecahnisms? Insights from the brain’s topography. Molecular Psychiatry, in press.

2.     Fritze S, Topor CW, Kubera KM, Northoff G, Schmitgen MM, Wolf RC*, Hirjak D* (2020) Midbrain alterations contribute to motor catatonic symptoms in schizophrenia spectrum disorders. Schizophrenia Research, in press. * shared senior authorship.

3.     Wolf RC*, Rashidi M*, Schmitgen MM, Fritze S, Sambataro F, Kubera KM, Hirjak D (2020) Neurological Soft Signs predict auditory verbal hallucinations in patients with schizophrenia. Schizophrenia Bulletin, in press. * shared senior authorship.

4.     Fritze S, Sambataro F, Kubera KM, Bertolino AL, Topor CE, Wolf RC*, Hirjak D* (2020) Neurological Soft Signs in schizophrenia spectrum disorders are not confounded by current antipsychotic dosage. European Neuropsychopharmacology, 29:925-935 * shared senior authorship.

5.     Hirjak D, Northoff G, Taylor SF, Wolf RC (2020) GABAB receptor, clozapine and catatonia - a complex triad. Molecular Psychiatry, in press

6.     Hirjak D, Rashidi M, Kubera KM, Northoff G, Fritze S, Schmitgen MM, Sambataro F, Calhoun VD, Wolf RC (2020) Multimodal MRI data fusion reveals distinct patterns of abnormal brain structure and function in catatonia. Schizophrenia Bulletin, 46:200-210

7.     Krämer J, Huber MK, Mundinger C, Schmitgen MM; Pycha R, Kirchler E, Macina C, Karner M, Hirjak D, Kubera KM, Depping MS, Romanov D, Freudenmann RW, Wolf RC (2020) Abnormal cerebellar volume in somatic vs. non-somatic delusional disorders. Cerebellum & Ataxias, doi: 10.1186/s40673-020-0111-8. eCollection 2020

8.     Schmitgen MM, Kubera KM, Depping MS, Nolte HM, Hirjak D, Hofer S, Hasenkamp JH, Seidl U, Stieltjes B, Maier-Hein KH, Sambataro F, Sartorius A, Thomann PA*, Wolf RC* (2020) Exploring cortical predictors of clinical response to electroconvulsive therapy in major depression. European Archives of Psychiatry and Clinical Neuroscience, 270:253-26 * shared senior authorship.

9.     Listunova L, Bartolovic M, Kienzle J, Jaehn J, Grützner TM, Wolf RC, Weisbrod M, Roesch-Ely D  (2020) Predictors of cognitive remediation therapy improvement in (partially) remitted unipolar depression. Journal of Affective Disorders, 264:40-49

10.     Wolf RC*, Hildebrandt H*, Schmitgen MM, Pycha R, Kirchler E, Macina C, Karner M, Hirjak D, Kubera KM, Romanov D, Freudenmann RW, Huber M (2020) Aberrant gray matter volume and cortical surface in paranoid type delusional disorder. Neuropsychobiology, doi:10.1159/000505601, * shared first authorship.

11.     Wolf RC*, Rashidi M*, Fritze S, Kubera KM, Northoff G, Sambataro F, Calhoun VD, Geiger LS, Tost H, Hirjak D (2020) A neural signature of parkinsonism in patients with schizophrenia spectrum disorders: a multimodal MRI study using parallel ICA. Schizophrenia Bulletin, doi:10.1093/schbul/sbaa007 * shared first authorship.

12.     Horvath J, Mundinger C, Schmitgen MM, Wolf ND, Sambataro F, Hirjak D, Kubera KM, Koenig J, Wolf RC (2020) Structural and functional correlates of smartphone addiction. Addictive Behaviors, in press

13.     Schneider I, Schmitgen MM, Boll S, Roth C, Nees F, Usai K, Herpertz SC, Wolf RC (2020) Oxytocin modulates intrinsic neural activity in patients with chronic low back pain. Eur J Pain, in press,

14.     Schneider I, Schmitgen MM, Bach C, Listunova L, Kienzle J, Sambataro F, Depping MS, Kubera KK, Roesch-Ely D, Wolf RC (2020) Cognitive remediation therapy modulates intrinsic neural activity in patients with major depression. Psychological Medicine, 16:1-11

15.     Schaier M*, Wolf RC*, Kubera K, Nagel S, Bartsch A, Zeier M, Bendszus M, Herweh C (2020) In-vivo MR assessment of vasogenic brain edema during maintenance hemodialysis. Clinical Neuroradiology, in press * shared first authorship.

16.     Kubera KM, Wolf ND, Rashidi M, Hirjak D, Northoff G, Schmitgen MM, Romanov DV, Sambataro F, Frasch K, Wolf RC (2020) Functional decoupling of language and self-reference networks in patients with persistent auditory verbal hallucinations. Neuropsychobiology, in press

17.     Schmitgen MM, Horvath J, Mundinger C, Wolf ND, Sambataro F, Hirjak D, Kubera KM, Koenig J, Wolf RC (2020) Neural correlates of cue reactivity in individuals with smartphone addiction. Addictive Behaviors, in press

18.     Sambataro F, Fritze S, Rashidi M, Bertolino AL, Kubera KM, Wolf RC*, Hirjak D* (2020) Moving forward: distinct motor symptoms predict clinical outcome after 6 months in patients with schizophrenia. European Neuropsychopharmacology, in press *shared senior authorship

19.     Wasserthal J, Maier-Hein KH, Neher PF, Northoff G, Kubera KM, Fritze S, Harneit A, Geiger LS, Tost H, Wolf RC, Hirjak D (2020) Multiparametric mapping of white matter microstructure in catatonia. Neuropsychopharmacology, in press

20.     Depping MS, Schmitgen MM, Bach C, Listunova L, Kienzle J, Kubera KM, Roesch-Ely D, Wolf RC (2020) Abnormal cerebellar volume in patients with remitted major depression with persistent cognitive deficits. The Cerebellum, in press

21.     Wittemann M, Brielmaier J, Rubly M, Kennel J, Werler F, Schmitgen MM, Kubera KM, Hirjak D, Wolf ND, Reith W, Wolf RC (2020) Cognition and cortical thickness in heavy cannabis users. European Addiction Research, in press

22.     Listunova L, Kienzle J, Bartolovic M, Jähn A, Grützner TM, Wolf RC, Aschenbrenner S, Weisbrod M, Roesch-Ely D (2020) Cognitive remediation therapy for partially remitted unipolar depression: a single-blind randomized controlled trial. Journal of Affective Disorders, 276:316-326

23.     Hirjak D, Kubera KM, Wolf RC, Northoff G (2020) Going back to Kahlbaum’s psychomotor (and GABAergic) origins - Is catatonia more than just a motor and dopaminergic syndrome? Schizophrenia Bulletin, 46(2):272-285

24.     Northoff G, Hirjak D, Wolf RC, Magioncalda P, Martino M (2020) All roads lead to the motor cortex - Psychomotor mechanisms and their biochemical modulation in psychiatric disorders. Molecular Psychiatry, in press

25.     Huber M, Kirchler E, Wolf RC (2020) Pharmakotherapie der wahnhaften Störung. NeuroTransmitter 31(6), 47-52

26.     Hildebrandt V, Huber M, Wolf RC (2020) Neuronale Korrelate wahnhafter Störungen. NeuroTransmitter, in press

27.     Wolf ND, Wolf RC (2020) “Smartphone addiction”: fact or fiction? Eine narrative Übersicht zu einem neuen Phänomen. Nervenheilkunde, in press

28.     Walther S, van Harten PN, Waddington JL, Cuesta MJ, Peralta V, Dupin L, Foucher JR, Sambataro F, Morrens M, Kubera KM, Pieters LE, Stegmayer K, Strik W, Wolf RC, Hirjak D (2020) Movement disorder and sensorimotor abnormalities in schizophrenia and other psychoses - European consensus on assessment and perspectives. European Neuropsychopharmacology, in press



1.     Schmitgen MM, Depping MS, Bach C, Wolf ND, Kubera KM, Vasic N, Hirjak D, Sambataro F, Wolf RC (2019) Aberrant cortical neurodevelopment in major depressive disorder. Journal of Affective Disorders, 243:340-347

2.     Cattarinussi G, Di Giorgio A, Wolf RC, Balestrieri M, Sambataro F (2019) Neural signatures of the risk for Bipolar Disorder: a meta-analysis of structural and functional neuroimaging studies. Bipolar Disorders, 21(3):215-227

3.     Sartorius A, Demirakca T, Böhringer A, Clemm von Hohenberg C, Aksay SS, Bumb JM, Kranaster L, Nickl-Jockschat T, Grözinger M, Thomann PA, Wolf RC, Zwanzger P, Dannlowski U, Redlich R, Zavorotnyy M, Zöllner R, Methfessel I, Besse M, Zilles D, Ende G (2019) Electroconvulsive therapy induced gray matter increase is not necessarily correlated with clinical data in depressed patients. Brain Stimulation, 12(2):335-343

4.     Hirjak D, Kubera KM, Northoff G, Fritze S, Bertolino AL, Topor CE, Schmitgen MM, Wolf RC (2019) Cortical contributions to distinct symptom dimensions of catatonia. Schizophrenia Bulletin, 45(6):1184-1194

5.     Fahmy R , Wasfi M, Mamdouh R, Moussa K, Wahba A, Schmitgen MM, Kubera KM, Wolf ND, Sambataro F, Wolf RC (2019) Mindfulness-based therapy modulates default-mode network connectivity in patients with opioid dependence. European Neuropsychopharmacology, 29(5):662-671

6.     Kubera KM, Rashidi M, Schmitgen MM, Barth A, Hirjak D, Sambataro F, Calhoun VD, Wolf RC (2019) Structure/function interrelationships in patients with schizophrenia who have persistent auditory verbal hallucinations: a multimodal MRI study using parallel ICA. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 93:114-121

7.     Thomann AK, Reindl W, Wüstenberg T, Kmuche D, Ebert MP, Szabo K, Wolf RC, Hirjak D, Niesler B, Griebe M, Thomann PA (2019) Aberrant brain structural large-scale connectome in Crohn’s disease. Neurogastroenterology & Motility, 31:e13593

8.     Herpertz SC, Schmitgen MM, Fuchs C, Roth, Wolf RC, Bertsch K, Flor H, Grinevich V, Boll S (2019) Oxytocin Effects on Pain Perception and Pain Anticipation. Journal of Pain, 20(10):1187-1198

9.     Fritze S, Bertolino AL, Kubera KM, Topor CE, Schmitgen MM, Wolf RC*, Hirjak D* (2019) Differential contributions of brainstem structures to Neurological Soft Signs in first- and multiple-episode schizophrenia spectrum disorders. Schizophrenia Research, 210:101-106 * shared senior authorship

10.     Sambataro F, Thomann PA, Nolte HM, Hasenkamp JH, Hirjak D, Kubera KM, Hofer S, Seidl U, Depping MS, Stieltjes B, Maier-Hein KH, Wolf RC (2019) Transdiagnostic modulation of brain network dynamics by electroconvulsive therapy in schizophrenia and major depression. European Neuropsychopharmacology, 29:925-935

11.     Kubera KM, Schmitgen MM, Hirjak D, Wolf RC* Orth M* (2019) Cortical neurodevelopment in pre-manifest Huntington’s disease. NeuroImage Clinical, 23:101913. doi: 10.1016/j.nicl.2019.101913 * shared senior authorship

12.     Hirjak D, Rashidi M, Fritze S, Bertolino AL, Geiger LS, Zang Z, Kubera KM, Schmitgen MM, Sambataro F, Calhoun VD, Weisbrod M, Tost H, Wolf RC (2019) Patterns of co-altered brain structure and function underlying neurological soft signs in schizophrenia spectrum disorders. Human Brain Mapping, 40(17):5029-504

13.     Camilleri JA, Hoffstaedter F, Zavorotny MZöllner R, Wolf RC, Thomann PA, Redlich R, Opel N, Dannlowski U, Groezinger M, Demirakca T, Sartorius A, Eickhoff SB, Nickl-Jockschat T (2019) Electroconvulsive therapy modulates grey matter increase in a hub of an affect processing network. NeuroImage Clinical, Volume 25, 2020, 102114

14.     Kubera KM, Schmitgen MM, Nagel S, Hess K, Herweh C, Hirjak D, Sambataro F, Wolf RC (2019) A search for cortical correlates of trait impulsivity in Parkinson´s disease. Behavioral Brain Research, Sep 2;369:111911

15.     Hirjak D, Kubera KM, Bienentreu S, Thomann PA, Wolf RC (2019) Strategien für den Umgang mit antipsychotika-assoziierten motorischen Symptomen bei schizophrenen Psychosen. Teil 1: Dystonien, Akathisie und Parkinsonismus. Der Nervenarzt, 90:1-11.

16.     Hirjak D, Sartorius A, Kubera KM, Wolf RC (2019) Strategien für den Umgang mit antipsychotika-assoziierten motorischen Symptomen bei schizophrenen Psychosen Teil 2: katatone Symptome und malignes neuroleptisches Syndrom. Der Nervenarzt, 90:12-24.

17.     Hirjak D, Kubera KM, Bienentreu S, Thomann PA, Wolf RC (2019) Strategien für den Umgang mit antipsychotika-assoziierten motorischen Symptomen bei schizophrenen Psychosen. Teil 3: Spätdyskinesien. Der Nervenarzt, 90: 472-484.

18.     Molent C, Olivo D, Wolf RC, Balestrieri M, Sambataro F (2019) Functional neuroimaging in Treatment Resistant Schizophrenia: a systematic review. Neurosci Biobehav Rev, 104-178-190

19.     Sambataro F, Wolf RC (2019) Embarking on antidepressant response prediction using brain perfusion estimation. EClinMedicine, 10:4-5.

20.     Hirjak D, Wolf RC, Northoff G (2019) GABA and negative affect - Catatonia as model of RDoC-based investigation in psychiatry. Schizophrenia Bulletin, 45(6):1168-1169

21.     Hirjak D, Kubera KM, Sambataro F, Wolf RC (2019) Motor domain in psychotic disorders: the rebirth of a concept. European Archives of Psychiatry and Clinical Neuroscience, Jun 25. doi: 10.1007/s00406-019-01036-7


1.     Depping MS, Wolf ND, Vasic N, Sosic-Vasic Z, Schmitgen M, Sambataro F, Wolf RC (2018) Aberrant resting-state cerebellar blood flow in major depression.  Journal of Affective Disorders, 15; 226:227-231

2.     Huber M, Wolf RC*, Lepping P, Kirchler E, Karner M, Sambataro F, Herrnberger B, Corlett PR, Freudenmann RW (2018) Regional gray matter volume and structural network strength in somatic vs. non-somatic delusional disorders. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 73: 31-35 * shared authorship

3.     Kubera KM, Hirjak D, Wolf ND, Sambataro F, Thomann PA, Wolf RC (2018) Intrinsic network connectivity patterns underlying specific dimensions of impulsiveness in healthy young adults. Brain Topography, 31(3):477-487

4.     Kubera KM, Thomann PA, Hirjak D, Barth A, Sambataro F, Vasic N, Wolf ND, Frasch K, Wolf RC (2018) Cortical folding abnormalities in patients with schizophrenia who have persistent auditory verbal hallucinations. European Neuropsychopharmacology 28(2):297-306

5.     Sambataro F, Doerig N, Hänggi J, Wolf RC, Brakowski J, Holtforth MG, Seifritz E, Spinelli S (2018) Anterior cingulate volume predicts response to psychotherapy and functional connectivity with the inferior parietal cortex in major depressive disorder. European Neuropsychopharmacology, 28(1):138-148

6.     Fahmy R, Wasfi M, Mamdouh R, Moussa K, Wahba A, Wittemann M, Hirjak D, Kubera KM, Wolf ND, Sambataro F, Wolf RC (2018) Mindfulness-based interventions modulate structural network strength in patients with opioid dependence. Addictive Behaviors, 82:50-56

7.     Kubera KM, Schmitgen MM, Maier-Hein KH, Thomann PA, Hirjak D*, Wolf RC* (2018) Differential contributions of cortical thickness and surface area to trait impulsivity in healthy young adults. Behavioral Brain Research, 17;350:65-71 * shared authorship

8.     Depping MS, Thomann PA, Wolf ND, Vasic N, Sosic-Vasic Z, Schmitgen MM, Sambataro F, Wolf RC (2018) Common and distinct patterns of abnormal cortical gyrification in major depression and borderline personality disorder, European Neuropsychopharmacology, 28(10):1115-1125

9.     Hirjak DKubera KMThomann PA, Wolf RC (2018) Motor dysfunction as an intermediate phenotype across schizophrenia and other psychotic disorders: Progress and perspectives. Schizophr Res. 200: 26-34

10.     Hirjak D, Northoff G, Thomann PA, Kubera KM, Wolf RC (2018) Genuine motorische Phänomene bei schizophrenen Psychosen: Teil 1 - Theoretischer Hintergrund und Kontextdefinition. Der Nervenarzt, 89:44-50

11.     Hirjak D, Northoff G, Thomann PA, Kubera KM, Wolf RC (2018) Genuine motorische Phänomene bei schizophrenen Psychosen: Teil 2 - Neuronale Korrelate und Pathomechanismen. Der Nervenarzt, 89:27-43

12.     Hirjak D,  Meyer-Lindenberg A, Kubera KM, Thomann PA, Wolf RC (2018) Motor dysfunction as research domain in the period preceding manifest schizophrenia: A systematic review. Neurosci Biobehav Rev 87:87-105

13.     Hirjak D,  Meyer-Lindenberg A, Fritze S, Sambataro F, Kubera KM, Wolf RC (2018) Motor dysfunction as research domain across bipolar, obsessive-compulsive and neurodevelopmental disorders. Neurosci Biobehav Rev, 95:315-335

14.     Hirjak D, van Harten PN, Wolf RC (2018) Motor system dysfunction in the schizophrenia diathesis: From neural systems to neurotransmitters. European Psychiatry, 48:49-50