ELUCIDATION OF INTRACELLULAR PK/PD RELATIONSHIPS
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Research focus
Highly sensitive mass spectrometric quantification methods and pharmacodynamic assays are used to elucidate relationships between the concentration of a drug in the target cell and its effect. In addition, factors (such as uptake or efflux transporters) that influence concentration and effect are identified.
Mission
Elucidating relationships between intracellular concentration and effect.
Background
Plasma concentrations are often not an appropriate surrogate for the effect of a drug; rather, the concentrations at the site of action, i.e., usually in the target cell, are crucial.
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