Kliniken & Institute … Institute Zentrum für… Parasitology Unit Research Sumaya Lab

Malaria research: Sumaya Lab

Projects

Malaria vaccine: Our malaria vaccine candidate is based on the merozoite surface protein 1, which is involved in the invasion of red blood cells by the parasite and the release of daughter cells from the infected erythrocytes. MSP1 as the protein is called is further expressed during the liver stage of the parasite. A recent screen of 500 malaria proteins has identified MSP1 as a top antigen for a protective malaria vaccine. Our vaccine will have two components: a viral MSP1 delivery system to elicit a cellular immune response against liver stages and a protein component to induce a humoral immune response directed against blood stages. The protein component was tested in a first in human clinical trial and was found to be safe and immunogenic, inducing functional antibody responses. 

Malara drug: Our small molecule approach is intended to treat cases of severe malaria. The compound has a novel chemical entity. It is highly active and drug resistance breaking and it has a new mode of action. It’s safety profile is better than that of artesunate, the current treatment of severe malaria. 

News - Sumaya group

EU Malaria Fund supports Sumaya Biotech

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The EU Malaria Fund (EUMF) is a public-private partnership between the European Union, International Organizations, corporations, and organized civic society, providing a novel funding instrument to address market failures in infectious diseases with significant relevance to public health globally. On 30 September the EUMF finalized its investments into four innovative companies active in malaria R&D, among these Sumaya Biotech. In total, nine promising and innovative malaria projects, covering treatments, vaccines, and diagnostics are being supported.

The focus of Sumaya Biotech GmbH & Co. KG is on the clinical development of a novel, innovative malaria vaccine based on the full - length MSP - 1 protein. The second project of Sumaya targets the development of SC83288, an anti - malarial compound. The two projects are carried out in close cooperation with our unit.

1 October 2021: Sumaya lab officially starts work

The Sumaya lab team is growing quickly: on 1st November our new staff member responsible for Quality Management, Dr. Arin Ali, starts and on 15 November a new PhD student, Julia Hibbert, joins the team. In addition, the lab at our unit consists of Richard Thomson Luque, the scientific director and former Postdoc in the alumni lab of Silvia Portugal, Kristin Fürle, senior technician and formerly in the alumni lab of Faith Osier and Micha Rosenkranz, PhD student (also formerly in Faith's lab). The team is further assisted by our MD Philip Hoepffner as Chief Medical Officer. Currently, the Sumaya lab team is situated in INF 345 but is supposed to move to INF 324 once the respective lab space there has been refurbished.

Contact until end of 2021 (ground floor of INF 345)

Office: room 062, tel. 06221-567438

Labs: rooms 005/006, tel. 06221-564415

How to get in touch:

Richard Thomson Luque

Scientific Director Sumaya Lab

Centre for Infectious Diseases, Parasitology
Heidelberg University Hospital
Im Neuenheimer Feld 345
69120 Heidelberg, Germany

Tel. +49 (0)6221 56-7438