Kliniken &… SFB / DZG SFB TRR 156 Research 1. Funding Period Research Area B: Immune…

B04: Analysis and modulation of the interplay between T cells and keratinocytes in allergic contact dermatitis

Institut für Immunologie Heidelberg

Project B04 concentrates on the interplay between T lymphocytes and keratinocytes (KC) in allergic contact dermatitis. One aim is to characterize the so far unknown structure and function of immune synapses between T cells and KC and to identify allergy related parameters that decide whether antigen recognition on KC leads to T cell activation or anergy (human and mouse models). In collaboration with dermatologists it will be investigated whether disturbing intracellular costimulatory signals is able to prevent the induction or elicitation of allergic contact dermatitis.

Quelle: Institut für Immunologie Heidelberg

Principal investigators

Prof. Dr. med. Yvonne Samstag

Universitätsprofessorin für Zelluläre Immunologie
Leiterin der Sektion Molekulare Immunologie am Institut für Immunologie
Sprecherin von AZKIM, KIG BaWü und train4CIM

06221 56-4039