The Small Animal Imaging Laboratory (SAIL)

Pioneering High-Resolution Imaging for Preclinical Research

The Small Animal Imaging Laboratory (SAIL) is a research facility centered around advanced imaging capabilities within the INF156 Translational Pneumology Site. Anchored by an in vivo Bruker Micro-CT, Model SkyScan 1176, SAIL offers a dynamic environment for conducting both in vivo and ex vivo experiments as well as down stream correlative imaging.

The Bruker SkyScan 1176 is a cutting-edge micro-computed tomography (micro-CT) scanner designed to meet the exacting needs of preclinical and translational research. This advanced imaging system offers unparalleled resolution and versatility, making it an indispensable tool for scientists across the broad range of disease areas in lung research.

 

Key Features of the SkyScan 1176

1. Superior Image Quality:

The SkyScan 1176 delivers exceptional high-resolution images, with isotropic voxel sizes down to 9 µm. This level of detail allows researchers to visualize and analyze intricate internal structures of the lung with outstanding clarity, providing insights that are crucial for advanced scientific investigations.

2. Versatile Imaging Capabilities:

Capable of scanning a wide variety of samples, from small animals to biological specimens and materials, the SkyScan 1176 offers remarkable flexibility. It supports a broad range of applications, including biomedical research, material science, and preclinical studies.

3. Non-Invasive Imaging:

As a non-destructive imaging modality, the SkyScan 1176 enables longitudinal studies by allowing researchers to monitor changes over time without harming the subjects. This is particularly beneficial for preclinical studies involving small animal models, where repeated measurements are often necessary.

4. Advanced Reconstruction and Analysis Software:

The system is equipped with powerful reconstruction software that generates high-resolution 3D images from the acquired scan data. In addition, advanced analysis tools facilitate detailed quantitative assessments, including volumetric, densitometric, and morphometric analysis.

 

Technical Specifications:

Voxel Size: Down to 9 µm

X-ray Source: Micro-focus X-ray tube with variable energy settings

Detection System: High-resolution CCD camera with a large field of view

Scan Modes: Standard, Fast, and Low-Dose

Software: Bruker’s NRecon, Dataviewer, and CTAn for reconstruction and analysis

 

SAIL plays a pivotal role in facilitating research initiatives within the TLRC (Translational Lung Research Center Heidelberg) and the broader DZL (German Center for Lung Research) community. While primarily serving internal researchers, SAIL also fosters collaborations with external partners who share our vision.