Sektion Immuno-Imaging

• Molecular and cellular imaging
• High field MRI (Bruker, 9.4 Tesla)
• Optical Imaging
• Iron oxide nanoparticles
• Theranostics nanoparticles
• Preclinical therapy development
• Gliom-Modelle
• Multiple Sklerose und Experimentelle Autoimmune Enzephalomyelitis)

Es kommen neuartige MRT-Kontrastmittel (Eisenoxid-Nanopartikel) zum Einsatz, welche spezifisch von Immunzellen des Tumormikromilieus aufgenommen werden. Mit diesen Sensoren kann das Tumormikromilieu nicht invasiv charakterisiert werden. Korrelativ kommen optische Bildgebungsverfahren (2-Photonen Mikroskopie, Ultramikroskopie von geclearten Geweben, Konfokalmikroskopie, Immunhistochemie) sowie molekularbiologische und immunologische Techniken (FACS, RT-PCR etc.) zum Einsatz.

Leitung

Team

• Klinische Kooperationseinheit Neuroimmunologie und Hirntumorimmunologie, DKFZ, Leiter Prof. Michael Platten)

• Klinische Kooperationseinheit Neuroonkologie und Experimentelle Neuroonkologie (Prof. Wolfgang Wick, Prof. Frank Winkler)

• AG Translational Modelling (Neuroradiologie, Felix Kurz)

• Sektion Computational Neuroimaging (Neuroradiologie, Philipp Kickingereder)

• AG Eisenstoffwechsel, Molekulare Medizin, Zentrum für Kinder- und Jugendmedizin (Prof. Dr. Martina Muckenthaler)

• Center for System Biology, Massachusetts General Hospital / Harvard Medical School, Boston, USA  (Ralph Weissleder)

• Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School (John W. Chen)

• School of Biomedical Engineering, Drexel University (Christopher Rodell)

seit 9/2021               Emmy Noether Gruppe (DFG)

9/2019 – 8/2021      Memorial Stipendium, Else Kröner-Fresenius Stiftung

7/2019 – 6/2023      Projektleiter: “Imaging immune signatures of glioma response and resistance towards immunotherapy”  im SFB 1389 “Understanding

                                      and targeting resistance in glioblastoma”

1/2018                        Projektförderung: „Gd-MRT Kontrastmittel im Therapiemonitoring bei Multipler Sklerose“, Novartis

4/2017                        Einzelantrag, Else Kröner-Fresenius Stiftung

6/2016                        Graduiertenstipendium Novartis Stiftung

2015 – 2016              Physician-Scientist Fellowship, Medizinische Fakultät Heidelberg

2015 – 2016              Hoffmann-Klose Stiftung, „MRT von vaskulären und immunologischen Krankheitssignaturen in Neuroonkologie und

                                      Neuroinflammation“   

Michael Breckwoldt:

12/2022                 Chica und Heinz Schalller Research Award für biomedizinische Forschung

9/2019                   Lucien Appel Award, European Society of Neuroradiology

10/2016                 Marc Dünzl Preis, Nachwuchspreis dt. Gesellschaft für Neuroradiologie

6/2016                   Best lecture award, ISMRM Workshop Molecular and Cellular MRI

2014                       Neurowind Nachwuchspreis für experimentelle Neurologie

2008                       Kurt-Decker Preis, Nachwuchspreis der dt. Gesellschaft für Neuroradiologie

Kianush Karimian Jazi:

2020                      Past and Pioneers Award, European Society of Neuroradiology (ESNR)

Katharina Schregel:

2016                      Otto-Roth-Preis, Promotionspreis der Medizinischen Fakultät der Universität zu Lübeck

1. Grassl N, Poschke I, Lindner K, Bunse L, Mildenberger I, Boschert T, Jähne K, Green EW, Hülsmeyer I, Jünger S, Kessler T, Suwala AK, Eisele P, Breckwoldt MO, Vajkoczy P, Grauer OM, Herrlinger U, Tonn JC, Denk M, Sahm F, Bendszus M, von Deimling A, Winkler F, Wick W, Platten M, Sahm K, A H3K27M-targeted vaccine in adults with diffuse midline glioma.  Nat Med.2023
    
2. J  Hunger, K Schregel, B Boztepe, DA Agardy, V Turco, K Karimian-Jazi, I Weidenfeld, Y Streibel, M Fischer, V Sturm, R Santarella-Mellwig, M Kilian, K Jähne, K Sahm, W Wick, L Bunse, S Heiland, T Bunse, M Bendszus, M Platten and MO Breckwoldt, In vivo nanoparticle-based T cell imaging can predict therapy 1 response towards adoptive T cell therapy in experimental glioma, Theranostics 2023, in press
    
3. V Turco, K Pfleiderer, J Hunger, NK Horvat, K Karimian-Jazi, K Schregel, M Fischer, G Brugnara, K Jaehne, V Sturm, Y Streibel, D Nguyen, S Altamura, DA Agardy, Shreya S. Soni, A Alsasa, T Bunse, M Schlesner, MU Muckenthaler, R Weissleder, W Wick, S Heiland, P Vollmuth, M Bendszus, CB Rodell, MO Breckwoldt^# and M Platten^#, T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles, Nature Commun, 2023, 14:771
    
4. K Schregel^#, L Heinz, J Hunger, C Pan, J Bode, M Fischer, V Sturm, V Venkataramani, K Karimian-Jazi, D Agardy, Y Streibel, R Zerelles, W Wick, S Heiland, T Bunse, B Tews, M Platten, F Winkler, M Bendszus, and MO Breckwoldt^#, A cellular ground truth to develop MRI signatures in glioma models by correlative light sheet microscopy and atlas-based co-registration, J Neurosci, 2023 7:JN-RM-1470-22
    
5. K Karimian-Jazi, D F Vollherbst, D Schwarz, M Fischer, K Schregel, G Bauer, A Kocharyan, V Sturm, U Neuberger, J Jesser, C Herweh, C Ulfert, T Hilgenfeld, F Seker, F Preisner, N Schmitt, T Charlet, S Hamelmann^, F Sahm, S Heiland, W Wick, PA Ringleb, L Schirmer, M Bendszus, MA Möhlenbruch and MO Breckwoldt, MR microscopy to assess clot composition following mechanical thrombectomy predicts recanalization and clinical outcome, J Neurointerv Surg. 2023 Aug 1:jnis-2023-02059
    
6. M Platten, L Bunse, A Wick, T Bunse, L Le Cornet, I Harting, F Sahm, K Sanghvi, C Leng Tan, I Poschke, E Green, S Justesen, G Behrens, MO Breckwoldt, A Freitag, LM Rother, A Schmitt, O Schnell, J Hense, M Misch, D Krex, D Stevanovic, G Tabatabai, JP Steinbach, M Bendszus, A von Deimling, M Schmitt, W Wick, Phase 1 trial of IDH1-vac, a peptide vaccine for IDH1R132H glioma, Nature, 2021, 592, 463–468
    
7. K Karimian-Jazi*, P Münch*, A Alexander, M Fischer, K Pfleiderer, M Piechutta, MA Karreman, GM Solecki, AS Berghoff, M Friedrich, K Deumelandt, FT Kurz, W Wick, S Heiland, M Bendszus, F Winkler, M Platten and MO Breckwoldt, Monitoring innate immune cell dynamics in the glioma microenvironment by correlated magnetic resonance imaging and multiphoton microscopy (MR-MPM), Theranostics, 2020; 10(4): 1873-1883, *equal contribution  
    
8. A Hahn, J Bode, A Alexander, K Karimian-Jazi, K Schregel, D Schwarz, AC Sommerkamp, T Krüwel, A Abdollahi, W Wick, M Platten, M Bendszus, B Tews, FT Kurz and MO Breckwoldt, Large-scale characterization of the microvascular geometry in development and disease by tissue clearing and quantitative ultramicroscopy, J Cerebr Blood Flow Metab, 2020, 12:271678X20961854
    
9. K Aslan, V Turco, J Blobner, JK Sonner,  AR Liuzzi, N Gonzalo Núñez, D de Feo, P Kickingereder, M Fischer, E Green, A Sadik, M Friedrich, K Sanghvi, M Kilian, F Cichon, L Wolf, K Jähne, A von Landenberg, L Bunse, F Sahm, D Schrimpf, J Meyer, A Alexander, G Brugnara, R Röth, K Pfleiderer, B Niesler, A von Deimling, C Opitz, MO Breckwoldt, S Heiland, M Bendszus, W Wick, B 
Becher and Michael Platten
, Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas, Nature Commun, 2020 18;11(1):931
    
10. A Hoffmann, J Pfeil, AK Mueller, J Jin, K Deumelandt, X Helluy, C Wang, S Heiland, M Platten, JW Chen, M Bendszus, MO Breckwoldt, MRI of Iron Oxide Nanoparticles and Myeloperoxidase Activity Links Inflammation to Brain Edema in Experimental Cerebral Malaria, Radiology, 290(2):359-367
     
11. K Karimian-Jazi, B Wildemann, R Diem, D Schwarz, T Hielscher, W Wick, M Bendszus, MO Breckwoldt, Gd-contrast administration is dispensable in multiple sclerosis patients without new T2/FLAIR lesions on follow-up MRI, Neurol Neuroimmunol Neuroinflamm (2018). 5(5), e480.
     
12. K Kirschbaum*, J Sonner*, M Zeller, K Deumelandt, J Bode, R Sharma, T Kruewel, M Fischer, A Hoffmann, M Costa da Silva, MU Muckenthaler, W Wick, B Tews, JW Chen, S Heiland, M Bendszus, M Platten and MO Breckwoldt, In vivo nanoparticle imaging of innate immune cells can serve as a marker of disease severity in a mouse model of multiple sclerosis, PNAS, 2016 113(46), 13227–13232.  *equal contribution
     
13.  MO Breckwoldt^*, J Bode^*, FT Kurz, A Hoffmann, K Ochs, M Ott, K Deumelandt, T Krüwel, D Schwarz, M Fischer, X Helluy, D Milford, K Kirschbaum, G Solecki, S Chiblak, A Abdollahi, F Winkler, W Wick, M Platten, S Heiland, M Bendszus and B Tews Correlated MR imaging and ultramicroscopy (MR-UM) is a tool kit to assess the dynamics of glioma angiogenesis, eLIFE, 2015; 5:e11712, *equal contribution
     
14. Breckwoldt MO, Pfister F, Bradley, PM, Marinković P, Williams PR, Brill MS, Plomer B, Schmalz, A, St. Clair DK, Naumann R, Griesbeck O, Schwarzländer M, Godinho L, Bareyre FM, Dick TP, Kerschensteiner M* and Misgeld T*, Muti-parametric optical analysis of redox signals during neuronal physiology and pathology in vivo. Nature Medicine, 2014 May;20(5):555-60
     
15. MO Breckwoldt*, JW Chen*, L Stangenberg, E Aikawa, E Rodriguez, S Qiu, M Moskowitz, R Weissleder, Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase, PNAS, 2008, 25;105(47):18584-9. *equal contribution

Candidates interested in M.Sc., PhD, Dr med. or postdoc positions please contact Dr. Michael Breckwoldt (michael.breckwoldt(at)med.uni-heidelberg.de).

See Link.

Open Phd Position

Candidates should provide a CV including names of two references, as well as a letter of motivation. We seek highly motivated candidates with an interest in a translational research environment (imaging sciences, brain tumors, neuroimmunology). We offer a dynamic and supportive research environment within the Collaborative Research Center (CRC 1389, Unite Glioblastoma, www.unite-glioblastoma.de) with access to additional training in the graduate school of Neurooncology, international cooperations and plenty of opportunities to perform cutting edge research in one of the leading biomedical centers in Germany.

Ziel: Immun-Angriff auf Hirntumoren sichtbar machen (uni-heidelberg.de)

Chica und Heinz Schaller Preis: Förderung für heruasragende biomedizinische Forschung